요로결석 환자의 체외충격파쇄석술 치료경과와 결석 특성과의 관련성

김성길,김기순,류소연,한미아,이선옥,노준 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

요로 결석에 대한 비 침습적 치료 방법인 체외충격파쇄석술에 의한 치료경과와 결석 특성과의 관련성을 파악키 위해 2002년 12월부터 2008년 3월까지 G시 H병원에서 요로 결석으로 진단되어 체외충격파쇄석술을 받은 33l례를 대상으로 의무기록 자료를 이용하여 분석한 결과는 다음과 같다. 1. 조사 대상자 331례중 남자는 68.6%, 여자는 31.4%이었으며 평균연령(표준편차)은 44.2 (13.9)세 이었고 84%가 G시내 거주자였다. 2. 조사 대상자에게 시행된 체외충격파쇄석술의 평균 시술횟수(표준편차)는 1.9(1.5)회 이었으며 평균 통증제거기간(표준편차)은 3.2(2.1)일 이었고 요로결석 진단 시로부터 치료가 완료되었다고 의사가 판정했을 때까지의 치료기간의 평균(표준편차)은 10.3(8.4)일 이었다. 3. 시술횟수에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석크기, 결석의 방사선 투과성, 요관 폐색여부 이었으며 모형의 설명력은 13.5%이었다. 4. 통증제거기간에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석의 방사선 투과성 이었으며 모형의 설명력은 7.4%이었다. 5. 치료기간에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석크기와 결석의 방사선 투과성 이었으며 모형의 설명력은 13.5%이었다. 따라서 결석의 크기가 크거나 결석이 방사선에 비 투과성일 때, 요관이 폐색되어 있을 때 치료경과가 늦게 됨으로 이러한 사실을 참고 하여 추후 진료지침을 작성 시 보다 효과적이고 효율적인 치료법을 적용할 필요가 있다고 판단되며 보다 체계적인 평가와 연구가 필요할 것이다. Objectives & Methods: To find the treatment process by extracorporeal shock wave lithotripsy (ESWL) and its related stone characteristics in urinary tract stone patients, an analysis was done from medical records of 331 cases who were treated by ESWL from December 2002 to March 2008 at H hospital in G city. Results: Among 331 study subjects 68.6% were male and 31.4% were female. Their mean age (standard deviation, SD) was 44.2 (13.9) years old and 84.0% lived in G city. Average frequency of ESWL done toward study cases were 1.9±1.5 times. Mean duration of disappearance from pain was 3.2±2.1 days and total treatment period for a stone was 10.3±8.4 days. Statistically significant (p<0.01) stone and urinary tract characteristics related with frequency of ESWL were stone size, radio-opacity of the stone, and obstruction of urinary tract. The model composed of these 3 independent variables explained 13.5% of frequency of ESWL. Statistically significant (p<0.01) variable related with disappearance from pain was radio-opacity of the stone, and this model explained 7.4%. Statistically significant (p<0.01) variables related with treatment duration due to stone were stone size and radio-opacity of the stone. These two variables explained 13.5%. Conclusion: The bigger the size of stone are, the slower the treatment process will be. And when the stone is radio-opaque and urinary tract is obstructed, the treatment process will be slower than stone is radio-luscent and urinary tract is not obstructed. So to make effective and efficient treatment manual for ESWL, above fact must be considered and continuous systematic evaluation and research toward ESWL are necessary.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

일부 흡연 대학생의 지각된 스트레스와 흡연실태에 대한 상관관계 연구

강초록,권시내,권혜림,박수경,송인혜,오해인,이미지,한승아,황선아,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

In spite of the seriousness of smoking harm has been developed these days. the increase of national smoking rate and that the people in the twenties are especially leading the rise of national smoking rate is an important issue of national health. Smoking of the university students can occur health problem and cause loss of manpower and expenses in their social activity period. So then the actual state for prevention of smoking and development of a program to prohibit smoking has to be seized urgently and starting with the study of the realities of university students, the effort to find a related fluent of smoking has to be studied. Related to this, the purpose of this study is to seize the general characteristics of smoking university students and to find out the relationship between perceived stress and smoking status among smoking university students. In addition, by collating the relationship between perceived stress and smoking status among smoking university students we have the purpose to furnish the basal data of stress care, the best way to cope with stress through group training and the plan for nursing implementation to decrease the smoking rate. For this study, a survey was conducted for 204 smoking university students of 13 universities in Seoul from 9th of May to 16th of May, 2003. The collected data was analyzed by t-test, Pearson Correlation and ANOVA in the statistical packages SPSS/PC. Major findings of this study are as follows; 1. Of the 204 respondents 85.4% of them were male and 14.6% of them were female. The average age of the sample was 23.19 years old and 41.8% of them were in senior, 21.4% in junior, 16.9% in sophomore, 19.9% in freshman grade. The major motivation to start smoking was 'because of curiosity'(33.8%) and the first smoking experience was at 'senior high school' (41.9%) and at 'college' (41.9%). 2 The highest scored stress factor of smoking university students were stresses about school work. 3. 72.7% had experience to quit smoking at least one or more times. Most of the reason to keep on smoking was 'short will to quit'(51.0%) and the smoking place was usually at 'school' (41.4%). Most respondents for the number ofsmoking friends were '5 people and above' (73.2%). 4. There was a negative relationship between the general characteristics and the entire perceived stress, however, there was a positive relationship between the general characteristics and the perceived stress in 4 categories which is 'sex distinction', 'major of study', 'residence form' and' inmate'. 5. There was a negative relationship between the general characteristics and the entire smoking status, however, there was a positive relationship between the general characteristics and the smoking status in 2 categories which is 'presence of hobby' and 'number of smoking friends'. 6. There was a negative relationship between the perceived stress and the smoking status. Through this study we have seized the relationship between the general characteristics, perceived stress and the smoking status of smoking university students. There was a positive relationship between some of the general characteristics with the perceived stress and the smoking status of smoking university students. Also there was a negative relationship between the perceived stress and the smoking status.

