地域社會의 情報化 促進方案에 관한 硏究 : 大田·忠淸地域을 中心으로

李根植,金能鎭,鄭相喆 충남대학교 경상대학부설 경영경제연구소 1991 경영논집 Vol.7 No.2

울산지역 췌담관질환 환자의 간흡충 감염 실태 : 담즙검사를 기준으로 based on bile examination

이기영,주광로,김현수,신수진,이효섭,윤태권,추연익,박종호,신정우,방성조,김도하,박능화 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 간흡충증의 진단은 분변 또는 담즙에서 간흡충의 성충 또는 충란을 발견하는 것이다. 담즙을 통한 간흡충 진단은 간흡충이 존재하는 담관에서 검체를 직접 채취한다는 장점과 이 검체가 분변이나 체액에 의해 희석되지 않으며, 특히 담관 폐색이 있을 경우 담즙배설 장애로 인한 분변검사의 위음성을 줄일 수 있는 가장 정확한 간흡충의 기생충학적 검사로 생각된다. 이에 저자들은 울산지역 췌담관 질환 환자에서 담즙검사를 기준으로 한 간흡충의 감염 실태를 알아보고자 하였다. 방법 : 내시경적 또는 경피경간 담관배액술을 통해 담즙을 채취하여 간흡충 충란 유무를 확인한 309명의 췌담과 질환 환자에서 간흡충 감염 실태를 조사하였다. 결과 : 대상 환자 전체의 충란 양성률은 27.5%였고, 남녀의 충란 양성률은 각각 35.%와 17.6%로 남자에서 더 높았다. 연령별 충란 양성률은 30대 20.0%, 40대 26.7%, 50대 24.2%, 60대 29.9%, 70대 36.2% 그리고 80대 이상이 16.7%로 연량에 따른 통계적 차이는 없었다. 질병별 충란 양성률은 담관암 32.65, 담낭암 38.5%, 파터팽대부암 11.1%, 췌장암 24.0%, 담석질환 26.4%,간흡충담관염 61.5% 그리고 이외 질환이 12.5%로 간흡충 담관염ㅇ르 제외한 질병간 의미있는 차이는 없었으며 결석의 위치, 간흡충 연관질환인지 아닌지가 충란 양성률에 영향을 미치지 못했다. 담관 조영술을 포함한 방사선 검사에서 정상 담관을 보인 환자에서 충란 양성률은 17.0%였다. 결론 : 본 연구 결과 울산지역 췌담관 질환 환자에서 간흡충 감염률은 연령, 성별, 질병의 종류에 관계없이 전반적으로 매우 높았다. 따라서 이러한 자료를 근거로 생각해 볼 때 우리 나라가 아직도 심각한 간흡충 감염의 유행지임을 추론할 수 있겠다. Background : Bile examination is believed to be the most precise method for detecting Clonorchis sinesis (CS) eggs. We carried out bile examination to evaluate infestation state of CS in patients with pancreatobiliary diseases in Ulsan, known as an endemic area of CS infestation. Methods : We examined CS eggs in bile in three hundreds and nine patients with pancreatobiliary diseases. The bile was obtained from endoscopic nasobiliary or percutaneous transhepatic biliary drainage tubes. Results : The overall egg positive rate was 27.5% (35.3% in male,17.6% in female). The egg positive rate was not significantly different according to the age group: 20.0% in thirties, 26.7% in forties, 24.2% in fifties, 29.9% in sixties, 36.2% in seventies and 16.7% in eighties or more. The egg positive rate according to the disease, except CS cholangitis, was not also statistically different: 32.6% in bile duct cancer, 38.5% in gallbladder cancer, 11.1% in ampulla of Vater cancer, 24.0% in pancreatic cancer, 26.4% in gallstone diseases and 12.5% in the reminder. The location of gallstone and whether CS related diseases or CS unrelated diseases did not affect the egg positive rates. The egg positive rate in patients with normal radiological findings including cholangiography was 17.0%. Conclusion : This result shows that regardless of age, sex and sorts of diseases, the infestation rate of CS was very high. On the basis of our results, it if therefore presumes that clonorchiasis is still endemic disease in Korea.

