유방통을 호소하는 한국 여성에서 Gamma Linolenic acid의 임상적인 효과

정재헌,김권천,조현진,민영돈,김성환,김정용,장정환 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : Recently, the incidence of breast cancer is gradually increasing in korea. Many patients visit the hospital with a fear of breast cancer, if she had the pain in her breast. But Breast pain is not a cardinal sign of breast cancer. Only 7% of patient in breast cancer has breast pain. Materials and Method : To know the clinical effects of gamma-linolenic acid(GLA), we analyzed the medical records of 55 cases with breast pain, who visited the outpatient clinic of Chosun university hospital, between July of 1999 to December of 1999. Of the 55cases of breast pain, we analyzed 26 cases of patient with breast pain who was treated with GLA for 2 month and we excluded patients of breast pain who had breast mass or were treated with other drug. Results : 2 Patients we are dropped out because nausea and vomiting were developed, 4 Patient with breast pain were treated with GLA for 1 month, and relieved completely from mastalgia and 8 patients with breast pain were treated with GLA for 2 months and breast pain was relieved completelys. 4 patient had treatment for 2 months, were relieved slightly. But 8 patients with breast pain didn't reveal the relief of symptom after the intake of GLA. Conclusion : We conclude that GLA could be considered a first line drug in patients with mastalgia.

결장직장암 환자의 임상적 고찰 : 조선대학교 부속병원의 10년 간의 결과

나은종,문성표,장정환,김권천,민영돈,김성환,조현진,김정용,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: The colorectal cancer rates 4th in the total cancer prevalence in Korea. The clinical patient demographics were considered with the incidence rate of the colon and rectal cancer. The clinicopathological factors were analyzed for the 5 year survival rate. Materials Methods: Of the 282 patients who were operated from Jan. 1, 1992 to Dec. 31, 2001 and diagnosed by pathological biopsy as colo-rectal cancer, 234 patients were followed up. The age, sex, location of the cancer, TNM stage, operation method, histopathological classification, metastatic region, complications after operation and the survival rate were investigated. Results: Of the 234 patients, male and female consisted of 120 cases (51.3%) and 114 cases (46.7%), with an average age of 61.6 years. The average follow up period was 52.3 months and the peri operative mortality was 5.6%. The site of the cancer was most frequent at the rectum with 127 cases (54.3%). The patients were classified according to the TNM stages with 38 cases of stage 1 (16.2%), 98 cases of II (41.9%), 72 cases of III (30.8%) and 26 cases of IV (11.1%). The 5 year survival rate in the age group older than 50 was 63.3 % and 73.5% in the group younger than 50. In regard to the operation type, the 5 year survival rate was 65.4% for elective operation and 65.8% for emergency operation. The 5 year survival rate for well differentiated, moderately differentiated, poorly differentiated cancer, and mucinous adenocarcinoma was 73.7%, 60.2%, 58.3%, and 92.6%, respectively. The 5 year survival rate of each of the TNM stage is 81.1%, 74.8%, 57.0%, and 11.5% for Classes I, II, III, and IV, respectively. Conclusion: The clinical factors were analyzed for the 5 year survival rate with no statistical significance for the age, sex, and location of the cancer. The TNM stage and histopathological differentiation were statistically significant. The colon cancer showed better prognosis compared to the rectal cancer.

위암의 근치절제술 후 생존율과 예후인자

차윤정,박진영,장정환,김성환,김권천,조현진,민영돈 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives: Gastric cancer is still the leading cause of cancer death in Korea, and surgery remains the only method of treatment that offers the potential for a cure. Purpose: The aims of this study are to examine the outcome of the patients with gastric adenocarcinoma who underwent curative resection and to identify the prognostic factors leading to improved survival rates in these patients. Materials and Methods: The medical records of 278 patients with gastric adenocarcinoma, treated curatively at the Chosun University Hospital between January 1990 and December 1994, were reviewed retrospectively from January 2000 to March 2000. Follow-up was obtained for 250 patients(89.9%). The survival rates were calculated by the Kaplan-Meier method, and the significance of differences between patient factors(age and sex), tumor factors(location, size, gross type, tumor depth, lymph node metastasis, and stage) and treatment factors(operation method and reconstruction type) were evaluated statistically by the log-rank test. Results: The overall five-year survival probability was 59.6%. There was no survival difference according to age and sex. The 5-year survival rates according to the tumor depth were 97.0% for Tl, 74.5% for T2, 39.6% for T3, and 23.1% for T4(p=0.0000); to the lymph node metastasis were 81,4% for N0, 51.9% for N1, and 21.2% for N2(p=0.0000); to the TNM stage were 96.7% for stage I a, 79.5% for stage I b, 68.8% for stage II, 52.9% for stage III a, 25.9% for stage III b, and 7.5% for stage IV(p=0.0000). Other statistically significant differences were shown in tumor location, size, gross type, operation method, and reconstruction type after subtotal gastrectomy. Conclusion: The most definitive prognostic factors affecting the survival rate of gastric adenocarcinoma were tumor depth, lymph node metastasis, and tumor stage. The keys to successful outcome includes early diagnosis and curative resection with radical lymph node dissection at early stage as possible.

