발효 황기 추출물의 항산화, 항염, 콜라게나아제 및 엘라스타아제 활성 저해 효과

박지현(Ji Hyeon Park),신재영(Jae Young Shin),허지환(Ji Hwan Heo),김상준(Sang Jun Kim),강은서(Sang Jun Kim),정세연(Se Yeon Jeong),김태준(ae Joon Kim),장선일(Seon Il Jang),조병옥(Byoung Ok Cho) 한국식품과학회 2024 한국식품과학회지 Vol.56 No.3

본 연구는 발효 황기 추출물이 발효 전 황기 추출물 보다 항산화, 항염, 콜라게나아제 및 엘라스테아제 억제 효과가 뛰어난지 평가하고자 하였다. FAE의 총 폴리페놀 및 플라보노이드 함량이 AE보다 높은 것으로 나타났으며, DPPH, ABTS 및 환원력 측정에서 FAE에서 AE보다 높은 항산화 활성을 보였다. HaCaT 세포에 SIN-1을 처리하여 효소 활성을 측정하였을 때 FAE 추출물의 처리는 감소된 SOD, catalase, GPx 활성을 AE보다 증가시키는 것을 확인하였다. 또한 LPS로 자극된 RAW264.7 세포에서 증가된NO, PGE2 및 IL-6의 발현을 AE보다 FAE에서 더 억제하는 것을 확인하였다. 또한, collagenase와 elastase의 억제활성이 AE보다 FAE에서 우수하였다. 종합하자면, FAE는 AE보다 항산화, 항염, 콜라게나아제 및 엘라스타아제 억제 효능이 있는 천연기능성 소재 및 건강기능식품 등의 소재로 활용될 수 있을 것이라 사료된다. We aimed to evaluate the antioxidant, anti-inflammatory, anti-collagenase, and anti-elastase effects of fermented and non-fermented Astragalus membranaceus extracts (FAE and AE). The total polyphenol and flavonoid contents of FAE were higher than those of AE. DPPH, ABTS, and reducing power assays confirmed that the radical scavenging efficacy and reducing power of FAE were higher than those of AE. In SIN-1-stimulated HaCaT cells, reduced superoxide dismutase, catalase, and glutathione peroxidase activity levels were rescued in the FAE group but not in the AE group. FAE also suppressed increases in NO, PGE2, and IL-6 levels more potently than AE in LPS-stimulated RAW264.7 cells. FAE also exhibited more potent collagenase and elastase inhibitory activities than AE. In summary, this study suggests that FAE can be used in functional foods and cosmetics with antioxidant, anti-inflammatory, anti-collagenase, and anti-elastase properties.

Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

특수 콘크리트를 이용한 공원시설 관련 제품에 관한 연구

박봉우,김진아,신애란,전병건 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

본 연구는 특수 콘크리트를 사용하여 공원시설 관련 제품을 생산하기 위한 기초 자료를 얻을 목적으로 수행하였다. 현재 국내에서 생산하여 사용되고 있는 공원 관련 시설물을 대상으로 소재에 대한 선호도와 소재의 특성을 우편을 통한 설문 조사를 하였다. 설문의 결과 가장 선호하는 소재는 목재, 인조목, 철금속, 비철금속, 석재 등의 순서로 나타났다. 재료 별 특성은 12개 공원 관련 시설과 7개 시멘트 콘크리트 제품을 대상으로 재료별로 10개 항목에 대한 특성을 조사하여 matrix로 나타내었다. 이렇게 조사된 결과를 토대로 하여 공원 관련 제품 생산을 위한 시험적인 모델로 특수 콘크리트를 사용한 블라드와 콘크리트 판넬의 모형을 제시하였다. The purpose of this study was to obtain basic information in order to produce of park facility products using by special concrete. This study made a survey of preference and character of the raw materials on park facility products throughout the country by mail questionnaire. As a result, the ranking of preference on raw materials were wood, imitation wood made from cement concrete, steel, and nonferrous metal. Also, the 10 characters of raw material on the 12 items of park facility products and 7 items of cement concrete products investigated and their results showed by matrix. Based on these results we suggest the pilot models of bollard and concrete panel for pedestrian using special concrete.

