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Sarcomatoid Carcinoma Arising from Mature Cystic Teratoma
Ho-Chang Lee1, Seung-Myoung Son, Yong-Moon Lee, Ji Hae Koo, Song-Yi Choi, Ok-Jun Lee, Eun-Hwan Jeong 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2
Malignant transformation of mature cystic teratoma (MCT) is rare. Sarcomatoid carcinoma is a neoplasm comprising malignant mesenchymal cells and a conventional carcinomatous area. Here, we report on a case of sarcomatoid carcinoma arising from an MCT in the left ovary of a 45-year-old female. A unilocular cyst consistent with MCT was observed; however, a nodule within the cyst was confirmed from the resected ovary. Microscopically, the nodule showed both squamous cell carcinoma and pleomorphic sarcomatous components admixing with each other. Lining epithelial cells at the periphery of the main tumor showed squamous metaplasia. When a sarcomatous component is observed in the ovary tumor, it is important to find a squamous cell component, either benign or malignant.
이윤형(Yun-Hyung Lee),안종갑(Jong-Kap Ahn),소명옥(Myung-Ok So),이준탁(Jun-Tack Lee) 한국마린엔지니어링학회 2007 한국마린엔지니어링학회 학술대회 논문집 Vol.2007 No.-
A simple tuning methods of PI, PD and PID controller are proposed for an integrating process with time delay. This is based on matching the coefficients of corresponding powers of s in the numerator and that in the denominator of the closed-loop transfer function. For set-point tracking problem, the derived controller is found to be a PD controller which is shown by Lee's tuning rule based on minimizing the performance indexes (lSE, IAE, ITAE) using a real-coded genetic algorithm. A method can be also proposed PI, PID controllers according to tuning parameter lambda (A) similar to IMC method. Simulation example is given to illustrate the set-point tracking performance of the proposed method.
Lee, Ha Yoon,Chang, Jee Suk,Lee, Ik Jae,Park, Kwangwoo,Kim, Yong Bae,Suh, Chang Ok,Kim, Jun Won,Keum, Ki Chang The Korean Society for Radiation Oncology 2013 Radiation Oncology Journal Vol.31 No.4
Purpose: We explored whether the deep inspiration breath hold (DIBH) technique using Abches during left-sided breast irradiation was effective for minimizing the amount of radiation to the heart and lung compared to free breathing (FB). Materials and Methods: Between February and July 2012, a total of 25 patients with left-sided breast cancer underwent two computed tomography scans each with the DIBH using Abches and using FB after breast-conserving surgery. The scans were retrospectively replanned using standardized criteria for the purpose of this study. The DIBH plans for each patient were compared with FB plans using dosimetric parameters. Results: All patients were successfully treated with the DIBH technique using Abches. Significant differences were found between the DIBH and FB plans for mean heart dose (2.52 vs. 4.53 Gy), heart V30 (16.48 vs. $45.13cm^3$), V20 (21.35 vs. $54.55cm^3$), mean left anterior descending coronary artery (LAD) dose (16.01 vs. 26.26 Gy, all p < 0.001), and maximal dose to $0.2cm^3$ of the LAD (41.65 vs. 47.27 Gy, p = 0.017). The mean left lung dose (7.53 vs. 8.03 Gy, p = 0.073) and lung V20 (14.63% vs. 15.72%, p = 0.060) of DIBH using Abches were not different significantly compared with FB. Conclusion: We report that the use of a DIBH technique using Abches in breathing adapted radiotherapy for left-sided breast cancer is easily feasible in daily practice and significantly reduces the radiation doses to the heart and LAD, therefore potentially reducing cardiac risk.
Local-dependency of morphological and optical properties between breast cancer cell lines
Lee, Seung Ho,Kim, Ok-Kyun,Lee, Sanghwa,Kim, Jun Ki Elsevier 2018 Spectrochimica acta. Part A, Molecular and biomole Vol.205 No.-
<P><B>Abstract</B></P> <P>Breast cancer is the most malignant type of cancer in women and is a global health problem, with mortality by metastasis being the main factor among others. Currently, detection and diagnosis of breast cancer is achieved through a variety of procedures, such as clinical examination, medical imaging, biopsy, and histopathological analysis. In contrast, spectroscopic analysis has a variety of advantages such as being noninvasive, not destroying biological materials, and not requiring additional histological analysis. In this study, various approaches using Raman spectroscopy, atomic force microscopy (AFM), and optical microscopy were used together to differentiate between and characterize normal breast cell lines (MCF-10A) and breast cancer cell lines (MDA-MB-231, MDA-MB-453). Raman spectra of normal breast cell and breast cancer cell lines confirmed visual differences in the concentrations of various compounds. These spectra were also analyzed using principle component analysis (PCA), and the PCA results showed reliable separation of the three cell lines and the cancer cell lines (MDA-MB-231, MDA-MB-453). With these results, optically synchronizing the AFM morphology, the Raman spectroscopy, and the visible RGB optical transmission intensity provided contrasts for not only conformational differences but also intracellular variation between the normal and cancer cell lines. We observed the inherent characteristic that there is no local difference in cancer cells regardless of morphology in a wide range of optical properties such as absorption, scattering and inelastic scattering.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The inherent optical properties of cancer cells separated from normal cells in terms of local variation were observed. </LI> <LI> Raman spectra and its PCA results of normal breast cell and breast cancer cell lines were confirmed to be visual differences. </LI> <LI> The RGB transmission imaging is also compared to the morphological difference obtained from AFM. </LI> <LI> In cancer cells, the conformational difference did not appear to be dependent on the intracellular location. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
A 20 W GaN-based Power Amplifier MMIC for X-band Radar Applications
Lee, Bok-Hyung,Park, Byung-Jun,Choi, Sun-Youl,Lim, Byeong-Ok,Go, Joo-Seoc,Kim, Sung-Chan Institute of Korean Electrical and Electronics Eng 2019 전기전자학회논문지 Vol.23 No.1
In this paper, we demonstrated a power amplifier monolithic microwave integrated circuit (MMIC) for X-band radar applications. It utilizes commercial $0.25{\mu}m$ GaN-based high electron mobility transistor (HEMT) technology and delivers more than 20 W of output power. The developed GaN-based power amplifier MMIC has small signal gain of over 22 dB and saturated output power of over 43.3 dBm (21.38 W) in a pulse operation mode with pulse width of $200{\mu}s$ and duty cycle of 4% over the entire band of 9 to 10 GHz. The chip dimensions are $3.5mm{\times}2.3mm$, generating the output power density of $2.71W/mm^2$. Its power added efficiency (PAE) is 42.6-50.7% in the frequency bandwidth from 9 to 10 GHz. The developed GaN-based power amplifier MMIC is expected to be applied in a variety of X-band radar applications.
