Optical Properties of Pt-TiO₂, Catalyst and Photocatalytic Activities for Benzene Decomposition

Lee, Byung-Yong,Park, Sang-Hyuk,Lee, Sung-Chul,Kang, Misook,Park, Chang-Ho,Choung, Suk-Jin 한국화학공학회 2003 Korean Journal of Chemical Engineering Vol.20 No.5

In order to improve the photocatalytic decomposition activity of benzene, which has bee regarded as a typical volatile organic compound in air, TiO₂ catalysts modified with metals (Pt, Cu, and Fe) were prepared and tested. Certain correlations between the photocatalytic activities and the optical properties of those catalysts were also found and discussed by using UV-visible spectroscopy and a photoluminescence spectroscopy. Among the metal impregnated TiO₂, the Pt impregnated TiO₂showed the best activity and it was even better than that of P-25 which is widely used in commercial applications. For the various metal impregnated TiO₂samples, certain proportional relationships were found between the observed photoluminescence values and photocatalytic activities. On the other hand, in UV-visible sperctra for metal impregnated TiO₂samples, the transmittance value was reduced depending upon the loading of metals. It was thought that photocatalytic activity increases from initial reaction state because the number of photo-excited electrones, which exist at Pt surface augment due to the band gap energy change of Pt and TiO₂ by sintering and light energy-absorbed electrones excited casily to conduction. In conclusion, it was confirmed that the enhanced photocatalytic activity for high metal loading on TiO₂is related with the high concentration of excited electrons, which could be monitored through UV-visible spectra.

South Korea’s Democratization Movement of the 1970s and 80s and Communicative Interaction in Transnational Ecumenical Networks

Misook Lee(이미숙) 고려대학교 한국사연구소 2014 International Journal of Korean History Vol.19 No.2

Targeted Inhibition of the NCOA1/STAT6 Protein–Protein Interaction

Lee, Yeongju,Yoon, Heeseok,Hwang, Sung-Min,Shin, Min-Kyung,Lee, Ji Hoon,Oh, Misook,Im, Sin-Hyeog,Song, Jaeyoung,Lim, Hyun-Suk American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.45

<P>The complex formation between transcription factors (TFs) and coactivator proteins is required for transcriptional activity, and thus disruption of aberrantly activated TF/coactivator interactions could be an attractive therapeutic strategy. However, modulation of such protein–protein interactions (PPIs) has proven challenging. Here we report a cell-permeable, proteolytically stable, stapled helical peptide directly targeting nuclear receptor coactivator 1 (NCOA1), a coactivator required for the transcriptional activity of signal transducer and activator of transcription 6 (STAT6). We demonstrate that this stapled peptide disrupts the NCOA1/STAT6 complex, thereby repressing STAT6-mediated transcription. Furthermore, we solved the first crystal structure of a stapled peptide in complex with NCOA1. The stapled peptide therefore represents an invaluable chemical probe for understanding the precise role of the NCOA1/STAT6 interaction and an excellent starting point for the development of a novel class of therapeutic agents.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2017/jacsat.2017.139.issue-45/jacs.7b08972/production/images/medium/ja-2017-089727_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja7b08972'>ACS Electronic Supporting Info</A></P>

Probiotic characteristics of <i>Bacillus</i> strains isolated from Korean traditional soy sauce

Lee, Sangki,Lee, Joongjae,Jin, Yong-Ik,Jeong, Jin-Cheol,Chang, Yoon Hyuk,Lee, Youngseung,Jeong, Yoonhwa,Kim, Misook Elsevier 2017 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.79 No.-

<P>The objective of this work was to isolate Bacillus strains from Korean traditional soy sauces, and evaluate them for probiotic potential and safety. Three Bacillus strains, MKSK-E1, MKSK-J1 and MKSK-M1, were selected which were highly resistant to simulated gastrointestinal tract conditions, and showed antimicrobial activity against Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus and Escherichia coli. MKSK-M1 possessed the highest relative survival rate, with 96.0% survival in 0.1% pepsin solution (pH 2.0) and 99.3% survival in 3% bile salt solution for 3 h. All three strains exhibited amylase and protease activity, and utilized more than 19 carbohydrates among 49 tested carbohydrates. MKSK-E1 inhibited the growth of 11 of 13 tested foodborne pathogens. All three selected strains possessed strong antimicrobial activity against E. coli and B. cereus. They had antibiotic susceptibility against 8 tested antibiotics. Also, all strains were non-hemolytic on sheep blood, and non-biogenic amine producers. The results of this work indicate that MKSK-El, J1 and Ml could be used as probiotic cultures for human consumption and animal feeds and as probiotic starter cultures in food industries. (C) 2016 Elsevier Ltd. All rights reserved,</P>

Remarkable photoconversion of carbon dioxide into methane using Bi-doped TiO₂ nanoparticles prepared by a conventional sol–gel method

Lee, Jae Hyung,Lee, Homin,Kang, Misook Elsevier 2016 Materials Letters Vol.178 No.-

