VRE 감염증의 임상상, 미생물학적 특성 분석 및 유전적 관련성 비교 : 전국 6개 병원에서 분리된 VRE를 중심으로

정희진,박정원,엄중식,하경임,신종희,김정미,이혜수,박영희,김우주,박승철 대한감염학회 2002 감염 Vol.34 No.5

농촌소득증대를 위한 열대과수의 특성과 현황

정삼택,이우승 경북대학교 1986 새마을 硏究論叢 Vol.6 No.-

In order to know the characteristics and current cultivation situation of horticultural crops, specially fruit crop in Thailand, Java island of Indonesia Kenya, Costa Rica, Ponape island of Micronesia and Hawaii of United States of America are discussed based on review of literatures and statistics collected. 1. In Thailand, fruit and vegetables shared 8.9 and 4.4%, respectively, of the total agricultural product in value in 1976. The largest fruit crop in production was coconut and the most rapidly increasing one was pineapple. 2. In Java island of Indonesia, fruit trees, vegetables, and ornamentals occupy 10.2, 7.6 and 33.4% respectively, of the total 607 species of plants found in home gardens. In 1981, the largest crop in production was coconut and the most rapidly increasing one was citrus. Pineapple, papaya, banana and citrus are grown in both home garden and plantations. Coconut, durian, mangosteen and rambutan are grown only in home gardens.. Salak is grown in plantations. Fruit crops grown in home gardens are difficult to care and selection of dwarf stock is desirable. There are non-seasonal and seasonal fruits. Flowering physiology should be studied to stabilize the production of seasonal fruit. 3. In Kenya, about 17 fruit crops, 23 vegetables and 19 cut flowers and ornamentals are cultivated. Pineapple among fruit crops and tomatoes among vegetables are rising in kenya. Pineapple and cut flowers are rising as export crops. 4. In Costa Rica, banana is the biggest crop in planted area. Pineapple and tomto are rapidly rising. Banana and pineapple are produced in large scale farms and farms middle class. Coconut, citrus, avocado and papaya are cultivated in the farms of middle class. Especially in banana, technical level of cultivation was variable depending on the geographical region and size of farms, and generally high in large farms. 5. On the Ponape island of micronesia, eleven species of citrus and 2 species of Fortunella are grown. Oranges are growing widely from the fallen seeds and in mixture with other fruits. No cultivation cares are applied. However, there is a possibility that transition from home garden style to commercial cultivation may occur as diets and living standard are improved. 6. In Hawaii U.S.A., fruit, vegetables and flowers plus ornamentals share 18, 3 and 4% of total agricultural production in value, respectively. Especially, pineapple, macademia nuts, anthurium, carnation and orchids are important horticultural crops for export.

소아 특발성 중추성 요붕증의 임상경과, 내분비학적 소견 및 뇌자기공명 영상 소견의 경과 관찰

정윤하,정우영 인제대학교 2008 仁濟醫學 Vol.29 No.-

Idiopathic central diabetes insipidus (CDI) can be diagnosed when it occurs in the absence of a cause known to be responsible for diabetes insipidus. Some patients initially diagnosed as idiopathic CDI progressed to brain tumors. We reviewed clinical, endocrinological and brain MRI courses in patients with pediatric idiopathic central diabetes insipidus, to assess the predicting factors for progression to brain tumors. We reviewed the medical records of all patients who had documented cases of idiopathic CDI from 1988 to 2008, and studied clinical, endocrinological and brain MRI courses at diagnosis and during follow up. The patients include 6 males and 5 females. Their mean age at diagnosis was 10.0±4.5(4-19) years and mean follow up duration is 4.3±4.7(0.3-14) years. After mean follow up duration of 4.3±4.7(0.3-14) years, follow up Brain MRI showed brain tumor in 3(27%) patients and no interval change in 4(36%) patients with pituitary stalk thickening and in 3(27%) patients with loss of posterior pituitary signal. 4(27%) patients had growth hormone deficiency and 3(27%) patients had multiple pituitary hormone deficiency. Because some patients of idiopathic CDI progressed to brain tumor, we should follow up more carefully brain MRI and pituitary hormone deficiency.

열대 원예작물의 특성과 재배법에 관한 조사

정삼택,이우승,김익홍 경북대학교 1987 새마을 硏究論叢 Vol.7 No.-

This investigation was conducted to know the characteristics and cultivation method of some tropical crops; fruit tree, vegetable and ornamental flowers growing in Tropical regions by literatures. 1) Most of fruits were utilized as raw-fruit itself and processing techniques are needed for the merchandise. Some fruit is lack of cultivation method. Pine apple and banana are the most common fruit in these regions. These fruit products can be exported to the temperate zone regions for the net-income of the farmers. 2) Vegetables are cultivated for the part of vitamin supply and on the whole, cultivation method is underdeveloped yet. But some vegetables are grown for the industrial oil, medicine manufacture, feed forage and green manure. 3) Ornamental flowers are grown for the cutflower and garden flower. From these results, It is believed that introduction and adaptability test must be conducted for the increased net-income of Korean farmers.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

골조구조물의 소성해석을 위한 알고리즘 개발 및 소성붕괴의 고찰

정명채,조우람 전주대학교 공학기술종합연구소 2003 전주대학교 공학기술종합연구소 학술논문집 Vol.9 No.1

Some members of building frame under severe cyclic loads may be experienced inelastic behavior. In seismic design of building frames elasto-plastic analysis of flame structures are needed to understand the inelastic behavior. In this study, simple and clearer elasto-plastic analysis algorithm is used to investigate the collapse mechanism of a building frame. This algorithm is simple and clear to understand the inelastic behavior of the frame. Two-bay frame is used as a model. The analysis results are very reasonable to describe the collapse of the frame.

