Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

Pender의 건강증진모형을 적용한 간호대학생의 건강증진행위 관련요인

한석영(Han, Seok­Young) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.8

본 연구목적은 Pender의 건강증진모형을 적용하여 간호대학생의 건강증진행위의 관련변인과 영향요인들을 확인함으로써 간호대학생의 건강증진을 위한 간호중재 방법의 개발을 위한 기초자료를 파악하는데 있다. K 광역시에 소재한 간호대학교의 간호대학생 399명을 대상으로 자료수집을 하였고, 자료분석은 SPSS/WIN 19.0을 사용 하여 대상자의 일반적 특성은 빈도와 백분율을, 대상자의 일반적 특성에 따른 건강 증진행위의 차이는 t-test와 ANOVA로 분석하여 Scheffé test로 사후검증하였고, 건강증진행위 관련요인들과의 상관관계는 Pearson’s correlation coefficient로, 건강증 진행위에 영향을 미치는 요인은 step­wise multiple regression을 이용하였다. 간호대 학생의 건강증진행위 평균은 2.66점이었고, 건강증진행위와 변수들과의 상관관계는 이전 건강관련행위(r=.300, p=.000), 지각된 장애성(r=.178, p=.000), 행위관련 감정 (r=.106, p=.034), 행동계획수립(r=.195, p=.000)과 유의한 순상관관계를 보였다. 간호 대학생의 건강증진행위에 영향을 미치는 가장 중요한 요인은 학년으로 2학년 이 전체 변이의 21.8%를 설명하였고, 이전 건강관련행위, 행동계획수립, 행위관련 감정, 지각된 장애성, 연령과 함께 전체 변이의 36%를 설명하였다. 따라서 본 연구에서 간호대학생의 건강증진행위를 가장 잘 설명해주는 요인으로는 개인적인 특성에서 학년으로 나타났다. 이상의 연구결과를 바탕으로 간호대학생의 학년 및 연령에 따른 건강증진 프로그램이 요구되고, 이전의 건강관리행위, 행동계획수립, 행위관련 감정, 지각된 장애성을 고려한 건강증진 프로그램으로 효과를 높일 수 있는 전략이 필요하 다. The purpose of this study was to identify the factors influencing health promoting behaviors and the related determinants affecting nursing college student’s health based on the Health Promotion Model by Pender(1996). The data was collected by self-reported questionnaire from 399 participants under the permission of data collection in at K metropolitan city. For data analysis, SPSS/ WIN 19.0 program was utilized for descriptive statistics, t­test, ANOVA, Scheffé test, Pearson’s correlation, and step­wise multiple regression. The average score for the HPBs, consisting of 6 subscales was 2.66. The highest mean score was 2.80 in ‘interpersonal relations’ and the lowest one was 2.54 in ‘Physical activity’. The HPBs were positively associated to ‘prior related behavior’ (r=.300, p=.000), ‘perceived barriers to action’ (r=.178, p=.000), and ‘activity related affect’ (r=.106, p=.034), and ‘commitment to a plan of action’ (r= .195, p=.000). The most important variable in HPBs was ‘2nd grade’. It explained 21.8 % out of the total variance of HPBs. ‘Prior related behavior’, ‘perceived barriers to action’, ‘activity related affect’, ‘commitment to a plan of action’, and ‘age’ explained 36%. According to the results of this study, the suggestions were as follows. It is necessary to develop program considering the grade of nursing college students. To facilitate and maintain HPBs of nursing college students must be mutually planned interactive health prevention programs.

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

전파조정기를 이용한 마이크로파 소자용 Calibration

석은영,조현광,서영석,한교용 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

A microwave device measurement tool kit using the TRL method for microwave tuner was developed. Teflon substrate was used for easy manufacturing. An adapter from CDI was used for the junction transition between microstrip and coaxial line. Mask production procedure which have the 3:1 reduction ratio was developed for microstrip transmission line manufacturing. Using these procedure the Cal Kit which can have Thru, Reflect, and Line was manufactured. TRL error correction method can be applied to the Kit. We tested the Cal kit and the error due to the microstrip line could be corrected. It can be applicable to the accurate measurement of microwave transistors.

