사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

LNT를 통해 분석한 국립공원 탐방목적과 산행 윤리 의식의 상관성 : 내장산국립공원 백양사지구와 남창지구를 중심으로

최형철(Choi Hyung Chul),박재철(Park Jae Chul),노재현(Roh Jae Hyun),신상섭(Shin Sang Sup),허준(Huh Joon) 한국산림휴양학회 2010 한국산림휴양학회지 Vol.14 No.3

본 연구는 LNT 항목의 분석을 통해서 산행 목적과 산행윤리의식 사이의 차이를 규명하기 위하여 수행되었다. 이를 위해서, 내장산국립공원의 백양사지구와 남창지구를 사례로 연구를 수행하였다. 이를 통해 국립공원 방문목적에 따라서 윤리 의식이 유의한 차이가 있음을 확인할 수 있었다. 다시 말하면, 산행목적의 탐방객이 행락 목적의 탐방객보다 윤리 의식이 높은 것을 확인할 수 있었다. This study was performed to identify the difference between purpose and ethics consciousness of national park visit through analysis of LNT(Leave No Trace) items. For this, case study was performed in the Baekyangsa and Namchang district in Naejang national park. Study methods were questionnaire and statistic analyses. Through these, the difference of Ethics Consciousness of national park visit according to visit purpose of one was identified. In other words, it was identified that visitors for climbing purpose had higher than those for pleasure-making in Ethics Consciousness of National Park Visit.

국내 말라리아 퇴치사업의 현황 분석과 개선 방안

박재원,홍지영,염준섭,조성래,오대규 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Vivax malaria had spread rapidly in areas adjacent to the Demilitarized Zone to reach more than 4,000 cases in 2000 in the Republic of Korea (ROK). After year 2000, annual cases decreased rapidly to reach less than 1,000 cases in 2004. However, the number increased again since 2005. Epidemiological characteristics of vivax malaria in the ROK are different before and after 2000. This article was aimed to evaluate the current status of malaria elimination project in the ROK for providing suggestions for its improvement. Materials and Methods : We analyzed the total reported malaria cases during 2005 to 2007 and reviewed the record on the malaria eradication project performed by the authorizations including the Korea Center for Disease Control and Prevention. Results : During 2005 to 2007, 45% of all the vivax malaria occurred in patients living in the non-prevalent areas; the interval between first symptom onset and diagnosis was longer in the non-prevalent areas compared to that in the prevalent areas. Education and publicity on malaria has not been properly performed in the non-prevalent areas. The military didn't take part in the control of the malaria infected discharged soldiers, most of whom might have been infected with malaria during their military service. Conclusion : For the efficient control of malaria and thus improving the effectiveness of the elimination project education and publicity on malaria in the non-prevalent areas should be strengthened and cooperation between private and military sector regarding the ex-soldiers infected with malaria is essential, In addition, there should be bilateral communication among malaria-related teams within the Korea Centers for Disease Control and Prevention and also among all the malaria-related sectors. Furthermore a common database on malaria patients and vector mosquitoes should be formed to grant access to all the malaria-related sectors, Improvement on report and surveillance system is also necessary.

유도기술의 체급별 사용기술에 관한 연구 : 제 27회 회장기 전국유도대회를 중심으로 The 27th hoejanggi National Judo Games

