사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

LNT를 통해 분석한 국립공원 탐방목적과 산행 윤리 의식의 상관성 : 내장산국립공원 백양사지구와 남창지구를 중심으로

최형철(Choi Hyung Chul),박재철(Park Jae Chul),노재현(Roh Jae Hyun),신상섭(Shin Sang Sup),허준(Huh Joon) 한국산림휴양학회 2010 한국산림휴양학회지 Vol.14 No.3

본 연구는 LNT 항목의 분석을 통해서 산행 목적과 산행윤리의식 사이의 차이를 규명하기 위하여 수행되었다. 이를 위해서, 내장산국립공원의 백양사지구와 남창지구를 사례로 연구를 수행하였다. 이를 통해 국립공원 방문목적에 따라서 윤리 의식이 유의한 차이가 있음을 확인할 수 있었다. 다시 말하면, 산행목적의 탐방객이 행락 목적의 탐방객보다 윤리 의식이 높은 것을 확인할 수 있었다. This study was performed to identify the difference between purpose and ethics consciousness of national park visit through analysis of LNT(Leave No Trace) items. For this, case study was performed in the Baekyangsa and Namchang district in Naejang national park. Study methods were questionnaire and statistic analyses. Through these, the difference of Ethics Consciousness of national park visit according to visit purpose of one was identified. In other words, it was identified that visitors for climbing purpose had higher than those for pleasure-making in Ethics Consciousness of National Park Visit.

灣曲管路의 水理特性 分析을 위한 數値的 解析

朴魯參,李曾錫,安勝燮 慶一大學校 1993 論文集 Vol.9 No.1

This study has been aimmed at the development of the analytical model for the hydraulic characteristics of miter bend by Finite Element Method(FEM). In this study, velocity potential function is defined such that the negative of its derivative with to distance in any direction yields the velocity in that direction. Thus all practical flow must satisfy the Laplacian equation in terms of velocity potential function. Therefore, the Finite element method for the solution of the Laplace equation is presented. The proposed analytical technique which deal with the potential flow was applied to the bend-type pipe, and which was computed velocity compotent for the finite element mesh. From results of this study, the velocity modulus for elements of corner region indicates the flow perturbation.

간세포암의 경도관동맥화학색전술후 이중시기 전산화단층촬영의 유용성

박길선,이지혜,송경섭,배일헌,한기석,차상훈,김성진 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2

목적: 간세포암의 경도관동맥화학색전술후 잔류간암 유무를 판정하는 추적검사로서 이중시기 전산화단층 촬영의 유용성에 대해 알아보고자 하였다. 대상 및 방법: 간세포암으로 진단되어 경도관동맥화학색전술을 시행하고, 리피오돌 CT와 이중시기 전산화단층될영으로 추적검사한 환자들 중, 혈관조영술이나 수술 후 병리조직 소견으로 잔류 간암의 확인이 가능했던 37명의 52개 간세포암을 대상으로 하였다. 전산화단층촬영은 경도관동맥화학색전술 후 2주 전후에 시행하였다. 수용성조영제 주입전(리피오돌 CT)과 주입후 30초와 60초에 동맥강조기와 문맥강조기의 영상을 얻었다. 리피오돌 CT 소견에서 리피오돌의 침착 상태에 따라 완전과 불완전침착군으로 구분하여 이중시기 전산화단층촬영에서 조영증강 유무를 두 명의 방사선과 의사에 의해 평가하였고, 혈관조영술과 수술 후 병리조직 소견 등에 의한 잔류간암 유무와 비교하였다. 결과: 리피오돌 완전침착군 24예중 19예는 조영증강이 없었으나 5예에서 조영증강이 있었다. 불완전침착군 28예중 24예는 조영증강이 있었고, 나머지 4예는 조영증강이 없었다. 추적검사에서 완전침착군 중 전산화단층촬영에서 조영증강이 없다고 판정한 19예 중 17예에서 잔류간암이 없었고, 2예에서 잔류간암이 있는 것으로 확인되었으며 조영증강이 있다고 판정한 5예 전부 잔류간암이 있었다. 불완전 침착군 중 조영증강이 있다고 판정한 23예 중 22예는 잔류간암이 있었고 1예에서 잔류간암이 없었으며, 조영증강이 없다고 판정한 4예 전부 잔류간암이 없었다. 이중시기 전산화단층촬영에 의한 잔류간암 발견의 민감도, 특이도 및 정확도가 각각 93.3%, 91.3%, 94.2%이었다. 결론: 이중시기 전산화단층촬영은 간세포암의 경도관동맥화확색전술후 잔류간암 유무의 평가에 유용하고, 리피오돌 CT에서 완전침착일 때 이중시기 전산화단층촬영에서 조영증강이 없어도 잔류간암이 있을 수 있으므로 주의를 기울여야 할 것이다. Purpuse : To assess the usefullness of dual-phase CT for the detection of residual tumor after transcatheter arterial chemoembolization(TACE) of hepatocellular carcinomas(HCCs) Materials and Methods: 52 HCCs of 37 patients who had undergone TACE using an emulsion of iodized oil and doxorubicin hydrochloride were evaluated using dual-phase CT. About 2weeks after TACE, CT was done before and 30, 60 second after contrast media injection. The presence of contrast enhancement was evaluated by two radiologists. Selective hepatic arteriography and histologic evaluation were considered as a gold standard of the study. Results: On dual phase CT, 19 of 24 complete lipiodol uptaken turners showed no contrast enhancement, other 5 showed enhancement. 24 of 28 incomplete lipiodol uptaken tumors showed enhancement, other 4 showed no enhancement. 17 of 19 complete lipiodol uptaken tumors which showed no contrast enhancement proved to have no residual tumor, but 2 proved to have residual tumor. All five complete lipiodol uptaken tumors which showed contrast enhancement proved to have residual tumors. Incomplete lipiodol uptaken tumors which showed contrast enhancement proved to have residual tumor except one that proved to have no residual tumor. Four incomplete lipiodol uptaken tumors which showed no contrast enhancement proved to have no residual tumor. The sensitivity, specificity, and accuracy of dual-phase CT for the detection of residual tumor were 93.3%, 91.3%, and 94.2%, respectively. Conclusion Dual-phase CT is usueful for the detection of residual tumor after TACE of HCC. Complete lipiodol uptaken HCCs which showed no contrast enhancement could have residual tumor.