능력스펙트럼법에 의한 복층 래티스돔의 성능점 산정에 관한 연구

정명채,조우람,김홍건 전주대학교 공학기술종합연구소 2002 전주대학교 공학기술종합연구소 학술논문집 Vol.8 No.1

Performance based seismic design is a very efficient method in checking the seismic capacity of buildings. In this study, the method evaluating performance point of a double layered lattice dome based on capacity spectrum method (CSM) is proposed Because behaviors of a double layered lattice dome are affected by higher modes of vibration, they need to be included in evaluating seismic resistant capacity. In this paper, they are considered in the lateral bad distribution on for the pushover analysis process. The proposed method is successfully applied to estimate the performance point of a double layered lattice dome.

NK/T 세포 림프종 환자에서 시행된 비골수제거성 조혈모세포이식

정준원,김진석,장준호,서형찬,이승태,김현옥,양우익,민유홍,한지숙,고윤웅 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

저자 등은 맹장, 충수돌기 및 흉막을 침범한 고위험군 NK/T 세포 림프종 환자에서 비골수제거 조혈모세포이식을 시행한 후 이식연관 합병증 없이 무병생존하였기에 보고하는 바이다. NK/T cell lymphoma is a rare type of non-Hodgkin"s lymphomas. It has the histological features of angiocentric lymphoma characterized by prominent angio-invasion by tumor cells, and commonly presents in nasal and paranasal structures. Non-nasal form of NK/T cell lymphoma involves skin, gastrointestinal tract, or liver. With conventional chemotherapy and/or radiotherapy, NK/T cell lymphoma shows poor response rate and seldom results in long term survival. Especially, non-nasal form has more aggressive clinical manifestations and grave outcome than nasal form. We report a case of NK/T cell lymphoma presenting with small bowel perforation and malignant pleural effusion due to lymphoma infiltration, transplanted with allogeneic peripheral blood stem cells from HLA identical sibling donor after fludarabine-based nonmyeloablative chemotherapy. After transplantation, the patient achieved an enduring tri-lineage hematological complete response without any evidence of relapse for 10 months.

복합막을 이용한 막수송의 특성연구

정우준,조성우,양원강 동국대학교 경주대학 1997 東國論集 Vol.16 No.2

2종 콜로디온-복합막을 제조하여서 하전막을 통한 물질수송에 대한 조직과 비교적 방법으로 연구하였다. 하나는 퍼풀루로벤조익 산(perfluorobenzoic acid, PFBA)의 여러 가지 양에 콜로디온을 합성시켜 만든 복합막이고, 다른 하나는 이 복합막에다 염소산나트륨(NaClO_4)을 가하여 포아를 갖는 복합막을 합성하였다. 몇가지 막-페러메타는 막전도도와 전기삼투압 계수의 실험값과 기본적인 비교로 열역학적 관점에서 검토하였다. 두 복합막의 차이는 막을 구성하는 골격이 되는 물질의 구조와 또 복합막내에 존재하는 하전밀도와 관련해서 검토하였다. In order to get a better understanding regarding material transport through charged membranes, two kinds of the composite collodion membranes were prepared and investigated by systematic and comparative studies. One of the membranes is a composite collodion membrane incoporating different quantities of perfluobenzoic acid(PEBA) and the other is the same membrane but with pores formed by adding NaClO_4. Several membrane parameters defined by thermodynamics consideration such as membrane conductance and electroosmosis coefficient was estimated from the corresponding experiments and were examined on the basis of frictional consideration. The differences between two membranes were also discussed in relation to the structure of membrane skeleton of charge densities within the composite collodion membrane.