The Comparison between Human Hertwig`s Epithelial Root Sheath Cells and Periodontal Ligament Stem Cells

( Hyun Nam ),( Hyun Jeong Kweon ),( Soo Yeon You ),( Dae Hyun Jeon ),( Jae Jin Cho ),( Gene Lee ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4

It is well known that the interactions between epithelial and mesenchymal components are very important event for tooth development, and their coordination is crucial to tooth development. Recently it has been reported that human PDLSC might be a mesenchymal component for regeneration of periodontal tissue. In contrast, characteristics of human HERS cells and their roles in development and regeneration of tooth are not well elucidated. In this study, we investigated the phenotypes and the differentiation potentials of human HERS cells and PDLSCs. First of all, we simultaneously isolated human HERS cells and PDLSCs from the same periodontal ligament tissues. Hence we established the method for primary isolation of human HERS cells and PDLSC at the same time. Human HERS cells and PDLSCs showed different cell morphology and growth patterns from each other. In particular, human HERS cells showed epithelial cell-like morphology, while human PDLSCs showed fibroblast-like morphology. In the immunophenotype analysis of cell surface markers, human PDLSCs were positive for the mesenchymal stem cell markers but human HERS cells showed different expressions. Human PDLSCs were able to differentiate into osteoblasts and adipocytes by appropriate induction. On the other hand, human HERS cells acquired mesenchymal phenotypes by TGF-β1 through EMT. Taken together, our data suggest that human HERS cells and PDLSCs might play a role as a epithelial component or a mesenchymal component for the tooth regeneration,v respectively.

배추좀나방과 담배거세미나방 유충에 대한 한방식물체의 살충활성 및 섭식저해활성

Jeong Hyun Kweon,Young Joon Ahn,Hyung Wook Kwon,Kyung Soo Jang,Kwang Yun Cho 한국응용곤충학회 1994 한국응용곤충학회지 Vol.33 No.4

배추좀나방과 담배거세미나방 유충에 대한 30종 한방 식물체 메탄올 조추출몰의 살충활성 및 섭식 저해활성을 잎침지법을 이용하여 5,000ppm으로 검정하였다. 황련의 추출물은배추좀나방에 대해 살충작용을 보였다. 길경, 사삼, 세신, 오배자 및 자초의 추출물은 배추좀나방 유충에 대해, 목통 및 속새의 추출물은 담배거세미나방 유충에 대한 강한 섭식저해활성을 보였으나, 오배자와 황련의 추출물은 이들 나비목 유충 모두에 강한 섭식저해활성을 나타내었다. The methanol extracts from 30 species of oriental medicinal plants belonging to 24 families were tested for their lhicidal and antifeeding activit~es against diamondback moth (Plutello xylostella L) and tobacco cutworn (Spodoptera litura F.) by a leaf-dipping method at a concentration of 5, 000 ppm. The methanol extract from Copti chinensis only showed a potent larvicidal activity against P xylostello. Strong antifeeding activity against P. xylostello was observed from the extmds from Platycodon grandiflorurn, Codonopsis pilosula, Asomm sieboldii, Rhus chinensis and Uthospermum erythrorhizon And a potent antifeeding activity against S. liturn was obtained from Akebia quinata and Equlsetum hyemale extracts. A significant antifeeding activity against both species was obtained from R chinensis and C. chinensis extracts.