박순진,김도준,김성섭,조은복 龍仁大學校 武道硏究所 2001 武道硏究所誌 Vol.12 No.1

This study is the score distribution in use of a art for 288 men excellent grade Judo platers who participated in the hoejanggi national Judo game. By analyzing the sore classified by the art and the score classified by the attack, I got the result as mentioned below. 1) Considering the result of each grade, except -66kg grade and limitless grade, in every grade there was IPPON most frequently. Jumping to the conclusion based on these facts, players conduct most game for IPPON actively and sharply. 2) In the aspect of art, except 081 grade, in every grade platers tried the Ashi waza most frequently. 3) The important art to sequence by grade follows as below. ■ -60kg grade Doechigi - Seoi nage, Kuchiki taoshi, Uchi mata, O uchi gari - Moro te gart, Sasae tsurikomi, O sae waza, Kan setsu waza ■ -66kg grade Seoi nage - Moro te gari, Uchi mata - Ko uchi gari, Osae waza - Okuri ashi harai, O uchi gari, O soto gari, Harai goshi, Doechigi ■ -73kg grade O uchi gari - Seoi nage - Harai goshi - O soto gari, Doechigi - Uchi mata - Mor te gari ■ -81kg grade Seoi nage - Uchi mata - Taniotosh, O sad waza - Moro te gari, Ko uchi , O soto gari ■ -90kg grade Harai goshi - Doechigi - Ouch gari - Moro te gari, Sukul nage, Uchi mata ■ -100kg grade Hafai goshi - Uchi mata, O uchi gari, O soto gari - Sasae tsurikomi - Ko soto gari ■ +100kg grade O sae waza - Uchimata, Ko soto gari, O uchi gari, O soto gari - Harai goshi

3차원 직육면체 대공간 내에서의 열 및 기류 유동에 관한 연구

박원희,이상엽,황문섭,김태국 중앙대학교 기술과학연구소 2002 기술과학연구소 논문집 Vol.32 No.-

본 연구에서는 대공간 내에서의 열 및 기류 유동 현상을 연구하기 위하여 464×300× 950mm^3크기의 축소 모형으로 아트리움을 제작하였다. 가상 화재를 모사하기 위하여 대공간 하단에 히터를 설치하였으며, 히터의 온도에 따른 대공간 내의 온도분포를 측정하였다. 본 실험에서 얻은 결과는 아트리움과 같은 대공간에서 화재가 발생하였을 경우에 열 및 기류 현상을 해석하기 위한 기초자료 및 열유동 현상을 해석하는 수치해석 프로그램의 계산 결과의 기준 데이터로도 이용될 수 있을 것이다.

완전뇌허혈후 재관류시에 국소뇌혈류, 체성감각유발전위 및 신경학적 회복에 대한 Mannitol과 Thiopental의 효과

박춘근,이상원,박영섭,최승진,허필우,정동섭,강준기,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental studies have suggested that some drugs may protect the brain from ischemic injury, there are limitations in maintaining cerebral perfusion arrest without incurring neurologic deficits due to the initiation of detrimental processes including excitotoxic neuronal injury, activation of phospholipases, influx of calcium, and generation of damaging free radicals. The purpose of this study is to determine wheter mannitol or thiopental has any favorable effects on the recovery of neurologic deficits and on the regional cerebral blood flow(rCBF), somatosensory evoked potential(SEP) and electroencephalogram(EEG) in cats which underwent 15 minutes-complete global ishcemia-reperfusion. The complete global ischemia was produced in 38 cats by temporary intrathoracic occlusion of the innominate artery and the subclavian artery following ligation of bilateral mammary arteries and simultaneous induction of hypotension. The cats were allocated randomly to one of 4 treatment groups : (1) control group, 8 cats received equal volume of saline solution : (2) thiopental group, 10 cats received 45㎎/㎏ thiopental intravenously, (3) mannitol group, 10 cats received 2g/㎏ mannitol intravenously, (4) combined mannitol and thiopental group, 10 cats received equal dose of mannitol and thiopental intravenously. The drugs were administrated in a equally divided dosage before and after the ischemic episode. The results were as follos : 1) Eight animals which received saline showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours after the ischemia. 2) Ten thiopental-treated animals also showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours the ischemia. 3) Both mannitol-and combined treated groups showed early recovery of EEG, good recovery of SEP and EEG without the severe postischemic hypoperfusion, and 7 of 10 mannitol-treated animals and 8 of 10 combined treated animals were significantly recovered in all parameters. There were not significant differences in all parameters between the mannitol-and combined treated groups. 4) Thirty-four of 38 animals involved in this 15 minutes-ischemia resulted in the severe neurologic deficits inspite of treatment with mannitol, thiopental or both of them. These results suggest that, in cats, mannitol treatment is effective but not thiopental in preventing severe neurologic injury following complete global ischemia and the duration of complete ischemia should be far less than 15 minutes.