만성 간장 질환자에서 뇌 MRI 상의 pallidal index와 생물학적 망간지표들 간의 관련성

최영희,박능화,신정우,김효경,김성률,정태흠,박지강,이헌,유철인,이충렬,이지호,김양호 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : 만성 간장 질환자를 대상으로 T1강조 자기공명영상(MRI)에서 나타나는 담창구 부위의 고신호강도 소견(pallidal index, PI)과 생물학적 망간 지표들 간의 관련성을 알아본다. 방법 : B형간염 바이러스에 의한 간경변증으로 진단 받은 40세 이상의 환자 31명과 정상 대조군 10명을 대상으로 설문조사와 혈액 및 소변검사, 뇌 MRI를 시행하였다. 전체 41명 가운데 검사 전 수혈을 받았던 환자군 9명을 제외하고 전체 32명의 자료를 분석하였다. 망간 축적에 관련된 객관적 지표로서 T1 강조 MRI에서 나타나는 담창구 부위의 고신호강도를 전두부 백색질 신호강도로 나눈 수에 100을 곱하여 구한 PI를 택하였다. 환자군과 대조군 사이의 PI와 망간농도들의 평균을 비교하였다. 여러 변수들과 PI와의 상관성을 보기 위해서는 상관분석을 시행하였다. 결과 : 간장 질환자 22명 가운데 18명(81.8%)에서 뇌 MRI 상 고신호강도가 나타났다. 대조군 10명에서는 아무도 MRI 소견상 고신호강도가 나타나지 않았다. 간장 질환자에서의 평균 PI는 122.62로 대조군의 106.23보다 유의하게 높게 나타났다(p<0.01). 간장 질환자의 전혈에서 망간농도는 2.34㎍/㎗으로 대조군의 1.44㎍/㎗와 비교하여 유의하게 높게 나타났다(p<0.05). 혈장과 소변 내 망간농도는 대조군에서 다소 높게 나타났으나, 통계적으로 유의하지는 않았다. 또한 혈색소, 빌리루빈, AST가 대조군과 환자군 사이에서 유의한 차이가 있었다(p<0.05). 전혈(p=0.489, P<0.01, n=29)과 적혈구(p=0.573, P<0.01, n=22) 내 망간농도와 PI 사이에는 각각 유의한 상관관계가 있었다. 그러나 혈장과 소변 내 망간 농도와 PI와의 상관관계는 통계적으로 유의하지 않았다. 총빌리루빈 또한 PI와 유의한 상관관계를 나타내었다(p=0.509, P<0.01, n=32). 결론 : 전혈 또는 적혈구 내의 망간 농도가 뇌 내 망간 침착으로 인한 T1 강조 MRI상 담창구 부위의 고신호 강도를 잘 반영하는 유용한 지표이다. Objectives: The objectives of this study were to clarify which biological manganese exposure indices reflect the pallidal signal intensities in magnetic resonance imaging (MRI) in liver cirrhotics. Methods: We examined whole blood, plasma, RBC and urinary manganese concentrations, as well as, brain MRI in 22 cirrhotic patients and 10 healthy controls. From MRI scans we calculated the signal intensity of the globus pallidus using the pallidal index (PI), the ratio of the globus pallidus to subcortical frontal white-matter signal intensity in axial T1 -weighted MRl planes multiplied by 100. In addition, we studied the relationships between PI and other measurements. Results: The high signal intensity in the globus pallidus on T1-weighted MRI was observed in 18 (81.8%) patients. There was a significant correlation between whole blood and RBC manganese concentration, and PI on MRI. According to multiple linear regression, whole blood and RBC manganese concentration reflected PI on MRI better the other indices did. Conclusions: Whole blood and RBC manganese concentrations could be useful as biological manganese exposure indices that reflect PI on MRI.

A novel surface-attached carvedilol solid dispersion with enhanced solubility and dissolution

Sung Neung Lee,Bijay Kumar Poudel,Tuan Hiep Tran,Nirmal Marasini,Roshan Pradhan,Young Im Lee,Dong Won Lee,Jong Soo WOO,최한곤,용철순,김종오 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.1

A novel surface-attached, spray-dried soliddispersion containing poorly water-soluble carvedilol (CV)without any change in the crystallinity was prepared usingwater, polyvinylpyrrolidone (PVP K30) and Tween 80. Thesolid dispersion was optimized by investigating the effectsof the weight ratios of Tween 80/PVP K30 and carrier/drugon the aqueous solubility of CV. The optimum solid dispersionconsisted of a relatively low carrier to drug weightratio: the weight ratio of CV/PVP K30/Tween 80 was 12/4/2. Unlike conventional methods of solid dispersion preparation,this method yielded CV-loaded solid dispersion withno change in the crystallinity of the drug as was evidentfrom SEM, DSC and XRD. It was demonstrated that thesolid dispersions prepared had hydrophilic carriers attachedto the surface of the drug, thus changing it from a hydrophobicto a hydrophilic form without changing the crystallineform. The optimized solid dispersion improved thedrug solubility and dissolution rate by about 11,500-foldand twofold, respectively. It was further suggested that thismethod of solid dispersion preparation is better than conventionalmethods in terms of environmental and industrialstandpoints. Thus, it was concluded that CV-loaded soliddispersion prepared using this method would be of use fordelivering poorly water-soluble CV with enhanced solubilityand dissolution, but without crystalline changes.

