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Hydrogen Water - A Preliminary Therapeutic for Non-Alcoholic SteatoHepatitis (NASH)
( Gang Cui ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Nonalcoholic fatty liver disease (NAFLD) is characterized by a wide spectrum of liver damages spanning from steatosis, nonalcoholic steatohepatitis (NASH), cryptogenic liver cirrhosis, even to hepatocellular carcinoma. Oxidative stress is a strong contributor to the progression from simple fatty liver to nonalcoholic steatohepatitis (NASH). Our aim was to investigate the effects of hydrogen water on liver NASH and the mechanism underling these effects. Methods: A methionine choline deficient diet (MCD) was prepared for the mouse models. In our investigation we made two experimental groups as follows: (1) MCD diet + normal water group(n=12); (2) MCD diet + hydrogen water group(n=12). Both groups were fed for three different periods, which are 8 weeks, 12 weeks, and 16 weeks. Results: The control group and hydrogen water group average concentration of ROS at 8 weeks (588±24 FORT units vs 164±8; P=0.029), at 12 weeks (587±26 FORT units vs 163±5; P=0.029) and at 16 weeks (439±176 FORT units vs 160±0; P=0.029). From H&E staining the inflammation was vicissitudinous in control group at 8, 12, and 16 weeks (control group C:151.50 vs HW group HW:123.25; P=0.289)(control group C:104.33 vs HW group HW:84.75; P=0.077)(control group C:147.00 vs HW group HW:104.00; P=0.157). Conclusions: Daily consumption of hydrogen water reduces nonalcoholic fatty liver disease and may be an effective treatment for NASH by reducing hepatic oxidative stress, apoptosis, and inflammation.
Cui, Zhi-Gang,Kim, Bo-Youn,Kang, Shin-Hae,Lee, Young-Jae,Lee, Dae-Ho,Lee, Young-Ki,Park, Deok-Bae Korean Society of Food Science and Technology 2007 Food Science and Biotechnology Vol.16 No.2
Citrus sunki Hort. ex Tanaka is one of several Jeju-native citrus fruits. A number of biological properties for citrus fruits have been suggested, however little is known about those of C. sunki. The present study tested whether fermented product of C. sunki peel (FSP) might affect the activities of enzymes regulating ethanol metabolism. Effects on body weight gain as well as on fatty liver formation were also investigated. The activities of alcohol dehydrogenase and aldehyde dehydrogenase were stimulated remarkably by FSP. Excessive ethanol-induced cytotoxicity was also prevented by FSP in HepG2 cells. FSP decreased the weight gain and fatty liver formation induced by a high-fat diet in mice. From these results, FSP might be a potent source of neutraceuticals useful for preventing ethanol-induced health problems.
p-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells
Zhi Gang Cui,이영일,이영기,박덕배 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.1
p-Synephrine, the primary protoalkaloid in the extract of bitter orange and other citrus species, has gained interest due to its lipolytic activity in adipose tissues. We previously found that p-synephrine stimulates glucose consumption via AMP-activated protein kinase (AMPK) in L6 skeletal muscle cells. This study investigated the effect of p-synephrine on glucose production and lipid accumulation in H4IIE rat liver cells. Glucose production was increased in H4llE cells that were incubated in glucose-free medium but decreased dose dependently (1–100 lM) with p-synephrine treatment. Protein levels of glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase (PEPCK) were also decreased by treatment (4 h) with p-synephrine. Antagonists against α- and β-adrenergic receptors (phentolamine and propranolol) and other inhibitors against signaling molecules did not interrupt p-synephrine-induced suppression in glucose production. However, H7 (an inhibitor of serine/threonine kinases PKA, PKC, and PKG) significantly blocked psynephrine-induced suppression of glucose production and further increased basal glucose production. Unlike the suppressive effect on glucose production, p-synephrine failed to affect palmitic acid-induced cytoplasmic lipid accumulation. Protein levels of fatty acid synthase (FAS) and phosphorylation levels of AMPK and ACC were not changed by p-synephrine. Altogether, p-synephrine can suppress glucose production but does not affect lipid accumulation in H4IIE liver cells.
