플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

혈관질환 정보관리 시스템

김동익,김덕경,허세호,이병붕,김용신,김은숙,문지영,도영수,신성욱,김동수,김만태,진재욱,김용신 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

As medical technology progresses rapidly, there is a rise in the average age along with the Korean dietary lifestyle becoming more westernized, which leads to an increase in the number of vascular disease patients in Korea. Thus, we need to manage the medical information of a disease systematically in order to diagnose and treat constructively. However, since there has been no standardized method of man agement to date, a great deal of information could not be properly utilized nor studied. Therefore, the departments of Cardiology, Radiology and Neurology of Samsung Seoul Hospital recently got together to develop an information management system called the Vascular Data System. This program was developed to be run on win98 O/S, upper Pentium Ⅲ, and upper 128 MB Memory, and its source code is Dephi 4.0. It was configured for the user to set the configurations as well as do a variety of search and analysis. If this program were to be updated continuously, it may be used extensively as well as in various parts of clinical research activities.

Effect of simultaneous therapy of arthrocentesis and occlusal splints on temporomandibular disorders: anterior disc displacement without reduction

Hye-Sung Lee,Hyun-Su Baek,Dong-Suk Song,Hee-Chul Kim,Hyo-Geun Kim,Bok-Joo Kim,Myung-Soo Kim,Sang-Hoon Shin,Sung-Hee Jung,Chul-Hoon Kim 대한구강악안면외과학회 2013 대한구강악안면외과학회지 Vol.39 No.1

Objectives: This study sought to evaluate the effect of simultaneous application of arthrocentesis and occlusal splint. Materials and Methods: A retrospective study of 43 patients (3 males, 40 females) whose symptoms had improved was conducted at the Department of Oral and Maxillofacial Surgery, Dong-A University Hospital between 2008 and 2010. Subjects were divided into three groups: Group A (17 patients with arthrocentesis and occlusal splints simultaneously applied), Group B (13 patients whose symptoms did not improve with occlusal splints, undergoing arthrocentesis after occlusal splint use for 8 weeks), and Group C (13 patients that only used occlusal splints). We compared these groups in maximum comfortable opening (MCO) and the visual analogue scale of pain and noise. Follow-up was performed at 1 week, 1 month, 3 months, and 6 months. Results: The improvement of symptoms was noted in all three groups, but Group A had a quicker improvement than the other groups, in terms of pain reduction and MCO increases. Conclusion: The simultaneous application of arthrocentesis and occlusal splints can reduce patient discomfort more quickly.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

불포화폴리에스터(USPE)수지의 경화동역학에 관한 연구

申東明,林成澤 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

In this work we investigated the curing process of unsaturated polyester resing in styrene system. An thermosetting resin experiences a complicated mechanism in curing reaction with many annexes. We used the Lee's and Ryan & Dutta's model to predict such mechanism. The octadodecanoxy derivative of thephthalocyanine which has such long hydrocarbon chains around the skeleton of the phtalocyanine was synthesized. First of all, ortho-catechol was treated with 2 moles of 1-bromododecane to yield ortho-didodecanoxybenzene(I). Second, bromination of I resulted in dibromo-didodecanoxy-benzene(Ⅱ) where the para positions to the dodecanoxy groups were brominated. Finally, reaction of Ⅱ with an excess of CuCN under an N₂atmosphere gave the intermediate dicyano-didodecanoxy-benzede(Ⅲ), in situ, and futher heating in dry DMF with more CuCN gave the final product, octadodecanoxy derivative of the phthalocyanine. The synthetic method developed herein provides a general way to synthesize the variety of the phthalocyanines which displays many different substituents such as long hydrocarbons around its skeleton and contains a various metal inside of the phthalocyanine.