The Effect of Long-lasting Permethrin Impregnated Socks on Tick Bite in Korea

Mi Ah Han,Choon-Mee Kim,Na Ra Yun,김동민,박선미,Hyoju Kim,Hwan Ho Shin 대한의학회 2021 Journal of Korean medical science Vol.36 No.7

Background: The risk of tick-borne diseases is decreased by increasing awareness and knowledge through prevention education. The aim of the present study was to evaluate the effect of long-lasting permethrin impregnated (LLPI) socks for tick bites. Methods: A randomized open label study was conducted to determine the effectiveness of LLPI socks for prevention of tick bites among 367 adults living in a rural area. Participants completed questionnaires at the start of follow-up (July 2014) and at the end of follow-up (December 2014), and tick bites were reported. Results: A total of 332 subjects completed the follow-up survey. The tick bite rate of the two groups was not significantly different (3.6% vs. 3.1%). But the tick bite rate of lower extremities of subjects wearing LLPI socks was significantly lower compared to that of subjects wearing general socks. Conclusion: The tick bite rate was not different between the two groups, but the tick bite rate of lower extremities of LLPI was significantly lower than general groups. Further study is needed to investigate the effect of LLPI clothes with larger populations.

Berberine Promotes Axonal Regeneration in Injured Nerves of the Peripheral Nervous System

Ah Mi Han,Hwon Heo,김윤희 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4

Berberine, an isoquinoline alkaloid component of Coptidis Rhizoma (goldenthread) extract, has been reported to have therapeutic potential for central nervous system disorders such as Alzheimer’s disease, cerebral ischemia, and schizophrenia. We have previously shown that berberine promotes the survival and differentiation of hippocampal precursor cells. In a memory-impaired rat model induced by ibotenic acid injection, the survival of pyramidal and granular cells was greatly increased in the hippocampus by berberine administration. In the present study, we investigated the effects of berberine on neurite outgrowth in the SH-SY5Y neuronal cell line and axonal regeneration in the rat peripheral nervous system (PNS). Berberine enhanced neurite extension in differentiating SH-SY5Y cells at concentrations of 0.25–3 lg/mL. In an injury model of the rat sciatic nerve, we examined the neuroregenerative effects of berberine on axonal remyelination by using immunohistochemical analysis. Four weeks after berberine administration (20 mg/kg i.p. once per day for 1 week), the thickness of remyelinated axons improved approximately 1.4-fold in the distal stump of the injury site. Taken together, these results indicate that berberine promotes neurite extension and axonal regeneration in injured nerves of the PNS.

Association of family history with cancer recurrence and survival in patients with gastric cancer.

Han, Mi Ah,Oh, Myueng Guen,Choi, Il Ju,Park, Sook Ryun,Ryu, Keun Won,Nam, Byung-Ho,Cho, Soo-Jeong,Kim, Chan Gyoo,Lee, Jun Ho,Kim, Young-Woo Grune Stratton ; American Society of Clinical Onco 2012 Journal of clinical oncology Vol.30 No.7

<P>Family history of gastric cancer is a major risk factor for the disease. In this study, we investigated the prognoses of patients with gastric cancer with a family history.</P>

Status quo of systematic reviews published in high-impact journals in Korea: A study focused on protocol registration and GRADE use

Han Mi Ah,김성중,Hwang Eu Chang,Jung Jae Hung 한국역학회 2022 Epidemiology and Health Vol.44 No.-