신장이식술을 받은 여성의 산과적 예후

이현정(Hyun Jung Lee),이지현(Jee Hyun Lee),배정훈(Jeong Hoon Bae),정선영(Sun Young Jeong),안현영(Hyun Young Ahn),권인(In Kweon),신종철(Jong Chul Shin),나종구(Jong Gu Ra),김수평(Soo Pyung Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7

목적 : 신장이식이 임신에 어떤 영향을 미치는지 관찰하고, 이식후 임신까지의 기간이 주산기 예후와 관계가 있는지 분석하기 위하여 본 연구를 시행하였다. 방법 : 강남성모병원에서 1990년 1월부터 2000년 12월까지 신장 이식을 받은 822명 중에 가임기 여성 295명을 대상으로 임신 여부와 그 예후에 대하여 전화면담과 의무기록 조사를 통하여 분석하였으며, 임신이 확인된 경우, 내과, 산과 및 소아과 의무기록을 검토하였으며, 타병원에서 산과적 처치를 받은 경우 전화면담을 시행하였다. 결과 : 1) 연구 기간동안 21명의 여성에서 총 31예의 임신이 있었으며, 그중 개인적 이유나 의사의 권유로 인공유산을 한 경우가 5예, 임신 1분기에 자연 유산이 된 경우가 3예 있었으며, 분만까지 이어진 경우가 23 예 있었다. 임신 1분기를 지나 분만까지 임신이 지속된 군의 평균 임신 기간은 36.18±0.61주이었으며 신생아의 평균 몸무게는 2,525±137 gm이었다. 2) 임신 37주 이상까지 임신을 유지한 경우가 전체의 43.4%이었으며 37주 미만에서 분만된 경우가 56.5% 이었다. 주산기 합병증으로는 자궁내 발육부전 (39%), 조기진통 (35%), 양막파수 (30%), 임신성 고혈압 (30%) 순으로 나타났으며, 모성 합병증으로는 거부반응 (18%)과 신기능악화 (5%) 순으로 나타났다. 3) 신장 이식 후 임신까지의 평균 기간은 4.7년이었으며, 이식 후 2년 이내에 임신이 된 경우가 12명이었으며, 2년 이후에 임신된 경우가 19명이었다. 이식후 임신 기간별 신생아체중에는 차이가 없었으며 (p=0.824), 이식후 임신까지의 기간도 분만군 (5.21±0.94년)과 유산군 (4.57±1.17년)에 차이가 없었다 (p=0.207). 4) 모든 산모는 임신 중에 면역억제제와 스테로이드 제제를 복용하였으나 출생 후 신생아에게 특이할 만한 부작용은 발견되지는 않았으며, long term하게 follow up 했을 때 (4 mo에서 8살) Neurofibromatosis 1예 (7살)와 반복성 혈뇨를 보이는 1예 (4살)외는 이상소견이 발견되지는 않았다. 결론 : 신 이식을 받은 여성에서의 임신은 다양한 합병증을 유발할 수 있어 고위험임신으로 분류되나 임신 전 신기능이 양호한 경우에는 좋은 주산기 예후를 기대할 수 있다. Objective : To evaluate the outcome of pregnancy in kidney transplanted women, and correlate this with the time of transplantation to conception. Material and Methods : We analyzed the outcome of 31 pregnancies from 21 allograft recipients at Kangnam St. Mary`s Hospital, Catholic Medical Center from January 1990 through December 2000. For each reported pregnancy we reviewed obstetrical, medical and pediatric records. For children follow-up and for those whose obstetric procedures were taken in other hospitals, we did a questionarie and telephone interviews. Results : Of the 31 pregnancies followed by us, there were 23 live-born offspring delivered by 21 mothers and 8 stillborn/abortuses, including five artificial abortuses. The mean gestational age at delivery was 36.18±0.6 weeks and the mean birth weight of the offspring was 2,525±137gm. Only 43.4% was delivered after 37weeks of gestation. Preterm delivery rate (delivered before 37weeks of gestation) was 56.5%. Common obstetric complications were intrauterine growth restriction (39.1%) preterm labor (35%), premature rupture of membrane (30%), preeclampsia (30%), and maternal complications were deterioration of renal function (5%) and rejection of allograft (18%) after delivery. Mean interval from transplantation to pregnancy was 4.7 years. Twelve pregnancies occurred within the first 2 years of transplantation, while 19 pregnancies occurred after that period. No difference was noted in neonatal body weight between 2 groups (p=0.824). There was no difference in mean interval from transplantation to pregnancy in the delivery group (5.21±0.9 years) vs. the abortion group (4.57±1.1 years) (p=0.207). All women continued with her medication during pregnancy, based on cyclosporine and/or azathioprine and steroids. No congenital anomaly was noted in the newborn. When follow up lately, one boy with neurofibromatosis and a girl with recurrent hematuria were noted. Conclusion : Although pregnancy in renal allograft patient is hazardous, good outcome can be expected if function of the allograft is good before conception.