RESEARCH ARTICLE : A novel surface-attached carvedilol solid dispersion with enhangced solubility and dissolution

( Sung Neung Lee ),( Beijay Kumar Poudel ),( Tuan Hiep Tran ),( Nirmal Marasini ),( Roshan Pradhan ),( Young Im Lee ),( Dong Won Lee ),( Jong Soo Woo ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Ki 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

A novel surface-attached, spray-dried solid dispersion containing poorly water-soluble carvedilol (CV) without any change in the crystallinity was prepared using water, polyvinylpyrrolidone (PVP K30) and Tween 80. The solid dispersion was optimized by investigating the effects of the weight ratios of Tween 80/PVP K30 and carrier/drug on the aqueous solubility of CV. The optimum solid dispersion consisted of a relatively low carrier to drug weight ratio: the weight ratio of CV/PVP K30/Tween 80 was 12/4/2. Unlike conventional methods of solid dispersion preparation, this method yielded CV-loaded solid dispersion with no change in the crystallinity of the drug as was evident from SEM, DSC and XRD. It was demonstrated that the solid dispersions prepared had hydrophilic carriers attached to the surface of the drug, thus changing it from a hydrophobic to a hydrophilic form without changing the crystalline form. The optimized solid dispersion improved the drug solubility and dissolution rate by about 11,500-fold and twofold, respectively. It was further suggested that this method of solid dispersion preparation is better than conventional methods in terms of environmental and industrial standpoints. Thus, it was concluded that CV-loaded solid dispersion prepared using this method would be of use for delivering poorly water-soluble CV with enhanced solubility and dissolution, but without crystalline changes.

Prevalence of Toxoplasma gondii Infection in Feral Cats in Seoul, Korea.

Lee, Sang-Eun,Kim, Neung-Hee,Chae, Hee-Sun,Cho, Shin-Hyeong,Nam, Ho-Woo,Lee, Won-Ja,Kim, Sun-Heung,Lee, Jung-Hark American Society of Parasitologists] 2011 The Journal of parasitology Vol.97 No.1

<P>Abstract The present study assessed the prevalence of Toxoplasma gondii infection in feral cat populations in Seoul using enzyme-linked immunosorbent assay (ELISA) and nested polymerase chain reaction (PCR). A total of 456 feral cats from 17 wards in Seoul was surveyed. The overall prevalence of T. gondii infection was 15.8% (69/456) by ELISA and 17.5% (80/456) by PCR; by gender, 17% (44/259) by ELISA and 16.2% (42/259) by PCR in males and 14.3% (28/196) by ELISA and 19.4% (38/196) by PCR in females. On a baseline of the Han River, prevalence was 15.1% (29/192) by ELISA and 15.6% (30/192) by PCR in the upper region and 16.4% (43/264) by ELISA and 18.9% (50/264) by PCR in the lower area. This suggested that toxoplasmosis is widespread throughout Seoul's feral cat population and it is critical that the city institute policies for the control of the feral cat population to reduce the risk of toxoplasmosis transmission to animals, including humans.</P>

ZnO를 이용한 air-gap 형태의 FBAR 소자 제작에 대한 연구

박성현(Sung-Hyun Park),이순범(Soon-Beom Lee),신영화(Young-Hwa Shin),이능헌(Neung-Heon Lee),이상훈(Sang-Hoon Lee),추순남(Soon-Nam Chu) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7

Air-gap type film bulk acoustic wave resonator device using ZnO for piezoelectric layer and sacrifice layer, deposited by RF magnetron sputter with various conditions, fabricated in this study. Also, membrane(SiO₂) and top and bottom electrode(both Al) of piezoelectric layer deposited by RF magnetron sputter. Using micro electro mechanical systems(MEMS) technique, sacrifice layer removed and then air-gap formed. The results of each process checked by XRD, AFM, SEM to obtain good quality device.

