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김희숙 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.1
Objective: The purpose of this study is to evaluate the histologic correlations and the clinical significance among patients with atypical squamous cells of undetermined significance (ASCUS), atypical glandular cells of undetermined significance(AGUS) and benign endometrial cells identified on cervical Pap smear screening. Materials & Methods: The computerized files of the Department of Pathology at Samsung Cheil Hospital were searched from 1991 to 1997 to evaluate the annual statistics of cytologic diagnoses including normal/benign, ASCUS, AGUS, low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion(HSIL) and cancer classified by the Bethesda System(TBS). Cytohistologic correlations on follow-up were separately analysed in ASCUS(190 cases), AGUS(268 cases) and benign endometrial cells(169 cases), respectively. Additionally, post-menopausal squamous atypia(83 cases) were also included in this study. TBS terminology was used in both cytologic and histologic diagnoses. Results: During 7-year period (1991-1997), 447,049 cervicovaginal smears were evaluated. The median rate of abnormal cytology was 4.4%, with 2.1% of ASCUS, 2.06% of squamous intraepithelial lesion(SIL), and 0.08% of AGUS. The median ratio of ASCUS versus SIL was 1.24. Specimen adequacy was evaluated on 47,525 cases, of which categories of “satisfactory for evaluation but limited by” and “unsatisfactory for evaluation” were 28.3% and 0.03%, res-pectively. Follow-up of 190 patients with ASCUS cytology showed 30%(57 cases) with SIL on biopsy; 18%(35cases) with LSIL, 11%(21cases) with HSIL, and 1%(1case) with microinvasive squamous cell carcinoma. On histologic examination, 77%(37/48cases) with ASCUS favoring SIL revealed SIL in contrast to 14%(20/142cases) with ASCUS favoring reactive change, which is statistically significant.(Chi-Square test, P <0.0001). Of 83 cases of post-menopausal squamous atypia(PSA), smears with LSIL showed 34.9%(15/43cases) with LSIL on biopsy. 268 patients with AGUS smears had 25%(67cases) with clinically significant cervical or endometrial lesions on histologic examinations. Among 17.9%(48cases) with cervical lesions, squamous abnormalities were 10.5%(28cases); including 1.5%(4cases) with LSIL and 9.0%(24cases) with HSIL. Glandular lesions in cervix were 7.5%(20cases); 3.0%(8cases) of glandular atypia or dysplasia, 1.9%(5cases of adenocarcinoma in situ, 1.1%(3cases) of microinvasive adenocarcinom and 1.5%(4cases) of adenocarcinoma. Of 7.1%(19cases) of endometrial lesions, 2.2%(6cases) was endometrial hy-perplasia, 4.1%(11cases) endometrial carcinoma, 0.4%(1case) MMMT and 0.4%(1case) metastatic adenocarcinoma from stomach were verified. The pathologies of 169 cases with benign endometrial cells shed in cervicovaginal smears were confirmed to be endometrial polyp(8.3%), endometrial hyperplasia(4.1%) and endometrial carcinoma(5.9%). Conclusion: The results of this study indicates that clinicians should communicate with pathologists for proper management of abnormal cytology. Further evaluation and decision of management should be made based on input from pathologists as well as on clinical setting and professional guidelines.$quot;
자궁경수술로 성공적으로 치료된 점막하 낭성자궁선근종 2예
김남숙 ( Nam Sook Kim ),김주명 ( Joo Myung Kim ),김미라 ( Mi La Kim ),이시원 ( Si Won Lee ),주관영 ( Kwan Young Joo ),김혜선 ( Hye Sun Kim ),김희숙 ( Hy Sook Kim ),홍성란 ( Sung Ran Hong ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.2
Two women presented with history of vaginal bleeding and abnormal transvaginal ultrasound findings. Saline infusion sonohysterography was done for preoperative evaluation and this imaging study revealed centrally located uterine mass with internal cystic portion. Our initial impression was submucosal myoma with cystic degeneration and hysteroscopic removal of the mass was performed. During the procedure, dark brownish cystic fluid was drained. The excised submucosal mass was pathologically diagnosed as adenomyosis and clinically as submucosal adenomyotic cyst. Submucosal adenomyotic cyst should be part of the differential diagnosis of submucosal uterine masses with cystic portion. We report two cases of submucosal adenomyotic cyst successfully treated with hysteroscopic resection and brief review on this topic.