( Xin Gang Cui ),( Dan Feng Xu ),( Chao Lv ),( Fa Jun Qu ),( Jin He ),( Ming Chen ),( Yu Shan Liu ),( Yi Gao ),( Jian Ping Che ),( Ya Cheng Yao ),( Hong Yu Yu ) 생화학분자생물학회 2011 BMB Reports Vol.44 No.8
MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus- mediated short hairpin (shRNA), and analyzed the effect of inhibition of MED19 on prostate cancer cell proliferation and tumorigenesis. The in vitro prostate cancer cell proliferation, colony formation, and in vivo tumor growth in nude mice xenografts was significantly reduced after the downregulation of MED19. Knock- down of MED19 caused S-phase arrest and induced apoptosis via modulation of Bid and Caspase 7. It was suggested that MED19 serves as a novel proliferation regulator that promotes growth of prostate cancer cells. [BMB reports 2011; 44(8): 547-552]
cAMP antagonizes ERK-dependent antiapoptotic action of insulin
( Zhi Gang Cui ),( Na Young Hong ),( Jian Guan ),( Hee Kyoung Kang ),( Dae Ho Lee ),( Young Ki Lee ),( Deok Bae Park ) 생화학분자생물학회 2011 BMB Reports Vol.44 No.3
Insulin has antiapoptotic activity in various cell types. However, the signaling pathways underlying the antiapoptotic activity of insulin is not yet known. This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin receptors (CHO-IR). Insulin-stimulated ERK activity was completely suppressed by cAMP-elevating agents like as pertussis toxin (Ptx) and cholera toxin (Ctx) after 4 h treatment. Insulin-stimulated PKB/Akt activity was not affected at all. Ptx treatment together with insulin increased the number of apoptotic cells and the degree of DNA fragmentation. Ctx or 8-br-cAMP treatment also increased the number of apoptotic cells and stimulated the cleavage of caspase-3 and the hydrolysis of PARP. Taken together, cAMP antagonizes the antiapoptotic activity of insulin and the main target molecule of cAMP in this process is likely ERK, not PI3K-dependent PKB/Akt. [BMB reports 2011; 44(3): 205-210]
Expression and Clinical Significance of miRNA-34a in Colorectal Cancer
Ma, Zhi-Bin,Kong, Xiao-Lin,Cui, Gang,Ren, Cui-Cui,Zhang, Ying-Jie,Fan, Sheng-Jin,Li, Ying-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: The aim of this study was to investigate differences of miRNA-34a expression in benign and malignant colorectal lesions. Materials and Methods: Samples of cancer, paraneoplastic tissues and polyps were selected and total RNA was extracted by conventional methods for real-time PCR to detect the miRNA-34a expression. In addition, the LOVO colorectal cancer cell line was cultured, treated with the demethylating agent 5-azacytidine and screened for differentially expressed miRNA-34a. Results: After the drug treatment, the miRNA-34a expression of colorectal cancer cell line LOVO was increased and real-time PCR showed that levels of expression in both cell line and colorectal cancer tissues were low, as compared to paraneoplastic tissue (p<0.05). Polyps tissues had significantly higher expression than paraneoplastic and colorectal cancer samples (p<0.05). Conclusions: miRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation.
Relative Entropy Model of Uncertain Random Shortest Path
Gang SHI,Yuhong SHENG,Qing CUI 국제이네비해양경제학회 2015 International Journal of e-Navigation and Maritime Vol.2 No.1
The shortest path problem is one of network optimization problems. This paper considers a shortest path problem under the situation where lengths of arcs in a network include both uncertainty and randomness, and focuses on the case that the lengths of arcs are expressed by uncertain random variables. This paper presents a new type of model: relative entropy model of shortest path. By the definition of relative entropy of the uncertain random variables, relative entropy model of shortest path problem is proposed to find the shortest path which fully reflects uncertain and random information. This model is formulated to find a shortest path whose chance distribution minimizes the difference from the ideal one. A numerical example is given to illustrate the model’s effectiveness.
Cui Xiangyang,Zheng Gang,Li Guangyao 한국소성가공학회 2010 기타자료 Vol.2010 No.6
This paper presents an efficient triangular shell element based on edge-based smoothing technique for sheet forming simulation. The sheet model is first discretized into a set of triangular elements and linear shape functions are used. The smoothing domains associated with the edges of the triangles are then further formed and an edge local coordinate system is introduced for performing strain smoothing operations. The discretized system equations are obtained using the smoothed Galerkin weak form, and the numerical integration is applied based on the edge-based smoothing domains. The smoothing operation can provide a much needed softening effect to the FEM model to reduce the well-known “overly-stiff” behavior caused by the fully-compatible implementation of the displacement approach based on the Galerkin weak form, and hence improve significantly the solution accuracy. There is no extra sampling point introduced to evaluate the stiffness matrix in present formulation. Hence the present method is very simple and can be easily implemented. Some academic examples and benchmark tests show the accuracy and efficiency of the proposed element.
A Genetic Heterogeneity of Renpenning Syndrome Mapped to Chromosome Xq21-Xqter
Cui, Bin,Sun, Yuming,Sun, Yuqin,Shi, Yuefeng,Pei, Gang,Kong, Xiangyin,Hu, Landian 한국유전학회 2004 Genes & Genomics Vol.26 No.1
Renpenning sysndrome is an X-linked mental retardation associated with short stature, moderate microcephaly, unremakdable facies, and no other neurological abnormality. Renpenning first reported this disorder in a Mennonite family, and using this family, Renpenning Syndrome (RENS) has been mapped to Xp11.2-p11.4 Xu Cs found a Chinses family with an X-linked hereditary disease, and the clinical phenotype is similar to RENS. Recently, we performed the linkage analysis, and the result has shown ht egenetic heterogeneity of Renpenning Syndrome: a suggestive novel locus mapped to Xq21-Xqter in this Chinese family.