임상 검체에서 분리된 vancomycin 내성 장구균에 대한 Quinupristin/dalfopristin(Synercid®)을 포함한 10종 항균제의 시험관내 항균력

정희진,박기호,김동림,김우주,김민자,박승철,신종희 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

목적 : 본 연구에서는 고려대 병원과 전남대 병원에서 임상 검체로부터 분리된 VRE 16균주를 대상으로 하여 장구균 감염의 치료에 흔히 사용되는 항균제인 ampicillin, gentamicin, vancomycin, teicoplanin과 VRE에 대해서도 비교적 항균력이 있는 것으로 알려진 기존의 chloramphenicol, doxycycline, erythromycin, ciprofloxacin, rifampicin, 그리고 다제 내성 그람 양성균의 치료를 위하여 새로이 개발된 quinupristin/dalfopristin을 이용한 시험관내 항균력을 조사하고자 하였다. 방법 : 총 16균주의 VRE faecium을 대상으로 quinupristin/dalfopristin (Synercid^(R))를 포함한 10종 항균제에 대한 최소 발육 억제 농도(MIC)를 한천희석법을 이용하여 측정하였다. 각각의 항균제에 대한 감수성은 NCCLS에서 제시한 기준에 의거하여 해석하였다. 결과 : 1) 5균주의 vanB VRE에 대한 항균제의 MIC_(90)은 ampicillin, erythromycin, gentamicin, cipro- floxacin에서 각각 64㎍/㎖, 512㎍/㎖, 512㎍/㎖, 4㎍/㎖로서 100%에서 내성을 보였고, doxycycline, chloramphenicol의 경우 4㎍/㎖, 4㎍/㎖로서 100%에서 감수성을 보였다. Teicoplanin의 MIC_(90)은 1㎍/㎖로서 모두 감수성을 보였고 quinupristin/dalfopristin에 대해서도 MIC_(90) 0.25㎍/㎖로서 감수성을 보였다. 2) 11균주의 vanA VRE에 대한 항균제들의 MIC 범위는 vanB VRE보다는 다양하였다. MIC_(90)을 보면 amplicillin, erythromycin의 경우 256㎍/㎖, 512㎍/㎖으로 100%에서 내성을 보였응며, gentamicin은 MIC_(90) ≥500㎍/㎖의 고도내성을 보인 경우가 8 균주로서 73%에서 내성을 보였다. Ciprofloxacin은 vanB VRE에서와 마찬가지로 MIC≥32㎍/㎖의 100%의 내성을 보였다. Chloramphenicol의 경우는 MIC_(90)이 16㎍/㎖로서 vanA VRE faecium에 대해서도 감수성이 있는 약제로 남아 있었다. 반면에 doxycycline은 MIC_(90)이 4㎍/㎖로서 시험관내에서는 100% 감수성을 보였고, quinupristin/dalfopristin은 MIC_(90)이 2㎍/㎖로서 내성을 보인 균주는 한 균주도 없었다. 결론 : 국내 임상분리 VRE 16균주는 기존에 사용되어 오던 chloramphenicol, doxycyline등의 항균제에 대하여 시험관내에서 100% 감수성을 보였으며 quinupristin/dalfopristin과 같은 새로운 항균제에 대해서도 중등도 또는 완전 감수성을 보여 향후 VRE에 의한 감염증 치료에 있어 이들 약제의 병합요법등이 고려될 수 있을 것이라 사료된다. Background : Vancomcyin-resistant enterococci (VRE) have become a major nosocomial pathogen in the USA during 1990s. In Korea, VRE have recently emerged as a important nosocomial pathogen and posed therapeutic difficulty. We evaluated the antimicrobial susceptibility of clinical VRE isolates to the antimicrobial agents that are commonly used to treat enterococcal infections and to some alternative drugs and to a newer antibiotic such as quinupristin/dalfopristin(Synercid®). Methods : We evaluated 16 clinical VR-E. faecium (5 vanB VRE, 11 vanA VRE) strains that were isolated from Korea Universtiy and Chonnam University hospital during the last five years (1994-1998). The isolates were identified to the species level by using API 20system. The in vitro susceptibility testing was performed by the agar dilution methods, following the criteria described by the National Committee for Clinical Laboratory Standards (NCCLS). The VRE isolates were tested against antimicrobial agents commonly used to treat enterococcal infections (vancomycin, teicoplanin, ampicillin, gentamicin), potential alternative drugs (chloramphenicol, doxycycline, ciprofloxacin, erythromycin, rifampicin) and a newer antibiotic (quinupristin/dalfopristin). Results : 100% (5/5) of vanB VR-E. faecium were resistant to ampicillin, gentamicin and ciprofloxacm, but 100% (5/5) were susceptible to chloramphenicol, doxycycime, teicoplanin and quinupristin/dalfopristm. 100% (11/11) of vanA VR-E. faecium were resistant to ampicillin, ciprofloxacm, 73% were resistant to gentamicin, and 100% (11/11) were susceptible to chloramphenicol and doxycycline. Quinupristin/dalfopristm showed intermediate or high level susceptibility against all vanA VRE isolates. Rifampin is less susceptible (MIC: 4-16 ㎍/mL) against both vanA and vanB VR-E. faecium. Conclusion : The treatment options for infections caused by VRE seem to be very narrow since a small percentage of those isolates were susceptible to the other antmicrobial agents commonly used to treat these infections. And only a few of the alternative drugs including quinupristin/dalfopristm tested showed good in vitro activity. This study suggested that chloramphenicol, doxycycline and qumuprisitin/dalfopristin would be a good candidate to treat VRE infection, but further studies are necessary to demonstrate the clinical role of these antimicrobial agents.