부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

정신분열병 환자들의 自己灣入에 관한 예비 연구

박성봉,김영미,전성일,이기철,김영훈,정영조,이영렬,이정호,최영민 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

목 적 : 정 신분열병 환자의 자기만입 정도에 영향을 미치는 인구학적 변인들 및 질병연관 변인들을 규명해 보고자 하였다. 또한. 환자들의 자기만입과 병식 사이의 연관성. 자기만입과 자존심 사이의 연관성을 알아보고자 하였다. 방 법 : 정신과 의사가 병록지와 면담을 통하여 대상 정신분열병 환자들의 인구학적 변인들 및 질병연관 변인들에 관한 자료를 얻고 환자들의 병식 정도를 평가한 후, 환자들로 하여금 자기보고형의 자기만입 척도와 자존심 척도를 시행하게 하였다. 총 111명의 환자가 연구대상으로 선택되었다. 결과: . 1) 여자가 남자보다 유의하게 높은 자기만입 척도 점수를 나타내었다 2) 질병연관 변인들 중 하위집단 사이에 자기만입 척도 점수의 유의한 차이를 보이는 변은 없었다. 3) 자기만입 척도 점수와 병식 점수 사이에 유의한 상관관계가 없었다. 4) 자기만입 척도 점수와 자존심 척도 점수 사이에 유의한 역상관 관계를 보였다. 결 론 : 본 예비 연구의 결과로 보아 정신분열 병 환자의 병식이 부족한 상태에서도 자기만입이 진행될 수 있으며. 자기만입이 심할수록 환자의 자존심이 저하되는 것으로 생각된다. 또한 여자 환자들이 남자 환자들보다 자기만입에 더 취약한 것으로 생각된다. 따라서 정신분열 병 환자의 이해와 치료를 위하여 자기만입에 관한 지속적인 연구가 필요할 것으로 생각된다. objective : This study was conducted to identify demographic variables and illness related variables which may affect the severity of self-engulfment in the patients with schizophrenia. We also studied the relationship between self-engulfment and insight, and the relationship between self-engulfment and self-esteem. Methods : Data on demographic variables and illness related variables for the subjects were gathered from hospital records and clinical interviews by the psychiatrists. Degree of insight for the subjects was assessed through clinical interviews by the psychiatrists. Degree of self-engulfment and self-esteem for the subjects was assessed from the self-engulfment scale and the self-esteem scale respectively. A total of 111 patients with schizophrenia were selected for statistical analysis. Results 1) The females exhibited significantly higher scores than the males on the self-engulfment scale. 2) There was no illness related variable, which exhibited a significant difference among subgroups on the self-engulfment scale. 3) There was no significant correlation between the self-engulfment scores and the insight 4) There was a significantly inverse correlation between the self-engulfment scores and the self-esteem scores. Conclusion : The results of this preliminary study suggest that self-engulfment may develop despite lack of insight and that there was inverse relationship between self-engulfment and self-esteem in the patients with schizophrenia. It also suggests that females are more subject to self-engulfment than males. So, authors suggest that it is valuable to do further studies of self-engulfment in the patients with schizophrenia.

WWW 탐색도구의 색인 및 탐색 기능 평가에 관한 연구

정영미,김성은 한국문헌정보학회 1997 한국문헌정보학회지 Vol.31 No.1

WWW 탐색도구들은 인터넷 정보자원의 탐색에 있어서 매우 중요한 역할을 하고 있다. 본 연구에서는 주요한 WWW 탐색도구들의 성능을 평가할 목적으로 먼저 각 탐색도구의 색인 데이터베이스 특성, 탐색 기능, 적합성 순위 부여 방법 등을 비교한 후, 탐색실험을 통하여 검색효율, 중복탐색의 정도, 탐색결과의 유사도 등을 측정하였다. 탐색실험 결과 탐색질문의 유형에 관계없이 Alta Vista, HotBot, Open Text Index가 비교적 좋은 검색효율을 보였으며, 대부분의 탐색도구가 질문의 유형에 따라 검색효율에 있어서 차이를 보였다. 동일한 사이트를 중복하여 탐색하는 탐색의 중복도는 Magellan, WebCrawler, Yahoo!를 제외한 나머지 탐색도구들에서 모두 높게 나타났다. 탐색결과의 유사도를 측정한 결과 대부분의 탐색도구들이 매우 낮은 유사도를 보였다 The importance of WWW search services is increasing as Internet information resources explode. An evaluation of current 9 search services was first conducted by comparing descriptively the features concerning indexing, searching, and ranking of search results. Secondly, a couple of search queries were used to evaluate search performance of those services by the measures of retrieval effectiveness, the degree of overlap in searching sites, and the degree of similarity between services. In this experiment, Alta Vista, HotBot and Open Text Index showed better results for the retrieval effectiveness. The level of similarity among the 9 search services was extremely low

