정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

외상성 뇌손상 환자의 삶의 질에 대한 임상적 고찰

노승호,천영훈 圓光大學校 醫科大學 神經精神科學敎室 1998 圓光精神醫學 Vol.14 No.1

목적 : TBI 후유증의 증상이 안정된 이후 환자들의 삶의 질은 어느 정도의 수준인지, 그리고 삶의 질 수준이 높은 집단과 낮은 집단은 인구 통계적 변인, 정신사회적 기능 및 신경행동 증상들의 측면에서 어떤 차이가 있는지를 알아보고자 하였다. 방법 : TBI 환자 46명 중 삶의 목적 수준이 높은 집단과 낮은 집단을 각각 15명씩 선정하여 대상군으로 하였고, TBI 환자의 친지들 중 연령과 성 및 교육수준이 비슷한 사람들을 선정하여 대조군으로 하였다. QOLI, SIP, PIL, HISC, NRS를 사용하여 삶의 질, 정신사회적 기능, 삶의 목적, 자각적 및 타각적 신경행동 증상을 평가하여 서로 비교하였다. 결과 : 1)TBI군의 삶의 질은 정상 대조군의 1/3 수준(66.1±23.4 : 6.5±2.5)이었으며, 정신 사회적 기능 및 삶의 목적 수준은 대조군보다 유의하게 낮았고, 자각적 및 타각적 신경행동 증상은 유의하게 심했다(P<.01). 2)TBI군 중 삶의 질 수준이 높은 집단은 낮은 집단에 비해 외상 전과 외상 후 지능이 유의하게 높았다(각각 p<.05, p<.01). 그러나 연령, 성비, 교육수준, 결혼 및 직업상태, 외상의 원인 및 심각도, 외상후 기간에서는 두 군 간에 차이가 없었다. 3)TBI군 중 삶의 질 수준이 높은 집단은 낮은 집단에 비해 정신사회적 기능과 삶의 목적 수준이 유의하게 높았으며, 자각적 및 타각적 증상은 더 적었다(각각p<.01, p<.05, p<.01, P<.05). 4)STBI는 MTBI보다 정신사회적 장해와 자각적 증상이 유의하게 심했다(p<.05, p<.05).그러나 삶의 질 및 목적 수준과 타각적 증상은 두 군간에 차이가 없었다. 결론 : TBI 환자의 삶의 질은 증상이 고정된 이후에도 비장애인보다 현저히 낮은 수준에 머물고 있었으며, 삶의 질 수준이 상대적으로 높은 집단은 낮은 집단에 비해 수상 전, 후의 지능이 높았고, 외상의 심각도가 낮았으며, 정신사회적 기능과 삶의 목적 수준은 더 높았고, 자각적 및 타각적 증상은 더 적었다. This study was designed to investigate the quality of life(QOL) level of the patients with TBI after the symptoms of sequelae was stabilized, and the differences between the patients with higher QOL and those with lower QOL and those with lower QOL in demographic variables, psychosocial functioning, and neurobehavioral symptoms. The subjects were composed of patients with higher QOL(N=15, Group 1) and those with lower QOL(N=15, Group 2), who were assigned according to the level of QOL among 46 patients with TBI, and 30 normal control group. The levels of QOL, psychosocial functioning, purpose in life, and subjective and objective neurobehavioral symptoms were rated by QOLI, SIP, PIL, HISC, and NRS. The results was as follows. 1)In comparing to the normal control group, QOL level of TBI group remained about 1/3 of that of control(66.1±23.4 : 6.5±2.5, respectively). The brain injured patients had significantly lower levels of psychosocial functioning and purpose in life(p<.01), and more severe subjective and objective neurobehavioral symptoms(p<.01). 2)In comparing demographic and clinical variables between Group 1 and 2, pre- and post- injury IQ of Group 1 were significantly higher than those of Group 2(p<.05, p<.01, respectively). But significant differences were not found in other variables(e.g., age, sex, education, marital status, cause and severity of injury, and duration after injury). 3)Group 1 had significantly higher psychosocial function and purpose in life levels, and less subjective and objective symptoms than Group 2(p<.01, p<.05, p<.01, p<.05, respectively). 4)STBI experienced more severe psychosocial impairment and subjective symptoms than MTBI(p<.05, p<.05). However, in QOL and purpose in life level and objective symptoms there were no difference between STBI and MTBI.

마케팅 커뮤니케이션 도구로서의 스포츠 스폰서십에 관한 연구

노영태,이영덕,이상봉,박병주,전동호 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

The objective of this paper is to build sports sponsorship strategic through studying the state of sports sponsorship and the case study in foreign country. I propose the sports sponsorship strategic in new approach to build the structure of more positive sports sponsorship and the understanding of sports player management in korea that greets 2002 World Cup. For that, To build newly sports sponsorship strategic must have the following requires; 1. The transition of think ; from cost concept to investment concept It is necessary the transition of think from cost concept which is a short startegic to investment concept. That is, it hope to the possibility of player lastingly than to immediately short effect which is used by activating player popular in advertisements. 2. More intensive services for customs It is necessary to show the goal accomplished possible for sports fans, ad maintain sponsorship in long run. In same time, we must aware the publics to be understood of a better cooperate image. 3. To secure a specialty It is necessary to bring up the linkage industry and the manpower of specialist for activating sports as a business dimension, not as a hobby and a nation representative. It must expand specialist to the scout management, the advertisement and the event opening.