완전뇌허혈후 재관류시에 국소뇌혈류, 체성감각유발전위 및 신경학적 회복에 대한 Mannitol과 Thiopental의 효과

박춘근,이상원,박영섭,최승진,허필우,정동섭,강준기,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental studies have suggested that some drugs may protect the brain from ischemic injury, there are limitations in maintaining cerebral perfusion arrest without incurring neurologic deficits due to the initiation of detrimental processes including excitotoxic neuronal injury, activation of phospholipases, influx of calcium, and generation of damaging free radicals. The purpose of this study is to determine wheter mannitol or thiopental has any favorable effects on the recovery of neurologic deficits and on the regional cerebral blood flow(rCBF), somatosensory evoked potential(SEP) and electroencephalogram(EEG) in cats which underwent 15 minutes-complete global ishcemia-reperfusion. The complete global ischemia was produced in 38 cats by temporary intrathoracic occlusion of the innominate artery and the subclavian artery following ligation of bilateral mammary arteries and simultaneous induction of hypotension. The cats were allocated randomly to one of 4 treatment groups : (1) control group, 8 cats received equal volume of saline solution : (2) thiopental group, 10 cats received 45㎎/㎏ thiopental intravenously, (3) mannitol group, 10 cats received 2g/㎏ mannitol intravenously, (4) combined mannitol and thiopental group, 10 cats received equal dose of mannitol and thiopental intravenously. The drugs were administrated in a equally divided dosage before and after the ischemic episode. The results were as follos : 1) Eight animals which received saline showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours after the ischemia. 2) Ten thiopental-treated animals also showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours the ischemia. 3) Both mannitol-and combined treated groups showed early recovery of EEG, good recovery of SEP and EEG without the severe postischemic hypoperfusion, and 7 of 10 mannitol-treated animals and 8 of 10 combined treated animals were significantly recovered in all parameters. There were not significant differences in all parameters between the mannitol-and combined treated groups. 4) Thirty-four of 38 animals involved in this 15 minutes-ischemia resulted in the severe neurologic deficits inspite of treatment with mannitol, thiopental or both of them. These results suggest that, in cats, mannitol treatment is effective but not thiopental in preventing severe neurologic injury following complete global ischemia and the duration of complete ischemia should be far less than 15 minutes.

3차원 직육면체 대공간 내에서의 열 및 기류 유동에 관한 연구

박원희,이상엽,황문섭,김태국 중앙대학교 기술과학연구소 2002 기술과학연구소 논문집 Vol.32 No.-

본 연구에서는 대공간 내에서의 열 및 기류 유동 현상을 연구하기 위하여 464×300× 950mm^3크기의 축소 모형으로 아트리움을 제작하였다. 가상 화재를 모사하기 위하여 대공간 하단에 히터를 설치하였으며, 히터의 온도에 따른 대공간 내의 온도분포를 측정하였다. 본 실험에서 얻은 결과는 아트리움과 같은 대공간에서 화재가 발생하였을 경우에 열 및 기류 현상을 해석하기 위한 기초자료 및 열유동 현상을 해석하는 수치해석 프로그램의 계산 결과의 기준 데이터로도 이용될 수 있을 것이다.

