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( Hye-jin Boo ),( So Jung Park ),( Myungkyung Noh ),( Hye-young Min ),( Lak Shin Jeong ),( Ho-young Lee ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.3
Emphysema, a major component of chronic obstructive pulmonary disease (COPD), is a leading cause of human death worldwide. The progressive deterioration of lung function that occurs in the disease is caused by chronic inflammation of the airway and destruction of the lung parenchyma. Despite the main impact of inflammation on the pathogenesis of emphysema, current therapeutic regimens mainly offer symptomatic relief and preservation of lung function with little therapeutic impact. In the present study, we aimed to discover novel therapeutics that suppress the pathogenesis of emphysema. Here, we show that LJ-2698, a novel and highly selective antagonist of the adenosine A<sub>3</sub> receptor, a G protein-coupled receptor involved in various inflammatory diseases, significantly reversed the elastase-induced destructive changes in murine lungs. We found that LJ-2698 significantly prevented elastase-induced airspace enlargement, resulting in restoration of pulmonary function without causing any obvious changes in body weight in mice. LJ-2698 was found to inhibit matrix metalloproteinase activity and pulmonary cell apoptosis in the murine lung. LJ-2698 treatment induced increases in anti-inflammatory cytokines in macrophages at doses that displayed no significant cytotoxicity in normal cell lines derived from various organs. Treatment with LJ-2698 significantly increased the number of anti-inflammatory M2 macrophages in the lungs. These results implicate the adenosine A<sub>3</sub> receptor in the pathogenesis of emphysema. Our findings also demonstrate the potential of LJ-2698 as a novel therapeutic/preventive agent in suppressing disease development with limited toxicity.
Boo Hye-Jin,Min Hye-Young,Hwang Su Jung,Lee Hyo-Jong,Lee Jae-Won,Oh Sei-Ryang,Park Choon-Sik,Park Jong-Sook,Lee You Mie,Lee Ho-Young 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) promotes lung tumorigenesis through deregulation of the pulmonary RA system. Mechanistically, NNK binding to the nicotinic acetylcholine receptor (nAChR) induces Src-mediated signal transducer and activator of transcription 3 (STAT3) activation, resulting in transcriptional upregulation of angiotensinogen (AGT) and subsequent induction of the angiotensin II (AngII) receptor type 1 (AGTR1) signaling pathway. In parallel, NNK concurrently increases insulin-like growth factor 2 (IGF2) production and activation of IGF-1R/insulin receptor (IR) signaling via a two-step pathway involving transcriptional upregulation of IGF2 through STAT3 activation and enhanced secretion from intracellular storage through AngII/AGTR1/PLC-intervened calcium release. NNK-mediated crosstalk between IGF-1R/IR and AGTR1 signaling promoted tumorigenic activity in lung epithelial and stromal cells. Lung tumorigenesis caused by NNK exposure or alveolar type 2 cell-specific Src activation was suppressed by heterozygous Agt knockout or clinically available inhibitors of the nAChR/Src or AngII/AGTR1 pathways. These results demonstrate that NNK-induced stimulation of the lung RA system leads to IGF2-mediated IGF-1R/IR signaling activation in lung epithelial and stromal cells, resulting in lung tumorigenesis in smokers.