혈액암환자에서 조혈모세포 이식 후 따르는 헤르페스 바이러스 감영 양상

이호섭,탁희상,신성훈,김양수,남성진,김혜수,박진희,정수현,김성빈,김예나 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

배경 : 헤르페스바이러스과에는 단순포진 바이러스(HERPES SIMPLEX VIRUS, HSV), 수두대상포진 바이러스 (VARICELLA-ZOSTER VIRUS, VZV), 엡스타인-바 바이러스 (EPSTEIN-BARR VIRUS, EBV), 그리고 거대세포 바이러스 (CYTOMEGALOVIRUS, CMV) 등이 있다. 헤르페스바이러스 감염은 혈액암환자에서 조혈모세포 이식 환자에서 전파 (dissemination), 이차감염, 세균 중복 감염의 심각한 합병증을 일으킬 수 있다. 하지만 항암약물치료를 받는 림파종 환자에서 항 바이러스 약제의 사용 용량과 기간에 대한 concensus는 없다. 헤르페스바이러스 감염에 대한 발생율과 위험인자를 후향성으로 분석하였다. 방법 : 고신대학교 복음 병원에서 1995년 6월부터 2009 년 2월 사이에 새롭게 진단되어 조혈모세포 이식을 받은 전체 58명의 환자들이 후향적으로 현 연구에 등록했다. 헤르페스 바이러스 감염은 임상적 진단, 혈청학적 검사 또는 병리학적 진단에 기초하여 확진한다. 환자들의 특성은 다음과 같다: 평균 연령은 44세 (범위 19-62세)였고 남녀비는 30:28이었다. 등록된 질환은 백혈병 (n=9, 15.5%), 림프종 (n=30, 51.7%), 다발성 골수종 (n=12, 20.7%), 재생불량성 빈혈 (n=6, 10.3%) 그리고 골수이형성증후군 (n=1, 1.7%)이 포함되었다. 결과는 chi-squre test나 independent samples T test를 사용하여 분석되었다. Multivariate analysises에 대해 logistic regression test를 사용하였다. 결과 : 15명의 환자들 (25.9%)에서 조혈모세포 이식후 헤르페스 바이러스 감염이 발생하였다. 조혈모세포 이식 5년간 누적 발생율은 53.9%였다. Univariate analyses에서 헤르페스 바이러스 감염에 대한 유의한 위험 인자는 없었다. 하지만 조혈모세포 이식후 생존 기간(40.18 ± 30.14 months vs 20.06 ± 26.67 months, p=0.018)은 헤르페스 바이러스 감염의 낮은 발병율과 유의한 관련성이 있었다. 이식 편대 숙주질환 (GVHD)의 존재 (37.5% in developed GVHD vs 0% in no GVHD, p=0.200), 동종조혈 모세포 이식에서 면역억제요법의 기간 (15.98 ± 14.02 months vs 6.78 ± 3.67 months, p = 0.374)은 헤르페스 바이러스 감염에 대한 위험인자가 아니었다. 결론 : 조혈모세포 이식 후 생존 기간은 어사이클로비어 예방을 받은 혈액암 환자에서 헤르페스 바이러스 감염의 낮은 발병율과 연관성이 있는 것으로 보인다. 저용량의 어사이클로비어 예방은 헤르페스 바이러스 감염의 고위험군인 조혈모세포 이식을 받은 혈액암 환자에 필요하리라 생각된다. Background : Herpesviridae family includes herpes simplex virus, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus, etc. Herpesviridae viral infection (HVI) can lead to serious complications including dissemination, secondary infection, bacterial superinfection in patients with hematologic malignancy following hematopoietic stem cell transplantation (HSCT). But there was no consensus on the dose and duration of antiviral agents prophylaxis in patients undergoing chemotherapy. We retrospectively analyzed the incidence and the risk factors for HVI. Method : A total of 58 patients who newly diagnosed and received HSCT with prophylaxis of acyclovir at the Kosin University Gospel Hospital, Busan, Korea between June 1995 and February 2009 were enrolled retrospectively in the current study. HVI was confirmed based on clinical diagnosis, serologic test or pathologic diagnosis. The characteristics of the patients were as follows: the median age was 44 years (range 19-62 years) with a female-to-male ratio of 30:28. The enrolled diseases included leukemia (n=9, 15.5%), lymphoma (n=30, 51.7%), multiple myeloma (n=12, 20.7%), aplastic anemia (n=6, 10.3%) and myelodysplastic syndrome (n=1, 1.7%). The results were analyzed using a chi-square test and independent samples T test. For the multivariate analysis, we used logistic regression test. Results : Fifteen patients (25.9%) developed HVI after HSCT. The cumulative incidence of HVI was 53.8% at 5 years after HSCT. In univariate analysis, there was no significant risk factor for HVI. The presence of graft-versus-host disease (GVHD) (37.5% in developed GVHD vs. 0% in no GVHD, p=0.200), duration of immunosuppressive therapy (IST) in allo-SCT (15.98 ± 14.02 months vs. 6.78 ± 3.67 months, p = 0.374) were not risk factors for HVI. Conclusion : The incidence of HVI was similar to that in historical other studies. There was no risk factor associated with development of HVI. Most of the HVI occurred within the first 24 months after transplantation. So long term use of antiviral prophylaxis may be needed to prevention of HVI after HSCT.