남매에서 발생한 심한 용혈성 빈혈과 간경변증을 동반한 Wilson 병 2례

노영일,박동호,서우철,문경래,박상기,박영봉,이미숙,전호종 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

We experienced two case of Wilson's disease in female and male sibling. The first case was a 10 year-old female who showed jaundice. pancytopenia and cirrhotic change in liver biopsy. She died 10 days after diagnosis. The second case of 7 year-old male showed specific symptoms and revealed increased AST/ALT, low serun copper level and increased 24 hour urinary copper excretion level He is being treated with D-penicillamine and follow up examinations.

PECVD로 제작한 수소화된 비정질 탄소(a-C:H) 박막의 화학결합 구조에 관한 연구

노지연,이석호,오동선,박혁렬,김영산 木浦大學校基礎科學硏究所 1997 基礎科學硏究誌 Vol.15 No.-

Hydrogenated amorphous carbon(a-C:H) films were prepared by PECVD(Plasma enhanced-chemical vapor deposition) method. The films were characterized using various spectroscopic measurements such as Raman scattering, FTIR(Fourier transform infrared) absorption spectroscopy. FRIR absorption reflects only the optically active hydrogen in the a-C:H and, using it together with Raman spectroscopy. The spectral analysis indicated that changes in Raman spectroscopy intensity occurring with increasing substrate temperature 50℃~300℃ were determined to be caused by changes in optically resonant components in the films. Furthermore, a significant correlation was the two crystalline forms of carbon-graphite and -diamond consist of sp² and sp³ bonds, respectively. Significant changes in chemical bonding(sp²/sp³) and micro-structure of hydrogenated amorphous carbon thin films occur as the substrate temperature varies from 50 to 300℃ during.

한국기업의 時間基準 競爭을 위한 工程 慣行의 分析

노부호,박영수 서강대학교 경영학연구원 2003 서강경영논총 Vol.14 No.1

본 연구의 목적은 산업별로 시간기준 생산시스템을 수립하는데 기여하는 공정 관행을 분석하는 것이다. 연구의 결과는 다음과 같다. 첫째, 기계산업은 신속한 납기를 위해 기업 내부적인 동시공학과 설비의 보수유지 활동에 많은 투자가 필요하다. 둘째, 섬유산업은 장치형 산업의 특성 때문에 시간기준 생산시스템을 수립할 때 공정관행은 크게 기여하지 못한다. 단지 pull 생산만이 시간경쟁이 기여하는 것으로 나타났다. 셋째, 전기·전자산업은 유연성 향상을 위한 공정관행 즉 셀생산, 외부적인 동시공학 활동, 준비시간 단축 등을 위해 노력해야 한다. 특히 다른 산업과는 달리 고객의 요구를 제품에 반영하기 위해서 실시되는 외부적인 동시공학 활동을 수행함으로써 시간 경쟁능력을 향상시킬 수 있다. The purpose of this study analyzes the ways to establish time-based manufacturing system is the aspect of practices of process practices by the individual industry. The results of this study are as follows. First, the machine industry needs activities for internal CE and maintenance demand a lot of support for delivery promptly. Second, the textile industry show that process practices no contribute to establishment of time-based manufacturing system. Bur pull production contribute to time competition. Third, the electric Industry and the electronic industry must exert themselves to attain the process practices - cellular manufacturing, external concurrent engineering and reduction of setup time - to improve flexibility. Contrary to the different industries, performing external concurrent engineering to reflect customers' demands in products ran raise the ability for time competition.

나프탈렌슬폰산 축합물계와 말레인산 공중합체계 콘크리트용 유동화제가 첨가된 시멘트 현탁용액의 거동

노재성,류호석,조헌영 忠南大學校 産業技術硏究所 1994 산업기술연구논문집 Vol.9 No.1

The behavior of adsorption, the variations of zeta potential, the behavior of sedimentation in the cement suspensions added with Naphthalene Sulfonated Formaldehyde Condensate (β-NSF) and Maleic Anhydride Copolymer (MA) were investigated. Also the variations of mini slump, the time evolutions of mini slump and the setting times of the cement pastes fluidity with β-NSF and MA were tested. From this research, it is cleared that β-NSF has a strong effect on the fluidized of the cement paste and MA affects to keep the fluidity of the paste for a long time.

