Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)

Clinical significance of HIF-2α immunostaining area in radioresistant cervical cancer (초)

김민규 ( Min Kyu Kim ),( Tae Joong Kim ),( You Young Lee ),( Chel Hun Choi ),( Jeong-Won Lee ),( Duk Soo Bae1 ),( Je Ho Lee ),( Byoung Gie Kim ) 대한산부인과학회 2010 대한산부인과학회 학술대회 Vol.96 No.-

물리치료(학)과 학생들이 지각한 물리치료사의 이미지와 자아존중감과의 관련성 분석

김은애 ( Eun Ae Kim ),이건철 ( Geon Cheol Lee ),배원식 ( Won Sik Bae ),김지혁 ( Chi Hyok Kim ) 대한물리의학회 2013 대한물리의학회지 Vol.8 No.1

PURPOSE: The purpose of this study is to look into relationship between image of physiotherapist and self-esteem of physiotherapy students and desirable image of physiotherapists offer to establish basic materials. METHODS: The subjects of this study are consist of 603 students of department of Physical therapy university and college in Busan and Kim-hae. Data are collected from June 9 to July 9 in 2011 by structured questionnaires. RESULTS: The result are as follows. 1. at the physiotherapist image score, the highest score question is Physiotherapist is specialist(3.45) and the lowest score question is Physiotherapist is treated samely with doctor(2.15). 2. at the self-esteem score, the highest score question is I think that I am at least as valuable as others(3.37) and the lowest score question is I can be poorly sometimes(2.81). 3. at the static results of physiotherapist image score gap by general characteristics, there are significantly different in gender(t=2.27, p=.02), similar profession distinction(t=4.30, p=.00), major satisfaction(t=5.74, p=.00), school system (t=-2.54, p=.01). 4. at the static results of self-esteem score gap by general characteristics, there are significantly different in years (f=5.14, p=.00), gender(t=4.09, p=.00), religion(f=2.87, p=.04), similar profession distinction(t=3.97, p=.00), major satisfaction(t=4.26, p=.00). 5. at the static results of good reputation of physiotherapists increase self-esteem of physiotherapy students score question are significantly different(r=0.53, p=.00). CONCLUSION: Accordingly, these results of this study that there is a very correlation between image of physiotherapist and self-esteem of physiotherapy students. Therefore, good reputation of physiotherapists increase self-esteem of physiotherapy students.

권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

온수배관을 이용한 온실의 난방성능

윤용철(Yong Cheol Yoon),신익수(Yik Soo Shin),김현태(Hyeon Tae Kim),배승범(Seoung Beom Bae),최진식(Jin Sik Choi),서원명(Won Myung Suh) (사)한국생물환경조절학회 2012 생물환경조절학회지 Vol.21 No.2