Shannon의 정보이론과 문헌정보

정영미 韓國圖書館學會 1979 圖書館學 Vol.6 No.1

Information storage and retrieval in a part of general communication process. In the Shannon's information theory, information contained in a message is a measure of uncertainty about information source and the amount of information is measured by entropy. Indexing is a process of reducing entropy of information source since document collection is divided into many smaller groups according to the subjects documents deal with. Significant concepts contained in every document are mapped into the set of all sets of index terms. Thus index itself is formed by paired sets of index terms and documents. Without indexing the entropy of document collection consisting of N documents is log₂N, whereas the average entropy of smaller groups(W₁,W₂···Wm)is as small. Retrieval efficiency is a measure of information system's performance, which is largely affected by goodness of index. If all and only documents evaluated relevant to user's query can be retrieved, the information system is said 100% efficient. Documents file W may be potentially classified into two sets of relevant documents and non-relevant documents to a specific query. After retrieval, the document file W' is reclassified into four sets of relevant-retrieved, relevant-not retrieved. It is shown in the paper that the difference in two of document file W and document file W' is a proper measure of retrieval efficiency

환자들의 건강 행위와 건강 통제위가 보건 의료 가치 및 이용에 미치는 영향

정연강,박경숙,윤은자,장영미 중앙대학교 의과대학 의과학연구소 1994 中央醫大誌 Vol.19 No.1

This study was conducted to find out the Health Behavior and health Locus of Control of the patients, and to identify the factors influencing the value and utilization of Health Service. The data for this study obtained from 728 patients selected from Out Patient Department of Chung-Ang University Hospital in Seoul. Data was collected from Mar. 25 to June 20, 1992. Analysis of data was done by use Mean, S.D., t-test, ANOVA, Pearsons's correlation coefficient and SNK test on 5% significant level with SPSS/PC. The major findings were as follows : 1. The first hypothesis : The higher degree of Health Behavior, the higher degree of Health Values, Utilization & Health Service was rejected (P>.05). 2. The second hypothesis : The higher degree of Internal Health Locus of Control, the higher degree of Health Values, Utilization & Health Service was supported (P<.01). 3. The third hypothesis : The lower degree of External Health Locus of Control, the higher degree of Health Values, Utilization & Health Service was supported (P<.00). 4. Health behavior was Influenced by educational level, and External Health Locus of Control was Influenced by occupation, educational level, religion, age and income, Health Values and general characteristics in the relationship between occupation, educational level, religion, age, income and economic status are showed significant(P<.05).

신문 시소러스 개발의 이론과 실제

정영미 한국문헌정보학회 1993 한국문헌정보학회지 Vol.25 No.-

Effective indexing systems are required to enhance the performance of full-text retrieval system. The result of the analysis of index terms selected by human indexers without a newspaper thesaurus indicates that controlled indexing language is necessary for effective and consistent indexing of newspaper articles. In this paper, basic principles are established for keyword selection from Korean newspapers and significant problems identified in the process of developing a newspaper thesaurus are discussed in depth

정보검색 기법의 검색효율 비교연구

정영미,노영희 연세대학교 대학원 1992 延世論叢 Vol.28 No.1

Four major information retrieval techniques encompassing Boolean retrieval, probabilistic retrieval, cluster-based retrieval, and the retrieval based on matching function were evaluated theoretically and experimentally. In the retrieval experiments, retrieval effectiveness and retrieval time were measured. Experimental data consisted of controlled index terms, selected from 134 articles in zoology journals containing Korean abstracts. Twenty search questions were formulated for the experiments. The experimental results showed that the probalilistic retrieval model is the optimum retrieval technique among the four with matching function retrieval being the second best. The vecall recall ratio of the probabilistic retrieval was 0.9778 and the precision ratio was 0.8033. However, Boolean retrieval and cluster-based retrieval achieved rather low performance.

색인이론과 실제

鄭瑛美 연세대학교 대학원 1980 延世論叢 Vol.17 No.1

Index is represented as a paired set of index terms(t) and documents(D): I= {(t,D) | t∈V,D∈W} Where V is index vocabulary and W is document collection. Indexing is a communication process between documents and indexer, whose final product is an index Indexing process involves technical, semantic, syntactic, statistical and effectiveness problems. Indexing accuracy is primarily governed by the technical aspect of indexing. Indexer, index language and indexing policy are three significant variables involved in producing technically accurate index. Indexer's ability of analyzing subject, indentifying indexable concepts, and coding is required. The proper levis of indexing exhaustivity and index language specificity are also significant factors affecting the quality of index. Semantic problems in indexing are largely related to index language. The structured index language system consists of Index vocabulary and semantic association mapping. Index language system contains index terms(x), synonym-like terms(Tsx), hierachically related terms(Thx), and other semantically related terms(Trx): IL= {(x, Tsx , Thx, Trx)|x∈V} Index vocabulary list defines semantic relationships between index terms thus preventing semantic noise occurring in indexing process. Pre-coordinate index systems such as classification and subject heading index produce less semantic noise than post-coordinate keyword index due to the structure of index language itself. Keyword system thus employs links and roles in order to reduce semantic noise. The degree of statistical dependency is shown higher in classification and conventional subject heading system than in keyword system. Other statistical aspects of indexing are also discussed.