정토신앙 공동체와 향가

박애경 延世大學校 文科大學 2008 人文科學 Vol.88 No.-

이 글은 신라 향가의 발전과정을 신라 사회 불교 공동체의 동향과 관련하여 살피고자 시작되었다. 다른 시가 장르의 발생과 마찬가지로 향가 역시 민간의 노래에 기원을 두고 있지만, 장르적 정체성을 완성하는 과정에서 신앙의 집단적 표현과 의례를 위한 불교적 성격의 노래로 정착하게 되었다. 대승불교가 주를 이룬 신라사회에서는 승려와 신도가 신행을 수행하기 위한 다양한 형태의 불교공동체가 만들어졌다. 특히 신라 중대 이후 신라사회에 광범위하게 자리잡은 정토신앙은 상 · 하층을 아우르는 신앙으로 광범위하게 자리잡게 되었다. 내세를 위한 정토신앙의 신행법으로는 고도의 수행법과 함께 향가와 염불 같은 보다 대중적인 방식이 장려되었다. 이글에서는 향가가 정토신앙 공동체의 신행에 개입하는 방식을 크게 선업형, 수도형, 절속형으로 나눠 살피고 이들의 신행이 향가와 관련 기록에 구현되는 방식을 살펴보았다. 이러한 공동체의 유형은 기본적으로 사대대중의종교적 근기에 따라 나뉜다. 이 글에서는 그 외에 각각의 정토신앙 공동체가 각각 신라의 상대, 중대, 하대의 신행을 대표하는 방식이라는 점을 주시하고자 하였다. The main purpose of this paper is to inquire the process of the development of Hyangga with a relation to the Buddhist communists in the Shinla Dynasty. Like any other genres of Korean classical songs and poetry Hyangga has originated from the folk songs. In the process of forming the style, Hyangga has been rooted on the Buddhist community as a song for propagation of religion and ritual. The majority of Buddhist communists in the Shinla Dynasty were the communists for the Pure Land Faith, which showed the speciality of Mahayana Buddhism in that period. Among the believers who pursued the Pure Land, Hyangga was enjoyed as a way of ascetic exercises or religious confession. This paper categorized the types of Buddhlst communists shown in Hyangga and following prose writings into three parts; the type of good deed, ascetic exercise and supermundane. Basically each type of community could be differentiated by the religious perseverance of ascetics. This paper calls the question each type of community shows the representative way of ascetic exercise in each period of the Shinla Dynasty.

급성 췌장염의 합병이 추정되는 한국형 출혈열 1예

박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5

The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)

고등학교 체육수업에서의 재미 요인

박애희,부기원 江原大學校附設體育科學硏究所 2002 江原大學校附設體育科學硏究所論文集 Vol.- No.25

For the last decades, various changes in governmental policies on national education in Korea have brought about significant changes in gymnastics classes. In particular, the recent introduction of the 7th Curriculum is expected to trigger radical changes in gymnastics classes. For one, gymnastics will be offered as an optional course for high school seniors while the required class units for gymnastics will be reduced from 3 units to 2 units a week for 9th graders in junior high school. With gymnastics to be offered as an optional couse, the instruction methods of gymnastics should not only be revised to make it user-oriented; its direction should also be changed to foster students' interest and develop their skills and abilities in time. Gymnastics teachers should be particularly concerned about coping with these changes and instructing students more efficiently, since whether or not a student chooses to take gymnastics mainly depends on them. Teachers should pay special sttention to maximizing students experience of positively participating in class; fostering positive feeling and interest in gymnastics classes among students is the ultimate sine qua non. This study sought to analyze the merits of gymnastics as perceived by academic and vocational high school seniors on the basis of previous related research. Results of this study are expected to provide teachers with the necessary information to cope with the dramatic changes in the current educational reality and serve as basic data to help teachers develop efficient instruction methods. A total of 480 students in I metropolitan city were considered as subjects. Out of the 6 classes with 40 students each, 240 students from 3 classes were sampled from the 1st and 2nd graders in public schools and seniors in academic high schools for boys. Similarly, 240 students were sampled from the 6 classes in public schools and seniors in vocational high schools for boys. The results of this study show that the merits of the gymnastics class as perceived by students could be generally classified into 4 categories, i.e., provides a free class atmosphere since it is an outdoor class, interest in sports and feeling of achievement upon improving theit own skills, self-confidence and competence developed from sports, and shared common experience with the teacher. In addition, the comparative analysis by school type reveals that students of vocational schools regarded free class atmosphere, feeling of achievement, and self-confidence and competence acquired as more important merits compared with students of academic schools. On the other hand, students of academic schools considered shared common experience with the teacher as more important compared with students of vocational school. Finally, the comparative analysis by factor shows that students of academic schools regarded free class atmosphere as the most important merit. In contrast, students of vocational schools considered the feeling of achievement as the most important merit.