본 연구는 온실의 난방 에너지 절감을 목적으로 온실 내부에 알루미늄 온수배관을 설치하여 난방효과에 대한 기초자료를 구축하고자 수행되었다. 그 연구결과를 요약하면 다음과 같다. 전체 실험을 포함하여 온실내의 높이별 온도편차는 4.0~7.0℃ 정도의 범위로서 그 차이가 크게 나타났다. 팬코일유니트(FCU)를 작동시킨 경우가 작동시키지 않은 경우에 비해 유출입수의 온도차가 3.3℃ 정도 크고, 소비전력량은 36.2~40.1% 정도 증가하였으며, 시간당 방열량은 44.6~52.0% 정도 증가하는 것으로 나타났다. 실험기간동안 순환유량은 0.48~0.49L · s<SUP>?1</SUP> 정도의 범위에 있었고, 평균유속은 1.53~1.56m · s<SUP>?1</SUP> 정도였다. 유출입수의 평균 온도차는 6.24~11.50℃이었다. 최저 외기온 ?14.0~?0.6℃ 범위에서 설정온도별 방열량은 135,930~307,150㎉ 정도의 범위로서 시간당 9,610~19,630㎉ · h<SUP>?1</SUP> 정도의 범위에 있었다. 이것은 최대난방부하의 약 23~53% 정도의 난방에너지를 공급할 수 있을 것으로 나타났다. 전체 방열량과 소비전력량은 각각 2,548,306㎉ 및 3,075.7㎾h이다. 화석연료인 경유로 난방할 경우, 소요되는 경유의 총 소비량은 281.6L 정도이고 비용은 321,000won인 것으로 나타났다. 농가용 전력요금을 적용하면 전력사용에 대한 총비용은 110,730won 정도로서 경유 소비 비용의 33.5% 정도로 나타났다. 실험구의 온도가 대조구보다 약 8.3~14.6℃ 정도 높게 나타났다. This research was conducted to obtain basic data with regard to the heating performance that would be produced by installing an aluminum hot water pipe inside the greenhouse with the goal of reducing the heating energy in greenhouse. The research results are summarized as follows. The degree of difference in relation to the temperature by height within the greenhouse during the entire experiment was significant - within the range of 4.0~7.0℃. The temperature difference between incoming and outgoing water was about 3.3℃ greater when FCU was activated compared to when it was not activated. Meanwhile, the amount of energy consumed increased about 36.2~40.1%. The amount of pyrexia per hour also increased by 44.6~52.0%. During the experiment period, circulated flux was within the range of 0.48~0.49 L · s<SUP>?1</SUP> while average fluid speed was 1.53~1.56 m · s<SUP>?1</SUP>. The average temperature difference between incoming and outgoing water was 6.24~11.50℃. The amount of heating value by each set temperature within the minimum outdoor temperature range of ?14.0~?0.6℃ was 135,930~307,150 ㎉, and the range was within the 9,610~19,630 ㎉ · h<SUP>?1</SUP> per hour. This demonstrated that about 23~53% heating energy of the maximum heating load could be supplied. Total radiating value and amount of energy consumed were 2,548,306 ㎉ and 3,075.7 ㎾h, respectively. When heating takes place using oil, which is a fossil fuel, the total amount of light oil consumed was 281.6 L while the cost was 321,000 won. When the electricity cost for farms is applied, the total cost was about 110,730 won, which is about 33.5% of the cost required compared to oil consumption. The temperature at in the experiment area was about 8.3~14.6℃ higher compared to that of the control area.

경쟁불안이 수영 선수들의 경기력에 미치는 영향

김원배,윤영길,현종호 서울대학교 체육연구소 2000 서울大學校 體育硏究所論集 Vol.21 No.2

The purpose of this study was to identify the effects of performance on the competitive anxiety in competitive situation. To achieve the aim of this study, the subjects were surveyed 172 swimming athletes and all athletes who selected the represent from each province was participated in Busan's Korea National Senior Games on 2000. The CSAI-2 Inventory developed from Martens et al(1990) was used to measure the athlete's psychological anxiety level, the method of survey was visited the athletic club school accommodation before 2 days ago in main events. The results was analysed by SPSS/PC and Mean/Standard Diviation were yielded in each factor. The independant t-test was used to know the difference of cognitive anxiety and physical anxiety on sex, athletic carrear, win experience after Middle School. On the basis of the results analyzed in this study, the conclusion were drawn as follows; 1.The difference of anxiety on sex was significantly appeared. The anxiety of girl players was higher than one of boy players. 2.The difference of anxiety on athletic carrear was significantly appeared. The anxiety of less carrear players was higher than one of more carrear players. 3.The difference of anxiety on win experience didn't significantly appeared.