Sulfonylurea계 제초제를 이용한 올방개 방제 효과 증진 연구

노영덕,이민호,김영채,김현철 경희대학교 생명자원과학연구원 2000 硏究論文集 Vol.21 No.-

본 실험은 수도에서 문제 잡초로 대두되는 올방개의 효과적인 방제법을 구명하고자 sulfonylurea계 제초제를 각각의 약제간, 시기별로 구분하여 처리하였고, 주요 결과는 다음과 같다. 1 약제처리시기에 따른 올방개 방제효과는 이앙 후 10일 처리에서 Bensulfuron-methyl, Pyrazosulfurone-thyl, Azimsulfuron, Imazosulfuron, Halosulfuron, Cinosulfuron, Cyclosulfamuron 이상 7종이 올방개 방제효과가 우수했고, 이중 Bensulfuron-methyl, Pyrazosulfuron-ethyl, Azimsulfuron, Imazosulfuron은 이앙 후 20일 처리에서도 방제효과가 우수했다. 2 Pyrazosulfuron-ethyl + Mefenacet 합제를 시기별로 처리한 결과 이앙 후 14일과 21일 처리에서 90%이상의 방제가를 보여 우수한 방제효과를 보였던 반면, 이앙 후 7일과 28일 처리에서는 방제효과가 떨어졌다. 3. Befurasate는 Pyrazosulfuron-ethyl과 Azumsulfuron을 혼합사용하였을 때, Cyclosulfamuron은 Azimsulfuron과 혼합사용하였을 때 올방개의 방제가 증대되는 상승적 작용이 관찰되었다. 4. 이앙 동시처리제인 Imazosulfuron + Fentrazamude 합제, Imazosulfuron + Oxaziclo mefone + Dymron 합제, Bensulfuron-methyl + Fentrazamide합제의 경우 올방개의 방제가가 각각 68%, 76% 66%로, 이앙 후 10일에 처리한 Pyrazosulfuron-ethyl + Mefenacet 합제보다 방제가가 낮아, 올방개가 우점된 논에서의 이앙 동시처리제에 의한 올방개 방제는 어려운 것으로 판단되었다. Sulfonylureas are quite recent low dosage and wide spectrum herbicides, popularly used in paddy rice field. The acetolactate synthase inhibitors are effective for the control of broad leaf and perennial paddy weeds, however for the control of Eleocharis Kuroguwal Ohwi has been reported less than satisfactory. Therefore, present commercial sulfonylureas were evaluated for the control efficacy of Eleocharis Kuroguwal Ohwi and the time of application was studied for the better control. Among the tested sulfonylureas, Bensulfron-methyl, Pyrazosulfuron-ethyl, Azimsulfuron and Imazosulfuron exhibited 80% or better control efficacy at both treatments of 10 and 20 days after transplanting (DAT). While Halosulfuron, Cinosulfuron, and Cyclosulfamuron showed good weed control from 10 DAT treatment, but showed less than desirable results at 20 DAT treatment. Ethoxysulfuron showed low control efficacy at both of the time applied. Benfurasate, alone, appeared not effective for the control of Eleocharis kuroguwal Ohwi. Evaluation for the timing of the herbicide application showed that 14 to 21 DAT treatments appeared appropriate. When applied before the period, the weed regrowth became problematic. On the other hand, when applied the later, the weed outgrew to be controlled with the herbicide. For labor saving for herbicide application, herbicide application at transplanting was sought. However, Elevcharis kuroguwal Ohwi was difficult to control from the earlier application, the herbicide application at transplanting appeared impractical where Elevcharis kuroguwai Ohwi is dominant.

Pyranonaphthoquinone계 항생제 Nanaomycin A의 합성

趙仁鎬,魯永釗,柳東辰 全北大學校 1989 論文集 Vol.31 No.-

An efficient synthesis of 8-benzyloxy-6-phenylsulfonyl-3-octen-2-one(48), the Michael acceptor necessary to prepare nanaomhycin A(la) was accomplished via seven step reaction sequence using ethylacrylate(53) as the starting material. Thus, a Michael reaction of thiophenoxide with ethylacrylate gave 3-(phenylthio) propionate(54), which was reduced to propanol 55, and then converted to 3-(acetoxy) propylphenylsulfide(56). Oxidation of the sulfide 56 with mCPBA as an oxidizing agent gave sulfone 57. Anion of the sulfone 57 generated by using LDA was treated with chloroacetalde-hydedimethylacetal to provide dimethoxypenthanol 58. Benzylation of the alcohol 58, followed by acid catalyzed hydrolysis of the dimethoxy function gave pentanal 59. Wittig reaction of the pentanal 59 with triphenyphosphoranylidene-2-propanone purnish 3-octen-2 on 48.

4개월 남아에서 방광요관역류를 동반한 신농양 1례

김강호,노영일 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Renal abscess is uncommon in pediatrics and is rarely a cause of fever of unknown origin. It presents varying features which often lead to delay or error in diagnosis. It can develop by one to two general mechanisms. In past, hematogenous seeding from bacteremia most often causes a conical abscess. At present, ascending infection, usually due to gram negative organisms, begins in the bladder and ascends to the renal parenchyma. Renal ultrasonography and computerized tomography(CT) are sophisticated and available, permitting 82% to 90% accuracy in diagnosis of renal abscess. It is also useful in establishing percutaneous drainage, which appears to be the treatment of choice. We reported a case of 4-month-old boy with renal abscess in left kidney associated with bilateral vesicoureteral reflux and he was treated successfully with antibiotics alone.