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기저세포암, 피부전이암과 유사한 조직소견을 보인 안검 외 피지선암 1예
김상태,노효진,서기석 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1
Backgroud : Extraocular sebaceous carcinoma is a malignant tumor derived from the adnexal epithelium of sebaceous glands. A poorly differentiated sebaceous carcinoma shows variable histopathologic findings and mimics other primary tumor and cutaneous metastases mostly composed of clear cells. Case : Our patient consultation was requested for a 53 year?old female with solitary mild painful tumor on the scalp. The first histopathlogic impression of this case was basal cell carcinoma on the other hospital. After reevaluation, our diagnosis is not basal cell carcinoma but extraocular sebaceous carcinoma. Conclusion : A thorough exact recognition of characteristic histopathologic features of extraocular sebaceous carcinoma is necessary for making diagnosis, treatment plan and determining the prognosis.
이정은,함효주,이관용,노지웅,유진석,정우백 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2
Early repolarization is a common electrocardiographic (ECG) feature found in young adults, men and athletes, and has been considered to be a benign feature for the last several decades. But recent studies suggest that early repolarization may be related to idiopathic ventricular fibrillation and sudden cardiac death. We report a young man, 35 years old, who had life threatening ventricular fibrillation and sudden cardiac arrest. He was evaluated for cardiac causes of ventricular fibrillation. There was no explanation other than that his ECG showed an early repolarization pattern so we treated him with implantable cardioverter defibrillator. Thus, we suggest that early repolarization may be related with life threatening ventricular arrhythmia.
( Jin Young Jung ),( Hyun Sook Kim ),( Mi Ryung Roh ),( Hyo Jin Roh ),( Sang Yoon Lee ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.3
Background: A number of reports have been published regarding the use of imiquimod for the treatment of melanoma in situ and metastatic melanoma. Essential steps in the process of melanoma invasion and metastasis include degradation of basement membranes and remodeling of the extracellular matrix by proteolytic enzymes, including matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Objective: To evaluate the antiinvasive effect of imiquimod in human malignant melanoma cell lines, SK-MEL-2 and SK-MEL-24, in vitro, and to investigate imiquimod-induced changes in the expression of MMPs and TIMPs. Methods: Invasiveness of melanoma cell lines following imiquimod treatment was evaluated by invasion assays. In order to investigate the mechanism of the anti-invasive effect of imiquimod, mRNA and protein levels of MMP-2, -9, membrane type 1 (MT1)-MMP, TIMP-1, and -2 were assessed by real-time reverse transcription-polymerase chain reaction, gelatin zymography, and western blotting. Results: Imiquimod treatment decreased in vitro viability of melanoma cells in a concentration-dependent manner. Imiquimod also elicited a concentration-dependent suppression of invasion in both melanoma cell lines. A concentration- dependent decrease in MMP-2 and MT1-MMP protein levels and a concentration-dependent increase in TIMP-1 and -2 protein levels by imiquimod was observed in both melanoma cell lines. However, expression of MMP-9 protein was increased in SK-MEL-2 but decreased in SK-MEL-24 with increasing imiquimod concentrations. Imiquimod elicited alterations in MMPs and TIMPs mRNA levels that parallel the observed changes in protein levels. Conclusion: Imiquimod may elicit an anti-invasive effect on human melanoma cells by regulating
HBsAg 과 Anti - HBs 가 동시 양성예의 임상적 경과 관찰
박효진(Hyo Jin Park),김경희(Kyung Hee Kim),노형근(Hyung Keun Roh),박종훈(Chong Hoon Park),이관식(Kwan Sik Lee),문영명(Young Mung Moon),강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),송경순(Kyung Soon Song) 대한내과학회 1990 대한내과학회지 Vol.39 No.1
N/A To assess the clinical implication of concomitant HBsAg and anti-HBs in patients with HBV infection, we studied the longitudinal behavior of HBsAg, anti-HBs and their subtypes and the correlation of clinical events in 25 patients with concomitant HBsAg and anti-HBs. The results were as follows: 1) Concurrent markers were persistent in 12 (57.1%) out of 21 patients with chronic liver disease. In two patients, anti-HRs was detected intermittently during the follow-up period. In each, the recurrent antibody was persistently heterotypic, and the appearance, disappearance and reappearance of anti-HBs were not associated with alterations in the clinical course. 2) The mean level of anti-HBs was 16.6±17.7 SN ratrio and 61.9% of the patients were less than 10 SN ratio. 3) In the majority of patients, HBsAg subtype ad was accompanied by anti-y. In addition, in two patients with intermittent concomitance the recurrent amtibody was persistently heterotypic. 4) During the follow-up period, acute exacerbations of the disease occurred in four out of 21 patients with chronic hepatitis. All patients were initially HBsAg subtype ad and remained so during and after exacerbation. Therefore, the possibility of reinfection with HBV of a different subtype was not supported. In conclusion, concomitant HBsAg and anti-HBs are not uncommon in patients with acute and chronic hepatitis B and do not reflect changes in the clinical courses. The concomitance is of no practical or prognostic significance, and therefore, the attention devoted to it may be clinically unnecessary.
