수족냉증(手足冷症) 환자(患者)에 대(對)한 컴퓨터 적외선(赤外線) 체열촬영(體熱撮影)의 의의(意義)

조유경,오수완,조남희,김동묵,김진성,류봉하,박동원,류기원,Cho, Yu-Kyung,Oh, Su-Wan,Cho, Nam-Hee,Kim, Dong-Mook,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2

To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

금속 알콕사이드를 원료로하여 분무 건조법에 의해 제조된 코오디어라이트 세라믹의 전기적 특성

박희찬,류봉기,류수착 釜山大學校生産技術硏究所 1995 生産技術硏究所論文集 Vol.49 No.-

코오디어라이트 세라믹 원료 분말이 금속 알콕사이드를 원료로 하여 제조되었다. 가수분해에 의해 제조된 졸을 분무 건조법과 오븐 건조기 건조법으로 건조하였으며 800℃에서 하소 처리한 후 1300℃에서 코오디어라이트 세라믹 소결체를 제조하였다. 분무 건조분말의 소결체의 유전상수 및 유전손실은 1㎒에서 1.1과 0.035의 값을 나타내었고, 건조기 건조분말의 소결체는 1.6 및 0.08의 값을 나타내었다. 분무건조 분말의 소결체의 겉보기 기공율 및 부피비중은 평균 1.3%와 2.448g/㎤ 이였고, 건조기 건조 분말의 소결체의 겉보기 기공율과 부피비중은 평균 3.2%와 2.185g/㎤이였다. Cordierite ceramic precursor powders were prepared from metal alkoxides. Hydrolyzed also were dried by spray dryer and oven dryer, and then they were calcined at 800℃. Calcined cordierite powders were sintered at 1300℃. In the codierite ceramics that were prepared from spray drying powders, dielectric constant and loss factor have 1.1 and 0.035 in 1MHz, respectively. In the codierite ceramics that were prepared from oven drying powders, dielectric constant and loss factor have 1.6 and 0.08 in 1MHz, respectively, Spray dried and sintered cordierite ceramics have apparent porosity of 1.3% and bulk density of 2.448g/㎤. Oven dried and sintered cordierite ceramics have apparent porosity of 3.2% and bulk density of 2.185g/㎤.

高校 物理敎育에 對한 探究學習의 評價模型 定立과 評價紙 開發 (Ⅱ)

奇宇恒,崔宗洛,朴奉斗,李原鎭 경북대학교 과학교육연구소 1984 科學敎育硏究誌 Vol.8 No.-

The emphasis given to experimental problem-solving skills in the physics curriculum innovation has not been matched by the development of the evaluation istruments. The purpose of this study is to develope the instrument for high school physics teaching. The instrument consists of twenty-two pencil-paper test problems of the unit, "force and motion", in the textbook physics I. These problems are related to integrated process skills and logical thinking ability, and they are classified by means of Piagentian type of logic patterns. The instrument was applied to three high school senior classes. Two hundred ninety five students in total participated in this test. The results of the application showed a considerably good relationship between the score of the test and the intelligence quotient (r=0.7). The reasoning ability was, however, very poor.

高校 物理敎育에 對한 探究學習의 評價模型定立과 評價紙 開發

奇宇恒,崔宗洛,朴奉斗,李原鎭 경북대학교 과학교육연구소 1983 科學敎育硏究誌 Vol.7 No.-

Recently experimental scientific problem solving skills and scientific attitude have been emphasized on the science education. The method of evaluation of the skill and the attitude, however, has not been much introduces to the science teachers. In this paper the domains, the objectives and the methods of evaluation of physics in high school were discussed related with Piagetian formal operational pattern. The objectives of knowledge and comprehension were divided into six parts according to the Piagetian logical thinking pattern. The objectives of the problem solving skills however were divided into twenty parts. Related with the scientific attitues, the cognitive (analytical and empirical), the value (judgement, commending) and the attitude (emotional response, personal likes) were also discussed in this paper.