A NOMOGRAM FOR PREDICTING AMYLOID PET POSITIVITY IN AMNESTIC MILD COGNITIVE IMPAIRMENT
Kim, Si Eun,Woo, Sook-Young,Kim, Seon Woo,Chin, Juhee,Kim, Hee Jin,Lee, Byung In,Park, JinSe,Park, Kyung Won,Noh, Young,Ye, Byoung Seok,Yoo, Han Soo,San Lee, Jin,Kim, Yeshin,Kim, Seung Joo,Cho, Soo Hy ELSEVIER SCIENCE B.V. AMSTERDAM 2018 ALZHEIMERS AND DEMENTIA Vol.14 No.7
조정숙 ( Jung Sook Cho ),박종숙 ( Jong Sook Park ),김희숙 ( Hy Sook Kim ) 대한임상검사과학회 2001 대한임상검사과학회지(KJCLS) Vol.33 No.2
Tumor diathesis is defmed as a host response to tissue destruction by infiltrative growth of cancer. It is observed in smears as eosinophilic or cyanophilic granular proteineous material, Cytoplasmic debris, hemosiderin, fi버11, nuclear fragments and cells with karyorrhexis. The purpose of this study was to determine the prevalence and cytologic features of tumor diathesis in cervicovaginal smears from patients with invasive squamous cell carcinoma. Cervicovaginal smears of 63 patients with squamous cell carcinoma histologically confmned were reviewed to evaluate the presence of macro/micro tumor diathesis(MaTD/MiTD). Original cytologic diagnoses were HSIL with carcinoma in situ in 21 cases(33.3%), microinvasive carcinoma in 13 cases(20.6%) and invasive carcinoma in 29 cases(46%). Tumor diathesis was posItive in 49 cases(77.8%), lltεgative in 10 cases(15.9%) of smears with invasive squamous cell carcinoma and 4 cases(6.3%) were undetermined. Both MaTD and MiTD were seen in 36 cases(73.5%), only MaTD was 9 cases(18.4%) and MiTD was 4 cases(8.2%). As increasing the invasion depth, prevalence of tumor diathesis was increased, but it was not statistically significant(p>O.OO5). Twelves of control group were diagnosed as invasive squamous cell carcinoma cytologically, but they were histologically confmned as carcinoma in situ. Tumor diathesis was positive in 9 cases(75%) of the 12 smears, it was supposed of intraglandular karyorrhetic necrotic material in the glandular involvement with carcinoma in situ. Although tumor diathesis is an important criterion of invasive carcinoma, the smear should be veη carefully searched the presence of invasive carcinoma cells.
Lee, Jongmin,Kim, Young Kyoon,Seo, Ye Young,Choi, Eun Kyoung,Lee, Dong Soo,Kim, Yeon Sil,Hong, Sook Hee,Kang, Jin Hyoung,Lee, Kyo Young,Park, Jae Kil,Sung, Sook Whan,Kim, Hyun Bin,Park, Mi Sun,Yim, Hy The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4
Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure to evaluate suspicious lymph node involvement of lung cancer because computed tomography (CT) and $^{18}F$-fluorodeoxyglucose positron emission tomography-CT (PET-CT) have limitations in their sensitivity and specificity. There are a number of benign causes of false positive lymph node such as anthracosis or anthracofibrosis, pneumoconiosis, old or active tuberculosis, interstitial lung disease, and other infectious conditions including pneumonia. The purpose of this study was to evaluate possible causes of false positive lymph node detected in chest CT or PET-CT. Methods: Two hundred forty-seven patients who were initially diagnosed with lung cancer between May 2009 and December 2012, and underwent EBUS-TBNA to confirm suspicious lymph node involvement by chest CT or PET-CT were analyzed for the study. Results: Of 247 cases, EBUS-TBNA confirmed malignancy in at least one lymph node in 189. The remaining 58 patients whose EBUS-TBNA results were negative were analyzed. Age ${\geq}65$, squamous cell carcinoma as the histologic type, and pneumoconiosis were related with false-positive lymph node involvement on imaging studies such as chest CT and PET-CT. Conclusion: These findings suggest that lung cancer staging should be done more carefully when a patient has clinically benign lymph node characteristics including older age, squamous cell carcinoma, and benign lung conditions.
자궁경부 세포진에서 ASCUS 진단의 세분화 - "ASCUS, R/O HSIL" : 세포학적 소견 및 조직학적 상관성
김혜선,김복만,김의정,김희숙,Kim, Hye-Sun,Kim, Bock-Man,Kim, Yee-Jung,Kim, Hy-Sook 대한세포병리학회 2002 대한세포병리학회지 Vol.13 No.1
Cytologic and histopathologic features and human papillomavirus (HPV) DNA detection associated with 101 cervicovaginal smears which are ciassified as 'atypical squamous cells of undetermined significance, rule out high grade squamous intraepithelial lesion(ASCUS, R/O HSIL)' were reviewed and compared to 89 smears of 'ASCUS, not otherwise specified(NOS)'. Cytologic fieatures of ASCUS, R/O HSIL included atypical single small cells(36.6%), hyperchromatic tissue flagments(35.6%), atypical metaplastic cells(18.8%), endometrial cell-like clusters(5.9%), and atypical parakeratotic cells(3.0%). A final diagnosis of HSIL on biopsy was assigned to 47(54.0%) of 87 women with ASCUS, R/O HSIL and to 13(14.6%) of 89 women with ASCUS, NOS (p=0.000). There was no difference in HPV DNA detection late between ASCUS, R/O HSIL and ASCUS, NOS smears. These data suggest that subclassification of ASCUS is helpful to manage patients because ASCUS, R/O HSIL is more often associated with an underlying HSIL on biopsy. Therefore, women with ASCUS, rule out HSIL should be actively managed with colposcopic examination.
