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Kim, Won-Keun,No, Jin Sun,Lee, Seung-Ho,Song, Dong Hyun,Lee, Daesang,Kim, Jeong-Ah,Gu, Se Hun,Park, Sunhye,Jeong, Seong Tae,Kim, Heung-Chul,Klein, Terry A.,Wiley, Michael R.,Palacios, Gustavo,Song, Ji U.S. Department of Health and Human Services * Cen 2018 Emerging Infectious Diseases Vol.24 No.2
<P>Seoul virus (SEOV) poses a worldwide public health threat. This virus, which is harbored by <I>Rattus norvegicus</I> and <I>R. rattus</I> rats, is the causative agent of hemorrhagic fever with renal syndrome (HFRS) in humans, which has been reported in Asia, Europe, the Americas, and Africa. Defining SEOV genome sequences plays a critical role in development of preventive and therapeutic strategies against the unique worldwide hantavirus. We applied multiplex PCR–based next-generation sequencing to obtain SEOV genome sequences from clinical and reservoir host specimens. Epidemiologic surveillance of <I>R. norvegicus</I> rats in South Korea during 2000–2016 demonstrated that the serologic prevalence of enzootic SEOV infections was not significant on the basis of sex, weight (age), and season. Viral loads of SEOV in rats showed wide dissemination in tissues and dynamic circulation among populations. Phylogenetic analyses showed the global diversity of SEOV and possible genomic configuration of genetic exchanges.</P>
( Jeong Won Jang ),( Jin Seoub Kim ),( Hye Seon Kim ),( Kwon Yong Tak ),( Heechul Nam ),( Pil Soo Sung ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ),( Lewis R. Roberts ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1
Background/Aims: The role of hepatitis B virus (HBV) integration into the host genome in hepatocarcinogenesis following hepatitis B surface antigen (HBsAg) seroclearance remains unknown. Our study aimed to investigate and characterize HBV integration events in chronic hepatitis B (CHB) patients who developed hepatocellular carcinoma (HCC) after HBsAg seroclearance. Methods: Using probe-based HBV capturing followed by next-generation sequencing technology, HBV integration was examined in 10 samples (seven tumors and three non-tumor tissues) from seven chronic carriers who developed HCC after HBsAg loss. Genomic locations and patterns of HBV integration were investigated. Results: HBV integration was observed in six patients (85.7%) and eight (80.0%) of 10 tested samples. HBV integration breakpoints were detected in all of the non-tumor (3/3, 100%) and five of the seven (71.4%) tumor samples, with an average number of breakpoints of 4.00 and 2.43, respectively. Despite the lower total number of tumoral integration breakpoints, HBV integration sites in the tumors were more enriched within the genic area. In contrast, non-tumor tissues more often showed intergenic integration. Regarding functions of the affected genes, tumoral genes with HBV integration were mostly associated with carcinogenesis. At enrollment, patients who did not remain under regular HCC surveillance after HBsAg seroclearance had a large HCC, while those on regular surveillance had a small HCC. Conclusions: The biological functions of HBV integration are almost comparable between HBsAg-positive and HBsAg-serocleared HCCs, with continuing pro-oncogenic effects of HBV integration. Thus, ongoing HCC surveillance and clinical management should continue even after HBsAg seroclearance in patients with CHB. (Clin Mol Hepatol 2021;27:207-218)
Seung-Ok Lee,Yeon-Ji Bae,Yun-Seo Kim,Ji-Hong Bang,Van-Long Truong,Hanitranirina R. G. Rarison,Woo-Sik Jeong 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Oxidation and inflammation are involved pathogenesis of chronic diseases, including diabetes, aging, and cancer. Enhanced antioxidant and anti-inflammatory functions contribute to management of pathological conditions. This study aimed to evaluate antioxidant and anti-inflammatory effects of L. platyphylla fruit. Results showed that both pericarp and seed ethanol extracts of L. platyphylla fruit exhibited powerful antioxidant activities, based on in vitro antioxidant assays such as DPPH, ABTS<SUP>+</SUP>, and NO radical scavenging, in which pericarp exerted higher antioxidant activity than seed. Antioxidant activities highly correlated with total phenolic, flavonoid and saponin contents. In addition, these compounds enhanced cellular antioxidant defense by decreasing ROS formation and increasing expression of antioxidant enzymes, such as CAT and HO-1. Moreover, both pericarp and seed extracts exhibited anti-inflammatory properties by suppressing NO production and decreasing expression of iNOS, COX-2, and IL-1β in LPS-stimulated macrophages. These findings suggest that L. platyphylla fruit could be a source of antioxidant and anti-inflammatory compounds for functional food development.