호소 저질층의 총질소 및 총인 함량분석에 있어 Microwave와 Autoclave 분해법 비교

박종안,장봉기,민준호,이종화 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1

In order to search an efficient analytical method for analyzing the contents of nutrient salts [total nitrogen(T-N) and total phosphorus(T-P)] in sediments of reservoir, we compared microwave digestion method with autoclave method in sample preparation. The content of T-N obtained by microwave digestion method was lower(approximately 30%) than that obtained by autoclave method. But the content of T-P obtained by microwave digestion method was twice as much as that obtained by autoclave method. The desorption efficiency of T-N and T-P in both methods were good. The reproducibility of measurement results in microwave digestion method was better than that in autoclave method. A considerable amount of both nutrient salts was adsorpted on the sediment of Song-ak reservoir. Depending on the depth of sediment, differences in the contents of T-N were significant. The content of T-N in surface layer was highest. From these results, we recommend the microwave digestion method in sample preparation for analysis of T-N and T-P, because that method shows a higher reproducibility and provides a condition in which both nutrient salts can be simultaneously analyzed. We also suggest that in order to control water quality of reservoir a proper control measurement for nutrient salts adsorpted on sediments was needed.

카드뮴이 마우스 뇌에서 아연의 항상성에 관여하는 유전자발현에 미치는 영향

박종안,여은영,남상훈,장봉기,이종화,김완종 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.4

Metallothionein (MT), a small protein molecule which can bind of release metal tons, is involved in the regulation of cellular metal homeostasis This study was investigated the accumulation of cadmium in blood, tissue (liver, kidney and brain), and the effect of cadmium on several key genes (MT-Ⅰ, MT-Ⅱ, ZnT-1) in zinc metabolism m the mouse Mouses weighing 20-25g were randomly assigned to control and cadmium treated group (Cd group) Cd group was intraperitoneally injected with cadmium 2, 4, 8 mg/kg and control group was administerd with saline Mouses of each group were sacrificed by decapitation 4 hours after the administration of cadmium Cadmium contents in blood, fiver, kidney and brain were increased by a dose-dependent manner Accumulation of cadmium was mainly occurred in liver and kidney Induction of MT-I and MT-11 protein was increased, but ZnT-1 expression was decreased to a dose-dependent manner by the treatment of 2~8mg/kg cadmium These results suggested that cadmium can be transported to brain and alter the expression of several key genes in zinc homeostasis.

CT 영상에서 메쉬 필터를 이용한 장기의 추출

박종원,김원봉,한기선,유승화,성윤창 忠南大學校 産業技術硏究所 1999 산업기술연구논문집 Vol.14 No.1

In this paper, we studied on the segmentation of liver and spleen in CT image. The proposed algorithm used th information of gray value and location for these organs, and gray value of each organ is automatically estimated by using mesh filter. And also, th proposed algorithm in this paper used the position searching lines based on the information for each organ. Therefore, target organ is exactly segmented without separated organs loss. A trimming algorithm, which use a morphological filter, is provided to remove such noise in order for the organ to have a smooth contour. The small holes of the liver inside are filled up by erosion and the size of the organ reverts to the original state by dilation. The algorithms have been applied to the CT images of thirty persons, which results in 5% error rate of the volume of each organ

濟州地方에서 한라부추(Allium taquetii) 栽培法 確立에 關한 硏究 : Ⅰ. 赤色光과 植物生長調節劑가 種子發芽에 미치는 영향 Ⅰ. Effect of Red Light and Plant Growth Regulators on Seed Germination