생활력 있는 상악측절치에서 치내치로 인한 측방치주농양이 형성된 증례

김영진,남순현,김현정,배원수 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.2

치내치는 석회화가 되기전에 치관의 함입에 의해서 야기되어지는 치아의 형태이상이다. 영구치뿐만 아니라 유치에서 발생될 수 있지만 주로 상악 측절치에서 발생하며 그 발생빈도는 0.04-10%로 다양하게 보고되고 있다. 치내치는 치수와 치근단 조직으로 교통될 수 있어 이로 인해서 치수의 염증, 치근잔 농양, 낭종 등을 야기하거나 내흡수를 일으킬 수도 있으며 치관의 형태이상을 보이는 등 심미적인 문제도 초래할 수 있다. 치내치는 그 함입의 정도에 따라서 Oehlers씨에 의해서 3가지 형태로 구분된다. 치내치의 다양한 형태중 Type 3의 치내치는 치내치 함입부가 치수와의 교통없이 치근단공이나 측방치주조직으로 opening을 형성하는 형태로 치수감염의 여부에 따라 치료전략이 달라지며, 치수감염에 의한 병소가 존재하는 경우에는 함입된 형태와 복잡성을 고려하여 통상적인 근관치료, 외관적 치근단 절제술, 의도적 재식술 및 발치를 시행할 수 있다. 본 증례에서는 근첨이 개방된 측방 치주공을 가진 치내치로 해당치아가 생활력을 보이고 invagination의 형태가 단순하였기에 invagination에 한정된 근관치료와 근첨형성술을 통하여 성공적인 결과를 보였으며 다을과 같은 결과를 얻었다. 1. Type 3 치내치의 경우에서 치아의 생활력이 유지되고 invagination의 형태가 복잡하지 않다면, 그리고 치수와 invagination과의 교통의 증거가 없다면 invagination에 한정된 근관치료로서 병소의 해결과 해당치아의 생활력 유지가 가능했다. 2. 개방된 근첨을 가진 invagination을 보이는 치내치의 경우 근첨형성술로 개방된 근첨의 폐쇄를 유도할 수 있었고 이런 점을 이용 외과적 술식을 피할 수 있었다. Dens invaginatus is a developmental anomaly resulting from and invagination of the enamel organ. The incidence is highest with maxillary permanent lateral incisors. The reported occurrence ranges from 0.04 to 10%. This anomaly may involve the pulp and periapical tissues and cause pulpal inflammation, loss of vitality, apical and lateral periodontitis, periapical abscesses and cysts and stimulate internal resorption. Oehlers describes dens invaginatus as occurrence in three forms. In treating type 3 invaginatus, treatment strategy can be determined by considering the complexity and accessibility of invagination. In this case, showing simple invagination, it could be treated by simple endodontic treament confining to invagination without loss of vitality of tooth. After treatment of the present case, the results were as follows: 1. In type 3 dens invaginatus, if the tooth is vital and there is no evidence of communication between invagination and pulp, we can save the vitality of the tooth and resolve the lesion by endodontic treament confining to the invagnation. 2. In the invagination with opened apex, the closure of apex can be induced by apexification procedure doing this, we can avoid the neccessity of surgical invagination.

초경량성 재료인 Mg-10Li-3A1 합금의 TMP 처리를 통한 기계적 특성 향상 방안

김광배,홍준표,김영인,홍원식,배현근 한국 항공대학교 항공산업기술연구소 1998 航空宇宙産業技術硏究所 硏究誌 Vol.8 No.-

초경량 고강도 Mg-10Li-3Al 합금이 용탕단조법에 의해 제조되었다. 주도된 상태의 미세구조는 β상 기지에 균일하게 분포된 AlLi 및 MgAl₂Li를 포함하는 HCP α상과 BCC β상으로 이루어졌다. α상의 초기 결정립 크기는 100㎛였다. Mg-Li 합금에 Al을 첨가하는 것은 용체화 처리 및 시효를 통한 석출 경화에 기인하여 합금의 강도 및 경도를 향상시켰다. 결정립 미세화를 위한 TMP처리가 냉간 가공과 연이은 300℃, 30분 동안의 어닐링에 의해 수행되었다. 결과적으로 나타나는 미세구조는 재결정화되지 않은 α상과 재결정화된 β상으로 이루어졌다. 냉간 가공량이 증가함에 따라 합금의 결정립 크기가 감소하였고, 최종 결정립 크기는 3.5㎛였다. 가공 열처리된 Mg-10Li-3Al합금은 용탕단조된 합금보다 높은 강도와 연신율을 보였다. Superlight and high strength Mg-10Li03Al alloys were fabricated by squeeze casting. The as-casted microstructure was consisted of a mixture of a mixture of HCP α and BCC β phases including AlLi and MgAl₂Li precipitates, which were uniformly distributed in the βmatrix. Initial grain size of α phases was 100㎛. The addition of Al in Mg-Li alloy had improved the strength and hardness due to the precipitation hardening through solution heat treatment and aging. Thermomechanical Processing(TMP) for grain refinement was carried by cold working and immediate annealing for nucleation at 300℃ for 30 minutes. Subsequent microstructure was consisted of unrecrystallized α and recrystallized β phases. The more the amount of cold working increased, the more the grain size of the alloy was decresed. Final grain size was 3.5㎛. Thermomechanically processed Mg-10Li-3Al alloy had higher strength and elongation than as-casted alloy.

