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Effect of pH on the Iron Autoxidation Induced DNA Cleavage
Kim, Jong-Moon,Oh, Byul-Nim,Kim, Jin-Heung,Kim, Seog-K. Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.4
Fenton reaction and iron autoxidation have been debated for the major process in ROS mediated DNA cleavage. We compared both processes on iron oxidation, DNA cleavage, and cyclic voltammetric experiment at different pHs. Both oxidation reactions were preferred at basic pH condition, unlike DNA cleavage. This indicates that iron oxidation and the following steps probably occur separately. The ROS generated from autoxidation seems to be superoxide radical since sod exerted the best inhibition on DNA cleavage when $H_2O_2$ was absent. In comparison of cyclic voltammograms of $Fe^{2+}$ in NaCl solution and phosphate buffer, DNA addition to phosphate buffer induced significant change in the redox cycle of iron, indicating that iron may bind DNA as a complex with phosphate. Different pulse voltammogram in the presence of ctDNA suggest that iron ions are recyclable at acidic pH, whereas they may form an electrically stable complex with DNA at high pH condition.
고형암 환자에서 항암화학요법 후 호중구감소증에 대한 류코업(R) (Filgrastim, rhG-CSF)의 안전성 및 유효성: 그라신(R)과의 다기관 비교 임상시험
이소영 ( So Young Lee ),장흥문 ( Heung Moon Chang ),허대석 ( Dae Seog Heo ),류백렬 ( Baek Yeol Ryoo ),김태원 ( Tae Won Kim ),류민희 ( Min Hee Ryu ),김태유 ( Tae You Kim ),박연희 ( Yeon Hee Park ),이재훈 ( Jae Hoon Lee ),박근칠 ( K 대한내과학회 2005 대한내과학회지 Vol.69 No.1
융모상피암의 (絨毛上皮癌) 소장전이에 (小腸轉移) 의한 대량 장출혈 (腸出血) 2예
정재복,문영명,강진경,김기환,최흥재 ( Jae Bock Chung,Yong Myung Moon,Jin Kyung Kang,K Whan Kin,Heung Jai Choi ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1
Choriocarcinoma may occur with or without any gynecological symptoms and commonly presents with a variety of medical proolem resulting from metastasis in the lungs, central nervous system, or alirnentary tract. However choriocarcinoma presenting with massive intestinal bleeding is very rare. We have presented two cases of unusual choriocarcinoma presenting with massive intest- inal bleeding due to metastasis.
KIM, JIN C,KIM, HEE C,LEE, KANG H,YU, CHANG S,KIM, TAE W,CHANG, HEUNG M,RYU, MIN H,KIM, JONG H,HA, HYUN K,LEE, MOON G Blackwell Publishing Asia 2006 Journal of gastroenterology and hepatology Vol.21 No.6
<P>Abstract</P><P>Background and Aim: </P><P>Hepatic arterial infusion (HAI) chemotherapy has a number of limitations, including a low rate of complete response and frequent extrahepatic recurrence, in colorectal cancer patients with non-resectable hepatic metastases.</P><P>Methods: </P><P>Twenty-nine colorectal cancer patients with non-resectable hepatic metastases were consecutively enrolled for HAI alternating with systemic chemotherapy (HA + SC group). The protocol comprised six cycles of alternating HAI (5-FU + leucovorin for 14 days, and mitomycin C on the first day) and systemic chemotherapy (5-FU + leucovorin). Colorectal cancer patients with two or more hepatic metastases treated using hepatic resection and systemic chemotherapy (HR + SC group) were selected as a comparative group.</P><P>Results: </P><P>Within the HA + SC group, complete response was achieved in eight patients (28%), whereas 13 patients (45%) showed progressive disease. Six of the eight patients with complete response lived for more than 38 months. Extrahepatic recurrences were more frequent in the HR + SC group than the HA + SC group (47 <I>vs</I> 21%, <I>P</I> = 0.024). The two groups did not differ with respect to overall and hepatic progression-free survival (<I>P</I> = 0.947 and 0.444, respectively), displaying median ± SE values of 38 ± 7 and 20 ± 3 months in the HA + SC group, and 39 ± 9 and 33 ± 14 months in the HR + SC group, respectively. One patient in each group experienced toxic hepatitis, and sclerosing cholangitis occurred in one patient of the HA + SC group. Other complications were mostly grade 1 or 2.</P><P>Conclusions: </P><P>HAI alternating with systemic chemotherapy led to a promising response and hepatic progression-free survival, possibly reducing extrahepatic recurrence in colorectal cancer patients with non-resectable liver metastases.</P>
Microstructure Study of Electrochemically Driven LixSi
Son, Seoung-Bum,Trevey, James E.,Roh, Hyunchul,Kim, Sung-Hwan,Kim, Kee-Bum,Cho, Jong Soo,Moon, Jeong-Tak,DeLuca, Christopher M.,Maute, Kurt K.,Dunn, Martin L.,Han, Heung Nam,Oh, Kyu Hwan,Lee, Se-Hee Wiley (John WileySons) 2011 Advanced energy materials Vol.1 No.6