Cytokine Induction by a Polysaccharide-protein Complex Isolated from Agaricus blazei Murill

Hyun-Ok Ku,In-Cheon Kim,Young-Hwa Sim,Sang-Hee Jeong,Chang-Hee Kweon,Shin-Ja Park,Yun-Bae Kim,Han-Sang Yoo,Yong-Soon Lee 한국독성학회 1999 Toxicological Research Vol.15 No.3

A polysaccharide-protein (74.1 : 12.8%) complex was extracted from Agaricus blazei Murill, and its cytokine-inducing potency was investigated in vitro and in vivo. In peritoneal macrophage cultures, the polysaccharide-protein complex induced a high level of interleukin-1α and interleukin-6 production in a dose-dependent manner. In contrast, tumor necrosis factor-α was not detected in the culture supernatant of macrophages stimulated with the polysaccharide-protein complex. Such an increased production of interleukin-6 was also observed in splenocyte cultures, while interleukin-2, interleukin-4, tumor necrosis factor-α and inteljeron-y were not significantly increased following stimulation. Such a pattern in cytokine induction by polysaccharide-protein complex was observed in mice, though it was transient 1-2 hr after intraperitoneal challenge. High levels (5,000-7,500 pg/ml) of interleukin-6 were achieved 1 hr after administration of 5-20 mg/kg of stimulus. Serum interleukin-1α, tumor necrosis factor-α and interferon-y levels were also increased to some extent, while interleukin-2 and interleukin-4 were not responsive. Taken together, it is suggested that interleukin-6 is the most responsive cytokine to stimulation with polysaccharide-protein complex from Agaricus blazei Murill.

Fabrication of Novel Ag-Paste and Evaluation of its Electrical Properties in Bulk-Si Solar Cell

Jeong, Ji Hyun,Kim, Sung Jin,Son, Chang Rok,Ur, Soon Chul,Kweon, Soon Young Trans Tech Publications, Ltd. 2012 Materials science forum Vol.724 No.-

<P>Two kinds of Ag-pastes were prepared for integrating the bulk Si solar cell. One is the Ag-paste mixed with Pb-based glass frit and the other is that mixed with Pb-free glass frit. The major components in the silver paste were 84 wt% Ag, 2 wt% glass frit, 11 wt% solvent of buthyl-cabitol acetate, and 2 wt% the other additives. After fabricating the Ag-pastes, they were coated on the SiNx/n<SUP>+</SUP>/p<SUP>-</SUP> stacks of a commercial mono-Si substrate. The solar cell efficiency was 17.6% in case of the silver paste mixed with Pb-based glass frit, which was one of the world-best records in the technology. By the way, the efficiency was 16.2% in the solar cell integrated with the silver paste mixed with Pb-free glass frit. The lower performance in the Pb-free Ag-paste was caused by the higher serial resistance and the lower shunt resistance in comparison with the Pb-containing Ag paste.</P>

Comparison of the sensitivity of several methods to detect PrPsc in the murine Bovine Spongiform Encephalopathy prion protein

Hyun Joo Sohn,Yoon Hee Lee,Young Pyo Choi,Dong Seob Tark,Chan Lan Kim,Min Jeong Kim,Chang Hee Kweon 대한수의학회 2008 대한수의학회 학술대회발표집 Vol.2008 No.-

Process Design and Analysis for RF MEMS Switch with Uniform Wafer-level Pull-in Voltage using Silicon Wet Etching

Jeong-Ki Hwang(황정기),Yong-Seok Lee(이용석),Sung-Hyun Hwang(황성현),Yong-Kweon Kim(김용권) 대한전기학회 2012 대한전기학회 학술대회 논문집 Vol.2012 No.11