Lipopolysaccharide alleviates liver injury induced by thioacetamide in rats
( Jeong Ran Park ),( Eun Jeong Kim ),( Jung Won Yang ),( Han Byeol Lee ),( Seok Ho Hong ),( Seung Koo Lee ),( In Bum Seo ),( Se Min Ryu ),( Sung Joon Cho ),( Heung Myong Woo ),( Sung Min Park ),( Se R 한국예방수의학회 2013 예방수의학회지 Vol.37 No.3
Lipopolysaccharide (LPS) is the major of outer membrane of gram-negative bacteria and one of the most potent microbial initiators of inflammation. From the previous study showed that exposure to a low dose of LPS renders animals tolerant to a lethal dose of LPS, and protects against the toxicity of various chemicals. However, the effects of LPS treatment in thioacetamide (TA) - induced liver injury remain largely unknown. Liver injury caused by various toxic chemicals such as carbon tetrachloride, alcohol, dimethylnitrosamine. Here, we induced rat liver injury by intraperitoneal injection of TA, a representative hepatic fibrosis inducer. In this study, we investigated the effects of LPS in TA group, LPS group, LPS/TA group and vehicle control group on Sprague-Dawely rats (five rats for each group). All rats at the end of the experiment were sacrificed, and liver and serum were obtained. Serological analysis and hematoxylin and eosin staining showed that LPS/TA co-treatment was associated with decrease of aspartate aminotransferase (AST), alanine transaminase (ALT) and totalbilirubin and fibrosis than in TA-treated rats. RT-PCR showed that the levels of IL-6 and Cox2 mRNA were lower in the liver of LPS/TA-cotreated rats than in TA-treated rats. There were no significant differences ALT, ALP, AST, total-bilirubin, IL-6 and Cox2 between vehicle control and LPS-treated rats. These results imply that LPS/TA cotreatment partially alleviates the TA-induced liver injury of rats by reducing inflammatory response.
Evidence for Existence of a Water - Extractable Anticoagulant in an Earthworm , Lumbricus rubellus
Jeong Im Woo,Yun Kyung Bahk,Kyoung Hee Yu,Seung R . Paik,Chung Soon Chang 생화학분자생물학회 1996 BMB Reports Vol.29 No.6
We have isolated a water-extracted novel regulator for blood coagulation from an earthworm. Lumbricus rubellus. As a folk remedy, the earthworm has been known to facilitate blood circulation. After complete heat inactivation of endogenous proteases in the earthworm, an anticoagulants) was purified through ammonium sulfate fractionation and three consecutive gel permeation chromatography of Sephacryl S-300, Sephadex G-75, and G-150 by measuring activated partial thromboplastin time (APTT). The anticoagulant was further purified to 2,800 fold with a C4 reversed-phase HPLC. This activity was stable under heat (100℃ for 30 min) and acidic conditions (0.4 N HCl). The effects of this partially purified anticoagulant on thrombin were observed with various substrates such as Nα-benzoyl-DL-arginine-p-nitroanilide (BApNA), H-D-phenylalanyl-L-pipecoyl-L-arginine-p-nitroanilide (S-2238), Nα-p-tosyl-L-arginine methyl ester (TAME), and fibrinogen as a natural substrate. Only TAME hydrolysis, due to an esterase activity of the enzyme, was inhibited among the chromogenic substrates. In addition, the anticoagulant not only inhibited the conversion of fibrinogen to fibrin but also prolonged the fibrin clot formation monitored with the in vitro coagulation test. Based on these observations, we suggest the significance of measuring the ability of antithrombotic drugs to inhibit the esterase activity of thrombin. In this report. it was also shown that the earthworm indeed contained a water-extractable, heat- and acid-stable anticoagulant which could be used as a novel antithrombotic agent.
Seung R . Paik,Jeong Im Woo,Gyoung Mi Kim,Jin Mo Cho,Kyoung Hee Yu,Chung Soon Chang 생화학분자생물학회 1997 BMB Reports Vol.30 No.1
Earthworm extracts are known for anti-inflammatory, analgesic, antipyretic, and anticancer effects but can also influence blood circulation. It was previously shown that an earthworm, Lumbricus rubellus. contained a water-extractable anticoagulant which was a heat- and acid-stable molecule with hydrophilic property. In order to uncover the biochemical nature of this molecule, the anticoagulant was processed with various hydrolases such as trypsin, DNase. RNase. and lysozome. When the digested samples were analyzed with an in vitro coagulation test measuring activated partial thromboplastin time (APTT) and agarose gel electrophoresis, the anticoagulant proved to be a relatively homogeneous DNA fragment with relative molecular size around 72 base pairs. Interestingly, the activity was further stimulated with a trypsin digestion. RNA, on the other hand, did not prolong the APTT. It was also demonstrated that the DNA accelerated the antithrombin III (AT-III) inhibition of thrombin from IC_(50) of 0.34 to 0.16 unit determined with S-2238 as a substrate, whereas heparin, a popular anticoagulant, shifted the value to 0.05. Therefore, it is suggested that the DNA could be considered as an alternative antithrombotic agent to heparin, which would exhibits bleeding side effects.
Jeong, Myeong Seon,Kim, Eunha,Kang, Hyo Jin,Choi, Eun Joung,Cho, Alvin R.,Chung, Sang J.,Park, Seung Bum The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.52
<P>We report a Seoul-Fluor-based bioprobe, S<I>f</I>BP, for selective monitoring of protein tyrosine phosphatases (PTPs). A rational design based on the structures at the active site of dual-specific PTPs can enable S<I>f</I>BP to selectively monitor the activity of these PTPs with a 93-fold change in brightness. Moreover, screening results of S<I>f</I>BP against 30 classical PTPs and 35 dual-specific PTPs show that it is selective toward vaccinia H1-related (VHR) phosphatase, a dual-specific PTP (DUSP-3).</P> <P>Graphic Abstract</P><P>We developed a Seoul-Fluor-based bioprobe, S<I>f</I>BP, for selective monitoring of vaccinia H1-related (VHR) phosphatase, a dual-specific protein tyrosine phosphatase (DUSP3). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc31377d'> </P>