<P><B>Abstract</B></P> <P>Bi ions were inserted into a TiO<SUB>2</SUB> framework in order improve the CO<SUB>2</SUB> reduction. The x-mol% Bi ion-incorporated TiO<SUB>2</SUB>s were prepared by a conventional sol–gel method, and characterized by XRD, TEM, UV–visible spectroscopy, photocurrent spectroscopy, and CO<SUB>2</SUB>-TPD. The adsorption of CO<SUB>2</SUB> was significantly increased on Bi–TiO<SUB>2</SUB>s, which demonstrated superior photocatalytic behavior compared to that of pure TiO<SUB>2</SUB>. The 5.0mol% Bi–TiO<SUB>2</SUB> produced 3400μmolg<SUB>cat</SUB> <SUP>−1</SUP> L<SUP>−1</SUP> CH<SUB>4</SUB> gases after an 8h reaction. The photocatalytic activity was dramatically enhanced by the improved effective CO<SUB>2</SUB> gas adsorption and by the inhibited recombination of photogenerated electron–hole pairs due to the enhanced charge separation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Bi ions for narrower band gap and extended charge separation were inserted to TiO<SUB>2</SUB>. </LI> <LI> The adsorption of CO<SUB>2</SUB> significantly increased on the Bi–TiO<SUB>2</SUB>. </LI> <LI> Higher CH<SUB>4</SUB> was produced on Bi–TiO<SUB>2</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Remarkable photoconversion of carbon dioxide into methane using Bi doped TiO<SUB>2</SUB> nanoparticles prepared by a conventional sol–gel method.</P> <P>[DISPLAY OMISSION]</P>

Converting One-Face α-Helix Mimetics into Amphiphilic α-Helix Mimetics as Potent Inhibitors of Protein-Protein Interactions

Lee, Ji Hoon,Oh, Misook,Kim, Hyun Soo,Lee, Huisun,Im, Wonpil,Lim, Hyun-Suk American Chemical Society 2016 ACS Combinatorial Science Vol.18 No.1

<P>Many biologically active alpha-helical peptides adopt amphiphilic helical structures that contain hydrophobic residues on one side and hydrophilic residues on the other side. Therefore, alpha-helix mimetics capable of mimicking such amphiphilic helical peptides should possess higher binding affinity and specificity to target proteins. Here we describe an efficient method for generating amphiphilic alpha-helix mimetics. One-face alpha-helix mimetics having hydrophobic side chains on one side was readily converted into amphiphilic alpha-helix mimetics by introducing appropriate charged residues on the opposite side. We also demonstrate that such two-face amphiphilic alpha-helix mimetics indeed show remarkably improved binding affinity to a target protein, compared to one-face hydrophobic alpha-helix mimetics. We believe that generating a large combinatorial library of these amphiphilic alpha-helix mimetics can be valuable for rapid discovery of highly potent and specific modulators of protein-protein interactions.</P>

Path Dependence In North Korean Military Negotiation Agendas

( Misook Lee ) 이화여자대학교 통일학연구원 2018 Journal of peace and unification Vol.8 No.1

Analyzing the agendas of the North Korean military negotiations, we see that they were varied according to situations, but their objective for negotiations toward South Korea, “maintaining the North Korean system” did not change. In the early 1990s, proposals for “important military negotiations,” such as nonaggression and disarmament were mainly on the table, but they used to end up as declaratory military issues showing the characteristics of pseudo-military negotiations. However, in the early 2000s, such general military negotiations as connecting railways and roads and building military confidence were proposed and carried out to make them look like realistic negotiations, though they were still locked in the box of maintaining the regime. Therefore, the change was not in the character of the negotiations, but simply the negotiation items varied in favor of the situations in order to achieve the goal of “protecting the system.” As Thelen pointed out, the change was not targeted for the core element of maintaining the North Korean regime. Instead, the change was made in the military negotiation agendas in order to secure the regime in terms of the North’s strategy toward South Korea’s negotiation, thereby keeping up its path dependence.

Multilayer deposition on patterned posts using alternating polyelectrolyte droplets in a microfluidic device

Lee, Misook,Park, Wook,Chung, Changkwon,Lim, Jaehoon,Kwon, Sunghoon,Ahn, Kyung Hyun,Lee, Seung Jong,Char, Kookheon Royal Society of Chemistry 2010 Lab on a chip Vol.10 No.9