김은경,김의정,박종숙,김희숙,Kim, Eun-Kyung,Kim, Yee-Jeong,Park, Jong-Sook,Kim, Hy-Sook 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2
We studied cervical cytology of 175 cases of histologically confirmed microinvasive squamous cell carcinoma of the uterine cervix in Cheil General Hospital from 1991 to 1993. Excluding 32 cases of insufficient smear, 143 cases were reviewed in view of background, cellularity, smear pattern, nuclear chromatin and presence of nucleoli. The characteristic findings of microinvasive carcinoma were syncytia and/or individual tumor cells in the focally necrotic inflammatory background. Nuclear chromatin was clear or fine. Nucleoli were observed in 55%. The prediction rate of microinvasive carcinoma was 74%. There is no significant relationship between the cellular features and depth of invasion.
Bethesda system에 의한 "atypical squamous cells of undertermined significance"의 평가
김의정,홍성란,김희숙,박종숙,김계현,임경호,심재욱,박종택,전종수,Kim, Yee-Jeong,Hong, Sung-Ran,Kim, Hy-Sook,Park, Jong-Sook,Kim, Kye-Hyun,Lim, Kyung-Ho,Shim, Jae-Uk,Park, Chong-Taik,Chun, Chong-Soo 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2
The recently proposed Bethesda system for cervical/vaginal cytology has made a standardization related to "atypia". In cellular changes due to inflammation or repair, the word "benign cellular change" has been suggested as a substitute for atypia. Terminology related to atypical cells may become standardized, but the cytologic criteria has not been well defined yet. We evaluated 160 cases of atypical squamous cells of undetermined significance(ASCUS) by the Bethesda Sys4em(TBS). Among 30,428 cases screened, a cytologic diagnosis of ASCUS was made in 498 cases(1.6%) and 160 cases were histologically verified ASCUS was diagnosed based on nuclear enlargement and nonclassical signs of condyloma. The results are as follows: One hundred and twenty three cases(76.9%) revealed chronic cervicitis. Thirty seven cases(23.1%) demonstrated squamous intraepithelial lesion. Among intraepithelial lesions, condyloma and mild dysplasia were 28 cases(75.7%). Moderate and severe dysplasia were 5 cases(13.5%) and 4 cases(10.8%), respectively. it is concluded that patients with ASCUS should be colposcopically examined.
자궁경부와 질에 발생한 연화판증의 세포소견 -1예 보고-
전이경,홍성란,김혜선,김지영,김복만,김희숙,Chun, Yi-Kyeong,Hong, Sung-Ran,Kim, Hye-Sun,Kim, Ji-Young,Kim, Bok-Man,Kim, Hy-Sook 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2
Malakoplakia is an uncommon chronic granulomatous inflammation that usually involves the urinary and gastrointestinal tracts, but rarely affects the female genital tract. We experienced a case of malakoplakia in a cervicovaginal smear in a 54-year-old woman. Colposcopic examination showed a friable, easily bleeding tissue in the uterine cervix and the vaginal fornix. The cervicovaginal smear consisted of numerous isolated histiocytes, polymorphonuclear leukocytes, lymphocytes, and plasma cells. The histiocytes had an abundant, granular, and degenerated cytoplasm with inflammatory cell debris. Michaelis-Gutmann bodies were readily identified.
자궁경부세포진에 있어서 AutoPap 300 QC System의 임상경험과 민감도 검사
홍성란,박종숙,장회숙,김의정,김희숙,박종택,박인서,Hong, Sung-Ran,Park, Jong-Sook,Jang, Hoi-Sook,Kim, Yee-Jeong,Kim, Hy-Sook,Park, Chong-Taik,Park, In-Sou 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1
OBJECTIVE: False negatives of cervical smears due to screening errors pose a significant and persistent problem. AutoPap 300 QC System, an automated screening device, is designed to rescreen conventionally prepared Pap smears initially screened by cytotechnologists as normal. Clinical experience and sensitivity of the AutoPap 300 QC System were assessed and compared with current 10% random qualify control technique. MATERIALS AND METHODS: In clinical practice, a total of 18,592 "within normal limits" or "benign cellular changes" cases classified by The Bethesda System were rescreened by the Autopap System. In study for sensitivity of The AutoPap System to detect false negatives, a total of 1,680 "within normal limits" or "benign cellular changes" cases were rescreened both manually and by the AutoPap System. The sensitivity of the AutoPap System to these false negatives was assessed at 10% review rate to compare 10% random manual rescreen. RESULTS: In clinical practice, 38 false negatives were identified by the AutoPap System and we had achieved 0.2% reduction in the false negative rate of screening error. In study for sensitivity, 37 false negatives were identified by manual rescreening, and 23 cases(62.2%) of the abnormal squamous cytology were detected by the AutoPap System at 10% review rate. CONCLUSONS: The AutoPap 300 QC System is a sensitive automated rescreening device that can detect potential false negatives prior to reporting and can reduce false negative rates in the laboratory. The device is confirmed to be about eight times superior to the 10% random rescreen in detecting false negatives.