신공여자특이수혈에 따른 면역학적변화가 Cyclosporine - A 를 사용한 이식신의 예후에 미치는 영향

박능화(Neung Wha Park),지상근(Sang Keun Ji),최현묵(Hyun MOok Choi),김영우(Young Woo Kim),이신화(Sin Wha Lee),양상호(Sang Ho Yang),임학(Hark Rim),이재우(Jae Woo Lee),이승도(Seung Do Lee) 대한내과학회 1996 대한내과학회지 Vol.50 No.5

Objectives: Donor specific transfusion (DST) prior to kidney transplantation has been widely accepted due to its beneficial effect on the graft survival. The mechanisms of protective effect of DST are not clearly understood, although several hypotheses have been suggested including alterations of cell mediated immunity. The significance of DST, however, tends to be decreased following introduction of cyclosporine. Therefore, we investigated the prognostic effect of mixed lymphocyte culture (MLC) an<i other cell mediated immunological changes induced by DST. Methods: 98 HLA-haploidentical renal transplants operated during the period of 1985 through 1991 were evaluated. Among these 48cases were DST group and the remainder was control group. Immunological indices including MLC were examined and graft survivals were analyzed. Graft loss was de- fined as a loss of its function requiring dialysis. Results: 1) Following DST, stimulation index of MLC was significantly suppressed from 4.0.0.4 (mean±S.E.) to 2.6±0.1 (p<0.(E), Relative response appeared to be decreased after DST from 61.1±6.0% to 49.9±3.1%, although thc difference was not statistically significant. 2) No significant changes in CD3, CD4, CD8, DR' cell, T-cell stimulation test by PHA and spontaneous lymphocyte transformation were found after DST. For all indices there was no significant difference between the post DST and control groups. 3) The actuarial graft survival rates for 1 and 5 years were 94±4% and 75±57%, respectively, in DST group and 904Fo and 69±14%, respectively, in control group. The graft survivals of DST and control groups were not significantly different. 4) The 1- and 5-year graft survival rates were 94±4% and 71±8%, respectively, in the DST group with the SI value over 2.0, and 92±7% and 85±10%, respectively, in the DST group with SI value lesser than 2.0. 5) The 1- and 5-year graft survival rates were 91±5% and 72±8%, respectively, in the DST group with RR value greater than 40%, and 100% and 85±105, respectively, in the DST group with RR value lesser than 40% Conclusion: These results suggest that although DST suppresses stimulation index, it could not improve graft survival in HLA-haploidentical renal transplants treated with cyclosporine.

Real-World Efficacy and Safety of Daclatasvir/Asunaprevir Therpay for Patients with Hepatitis C Virus in Ulsan Metropolitan City

( Muyeol Lee ),( Dong-geon Lee ),( Yujin Yang ),( Dae Hyun Kim ),( Bo Sik Choi ),( Hyeong Uk Ju ),( Neung Hwa Park ),( Byung Uk Lee ),( Jae Ho Park ),( Seok Won Jung ),( In Du Jeong ),( Sung-jo Bang ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Daclatasvir/asunaprevir (D/A) combination therapy has approved as a first interferon free oral regimen for chronic hepatitis C in Korea. D/A combination therapy has shown a high virological response for chronic genotype 1 hepatitis C virus (HCV) infected patients in clinical trials and real world data of Japanese. In the present study, we analyzed the real world efficacy and the safety of D/A combination therapy for patients with (HCV) in metropolitan city Ulsan. Methods: We retrospectively analyzed clinical data of chronic HCV genotype Ib patients treated with D/A combination therapy at five hospitals in the metropolitan city Ulsan. Of 146 patients treated with D/A combination therapy, 117 patients completed treatment were included in safety and efficacy analysis. Results: D/A combination therapy was the first-line treatment for 64 (54.7%) patients. 44 (37.6%) patients were null responders or relapsers of previous interferon treatment and nine patients (7.7%) were found to be intolerant of interferon. Fifty two (44.4%) patients exhibited cirrhotic change. Sustained virologic response at 12 weeks (SVR 12) rate was 90.6% (106//117) overall, 93.87% the treatment- naive group, 86.4% in the treatment-failure group, and 88.9% in the treatment-intolerant group. SVR12 rates for patients with and without cirrhosis were 86.5% and 93.8%, respectively (p>0.05). SVR was achieved in 89.2 % of patients aged order 65 years and 92.4 % of younger 65 years. There was no significant difference in SVR12 rate (86.2% vs 97.8%) between high viral load (HCV RNA > 80,000 IU/mL) group and low viral load group. Adverse treatment-related events were reported in 00 (17.1%). One patient stopped drug due to severe general weakness and died from aspiration pneumonia. Conclusions: D/A combination therapy combination treatment should be considered as a safe and effective treatment option for genotype 1 HCV-infected patient.

양다래에 있어서 아린맛을 일으키는 calcium oxalate crystal

이상능(Lee Sang Neung),이승구(Lee Seung Koo),김호열(Kim Ho Yul) 한국원예학회 1994 한국원예학회 학술발표요지 Vol.12 No.2