Jun-Ying Zhang,Hyeon-Jin Sun,In-Ja Song,Tae-Woong Bae,Hong-Gyu Kang,Suk-Min Ko,Yong-Ik Kwon,Il-Woung Kim,Jaechun Lee,Shin-Young Park,Pyung-Ok Lim,Yong Hwan Kim,Hyo-Yeon Lee 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.3
An efficient in vitro protocol has been established for somatic embryogenesis and plantlet conversion of Korean wild ginseng (Panax ginseng Meyer). Wild-type and mutant adventitious roots derived from the ginseng produced calluses on Murashige and Skoog (MS) medium supplemented with 0.5 mg/L 2,4-dichlorophenoxyacetic acid and 0.3 mg/L kinetin; 53.3% of the explants formed callus. Embryogenic callus proliferation and somatic embryo induction occurred on MS medium containing 0.5 mg/L 2,4-dichlorophenoxyacetic acid. The induced somatic embryos further developed to maturity on MS medium with 5 mg/L gibberellic acid, and 85% of them germinated. The germinated embryos were developed to shoots and elongated on MS medium with 5 mg/L gibberellic acid. The shoots developed into plants with well-developed taproots on one-third strength Schenk and Hildebrandt basal medium supplemented with 0.25 mg/L 1-naphthaleneacetic acid. When the plants were transferred to soil, about 30% of the regenerated plants developed into normal plants.
A Case of Polyarteritis Nodosa Involving the Breasts
( Jun Hyeong Cho ),( Jeongmin Hong ),( Wonyong Jo ),( Yun-hong Cheon ),( Hyun-ok Kim ),( Sang-il Lee ),( Young Sun Suh ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Polyarteritis nodosa (PAN) is a necrotizing vasculitis of small- and medium-sized arteries affecting multiple organ systems. Generally, multi-organ involvement is more common than isolated organ involvement in classic PAN. A localized PAN involving breasts alone has rarely been reported. We describe an unusual case of a 72-year-old woman with a localized form of PAN manifested by acute onset of breast pain with fever. Ultrasonography of breasts showed increased echogenicity of subcutaneous fat tissue surrounding the arteries with wall thickening in both upper breasts. Excisional biopsy of left breast revealed leukocytoclastic small to medium-sized arteritis without giant cell infiltration, indicating PAN. Other imaging studies showed that there were no visceral organ involvements. We diagnosed a localized PAN involving breasts, and initiated corticosteroid and methotrexate. She rapidly responded to the treatment and has remained in clinical remission for 1 year.
( Jun Kwon Ko ),( Hang Lak Lee ),( Jin Ok Kim ),( Soon Young Song ),( Kang Nyeong Lee ),( Dae Won Jun ),( Oh Young Lee ),( Dong Soo Han ),( Byung Chul Yoon ),( Ho Soon Choi ),( Joon Soo Hahm ),( Sang 대한장연구학회 2014 Intestinal Research Vol.12 No.1
Background/Aims: Because of the similarities in the clinical presentations of Crohn`s disease (CD) and intestinal tuberculosis (ITB), differential diagnosis is critical. Mesenteric adipose tissue hypertrophy and creeping fat are characteristic features of CD. The purpose of this study was to assess the usefulness of visceral fat for the differential diagnosis of CD and ITB. Methods: We conducted a retrospective review of 50 patients with findings of CD or ITB between January 2005 and July 2008. Abdominal computed tomography (CT) was performed on all subjects during their first evaluation. The abdominal fat area was assessed using quantitative abdominal CT. Results: The ratio of visceral fat to total fat (VF/TF) was significantly higher in male CD patients than in male ITB patients. The ratio of visceral fat to subcutaneous fat (VF/SF) was also higher in CD patients than in patients with ITB. For a VF/TF cut-off value of 0.46, the sensitivity and specificity for the diagnosis of CD were 42.1% and 93.3% respectively, with positive and negative predictive values of 88.9% and 56.0%, respectively. Conclusion: Measurement of the abdominal fat area using CT can be clinically useful for the differential diagnosis of CD and ITB. (Intest Res 2014;12:42-47)