Ophthalmologic manifestations in patients with inflammatory bowel disease
( Hye Jin Lee ),( Hyun Joo Song ),( Jin Ho Jeong ),( Heung Up Kim ),( Sun-jin Boo ),( Soo-young Na ) 대한장연구학회 2017 Intestinal Research Vol.15 No.3
Background/Aims: Inflammatory bowel disease (IBD), including Crohn`s disease (CD) and ulcerative colitis (UC), has been reported to have various ophthalmologic manifestations. The aim of this study was to evaluate the prevalence of ophthalmologic manifestations associated with IBD in Korea. Methods: Sixty-one patients were examined between May 2013 and October 2014. We performed complete ophthalmologic examinations. Results: Findings included 36 patients with CD and 25 with UC. The mean age of the patients was 34±16 years and disease duration was 45.3±23.9 months. Ophthalmologic manifestations were positive in 44 cases. Primary complication was diagnosed in 5 cases, as follows; iritis in 2 cases, episcleritis in one case, iritis with optic neuritis in 1 case, and serous retinal detachment in 1 case, without secondary complications. The most common coincidental complication was dry eye syndrome (DES), in 35 patients (57.4%). The prevalence of DES in the control group was 21.3%. The proportion of DES in patients with IBD was significantly higher than in the control group (P=0.002). Conclusions: Ophthalmologic manifestations were high (72.1%) in IBD patients. Clinically significant primary ocular inflammation occurred in 8.2% of patients. The most common complication was DES. There was a higher rate of DES in patients with IBD compared to the control group. Evaluation of the eye should be a routine component in patients with IBD. (Intest Res 2017;15:380-387)
Hye-Jin Boo,So Jung Park,노명경,민혜영,정낙신,Ho-Young Lee 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.5
Chronic obstructive pulmonary disease (COPD)is the leading cause of human death worldwide. Currentlyavailable therapies for COPD mainly relieve symptoms andpreserve lung function, suggesting the need to develop noveltherapeutic or preventive regimens. Because chronic infl ammationis a mechanism of emphysematous lesion formationand because adenosine A 3 receptor signaling and peroxisomeproliferator-activated receptor gamma (PPARγ) regulateinfl ammation, we investigated the eff ect of LJ-529, aselective adenosine A 3 receptor agonist and partial PPARγagonist, on infl ammation in vitro and elastase-induced pulmonaryemphysema in vivo. LJ-529 markedly amelioratedelastase-induced emphysematous lesion formation in thelungs in vivo, as indicated by the restoration of pulmonaryfunction, suppression of airspace enlargement, and downregulationof elastase-induced matrix metalloproteinase activityand apoptotic cell death in the lungs. LJ-529 induced theexpression of PPARγ target genes, the activity of PPARγ andseveral cytokines involved in inhibiting infl ammation andinducing anti-infl ammatory M2-like phenotypes. Moreover,LJ-529 did not exhibit signifi cant cytotoxicity in normal celllines derived from various organs in vitro and induced minimalchanges in body weight in vivo, suggesting no overt toxicityof LJ-529 in vitro or in vivo. These results indicate thepotential of LJ-529 as a novel therapeutic/preventive agentfor emphysema with limited toxicity.
Fabrication of nano-structured hemispheres and pillars using laterally migrating polymer templates.
Nam, Hye Jin,Yi, Gi-Ra,Jeong, Seong-Hun,Boo, Jin-Hyo,Jung, Duk-Young American Scientific Publishers 2009 Journal of Nanoscience and Nanotechnology Vol.9 No.10
<P>We report herein a reliable method of fabricating 2D periodic gold nanopillars with well-defined anisotropic shapes by the combinational actions of colloidal crystals and gold evaporation. The deposition of gold on a polymer template produced dual functional Janus-like nanopillars up to 633 nm in height as well as hemispherical shells with 120 nm. The thermal-induced active migration of the nanopillars from the pristine position in the lateral direction occurred at the colloidal defects while some cavity space was formed inside the gold pillars. The nano-structured gold pillars exhibited a strong surface plasmon resonance at 598 nm, as compared to that of the solid gold nanospheres at 520 nm, and a noticeable red shift to 640 nm was induced by the removal of the polymer template.</P>
Anti-oxidant and anti-inflammatory activities of the various kinds of herbal tea