Cordycepin에 의한 피부 섬유아세포 세포노쇠화 개선효과
김효진 ( Hyo Jin Kim ),이소영 ( So Young Lee ),김도형 ( Do Hyung Kim ),진무현 ( Mu Hyun Jin ),노석선 ( Seok-seon Roh ),김형민 ( Hyung-min Kim ),최인화 ( In-hwa Choi ),이명수 ( Myeong Soo Lee ),이상화 ( Sang Hwa Lee ) 대한화장품학회 2015 대한화장품학회지 Vol.41 No.2
세포 노쇠화(cell senescence)는 나이 듦에 따른 내인성 노화 및 질병들에서 나타날 수 있는 세포의 노화인자 발현, 세포분열 정지 등의 현상으로 일컬어진다. 피부세포의 경우, 노화 및 외부요인으로 인한 세포노쇠화가 일어나 세포분열의 정지 및 기능 이상이 관찰되며 이는 피부노화를 가속화시키는 요인이 된다. 본 연구에서는, cordycepin을 이용하여 노화된 피부세포의 세포 노쇠화 억제 및 기능 향상을 유도하여 피부노화 개선의 가능성을 제시하였다. 사람에서 유래한 섬유아세포를 이용하여 세포의 β-galactosidase 활성 세포염색 결과, 많은 계대의 세포에서 발현이 높게 나타남을 알 수 있었다. 항산화 및 항염 효과가 알려진 cordycepin을 많은 계대의 세포에 처리하였을 때 β-galactosidase 활성이 확연히 떨어짐을 확인하였고 무혈청 배지 조건에서 많은 계대 세포의 증식 및 생존율을 높이는 결과를 보였으며 세포 노쇠화와 많은 연관성이 대두되고 있는 미토콘드리아의 기능관련 실험을 진행한 결과, 높은 ROS억제능이 나타났다. 본 연구를 통하여 노화된 사람 피부 섬유아세포에서의 cordycepin의 세포 노화 개선능을 알 수 있었으며, 피부 항노화소재로서의 가능성을 확인하였다. Cell senescence can be identified by cellular changes that occur as a result of intrinsic aging and/or diseases. In case of skin cells, aging and cell senescence caused by external factors results in cessation of cell proliferation and cellular malfunction, which, in turn, accelerates skin aging. In this study, inhibition of cell senescence and enhancement of cell function were studied using cordycepin to evaluate the potential for skin anti-aging agent. By comparing with the number of senescence associated with β-galactosidase (SA-β-gal) positive cells in young and replicative aged human fibroblasts, it was found that replicative aged cells showed higher expression of β-galactosidase. Treatment of cor dycepin - known as an anti-oxidative and anti-inflammatory agent - reduced β-galactosidase expression in senescent cells and enhanced cell survival in serum-free culture condition. Cordycepin also showed superb inhibition of ROS, which is another indicator of cell senescence. The results of this study proved the anti-aging effect of cordycepin on human fibroblasts and also proposed a possibility of its use as an anti-aging cosmetic ingredient.