신경증을 수반한 Paroxysmal Dystonic Seizure 2례

한기석,정영조 인제대학교 1989 仁濟醫學 Vol.10 No.3

신경증을 수반한 paroxysmal dystonic seizure 2례를 치험하였기에 문헌 고찰과 함께 이를 보고한다. The auther experienced a varient form of idiopathic reflex epilepsy ; paroxysmal dystonic seizure. The Two cases described in which motor seizure, consisting usually of focal or generalized paroxysmal dystonic writhing movements without loss of consciousness, were provoked by sudden movement. And they also suffered from panic disorder with agoraphobia, conversion disorder, avoident behavior and hypochondriacal ideation due to underlying paroxysmal dystonic seizure. This form of epileptic attack showed good response to anticonvulsant medication and the neurotic symptoms were relieved by supportive psychotherapy and behavioral therapy.

인체 방광암에서 p33^ING1의 발현 변화

이석영,신관희,한광희,이상철,김용태,김원재 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

청소년 자살의 원인과 치료적 개입

한기석,정영조 인제대학교 1992 仁濟醫學 Vol.13 No.2

최근 청소년 자살이 증가하고 있으므로 청소년 자살의 원인과 자살의 예측인자에 대한 고찰을 통하여 이들의 자살을 예방하고 치료에 도움이 되고자 하였는데 특히 부모, 교사 및 일반 타과 의사에게 도움이 되도록 기술하였다. Currently, the suicidal rate is rising most rapidly in adolescence. In this article, we review the recent research for causes and therapeutic intervention of adolescent suicide. The risk factors include psychiatric disorders-such as affective, conduct, and subatance abuse disorders-, developmental and personality types, familial and environmental factors, and biologic factors. It is important for us to prevent suicide that is extensive efforts for early identification and intervention. And it is also needed changes in value system, the attitude of repoters, and the way of bringing up children for prevention it,

