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      • KCI등재

        박인환 시에서의 우울과 시간의식

        박슬기(Park Seul-ki) 한국시학회 2012 한국시학연구 Vol.- No.33

        박인환 시에 만연한 우울과 슬픔의 감정은 허무와 죽음의식을 나타내는 것으로 평가되어 왔다. 초기 시에서 보였던 현실 지향적 의식이 전쟁을 경험하면서, 내면으로 침잠하는 페시미즘의 성향을 보이는 것으로 평가되어 왔다. 그러나 이 슬픔과 우울의 감정은 박인환의 시에서 시간의식과 밀접하게 관계되어 나타난다는 점에서, 역사적인 것으로 이해되어야 한다. 말하자면, 전쟁이라는 매우 구체적인 폭력의 현상을 목도하고 경험하는 순간에 얻어지는 감정은 이 경험의 순간을 역사적으로 고찰할 수 있는 판단력에 해당한다. 박인환의 시는 초기의 현실 지향적 경향에서 후퇴하여 내면으로 침잠한 것이라기보다는, 이 순간의 적극적인 인식을 통해서 여전히 현실에 대응할 수 있는 시의 가치를 견고하게 지켜내고자 했다고 할 수 있다. '우울'이라는 감정의 적극적 노출은 그가 페시미즘에 빠졌다는 것을 의미하는 것이 아니라, 당시에 전쟁을 대한 다른 사람들과 다른 위치에서 있었다는 것을 의미한다. 박인환의 시에서 시간은 적극적인 '현재'의 시간, '순간'의 시간이며, 이는 그러한 시간선 위에서 빠져나오는 것을 의미하기 때문이다. 박인환은 진보적 시간관에서 빠져나와 '순간'에 적극적으로 서는 것으로써 자신의 전쟁경험을 구성하고, 그것에 의미를 부여하려고 한다. '우울'은 전쟁이라는 당면한 역사적 비극 앞에서 그것을 '판단'하고 그 자리에서 '인간의 가치'를 찾아보려는 노력에 수반하여 나타났다. 비록 박인환은 요절함으로써 그 시적 성취를 끝까지 끌고 가지는 못했지만, 1950년대에 만연한 '감정'의 문제를 새로운 차원에서 바라볼 수 있는 단초를 마련하고 있다고 평가할 수는 있을 것이다. The overflowing emotions of melancholy and sorrow in Park, In-hwan's poems has been interpreted as his consciousness of the death; his keen attention toward the reality seems to have been transformed into pessimistic attitude, which turned him to the interior after he experienced the Korean war. However, in the sense that those emotions of melancholy and sorrow are in close connection with the poet's unique concept of time, we have to understand those as something with its own historicity. Park construes historical time through the moments and achieve the positive attitudes through his poetic method of recollection. He makes the past present through the recollection; what is not existent any more is associated with the present through this poetic imagination, and this allows humans to be saved from the momentary despair. The positive exposure of the melancholic emotion in his poems does not mean that he indulged himself with pessimism; it means that he took the different position toward the war from others. In his poems, time is always the time of the positive present and this unique conception allows him to break away from the general concept of the linear flow of time. Park tries to construct and reevaluate what he experienced at the war while positioning himself at the positive moments with escaping from the conceptual framework of the progressiveness of time. The melancholy is accompanied with Park's struggle to understand the historical tragedy of the war and to discover the human values at its site. Though Park's untimely death prevented him to take this poetic achievement to another level, his poetics allows us to comprehend the issue of overflowing emotions in the post-war Korean poetry from a new angle.

      • KCI등재후보

        중합효소연쇄반응법을 이용한 급성 치수 및 치근단 질환의 병원성 세균의 동정

        김지훈,유소영,임선아,국중기,임상수,박슬희,황호길 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.2

        The purpose of this study was to investigate the frequency of 7 putative pathogens in endodontic infections. The specimens were collected from infected pulpal tissue of patients who were referred for root canal treatment to the department of conservative dentisty, Chosun University. Samples were collected aseptically using a barbed broach and a paper point. The cut barbed broaches and paper points were transferred to an eppendorf tube containing 500 ml of 1 X PBS. DNAs were extracted from the samples by direct DNA extraction method using lysis buffer (0.5% EDTA, 1% Triton X-100). Identification of 7 putative pathogens was performed by PCR based on 16S rDNA. The target species were as follows: Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Bacteroides forsythus, Actinobacillus actinomycetemcomitans, and Treponema denticola. Our data revealed that the prevalence of P.endodontalis was found in 88.6% (39 / 54), P.gingivalis 52.3% (23 / 44), P.nigrescens 18.2%(8 / 44), P.intermedia 15.9% (7 / 44), B.forsythus 18.2% (8 / 44), A.actinomycetemcomitans 2.3% (1 / 44), T.denticola 25% (11 / 44) of the samples. The high prevalence of P. endodontalis and P.gingivalis suggests that they may play an important role in the etiology of endodontic infections.

