척수강내 Bupivavacain에 첨가한 소량의 Neostigmin의 진통효과와 부작용

소금영,정종달,김병철,유벙식,안태훈,김훈정,임경준 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background : Spinal cholinergic receptor has been shown to have a antinociceptive action, an effect that can be mimicked by spinal cholinesterase inhibitor. Intrathecal injection of neostigmine cause analgesia and adverse effect in a dose-dependent pattern in the patients. The purpose of this study was to determine whether small doses of intrathecal neostigmine (10, 25 and 50 ㎍) produce analgesia and any side effects. Method : After getting informed consents, 60 patients scheduled for orthopedic surgery of lower extremities under spinal anesthesia were randomly assigned to one of four groups. Using dose-ranging design, patients received either normal saline or neostigmine l0, 25 or 50 ㎍ in a 1-㎎ solution of 5% glucose in normal saline with heavy bupivacaine 12 ㎎. Heart rate, blood pressure, degree of motor and sensory block were recorded. The assessment of postoperative analgesia included time to first rescue, total number of rescue medication and pain score on visual analog scale (VAS) at 1, 3, 6, 9, 12, 24 hour. Nausea and vomiting were assessed by using the visual analog scale at 24 hr postperatively and the incidence of them was recorded postoperatively. Result : There were no significant differences among the four groups in characteristics of spinal blocks. Compared to saline, neostigmine groups significantly prolonged time to first rescue medication and decreased total number of rescue medication and pain visual analog scale score, but incidence of nausea and 24hr nausea VAS score were not increased in neostigmine group compared to control group. Conclusion : These data in patients injected intrathecal neostigmine suggest that analgesia may occur at doses less than neostigmine 50 ㎍ and neostigmine 50㎍ has a better analgesia effect with fewer side effects than other doses for postoperative analgesia.

비탈분극성 근육이완의 길항시 Atropine, Pyridostigmine과 Glycopyrrolate, Pyridostigmine의 혼합정주가 심박수에 미치는 영향

소금영,채종한,조남수,정종달,김용일 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

Changes in heart rate during reversal of neuromuscular block have been a subject of clinical investigation for many years. A number of studies, have compared the effect used anticholinergics and anticholinesterase. In most studies, the drugs were administered simultaneously. Atropine and glycopyrrolate were studied in dose of 15㎕/㎏, 20㎕/㎏ and 7㎕㎕/㎏, lO㎕/㎏, given intravenously in a mixture with pyridostigmine 200㎕/㎏ at the end of operation. 15 ASA Class Ⅰ, Ⅱ patients, aged between 16 to 65, were selected in each group. Anesthesia was maintained with halothane(1.0 vol%), N20(3L/ min), O2(3L/min) and vecronium bromide 0.07㎎/㎏ was used as a muscle relaxant. The results were as follows ; 1) Atropine 15㎕/㎏, 20㎕/㎏, showed significant initial increase in pulse rate, atropine ZO㎕㎕/㎏ showed more initial increase than atropine 15㎕/㎏ Atropine 15㎕/㎏ showed more rate decrease than atropine 20㎕/㎏. 2) Gylcopyrrolate 7㎕/㎏ 10㎕/㎏ showed significant initial increase in pulse rate gylcopyrrolate 7㎕/㎏, 10㎕/㎏ showed less initial increase than atropine 15㎕/㎏, 20㎕/㎏. Atropine 20㎕/㎏ showed more late decrease than glycopyrrolate 10㎕/㎏.

미성숙영구치의 복합항생제 적용에 의한 변색의 처치: 증례보고

박소연,김영재,김정욱,장기택,이상훈,김종철,한세현,현홍근 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

The concept of revascularization of necrotic pulps regained interest and became an alternative conservative treatment option for young permanent teeth with immature roots. Revascularization of immature teeth with apical periodontitis depends mainly on disinfection of the canal. Since the infection of the root canal system is considered to be polymicrobial, a combination of drugs would be needed to treat the diverse flora. A triple antibiotic mixture of metronidazole, ciprofloxacin, and minocycline was used as an intracanal medicament. However, discoloration was developed after applying the triple antibiotic mixture. It is believed that the marked discoloration is related to the use of minocycline. The aim of this article was to present cases of coronal discoloration after triple antibiotic therapy in immature tooth and was treated with bleaching technique to control coronal discoloration. In conclusion, revascularization by using triple antibiotics promotes a paradigm shift in treating endodontically involved permanent teeth. However, we should understand that triple antibiotics containing minocycline induces tooth discoloration. Further research to prevent coronal discoloration should be investigated and suggested for the safe use of triple antibiotics. 괴사된 미성숙영구치의 치수치료에 있어서 치수의 재혈관화를 통해 치근단 발육 및 치근형성을 지속하려는 개념이 소개됨 으로써 현재 미성숙영구치의 치수치료의 대안으로 제시되고 있다. 이러한 치근단 염증을 가진 미성숙 영구치의 재혈관화를 위해서는 가장 중요한 것이 근관내 감염된 부분을 확실히 제거하는 살균(disinfection)이다. 근관 내 감염은 여러 세균의 복 합작용으로 일어나기 때문에 철저한 살균에 사용되는 약제의 조합은 다양한 범위의 균주를 모두 제거 가능해야한다. Metronidazole(MN), ciprofloxacin(CF), minocycline(MC)의 세 가지 복합항생제가 약제로 사용되고 있으나 이 복합항생 제 적용 후 치관변색을 일으키는 사례가 보고되고 있다. 이러한 치관변색은 항생제의 성분 중 MC에 의한 것으로 여겨지고 있으며, 본 증례에서는 복합항생제 적용에 의해 야기된 치관변색의 증례를 소개하고 이를 표백술로 처치하여 최종 수복한 증 례를 보고하였다. 복합항생제 적용을 통해 미성숙영구치의 치수치료에 새로운 패러다임을 제시한 것은 분명하지만 치관변색 등의 부작용이 있음을 인지하고 치관변색을 사전에 예방하고 최소화하기 위해 다양한 방법이 강구되어야 할 것이다.