중파자외선에 대한 남극산 해조류의 광합성 및 자외선 흡수물질 형성 반응

한태준,박병직,한영석,강성호,이상훈 한국환경생물학회 2002 환경생물 : 환경생물학회지 Vol.20 No.3

남극에 생육하는 5종의 홍조류(Curdiea racovitzae, Gigartina skottsbergii, Mazzaella obovata, Myriogram- me manginii, Palmaria decipiens)를 대상으로 인공 중파 자외선과 태양광선에 대한 종별 생리적 반응을 광합성이라는 파라미터를 사용하여 조사 연구하였다. 실험실 연구 결과,종간에 중파 자외선에 대한 내성 차이가 확인되었으며 이러한 차이는 각 종들이 채집되기 전에 서식하고 있었던 수심과 매우 밀접한 관계가 있어서 20~30m의 수심에서 채집된 M. manginii와 P. decipi-ens의 자외선 내성이 다른 종들에 비하여 작게 나왔다. 본 연구 결과는 서식지 주변의 광환경이 해조류의 자외선 내성을 결정해 주는 한 요인이라는 가설을 입증해주었을 뿐 아니라 형광 변화를 이용한 광합성 측정법은 자외선 내성을 타진하는데 있어서 매우 신속하고 비파괴적인 방법으로 이용될 수 있음을 입증하였다. 두 종의 홍조류(M. manginii, P. decipiens)를 대상으로 태양광선 하에서의 광합성 효율을 관찰한 결과, 정오 에 최저 광합성을 보인 반면 저녁에는 광합성 능력이 회복되는 현상을 나타내었다. 이같은 동적인 광저해 현 상(dynamic photoinhibition)은 일종의 광적응 능력으로서 식물이 비교적 강한 태양광선에 노출된 지역에 성공적으로 서식하는데 크게 기여하는 것으로 사료된다. 본 연구에서는 또한 태양광선내 중파자외선 포함 유무에 따라 광합성 회복 속도에 차이가 나는 것을 볼 수 있었는데 중파자외선이 포함된 태양 광선 하에서는 광합성의 회복이 느린 반면,중파 자외선이 제거된 조건에서는 광합성이 비교적 빨리 회복되는 것을 관찰할 수 있었고 이는 중파 자외선이 광합성 회복 기작을 지연시키는 작용을 한 것으로 해석될 수 있다. 야외에서 자외선 민감성을 비교한 결과, P decipiens가 M. manginii에 비하여 자외선 내성이 큰 것으로 나타났는데,두 종 공히 조간대로부터 조하매 상부까지 서식하는 종임에도 불구하고 이러한 내성차이를 보인 이유는 자외선 흡수물질의 정량적인 차이에 기인한다고 할 수 있다. M. manginii와 P. decipiens에서 발견된 자외선 흡수물질의 양은 약 1.2 정도의 비율을 보였는데 이러한 정량적 차이가 자외선 민감성에 기여한 것으로 사료된다. 본 연구에서는 또한 계절별 그리고 채집 수심별로 자외선 흡수물질의 정량적 차이를 발견할 수 있었는데 태양광선이 풍부한 여름철에 그리고 고광량이 도달되는 수심 얕은 곳에 서식하는 개체가 더욱 많은 양의 자외선 흡수물질을 함유한 것으로 나타났다. Effects of artificial and solar UV-B radiation on five rhodophytes (Curdiea racovitzae, Gigartina skottsbergii, Mazzaella obovata, Myriogramme manginii, Palmaria decipiens) from Antarctica have been investigated using PAM fluorescence in laboratory and in the field. Laboratory studies showed that there were significant differences in the UV sensitivity between different species, and that the differences appeared to be correlated with the depth of collection of the specimens. It was apparent from the observations that the samples such as M. manginii and P. decipiens collected from 20∼30 m depths were more sensitive to UV-B radiation compared with those collected from shallower depths. The present study confirmed that an acclimation to the surrounding light regime could be an important factor to determine the UV-sensitivity of a species or individuals and that PAM measurements are rapid and non-destructive methods to evaluate UV influences. From field studies on M. manginii and P. decipiens it was observed that both plants exhibited changes in the effective quantum yield, with the minimum values at noon followed by a recovery in the evening. Photoinhibition occurred in these species could therefore be accounted for by so-called dynamic photoinhibition. It seems likely that this protective mechanism may contribute to survival of the species in shallow water where they may encounter intense solar radiation. The presence or absence of the UV-B component under solar radiation differently affected the photosynthetic recovery process, and the rate of recovery was much slower in UV-present than in UV-absent conditions. Functional role of UV-B appears to delay the recovery of photosynthesis in the studied macroalgae. Differential sensitivity to UV-B recognised between M. manginii and P. decipiens seemed to correspond well with the amount of UV-absorbing substances(UVAS) contained in the respective species. Higher tolerance to solar radiation by the latter species may be due to the higher amount of UVAS. There were variations of UVAS concentrations in algal thalli depending on the season and depth of collection.

당의 종류를 달리한 녹차다식의 제조특성

한영숙,김소라,최원석 誠信女子大學校 生活文化硏究所 2009 生活文化硏究 Vol.24 No.1

For this study, potato starch, an easily accessible ingredient, was used to make the traditional pressed sweet, dasik, with honey, sirup and fructooligosaccharides as the binding material and green tea powder added to create“ green tea dasik.”Green tea dasik were then examined on their qualities such as sugar content, moisture, Aw, pH, color and mechanical measurements and the sensory acceptability was evaluated. To improve the texture of green tea dasik with 8% green tea powder, honey and fructooligosaccharides were respectively used in place of sirup as the binding material. As a result, the sugar content was the highest when honey was used, but it was also higher with fractooligosaccharides than with sirup. The moisture content was the highest with honey; Aw was the lowest with fractooligosaccharides; and pH was the highest with sirup. The chromaticity test results showed that the L value was the lowest with honey, revealing dark colors. Dasik with fractooligosaccharides showed the brightest colors. As for the a value, dasik using honey, sirup and oligosaccharide showed -5.93, -2.64 and -8.85, respectively. The b value for yellow chromaticity was the highest with fractooligosaccharides. The mechanical measurement test results showed that dasik with fructooligosaccharides have the highest values in elasticity, cohesiveness, chewiness and gumminess. In the sensory acceptability test, the scores for dasik with honey were high in color, sweetness and moistness while the scores for dasik with fructooligosaccharides were the highest in adhesiveness, chewiness, hardness and overall acceptability. As a result of investigating the characteristics in the making of green tea dasik, fructooligosaccharides are evaluated highly as a possible ingredient of dasik.