한국절식에 대한 초등학교 영양사의 의식조사 : 서울과 인천지역을 중심으로

박수진,강영림,김애정 동아시아식생활학회 1998 동아시아식생활학회지 Vol.8 No.3

The purpose of this study was to investigate perceptions and uses of Korean festive foods by dietitians in elementary school food service. Questionnaires were distributed to 217 dietitians in Seoul(117) and Inchon(100). Statistical data analysis was completed by SAS package program. Results were as follows ; 1. Most dietitians(89.8%) who answered the inquiry had knowledge about Korean festive foods. 2. Most respondents applied Korean festive foods to their menu planning. 3. More than 85% of respondents used festive foods, especially Ddukguk, Mandu, Yaksik, Yukgaejang, Galbiggim, Tangpyungchae, Patjuk, among the 43 kinds considered for their menu planning. 4. The higher the perception of traditional foods, the more the respondents applied them to their menu planning, especially Injulmi, Shikhae, Yaksik, Bamchoe, Jeongpyun, Kalkuksu, Torantang, Hobakgigim, Namul. 5. Respondents got information sources about traditional foods from books, school, home, massmedia, and etc, in the order. 6. Most respondents(88.3%) wanted to simplify festive foods' cooking method or standardize the recipes. 7. On the necessity of education about festive food for children, 81.5% of respondents and festive foods were considered to be cultivated and developed to uphold the Korean traditional dietary life.

動物組織中의 脂質定量에 對하여

朴愛卿 이화화학회 1968 梨花化學會誌 Vol.- No.7

쥐의 뇌, 심장, 허파 등을 試料로 取하여 Thin layer chromatography에 依하여 脂質을 定量한 結果 cholesterol는 특히 뇌신경 조직과 부신에 많이 存在하며 Total cholesterol 含量은 뇌에 17.6㎎/g로 가장 많았고 심장에 3.2㎎/g로 가장 적었다. Free cholesterol 역시 뇌에 가장 많이 있고 심장에 가장 적었다. Glyceride는 Brain에 가장 많았고 大體로 Triglyceride가 많았다. Lipid is accumlated at adipose tissue, Adipose tissue consists of more than 90% triglyceride. Lipid is main energy source in the animal body as you know. In this experiment, we used brain, heart and lug from rat as samples. We tried to investigate the constituents of neutral lipid, and phospholipids. As a resalt, we separated six different material from nuetral lipid and four from the phospholipid. They were monoglyceride, diglyceride, triglyceride, free cholesterol esterified cholesterol fatty acids and phosphatidyl ethanol amine, phosphatidyl choline, phosphatidyl inositol, and one unknown lipid, respectively. Brain had the highest glyceride content and also highest cholesterol content which was about 4 times as high as that in the heart and lug. Phosphatidyl ethanol amine had the highest phospholipid and total cholesterol amount was the highest at the Brain.

헬스 케어 디자인을 위한 웨어러블 디바이스 시스템에 대한 고찰

박애진 신라대학교 IT · 디자인연구원 2014 IT · 디자인 연구 Vol.- No.10