서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

자가 산부식 프라이머의 적용시간이 상아질의 미세인장 결합강도에 미치는 영향

조영곤,이영곤,김종욱,박병철,김종진,최희영,진철희,유상훈 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.5

This study evaluated the influence of application time of self-etching primers on microtensile bond strength (μTBS) to dentin using three self-etching primer adhesive systems. Dentin surfaces were exposed from forty-eight human molars. They were conditioned with three self-etching primers (Clearfil SE Bond [SE], Unifil Bond [UF], Tyrian SPE + One Step Plus [TY]) and different primining times (10s, 20s, 30s and 40s). Composite resins were bonded to dentin surfaces and specimens were made. μTBS was tested and statistically compared using by one-way ANOVA and Tukey's Test. The results of this study presented that priming time for 10s in SE and UF groups and for 30s and 40s in TY group was highly decreased μTBS to dentin.

소아결핵

조성훈 대한가정의학회 1984 Korean Journal of Family Medicine Vol.5 No.9

위상배열 초음파를 이용한 터빈 블레이드 루트부내 결함평가 기법 연구

조용상,정계조,박상기,김재훈 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.2

초음파검사는 재료의 표면 또는 내부에 존재하는 불 연속부를 검출하기 위해, 초음파를 재료에 전달시켜 검사하는 비파괴검사법의 일종이다. 이러한 일반 초음파검사 방법 및 일반 결함평가 방법은 복잡한 현상에서 반사되는 신호로부터 결함을 구분하기가 어려워 결함의 평가 및 검사결과에 신뢰성이 떨어지고 있는 실정이다. 따라서 이러한 crack성 결함의 발생 가능성이 높으나 기존의 초음파검사 방법으로는 결함 판별에 어려움이 있는 설비에서의 검사방법 및 결함평가 방법의 제고가 필수 불가결한 실정이다. 본 연구에서는 위상배열 초음파를 사용하여 크랙 검출능력이 높고 길이 평가가 가장 정확한 방사각도를 규명하고, 주요발전설비중 하나인 터빈에 적용하였다. 기존의 초음파 검사 방식이 아닌 위상배열 초음파를 이용하여 결함의 크기를 평가할 수 있는 신 기법 및 이를 이용하여 터빈 블레이드 루트부 내에 존재하는 미세 결함에 대하여 크기평가 방법 및 결함탐지 방법에 대하여 고찰하였다. Ultrasonic testing is a kind of nondestructive test to detect a crack or discontinuity in materials or on material surfaces by sending ultrasound to it. This conventional ultrasonic technique has some limitations in reliably detecting crack or accurately assessing materials in the case of complex-shaped power plant components such as a turbine blade root. An alternative method for such a difficult inspection is highly needed. In this study, application of a phased array ultrasonic testing (UT) system to a turbine blade, one of the critical power plant components, has been considered, and the particular incident angle has been determined so that the greatest crack detectability and the most accurate crack length evaluation may be achieved. The response of ultrasonic phased array was also analyzed to establish a special method to determine the crack length without moving the transducer. The result showed that the developed method for crack length assessment is a more accurate and effective method, compared with the conventional method.