아황산가스가 흰쥐 허파조직내 Laminin 활서에 미치는 영향에 대한 면역조직학적 연구

배성만,정호삼,서윤경,백두진,김원규,윤지희 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.2

Sulfur dioxide (SO_2), a kind of air pollutant, causes harmful damage to human body. In particular, inhalation of sulfoxide dioxide has been demonstrated to result in the injury to the upper respiratory duct. However, mechanisms by which SO_2 affects these tissues remain to be clarified. In the present study, to investigate the mechanism of SO_2 effects, the influence of SO_2 exposure was examined in terms of the injury of lung and the expression pattern of laminin in the basal lamina. The basal lamina is an important tissue for the regulation of internal respiration by composing of air-blood barrier. Sprague-Dawley rats repetitively exposed to a mixture of O_2 gas and SO_2 gas (250 ppm) for 30 minutes a day were sacrificed to observe the distribution of laminin in the alveolar septum as well as the morphological alteration of alveoli using immunohistological methods. The resutls we observed were as follows: 1. Alveoli from SO_2-exposed rats (for 5 days) were strongly stained with anti-laminin antibody, suggesting laminin expressed at the high level, at week 1 to 3 upon exposure to SO_2 2. At week 1 to 3 after exposure of rats to SO_2, alveolar septa were collapsed, leading to the reduction of alveolar volume along with morphological changes to irregular shapes. 3. At week 4 to 6 after exposure of rats to SO_2, alveoli were weakly stained with anti-laminin antibody, suggesting laminin expression was decreased during this period. 4. Rats sacrificed at week 7 upon exposure to SO_2 exhibited the expansion of new alveoli and the expression of laminin was partially recovered up to the intermediate level. Taken together, these results demonstrate that the expression of laminin was enhanced in the early phase, followed by downregulation in the late phase. Moreover, lung injury and resolution were correlated with the level of laminin. Thus, these results suggest that SO_2 suppresses the expression of laminin, which may be associated with the neo-generation of lung tissue.

주택에서 Box Model을 이용한 평균 환기율 및 이산화질소 발생량 추정

배현주,양원호,손부순,김대원 한국환경과학회 2004 한국환경과학회지 Vol.13 No.7

Indoor air quality is affected by source strength of pollutants, ventilation rate, decay rate, outdoor level, and so on. Although technologies measuring these factors exist directly, direct measurements of all factors are not always practical in most field studies. The purpose of this study was to develop an alternative method to estimate these factors by application of multiple measurements. For the total duration of 30 days, daily indoor and outdoor NO₂ concentrations were measured in 30 houses in Brisbane, Australia, and for 21 days in 40 houses in Seoul, Korea, respectively. Using a box model by mass balance and linear regression analysis, penetration factor (ventilation divided by sum of air exchange rate and deposition constant) and source strength factor (emission rate divided by sum of air exchange rate and deposition constant) were calculated. Subsequently, the ventilation and source strength were estimated. In Brisbane, the penetration factors were 0.59±0.14 and they were unaffected by the presence of a gas range. During sampling period, geometric mean of natural ventilation was estimated to be 1.10±1.51 ACH, assuming a residential NO₂ decay rate of 0.8 hr^(-1) in Brisbane. In Seoul. natural ventilation was 1.15±1.73 ACH with residential NO₂ decay rate of 0.94 hr^(-1). Source strength of NO₂ in the houses with gas range (12.7±9.8 ppb/hr) were significantly higher than those in houses with an electric range (2.8±2.6 ppb/hr) in Brisbane. In Seoul, source strength in the houses with gas range were 16.8±8.2 ppb/hr. Conclusively, indoor air quality using box model by mass balance was effectively characterized.