      • SCIESCOPUSKCI등재

        Global knockdown of microRNAs affects the expression of growth factors and cytokines in human adipose-derived mesenchymal stem cells

        ( Seul Ki Park ),( Jung Shin Lee ),( Eun Kyung Choi ),( Dalsan You ),( Choung Soo Kim ),( Na Young Suh ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.8

        Cell therapies utilizing mesenchymal stem cells (MSCs) have agreat potential in many research and clinical settings. Themechanisms underlying the therapeutic effects of MSCs havebeen studied previously and the paracrine effects elicited bytheir production of various growth factors and cytokines wererecognized as being crucial. However, the molecular controlsthat govern these paracrine effects remain poorly understood. To elucidate the molecular regulators of this process, weperformed a global knockdown of microRNAs (miRNAs) inhuman adipose-derived mesenchymal stem cells (hADSCs) byinhibiting DGCR8, a key protein in miRNA biogenesis. Globaldisruption of miRNA biogenesis in hADSCs caused dramaticchanges in the expression of subsets of growth factors andcytokines. By performing an extensive bio in formatic an alysis, we were able to associate numerous putative mi RNAs with these genes. Taken together, our results strongly suggest thatmiRNAs are essential for the production of growth factors and cytokines in hADSCs.

      • [P036] A case of Fournier`s gangrene with anal fistula

        ( Seul Ki Lee ),( Se Ha Park ),( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Hee Joo Kim ),( Hyang Joon Park ),( Jin Ok Baek ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

        Fournier`s gangrene is a necrotizing fasciitis involved perineal, perianal or genital areas. It begins commonly from polymicrobial infection in anorectal, urogenital tract or skin of genitalia. We report a case of Fournier`s gangrene with anal fistula. The patient was a 51-year old male who presented with painful, erythematous and supprative swelling of perineum and left thigh. Escherichia coli, Enterococcus faecalis and Staphylococcus aureus were isolated from pus culture. Histologic finding of ulcerative lesion showed necrosis of the dermis, acute and chronic inflammation and hemorrhage in the dermis. Computed tomography showed an anal fistula extending to cutaneous layer of left buttock. Based on above findings, he was diagnosed with Fournier`s gangrene. Although he was treated with broad - spectrum antibiotics for several months, the cutaneous swelling and pus discharge persisted. Mixed bacteria were still identified by pus culture. We referred the patient to anorectal surgery department for extensive surgical treatment. Fournier`s gangrene is a rare but serious condition with very high mortality. The Keys to successful outcome are early diagnosis and appropriate surgical treatment. Therefore, Fournier`s gangrene should be considered in the differential diagnosis of patients presenting with perianal, perineal abscess.

      • Investigating the viability of silkworm seeds post extended low-temperature preservation

        Seul-Ki Park,Sang-Kug Kang,Jong-Woo Park,Seong-Ryul Kim,Ji-Hae Lee,Seong-Wan Kim 한국응용곤충학회 2024 한국응용곤충학회 학술대회논문집 Vol.2024 No.04

        누에씨는 매년 계대사육을 통해 자원을 보존하지만, 이 과정에서 잠종의 소실 및 혼합사고 등의 위험이 있어, 누에 유전자원의 효율적이고 안전한 장기보존법 개발이 필요한 상황이다. 본 연구에서는 2년 동안 저온에 보관 된 누에 보급품종(백옥잠, 대황잠, 백황잠)과 누에 유전자원(n29, sa2, yang2)의 누에씨를 봄과 가을 사육기에 맞추 어 점진법을 사용하여 부화를 유도하였다. 부화된 누에씨의 부화비율과 함께 전령 경과기간, 화용비율, 전견중 등의 사육 성적을 조사하였다. 2년간 저온 보관된 누에씨의 부화비율은 보급품종에서 87~88%, 유전자원에서는 71~75%로 나타났다. 화용비율은 보급품종에서 79~89%, 유전자원에서는 71~79%로 조사되었다. 품종 지정 시 사육 성적과 비교해 볼 때, 부화비율, 화용비율, 번데기 무게, 고치무게 모두 감소하는 경향을 보였다. 또한, 2년 동안 저온에 보관된 후의 누에씨 부화기간은 1년 동안 저온에 보관된 누에씨보다 1~2일 더 길었다.

      • Efficacy of omalizumab in chronic refractory urticaria: Practical experiences in Korean patients

        ( Seul Ki Lee ),( Shin Young Song ),( Se Ha Park ),( Jeong Soo Kim ),( Hee Joo Kim ),( Jin Ok Baek ),( Hyang Joon Park ),( Joo Young Roh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

        Background: More than half of chronic spontaneous urticaria ( CSU ) patients do not respond adequately to H1-antihistamine treatment. Omalizumab is a humanized anti-IgE monoclonal antibody that has proved to be effective in treatment of patients with chronic urticaria refractory to antihistamines. Objectives: We analyzed real world experiences with using omalizumab for CSU patients who did not respond to treatment with high dose antihistamine. Methods: Twenty five patients (male : female=12 : 13, mean age, 51.0 years) were treated with 150mg or 300mg omalizumab every 4 weeks more than 12 weeks. The duration of CSU ranged 3 months and 12 years (mean, 3.3 years). Mean serum IgE level was 127.4 IU/ml (2~362 IU/ml). Treatment efficacy were assessed primarily based on Weekly urticaria activity scores (UAS-7), Weekly itch severity score (ISS-7) and Investigator’s Global assessment (IGA) changes from baseline to week 12. Results: After 12 weeks of therapy, mean UAS-7 decreased from 26.0 to 3.8, mean ISS-7 decreased from 13.5 to 2.1 and mean IGA decreased from 3.3 to 1.0. Complete remission (UAS-7 =0) was seen in 54.5% of patients who started with 300mg and in 35.7% of those who started with 150mg. Partial response (UAS-7≤6) was observed in 84.0 % of patients. Four patients(16%) had treatment failure(UAS-7>6) to omalizumab treatment. Conclusion: This real world experience demonstrated that omalizumab is a well-tolerated, beneficial option for the treatment of CSU patient refractory to antihistamine.

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