朴庸奉,康勳,金基澤 제주대학교 1991 논문집 Vol.33 No.-

한라부추 種子發芽에 對한 溫度, 光質(赤色光), 低溫處里 및 몇가지 植生物長調節劑를 處里하여 發芽하는 狀態를 調査한 結果 다음과 같은 結論을 얻었다. 1. 한라부추의 發芽適溫은 20∼25℃였으며 高溫인 30℃에서는 發芽가 極히 抑制되었다. 2. 赤色光은 15∼20℃ 溫度에서는 發芽促進 效果가 있었지만 25℃以上의 溫度에서는 그 促進效果가 喪失되었다. 그리고 모든 溫度에서 暗處理와 類似한 發芽樣相을 보였다. 3. 低溫處理 한 것은 對照區와 거의 비슷한 傾向을 나타내었다. 4. NAA는 發芽抑制 效果가 나타나 對照區보다 오히려 發芽率이 떨어지는 傾向을 나타내었다. GA는 25㎎/ℓ, Ethephon은 50㎎/ℓ, BA는 10㎎/ℓ에서 發芽가 가장 促進되었으나, Ethephon과 BA의 경우 濃度가 높을 수록 發芽抑制 程度가 심하였다. In view of seed germination of Halla gynmigit (Allium taquetii) its known to grow wild (natually) at the 110m level of Mt. Halla. A study was conducted to see if several plant growth regulators, high and low temperature and red light treatment have any promotive influence on the germination of Halla gynmigit seed and its practical value, when applied at various concentrations. 1) 20~25℃ showed promotion of germination of Hallh gynmigit seeds and shortened the mean number of days necessary for germination, while deleyed germination was observed if 30℃ was applied. 2) Red light promoted the seed germination of Halla gynmigit at 15~20℃, but at the over 25℃, promotive effect was lost. 3) the low temperature treatment group was not more significantly influence than the control. 4) The NAA treatment showed the effect of germination retard, On the contrary, The germination percentage was decreased less than that of the control. However, GA 25㎎/ℓ, Ethephon 50㎎/ℓ, and BA 10㎎/ℓ promoted the germinaton percentage markedly. Especially. BA and Ethephon treatment at latively higher concentration levels resulted in less seed germination.

Triazole계 건묘육성제 처리가 '삼복꿀' 수박의 유묘생장에 미치는 영향

박유진,강봉화,정기윤,이정명 경희대학교식량자원개발연구소 2006 硏究論文集 Vol.25 No.-

수박의 시설재배 육묘 시 일조량이 부족하여 도장, 과번무가 필연적으로 발생하므로 이에 대한 생장억제물질의 이용도 폭넓게 실용화되고 있다. 본 실험은 수박 품종 중 가장 대표적으로 재배되는 삼복꿀 품종을 접목묘와 무접목묘로 나누어 triazole계 건묘육성제의 처리 방법, 처리 회수, 처리 농도에 따른 반응성을 비교하였는데 공시 물질로는 triazole계 살균제로 국내에 등록된 빈나리(diniconazole)와 Bonzi(paclobutrazol)을 유묘에 살포와 토양주입 처리하였다. 빈나리의 경우 토양주입처리보다 살포처리가 더 효과적이었고 Bonzi는 두 처리 수준 모두에서 강한 왜화 효과를 나타냈다. 처리 회수에 따른 반응성은 1회 처리만으로 충분하였으며 2회 처리는 왜화 효과가 지나치게 강하게 나타났다. 이러한 경향은 무접목묘나 접목묘에서 거의 유사하였다. 건묘육성제의 종류로는 농도조절만 적합하다면 어느 것이라도 소정의 건묘육성 효과를 거둘 수 있었는데 빈나리는 본엽 3~4매시 25 mg·L^(-1) 수준으로, 그리고 Bonzi는 5 mg·L^(-1) 수준으로 엽면살포하는 것이 가장 적절하였다. Use of commercial plug seedlings has been markedly increased in recent years with development of mechanized production systems. However, plug seedlings are prone to overgrow because of the short period maintaining the healthy seedling character when grown in small-volume cell. The triazole bioregulators are registered primarily as fungicides, even though some of them have been used as plant bioregulators due to the remarkable growth inhibitory effects. Spray treatments of diniconazole and paclobutrazol suppressed growth of watermelon seedlings especially when treated at earlier stages. The higher the treatment concentration, the stronger the growth retarding effect, in general. Foliar spray of diniconazole at 25 mg·L^(-1) was recommended for proper growth suppression in both grafted and non-grafted watermelon seedlings, while soil injection method was less effective. On the other hand, paclobutrazol at 5 mg·L^(-1) was effective in spray treatment and 25 mg·L^(-1) for soil treatment.