도서관·정보학에서의 인공지능의 응용에 관한 고찰

정영미 韓國圖書館學會 1987 圖書館學 Vol.14 No.1

In this paper, artificial intelligence applications in library and information science are reviewed. Especially, natural language processing and expert systems are represented as the two major application areas. In natural language processing, natural language interface systems and question-answering systems are discussed in detail with some specific examples. In the second part of the paper, online search intermidiary systems, reference expert systems, classification and cataloging expert systems are described as possible expert systems to be developed in libraries and information systems. As a conclusion, implications of the artificial intelligence applications for librarians and information scientists are suggested

한 남자에서 수면 박탈 시 cDNA Microarray 분석에 의한 유전자 발현

정영철,홍미숙,정주호,김종우 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2

목 적 : 본 연구에서는 약 8000개 이상의 사람의 주요 유전자를 검색할 수 있는 TwinChip Human 8K cDNA miceoarray를 이용하여, 수면 박탈이 이러한 주요 유전자의 발현 양상에 어떠한 영향을 미치는 지를 대량으로 확인하고 분석하고자 하였다. 방 법 : Mendelson이 시행한 수면 박탈 방법을 변형하여 4일간의 일정으로 수면 박탈을 시행하였으며 첫째날(baseline) 수면 박탈 시행전과 4일째 수면 박탈 실험 완료 후에 각각 혈액채취를 하였다. 수면 박탈전과 수면 박탈후에 채취한 혈액을 대상으로 단핵세포를 분리하여 RNA를 추출후 TwinChip Human 8K cDNA microarray 반응을 시킨 후 결과를 분석하였다. 결 과 : 분석된 8287개의 유전자들 중 fluorescence ratio (Cy5/Cy3)가 3 이상인, 즉 수면 박탈 후 3배 이상 발현에 증가되었다고 볼수 있는 유전자는 NTS, RHAG, CLIPR-59, FLJ0849, Homo sapiens TFT-I interacting peptide 20mRNA, GRM3, ELK3, ETS-domain protein(SRF accessory protein 2), RBMS1 등으로 8개였고, fluorescence ratio(Cy5/Cy3)가 0.33 이하인, 즉 수면 박탈 후 3배 이상 발현이 감소되었다고 볼 수 있는 유전자는 ESTs, IL-2, ATP6V0A1, Homo sapiens cDNS FLJ31377 fis, clone NESOP100008, CYP11A, RECQL4, IGSF3, CGI-94, CALR 등으로 9개로 나타났다. 결 론 : 본 연구 결과에서 발현의 변화를 보인 유전자들을 RT-PCR이나 western blot 등의 방법을 이용하여 확인하는 후속 연구가 이루어져야 할 것이다. 향후 수면의 다양한 양상이 유전자 발현에 미치는 영향을 더 자세하게 알기 위해서는 cDNA microarray를 이용한 연구가 더욱 유용할 것으로 생각한다. Objective : The purpose of this study was to evaluate the effect of sleep deprivation on gene expression by cDNA microarray analysis. Methods : Subject of this study is one 27 years old male physically and psychologically healthy without sleep/wake complaints. Baseline blood sample was done at 09:00 of the day 1. Subject slept 4 hours on the day 1, 2 hours on the day 2. and total sleep, deprivation on the day 3. Blood samples was done in the morning of the day 4. Using cDNA microarray technique. gene expression profile was assayed. Results : There were 8 qenes up-regulated and 9 genes down-regulated after sleep deprivation Up-regulated genes were NTS(neurotensin), RHAG(Rhesus blood group-associated glycoprotein), CLIPR-59(CLIP-170-related protein), FLJ0849(hypothetical protein FLJ10849). Homo sapiens TTF-l interacting peptide 20mRNA, GRM3(glutamate receptor, metabotropic 3), ELK3 ETS-domain protein(SRF accessory protein 2) RBMS1(RNA binding motif, single stranded interacting protein 1) and down-regulated genes were ESTs, IL-2(interleukin-2), ATP6V0A1 (ATPase, Htransporting, lysosomal V0 subunit a isoform), Homo sapiens cDNS FLJ31377 fis, clone NESOP100008 CYPl1A(cytochrome P450, subfamily XIA cholesterol side chain)), RECQL4(RecQ protein-like 4), IGSF3(immuno-globulin suerfamily, member 3), CGI-94(CGl-94 protein), CALR(calreticulin). Conclusion : The results of the present study cannot fully explain the effects of sleep deprivation with respect to the expression of certain genes, but they provide fundamental data for the involvement of sleep deprivation or gene expression profiles Further in-depth studies are required to confirm the differential expression of these genes by RT-PCR or Western blot.