Lee, Jin Wook,Eo, Hyun Ji,Park, Gwang Hun,Song, Hun Min,Woo, So Hee,Kim, Mi Kyoung,Eom, Jung Hye,Lee, Man Hyo,Lee, Jeong Rak,Koo, Jin Suk,Jeong, Jin Boo The Korea Association of Herbology 2014 大韓本草學會誌 Vol.29 No.2
Objectives : Reactive oxygen species (ROS) are involved in a wide spectrum of diseases including chronic inflammation and cancer. In this study, we investigated the antioxidant activities and anti-inflammatory effects of the extracts from the herbal teas such as Lonicera japonica Thunberg (L. japonica), Chrysanthemum morifolium Ramat (C. morifolium), Mentha arvensis L. (M. arvensis), and P.rhizoma. Methods : Anti-oxidant activity was evaluated using DPPH radical scavenging assay and $Fe^{2+}$ chelating assay. And DNA cleavage assay was performed to evaluate an anti-oxidative effect. Anti-inflammatory effect was performed using NO generation assay and western blot in LPS-stimulated RAW264.7 cell line. Results : L. japonica scavenged DPPH radical by 9.8% at 12.5 ${\mu}g/ml$, 24.8% at 25 ${\mu}g/ml$, 34.3% at 50 ${\mu}g/ml$, 61.1% at 100 ${\mu}g/ml$ and 75.8% at 200 ${\mu}g/ml$, respectively. In addition, C. morifolium and M. arvensis removed DPPH radical by 15.6% and 10.4% at 12.5 ${\mu}g/ml$, 34.8% and 22.8% at 25 ${\mu}g/ml$, 66.9% and 43.3% at 50 ${\mu}g/ml$, 87.4% and 69.1% at 100 ${\mu}g/ml$, and 92.1% and 73.2% at 200 ${\mu}g/ml$, respectively. However, P. rhizoma did not affect on DPPH radical scavenging. The $Fe^{2+}$ chelating activity was highest in L. japonica, but lowest in P. rhizoma among the herbal teas. In addition, the extracts from L. japonica, C. morifolium and M. arvensis inhibited oxidative DNA damage via its anti-oxidant activity. In anti-inflammatory effect, the extracts from C. morifolium inhibited NO production. In addition, it suppressed the $NF-{\kappa}B$ signaling pathway in LPS-stimulated RAW 264.7 cells. Conclusions : Together, this study indicates that L. japonica, M. arvensis and C. morifolium possess the protective effect against the oxidative DNA damage. Furthermore, C. morifolium exerts an anti-inflammatory effect.
( Boo Sung Kim ),( Youn Zoo Cho ),( Soon Koo Baik ),( Moon Young Kim ),( Won Ki Hong ),( Hye Won Hwang ),( Jin Hyung Lee ),( Myeong Hun Chae ),( Seung Yong Shin ),( Jung Min Kim ),( Mee Yon Cho ),( Sa 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Cirrhosis is a long-term consequence of chronic hepatic injury with fibrosis and no effective therapy except liver transplantation is currently available for decompensated cirrhosis. However, some practical limitations in liver transplantation lead us to a need for new therapeutic paradigm in this field. Recent reports have shown that the mesenchymal stem cells (MSCs) have the plasticity to differentiate into some kinds of tissue cells and improve organ function. Hence, we investigated the effect of direct inoculation of human bone marrow derived MSCs (BM-MSCs) in thioacetamide (TAA)-induced cirrhosis in a rat model. Methods: Adult Sprague-Dawley rats were allocated into three groups (each group, n = 15) as follows: G1, shame; G2, TAAcontrol; G3, TAA+BM-MSC. To induce cirrhosis, 200mg/kg TAA injection was done twice a week for 12weeks in G2 and G3. 2×106 cells of amplified human BM-MSCs were injected directly into the right liver lobe twice, at weeks 6 and 8 in G3. At 12 weeks, the effect of BM-MSCs on cirrhosis was analyzed histomorphologically using Laennec scores. α-Smooth muscle actin(α-SMA) expression by immunohistochemical staining, relative expression of collagen type 1, and transforming growth factor β (TGF-β) were also evaluated by real-time reverse transcriptase- polymerase chain reaction. Results: Laennec scores were 0, 5.4±0.7 and 3.7±1.06 in G1, G2 and G3, respectively. Histologically, BM-MSCs injected group (G3) showed significant suppression of hepatic fibrosis compared with TAA-control group (G2)(P<0.001). Expressions of α-SMA(%) were significantly lower in G3 than in G2 (3.08±1.26 vs. 7.00±4.12, P<0.05). Also, the relative expression of collagen type 1 and TGF-β1 in RT-PCR were 0.64±0.24, 2.06±0.51, 1.32±0.31 and 0.62±0.28, 5.89±3.05, 2.22±1.41 in G1, G2 and G3, respectively P<0.005). Conclusions: Our results showed that BM-MSCs could attenuate liver fibrosis in rats with TAA-induced cirrhosis, raising the possibility for clinical use of BM-MSCs in the treatment of cirrhosis.