OBJECTIVES: This study investigated the status quo of systematic reviews published in major journals in Korea from the perspective of protocol registration and adopting the grading of recommendation, assessment, development and evaluation (GRADE) system. METHODS: We examined systematic reviews published in Korea’s top 15 medical journals from 2018 to 2021. Teams of two reviewers assessed the study eligibility criteria and extracted data independently and in duplicate. We collected the information on study characteristics, protocol registration, GRADE use of reviews included, and reviewed the “Instructions to Authors” of the selected journals to assess any guidance related to systematic reviews. RESULTS: Out of the 126 identified reviews, 18 (14.3%) reported that they registered or published their protocol. Only 5 (4.0%) rated the certainty of evidence; and all 5 used the GRADE system. Only 6 of 15 journals mentioned systematic reviews in their “Instructions for Authors.” Six journals endorsed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for systematic review reporting; however, 2 were mandatory, 3 were recommended, and 1 was unclear. None of the journals included mentioned protocol registration or certainty of evidence in their authors’ guidelines. CONCLUSIONS: Overall, the proportion of prior protocol registration of systematic reviews and adoption of the GRADE approach to rate the certainty of evidence was very low. Our study highlights the adherence to the systematic review standards of medical journals in Korea, including a prior protocol registration and certainty of evidence assessment. Our review helps improve the quality of systematic reviews in Korea.

Midcourse evaluation of the second-term 10-year plan for cancer control in Korea.

Han, Mi Ah,Choi, Kui Son,Park, Jong-Hyock,Moore, Malcolm A,Park, Eun-Cheol Asian Pacific Organization for Cancer Prevention 2011 Asian Pacific journal of cancer prevention Vol.12 No.1

<P>The Korean Ministry of Health and Welfare and the Korean National Cancer Center (NCC) developed the Second-term 10-year Plan for Cancer Control, 2006-2015, on the basis of an evaluation of progress of the First-term Plan for Cancer Control (10-yr PCC) from 2005-2006. The second-term 10-yr PCC started with two main objectives and 35 specific aims in eight focus areas, with the overall goal of reducing the economic burden of cancer. We here assessed the status of the 10-yr PCC objectives by midcourse evaluation in 2010, mid-way through the second term. Based on our evaluation and comments received from the government and the NCC, the Cancer Control 2015 objectives were modified. Of the original two main and 35 specific objectives in eight focus areas, four specific objectives were deleted because they were not relevant to the focus areas and three were revised to reflect changes in data sources or projects. In addition, four new objectives were introduced to reflect new data sources or emerging projects. The 2015 targets of 13 objectives were also modified to reflect the midcourse evaluation. This mid-term exercise provided an opportunity to assess the progress made during the first half of the decade and thereby accurately characterize the current and future status of cancer control and effectively manage cancer-control programs.</P>

Satisfaction in the National Cancer Screening Program for Breast Cancer with and without Clinical Breast Examination

Han, Mi-Ah,Jun, Jae-Kwan,Choi, Kui-Son,Park, Eun-Cheol,Lee, Hoo-Yeon Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

The purpose of this study was to evaluate whether screening by clinical breast examination (CBE) in addition to mammography affected participant satisfaction in the National Cancer Screening Program (NCSP). Data were derived from the Quality Evaluation of National Cancer Screening satisfaction survey. This population-based nationwide telephone survey included participants who had been screened by the NCSP for breast cancer between June and August 2010 (n=2,370), and collected information on satisfaction with screening and screening service use. Five multiple regression models were used to determine satisfaction according to screening method, and according to each of five satisfaction measures (pre-screening information transfer, staff interpersonal skills, physical surroundings, reporting of results and general satisfaction). A total of 1,858 (78.4%) participants were screened by mammography alone and 512 (21.6%) by both mammography and CBE. Satisfaction was significantly higher in subjects screened by both mammography and CBE compared with those screened by mammography alone.

Inhibitory Effect of <i>Opuntia humifusa</i> Fruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression

Han, Ah-Ram,Lim, Tae-Gyu,Song, Young-Ran,Jang, Mi,Rhee, Young Kyoung,Hong, Hee-Do,Kim, Mi-Hyun,Kim, Hyun-Jin,Cho, Chang-Won MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.9

<P><I>Opuntia humifusa</I> is a type of cactus whose fruits have been used in folk medicine for the treatment of several diseases. In the present study, we aimed to determine whether <I>O. humifusa</I> fruit water extract (OHE) has inhibitory effects against solar ultraviolet (sUV)-induced matrix metalloproteinase-1 (MMP-1) expression. In ex vivo human skin, we found that OHE suppressed sUV radiation-induced MMP-1 expression. The inhibitory effect of OHE was confirmed in human dermal fibroblasts. OHE treatment reduced sUV-induced MMP-1 expression by suppressing reactive oxygen species (ROS) generation and phosphorylation of c-Jun, a component of transcription factor activator protein 1 (AP-1). On the other hand, OHE recovered the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and type 1 collagen production attenuated by sUV. As upstream signaling pathways for AP-1, MKK4-JNK, MEK-ERK, and MKK3/6-p38 phosphorylation were downregulated by OHE treatment. In addition, OHE exhibited DPPH radical scavenging activity. These findings demonstrate that OHE has a preventive effect against sUV-induced skin damage via suppression of pathways triggered by ROS.</P>