地骨皮 EA分劃의 CCl₄損傷肝에 대한 保護作用

曺永周,金聖勳 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.2

肝에 對한 東醫學的 實驗 硏究는 肝이 代謝物質에 의한 中毒에 敏感하게 反應하여 肝細胞의 變性, 壞死, 脂肪蓄積, 肝酵素의 漏出 등의 肝障碍가 나타나는 점에 着眼하여 肝毒性 誘發 物質인 CCl₄등의 肝損傷 病態 모델을 이용한 損傷肝에 대한 保護作用 實驗이 主를 이루고 있고, 最近에는 韓藥 혹은 韓方處方의 抽出物에서 補肝作用을 나타내는 主要 物質이 多糖類임이 實驗的으로 밝혀져 이에 對한 硏究도 활발히 進行되고 있다. 이에 본 연구는 대표적인 補肝藥物이라고 할 수 있는 拘杞子의 根皮인 地骨皮가 肝·肺·賢經에 入하고 淸熱凉血 作用이 있음을 勘案하여, in vitro에서 肝保護作用을 screening 하였던 바, 地骨皮 ethyl acetate(EA)層이 가장 有效하여, 本 實驗에서는 in vivo에서 四鹽化炭素(CCl₄)로 肝損傷을 誘發시킨 後 地骨皮 ethyl acetate層과 地骨皮 ethyl acetate層을 다시 SiO₂chromatograph 方法을 利用하여 分離한 細分劃(F-1, F-2, F-3, F-4)을 試科로 使用, 經口投與 後 肝機能과 相關된 各種 血淸分析 및 肝組機檢査 등을 實施하였다. CCl₄中毒 肝損傷에서 albumin과 cholesterol値는 對照群에 비하여 地骨皮 ethyl acetate層 投與群과 DDB 投與群에서 有意性있게 增加되었으며, alanine aminotransferase와 aspartate aminotransferase値는 對照群에 비하여 地骨皮 ethyl acetate層 投與群과 DDB 投與群에서 有意性있게 減少되었다. lactate dehydrogenase値는 對照群에 비하여 DDB 投與군에서 有意性있게 減少되었고, 地骨皮 ethyl acetate層 投與群에서 對照群에 비하여 減少되었으나, 有意性은 나타나지 않았다. 中毒에 의한 肝組織 變化에서는 正常群에 비하여 對照群에서 中心靜脈과 門脈周圍에서 공포성 변성이 나타나고, 細胞內의 核이 濃縮되며, 中性球의 浸潤이 뚜렷하게 나타났으며, 地骨皮 ethyl acetate層에서 投與群은 DDB 投與群 정도로 나타나 肝細胞의 損傷을 抑制하였다. Ethyl acetate層에서 특히 F-3와 F-4 분획 投與群이 對照群에 比하여 ALT, AST에서 모두 有意性있게 減少하였으며, 특히 F-3 投與群이 더욱 有效하였다. In order to evaluate the protective effect of ethyl acetate layer and its subfractions (F-1, F-2, F-3, F-4) of Lycii Cortex Radix (LCREA) on hepatic damage induced by CCl₄, the study was done. The blood chemistry and histological study were done following oral administration with materials. The results were obtained as follows: 1. In the hepatocytotoxicity with CCl₄, serum albumin and cholesterol were significantly increased in LCREA and DDB-treated groups as compared with the data of control. 2. In the hepatocytotoxicity with CCl₄, serum alanine aminotransferase (ALT) and aspartate aminotransferase(AST) were significantly decreased in LCREA and DDB-treated groups as compared with the data of control. 3. In the hepatocytotoxicity with CCl₄, serum lactate dehydrogenase (LDH) tended to decrease in LCREA-treated group with no significance while with significance in DDB-treated group as compared with control. 4. In histological changes of murine liver treated by CCl₄, LCREA inhibited the hepatic damage by CCl₄such as vacuolar degeration, lipid infiltration and pyknosis up to the efficacy by DDB as compared with control. 5. In the hepatocytotoxicity with CCl₄, serum alanine aminotransferase (ALT) and aspartate aminotransferase(AST) were significantly decreased in F-3 and F-4 treated groups as compared with the data of control and also F-3 subfraction was more effective. It was concluded that LCREA had protective effects on the hepatic damage, and especially F-3 isolated from LCREA was more effective, which suggest it is necessary to study more with F3 of Lycii Cortex Radix.

水紅花子의 抗癌活性 및 抗轉移 效果에 關한 硏究

曺永周,金聖勳,金東熙 대전대학교 한의학연구소 2002 혜화의학회지 Vol.10 No.2

To evaluate the antitumor activity and antimetastatic effects of Polygoni Orientalis Fructus(POF), studies were done experimentally. The results were obtained as follows: 1. In cytotoxicity against A549, and XF498 cell concentration inhibiting cell growth up to below 30% of control was recognized at 200㎍/㎖ of POF. Also POF inhibited cell growth up to below 30% of control against SK-OV-3, SK-MEL-2, HCT15 and MCF-7 cell at 100㎍/㎖. 2. The concentration inhibiting adhesion of A549 and SK-OV-3 to complex extracellular matrix up to below 70% of control was recognized at 100㎍/㎖ of POF. 3. In pumonary colonizatin assay, a number of colonies in the lungs were decreased signiicantly in POF treated group as compared with control group. These results suggested that POF extracts might be usefully applied for prevention and treatment of cancer.