제트베인형 추력편향장치의 공기역학적 특성

박종호,이성노,이은모,신완순,이택상,길경섭 충남대학교 공업교육연구소 2000 論文集 Vol.23 No.1

The aerodynamic study of jetvane type TVC(Thrust Vector Control) were conducted using supersonic cold-flow system. The use of TVC Systems in particular jet vanes, are currently being researched for use in air launch, ship launch, underwater launch and high altitude maneuvering of tactical missiles and rockets. The necessity to generate control forces to rapidly change the course of the missile is frequently required when traditional, exterior aerodynamic surfaces are unable to produce these forces, when the flow over the control surface is insufficient. This situation can occur at launch, or high angles of attack of the control surfaces. Jetvanes performed well at all altitudes and environmental conditions, and jet vanes are extremely effective at deflection angles up to as high as 30 degrees, make them ideal for the launch and maneuver applications. In this study, aerodynamic performance test of jetvane type TVC was conducted, and The effect of shape and deflection angle of various types of jetvanes are investigated

腦硬塞患者의 血壓·脈搏 및 腦血流에 대하여 水溝-承漿穴 電鍼刺戟이 미치는 影響

박성욱,문상관,고창남,조기호,김영석,배형섭,이경섭 경희대학교 1997 慶熙醫學 Vol.13 No.4

유한요소법을 이용한 철근콘크리트보의 비선형 해석

박정섭,장일영,송재호,한상묵 金烏工科大學校 1998 論文集 Vol.19 No.-

The method of finite element analysis is modified in this study to predict the material nonlinear behavior of reinforced concrete structure more properly. It is difficult to predict the behavior of reinforced concrete structure due to the development of concrete crack, the behavior of compressive failure, bond properties between concrete and steel, and shear resistance. To predict the material nonlinear behavior of reinforced concrete structure more properly, the stress-strain relationship of confined concrete which proposed by Attard, Setunge is considered. Also, shear retention model is considered. To prove the efficiency of the analysis, analytical results are compared to experimental results.