<P>We demonstrate that polyelectrolyte (PE) multilayer thin films deposited on patterned posts with incredibly large numbers of bilayers, which would not be possible with the conventional Layer-by-Layer (LbL) deposition methods, can be obtained in a short process time using alternating polyelectrolyte droplets generated in a microfluidic channel, representing a significant advantage over the conventional processes based on polyelectrolyte deposition followed by the separation of such substrates (typically colloidal particles) with centrifugation and sonication. Positively- and negatively-charged polyelectrolyte droplets were alternatively generated in a microfluidic channel by controlling the capillary number (<I>Ca</I>) as well as the fraction of dispersed phase over the continuous phase. Patterned posts, serving as the substrates for the PE deposition, were created with photo-curable polymers using the optofluidic maskless lithography. The impact of these PE droplets onto the patterned posts allowed the alternative adsorption of PEs, similar to the conventional LbL deposition methods. It was shown that the intensity of fluorescence dye tagged onto (+)-charged PEs adsorbed on the post(s), taken with confocal laser scanning microscopy, increases with deposition time and varies around the post(s). The effect of post shape and interval between the two posts for the droplet-based LbL deposition was also experimentally investigated and analyzed, in connection with the numerical simulations, to elucidate the underlying principles of relevant two-phase flows.</P> <P>Graphic Abstract</P><P>We demonstrate that polyelectrolyte (PE) multilayer thin films deposited on lithographically defined patterned posts can be achieved in a facile manner using alternating polyelectrolyte droplets generated in a microfluidic channel. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b919753b'> </P>

The textural properties of potato chips using both descriptive sensory analysis and Miniature Ottawa Kramer Cell

Sanghyeok Lee,Dain Kim,Minjeong Kang,Jiyoon Jung,Dodan Kwon,Hyukhwan Song,Yoonhwa Jeong,Misook Kim,Youngseung Lee 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10

학교 혁신문화 측정도구 개발 및 타당화 : 인천광역시 초·중등학교를 중심으로

이미숙(Lee, Misook),박주형(Park Ju-Hyoung),김종민(Kim, Chong Min),임현정(Lim, Hyunjung) 한국교육행정학회 2017 敎育行政學硏究 Vol.35 No.1

연구의 목적은 학교 혁신문화 측정도구를 개발하는 것이다. 이를 위해 문헌 분석과 전문가 및 현장교사 검토 협의, 연구진 협의를 통해 학교 혁신문화 측정 도구의 모형을 개발하였다. 구체적으로 인천광역시교육청에서 추진하고 있는 ‘2016 학교혁신 종합계획’과 ‘행복배움학교 추진계획’을 근간으로 하여 선행연구 자료, 전문가 집단의 의견, 연구진 협의를 통해 4대 측 정 영역과 13개 하위요소 그리고 각 요소를 대표할 수 있는 세부지표로 구성하였다. 측정도 구 초안에 대하여 델파이 방식으로 1차 의견을 수렴하고, 이를 반영하여 2차 의견을 수렴하 여 측정도구를 개발하였다. 측정도구의 구인 타당도를 검증하기 위하여 행복배움학교 준비교, 1년차 학교, 2년차 학교, 그리고 일반학교의 구성비를 고려하여 표집한 초∙중∙고 총 45교의 교원들을 대상으로 설문조사를 실시하였다. 설문조사 자료를 활용하여 문항의 신뢰도와 타당 도를 분석하였고, second-order 모형(4대 영역과 13 하위요소)으로 확인적 요인분석을 실시하 였다. 그 결과 4대 영역과 13개 하위요소로 구성된 본 연구의 측정도구 모형은 적합한 것으로 나 타났다. 또한 표준 적재치, Cronbach's  , 개념 신뢰도, 평균분산추출지수, 상관계수와 평균분 산추출지수 제곱근 분석결과, 학교 혁신문화 측정도구는 신뢰도와 타당도를 확보하고 있는 것으로 나타났다. 개발한 측정도구의 현장 타당성을 확인하기 위하여 행복배움학교와 일반학 교의 측정 결과를 비교하였다. 그 결과 1) 행복배움학교와 일반학교, 2) 행복배움학교 준비교, 1년차교, 2년차교, 그리고 일반교 사이의 각 영역별, 하위요소별 통계적으로 유의미한 차이를 나타났으며 이를 통해 개발된 측정도구가 학교 혁신문화를 측정하는 유용한 도구로 사용될 수 있음이 드러났다. The purpose of this study is to develop an instrument to measure school innovation culture. For this, we developed a measurement model of school innovation culture through literature analysis, consultation with experts and field teachers, and discussion with researchers. Based on the ‘2016 School Innovation Comprehensive Plan’ and the ‘Happy Learning School Promotion Plan’, which are being promoted by the Incheon Metropolitan City Office of Education, we developed an instrument to measure 4 domains, 13 sub-domains, and a detailed index of school innovation culture. The first and second draft of the instrument was reviewed by Delphi method. To verify the validity of the instrument, we collected data on teachers at elementary, middle, and high schools which were sampled considering the composition ratio of happiness learning schools, first year schools, second year schools, and general schools. We analyzed the reliability and validity of the instrument and conducted confirmatory factor analysis (CFA) with the second-order model. As a result, the developed instrument which consists of 4 domains and 13 sub -domains was found to be appropriate in the construct validity. In order to confirm the applicable validity of the developed instrument, we compared the results of happy learning schools and general schools. As a result, there were statistically significant differences in each domain and sub-domain of general schools, happiness learning preparation schools, first year schools, and second year schools. These results indicated that the developed instrument would be as a useful scale to measure school innovation culture.