자가 산부식 접착제로 접착된 광중합과 이원중합 복합레진의 법랑질 결합강도 비교

조영곤,유상훈 대한치과보존학회 2007 Restorative Dentistry & Endodontics Vol.32 No.1

본 연구는 자가 산부식 접착제를 적용한 법랑질에 광중합과 이원중합 복합레진을 접착시켜 접착제와 복합레진의 종류에 따른 미세전단 결합강도를 상호 비교하기 위하여 시행하였다. 발거된 상ㆍ하악 대구치를 근, 원심 방향으로 l mm 두께가 되도록 절단하여 사용된 접착제의 종류에 따라 Xeno 군 (Xeno Ⅲ), Adper 군 (Adper Prompt L-Pop), AQ 군 (AQ Bond)으로 분류하였다. 각 시편의 법랑질 표면에 각 군에 해당하는 접착제를 적용한 후 Tygon tube를 이용하여 광중합형 복합레진 (Z 250)이나 이원중합 복합레진 (Luxacore)을 접착하였다. 실온의 증류수에 24시간 동안 보관한 후, universal testing machine을 이용하여 각 시편의 복합레진과 법랑질의 접착계면이 파절될 때까지 분당 l mm의 crosshead speed를 가하여 미세전단 결합강도를 측정한 후 통계학적으로 분석하여 다음과 같은 결과를 얻었다. 1. 동일 접착제로 결합된 광중합과 이원중합 복합레진의 법랑질에 대한 미세인장 결합강도는 광중합 복합레진에서 통계학적으로 높게 나타났다 (p<0.05). 2. Z 250을 접착시킨 각 군의 미세전단 결합강도는 Xeno 군에서 7.73 ± 2.01 MPa, Adper 군에서 6.74 ± 1.80 MPa, AQ 군에서 9.59 ± 2.51 MPa를 나타내어 AQ 군이 Adper 군 보다 통계학적으로 높게 나타났다 (p<0.05). 3. Luxacore를 접착시킨 각 군의 미세전단 결합강도는 Xeno 군에서 5.19 ± 1.32 MPa, Adper 군에서 3.41 ± 1.19 MPa, AQ 군에서 4.50 ± 0.96 MPa를 나타내어 Xeno 군이 Adper 군 보다 통계학적으로 높게 나타났다 (p<0.05). This study compared the microshear bond strengtht (μSBS) of light-cured and dual-cured composites-ites to enamel bonded with three self-etching adhesives. Crown segments of extracted human molars were cut mesiodistally, and 1mm thickness of specimen was made. They were assigned to three groups by used adhesives : Xeno group (Xeno Ⅲ), Adper group (Adper Prompt L-Pop), and AQ group (AQ Bond). Each adhesive was applied to cut enamel surface as per manufacturer’s instruction. Light-cured (Filtek Z 250) or dual-cured composite (Luxacore) was bonded to enamel of each specimen using Tygon tube. After storage in distilled water for 24 hours, the bonded specimens were subjected to μSBS testing with a crosshead speed of 1 mm/minute. The mean μSBS (n = 20 for each group) was statistically compared using two-way ANOVA, Tukey HSD, and t test at the 0.05 probability level. The results of this study were as follows; 1. The μSBS of light-cured composite was significantly higher than that of dual-cured composite when same adhesive was applied to enamel. 2. For Z 250, the μSBS of AQ group (9.95 ± 2.51 MPa) to enamel was significantly higher than that of Adper goup (6.74 ± 1.80 MPa), but not significantly different with Xeno group (7.73 ± 2.01 MPa). 3. For Luxacore, the μSBS of Xeno group (5.19 ± 1.32 MPa) to enamel was significantly higher than that of Adper goup (3.41 + 1.19 MPa), but not significantly different with AQ group (4.50 ± 0.96 MPa).

배추 內婚系와 交配後代에서 自家不和合 遺傳因子의 活力變異에 대한 硏究

趙成大,閔炳訓,李政明 경희대학교 부설 식량자원개발연구소 1993 硏究論文集 Vol.14 No.-

배추의 自家不和合 因子組成이 다른 全球(S_(5)S_(5)) 및 野崎 2號(S_(6)S_(6))계통과 이들간의 交配에서 얻은 F₁식물(S_(5)S_(6)), 그리고 F₁을 自殖하여 얻은 F₂植物體群을 상호교배하여 自家不和合 遺傳因子에 대한 優劣關係의 遺傳과 發現樣相을 연구 하였다. F₁ 및 F₂식물체에서의 자가불화합 支配 對立因子間의 관계는 花粉에서 安定的이었으나 株頭에서의 환경적 요인등에 의해 다양하게 변화하는 것이 확인 되었다. F₁식물의 自家不和合 程度나 S-因子間의 優劣關係는 이를 自殖한 F₂식물에서 동일하게 나타나지 않았다. A series of experiments were conducted to investigate the dominance-recessive relationship of S-genes and degrees of self incompatibility in 2 inbred lines of known S-allele and their F₁and F₂ plants by full diallele crosses. The dominance-recssive relationship between S-genes in pollen was stable in F₁and F₂ plants throughout the experiment. In stigma, however, the relationship apparently changed or reversed in F₁or F₂ plants and also possibly by environmental and genetic factors. F₂ plants did not exhibit the same dominance-recessive relationship as in the F₁plants, especially in stigma.

하악골에 발생된 Low grade 골육종:증례보고

조현이,정종철,김호성,최재욱,성대경,서지훈,김성범,이계혁 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Osteosarcoma is a primary malignant tumor arising most often in the long bone, but rare in jaw bone. Especially osteogenic sarcoma of the mandible is a rare tumor, comprising less than 0.5% of all head and neck tumors. Osteosarcoma occurs cheifly in young persons, and presenting very survival rates. Histopathologically this tumor can be classified three types, osteoblastic, fibroblastic, chondroblastic and classified from low grade to high grade by anaplasia or mitosis of the tumor cells. Sometimes, the exact diagnosis of osteosarcoma is difficult especially in low grade osteosarcoma, even if clinical or radiographical findings suggest to osteosarcoma. So suspcious to malignant bone tumor in clinical or radiological findings, biopsy should be taked from deep portion and multiple area, and sharing the patient history and radiographs with pathologist will assist in the development of the diagnosis. We report a case of low grade osteosarcoma on the mandible initially difficulty in accurate diagnosis. The patient visited our hospital for routine dental treatment but radiographic findings displayed ill-defined radiolucency with osteoid formation on the mandible. Final diagnosis was difficulty in initial biopsy but subsequent biopsy taked from deep portion presented infiltrative growth and mitosis of the tumor cell in some area with small osteoid bone formation, so we could reach final diagnosis as low grade sarcoma. We treated this patient with bloc resection of the mandible and immediate reconstruction with iliac corticocancellous block.