바나듐과 크롬의 쿠페론 착물의 전기화학적 행동의 차이

권영순,이상미,정미영,박소영 가톨릭대학교 자연과학연구소 2004 자연과학논문집 Vol.25 No.-

바나듐과 크롬의 쿠페론 착물의 전기화학적 행동을 아세트산 완충용액(pH 5.0)과 붕산염 완충용액(pH 9.5)에서 조사해 본 결과 크롬-쿠페론 착물의 환원봉우리전위(E_(ct)^(p))가 쿠페론의 봉우리전위(E₁^(p))보다 작다 (E_(ct)^(P) < E₁^(P)). 붕산염 완충용액에서 크롬-쿠페론계의 전도된 봉우리가 크게 나타나는 것은 E_(ct)^(P)와 E₁^(P)의 차이가 큰 때문인 것으로 생각된다 (ΔE = 0.40V). When the peak potentials of V-cupferron and Cr-cupferron complex compare at both buffer solution(pH 5.0 and pH 9.5), the peak potential of Cr-cupferron(E_(ct)^(P)) is smaller the peak potential of cupferron (E₁^(P)) at both buffer solution (E_(ct)^(p)) < E₁^(p)). The appearance of larger inverted peak of Cr-cupferron in borate buffer solution results from large difference of E_(ct)^(p) and E₁^(p) (ΔE=0.40 V).

감나무탄저병에서 분리한 Gloeosporium kaki의 2계통

崔貞植,李貴宰,金炯武,蘇仁永 全北大學校 1993 論文集 Vol.35 No.-

A anthracnose symptom at persimmon tree was found out in the field, Chonju in Chonbuk province and Haenam Experiment Station in Chonnam province in 1991 and 1992. The cultivated character and the pathogenicity of the fungi were as follows : These fungi, Gloeosparium kaki which were isolated from the anthracnose were classified into strain Ⅰ and Ⅱ by the cultivated characteristics. The size of conidia in strain Ⅰ was 22.5 × 6.82 ㎛ and that of strain Ⅱ was 20.3 × 6.2 ㎛. In a PDA, the colour of strain I was light brown and made a central zone. The colour of strain Ⅱ was black brown and deep grey and didn't make a central zone. The pathogenicity of strain Ⅰ was similar to strain Ⅱ in the leaf, branches.

Duchenne 근이영양증 환자에서 Propofol과 Remifentanil을 이용한 전정맥마취 경험 : 증례보고

김상훈,이현영,소금영,정종달,고지현 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

Patients with Duchenne's muscular dystrophy are considered to be at risk of peri-operative complications. It's patients can be associated with cardiac arrest, rhabdomyolysis, malignant hyperthermia during anaesthesia. This is a case report of a 14 years old male patient who had known Duchenne muscular dystrophy was scheduled for open reduction and internal fixation of right humerus fracture. Regional anesthesia was refused by the patient. Total intravenous anesthesia (TIVA) was performed with propofol and remifentanil, which was started at the targeted effect concentration of 3.0μg/ml and 10ng/ml via target controlled infusion. After the end of operation, the patient was awaken without any problem and was transferred to recovery room.

수술후 통증조절을 위한 지주막하강내 모르핀 투여시 Epinephrine 첨가효과

송민엽,송경준,정종달,소금영,김용일 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

Preliminary Guidelines for the Clinical Evaluation and Management of Long COVID

Kim Yoonjung,Kim Seong Eun,Kim Tark,Yun Ki Wook,Lee So Hee,Lee Eunjung,Seo Jun-Won,Jung Young Hee,Chong Yong Pil 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.3

Long-lasting coronavirus disease 2019 (COVID-19) symptoms beyond 12 weeks, the so-called ‘long COVID’ have been increasingly reported worldwide. Long COVID can be manifested in various forms, and there is an increasing demand for proper assessment and management. However, it is challenging when trying to determine the best-practice standards of care based on the current evidence because there is no internationally agreed clinical definition or clear treatment pathway. Therefore, the present guidelines have been drafted to provide advice on diagnosis and management based on the latest updated available evidence and the consensus of expert opinion. So far, no standard test and drug treatment can be strongly recommended for patients with long COVID because of a lack of evidence. The present guidelines provide advice based on 12 key questions, including appropriate interventions for long COVID that can be used in clinical practice. Continuous careful observation and studies related to long COVID are needed for the long-term impact of COVID-19 and proper management for long COVID to be determined.

Antibacterial Activity of Water Soluble Components of Elfvingia applanata Alone and in Combinations with Quinolones

(Young So Kim),(Seong Kug Eo),(Ki Wan Oh),(Chong Kil Lee),(Young Nam Lee),(Seong Sun Han) 한국균학회 2001 Mycobiology Vol.29 No.1

N/A N/A

Levofloxacin Efflux and <i>smeD</i> in Clinical Isolates of <i>Stenotrophomonas maltophilia</i>

Chong, So Young,Lee, Kyungwon,Chung, Hae-Sun,Hong, Seong Geun,Suh, Younghee,Chong, Yunsop Mary Ann Liebert, Inc. Publishers 2017 Microbial Drug Resistance Vol.23 No.2