반응표면분석법에 의한 동충하초 첨가 증편 제조의 최적화

박금순,윤광섭,황성희,조현정,김정숙 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.4

To optimize the preparation process of Jeung-Pyun, an experiment was derived, using a central composite design, to find the optimal mixing conditions. The addition of Paecilomyces japonica powder, the volume of Tak-Ju and the second fermentation time were independent variables, with the pH, volume, color, sensory and texture properties of the Jeung-Pyun selected as response variables. As the Paecilomyces japonica powder and fermentation time were increased, the b values and volume after the second fermentation also increased. The color of the Jeung-Pyun became deeper with increases in the Paecilomyces japonica powder and fermentation time, and was deepest on the addition of 30% Tak-Ju. The pH increased with increasing fermentation time of the Jeung-Pyun, and on the addition of 3% Paecilomyces japonica rapidly increased more than with the other groups. The optimal mixing conditions for the best quality Jeung-Pyun, with restricted conditions above a b value of 3, a color intensity above 3, and a volume of 40㎖ and a pH of 4.02~4.04 after the second fermentation, were 4.0%, 20% and 45 mins for the Paecilomyces japonica powder, Tak-Ju and second fermentation time, respectively.

T형 합성보의 스터드 쉬어 콘넥더의 내력에 관한 연구

박복만,정구섭,최승용,김복순 명지대학교 공학기술연구소 1993 공학기술연구소 논문집 Vol.8 No.-

This study summarizes the results of tests on 18 Two-slab push out specimens. The main purpose of the investigation was to evaluate the capacity and behavior of stud shear connectors embedded in the normal concrete(F_c=173∼295㎏/㎠). Two different diameters(Φ16mm,Φ13mm) of steel shear connectors welded on T-shpaed steel were used for push out specimens. The following conclusions were drawn from this study. 1. The shear strength(q_u) of stud shear connectors embedded in concrete was influenced by the cross sectional area of the steel shear connector(A_s), concrete design strength(F_c) and elastic modulus of the concrete(E_c). The emperical function described the test results. q_u = 0.3A_s√FcEc 2. The maximum loads in this study were reached at slips varing from 1.5mm to 4.0mm 3. The webs of T-shaped steels welded by the steel shear connectors were safe under t≥d/2. Where t is the thickness of the webs, d, the diameter of stud shear connector.

腦硬塞患者의 血壓·脈搏 및 腦血流에 대하여 水溝-承漿穴 電鍼刺戟이 미치는 影響

박성욱,문상관,고창남,조기호,김영석,배형섭,이경섭 경희대학교 1997 慶熙醫學 Vol.13 No.4

국내 말라리아 퇴치사업의 현황 분석과 개선 방안

박재원,홍지영,염준섭,조성래,오대규 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Vivax malaria had spread rapidly in areas adjacent to the Demilitarized Zone to reach more than 4,000 cases in 2000 in the Republic of Korea (ROK). After year 2000, annual cases decreased rapidly to reach less than 1,000 cases in 2004. However, the number increased again since 2005. Epidemiological characteristics of vivax malaria in the ROK are different before and after 2000. This article was aimed to evaluate the current status of malaria elimination project in the ROK for providing suggestions for its improvement. Materials and Methods : We analyzed the total reported malaria cases during 2005 to 2007 and reviewed the record on the malaria eradication project performed by the authorizations including the Korea Center for Disease Control and Prevention. Results : During 2005 to 2007, 45% of all the vivax malaria occurred in patients living in the non-prevalent areas; the interval between first symptom onset and diagnosis was longer in the non-prevalent areas compared to that in the prevalent areas. Education and publicity on malaria has not been properly performed in the non-prevalent areas. The military didn't take part in the control of the malaria infected discharged soldiers, most of whom might have been infected with malaria during their military service. Conclusion : For the efficient control of malaria and thus improving the effectiveness of the elimination project education and publicity on malaria in the non-prevalent areas should be strengthened and cooperation between private and military sector regarding the ex-soldiers infected with malaria is essential, In addition, there should be bilateral communication among malaria-related teams within the Korea Centers for Disease Control and Prevention and also among all the malaria-related sectors. Furthermore a common database on malaria patients and vector mosquitoes should be formed to grant access to all the malaria-related sectors, Improvement on report and surveillance system is also necessary.