위내시경 검사환자에 대한 정신의학적 연구 : BDI와 STAI를 중심으로

신동균,조숙행,이성근 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6

The authors studied the emotinal status of the medical outpatient who underwent gastroscopy for gastrointestinal complaints by means of BDI(Beck Depression Inventory) and STAI(State-Trait Anxiety Inventory). Also, the authors compared the degree of anxiety and depression according to each factors of demographic and other data which might influence emotional status. The subjects were 674 patients who underwent gastroscopy at Guro Hospital, College of Medicine, Korea University. from March 1 to September 30, 1986. The results are as follows : 1) There were no statistically significant differences in BDI and STAI between the negative group and positive group, and between the ulcer group and gastritis group. 2) There were no statistically significant differences in BDI and STAI between the gastric ulcer group and duodenal ulcer group, and among the chronic superficial group and erosive gastritis group and atrophic gastritis group. In atrophic gastritis group, there was no statistically significant difference in BDI and T-A among patients with mild, moderate or severe pathology. But in S-A, patients with severe pathology showed higher degree of anxiety than patients with mild or moderate pathology. 3) 25% of the positive group and 13% of the ulcer group and 23% of the gastritis group were rated as depressed by BDI(a score of 21 was used as criterion). 4) In the negative group, according to sex, there was significant difference in BDI and STAI. According to economic state, there was significant difference in BDI, but not in STAI. According to sleep pattern, there were significant difference in BDI and S-A, but not in T-A. 5) In the ulcer group, according to sex, education level, and sleep pattern, there were significant differences in BDI and S-A, but not in T-A. According to economic state, there was significant differences in T-A, but not in BDI or S-A. 6) In the gastritis group, according to age, there was significant differences in BDI but not in STAI. According to marital state, there was significant differences in BDI and T-A, but not in S-A. According to sex, economic state, educational level, early parental death, and sleep pattern, there was significant differences in BDI and STAI.

유한요소법을 이용한 환자별 교정시스템 구축의 기초 알고리즘 개발과 적용 : Development and Application of the Basic Algorithm

신정욱,남동석,김태우,이성재 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

본 연구는 최근 많은 연구가 행해지고 있는 유한요소를 이용한 교정시스템구축에 있어서 정상교합자가 아닌 부정교합 환자별 유한요소 모델구출을 위한 기초 알고리즘 개발에 그 목표가 있다. 기존에는 유한요소 분석을 위해서 한 환자의 치열을 유한요소 모델로 재현하고자 할때, 전처리 과정에 대부분의 시간을 소요해야만 했다. 본 연구에서는 이 전처리과정을 자동화할 수 있는 기초 알고리즘을 마련하여, 향후 이 방면의 연구를 용이하도록 하였다. 이를 위하여 임의로 선택된 부정교합 환자의 상하악 모형을 이용하여 치아의 삼차원적인 위치를 계측할 수 있는 표준화된 방법을 제시하였으며, 또한 본 연구를 통하여 개발된 프로그램을 이용하여 유한요소의 전처리과정을 자동화할 수 있는 기초을 마련하였다. 본 연구는 아래와 같은 단계를 거쳐 수행하였다. 1. 상, 하악 중절치에서 제2대구치까지 14개의 치아 형상을 상, 하악 각각 구축하여 개별 화일로 저장한다. 2. 이 치아에 standard bracket을 치관의 FA point와 bracket slot의 중앙이 일치되도록 부착한다. 3. 대상 환자의 석고 모형을 제작한다. 4. 석고 모형에서 본 연구를 위해 제작된 기구들로 치아의 crown inclination, angulation, 그리고 교합면에서 치관첨까지의 수직거리를 계측한다. 5. 표준화하여 촬영한 석고모형의 사진을 이용하여 화상처리기법으로 치아의 치열궁 형태를 파악한다. 또한 사진상에서 치아의 수평적 위치 및 회전량을 측정한다. 6. 계측된 crown inclination, angulation, 수직거리, 그리고 치열궁의 형태 미 치아의 회전정도 등을 회전행열을 이용하여 만든 프로그램에 입력한다. 이 프로그램은 유한요소 전처리 과정에 필요한 치아의 배열상태를 담고 있는 데이터를 결과파일로 제공하는데, 이 결과 파일은 일반적인 상용 유한요소 프로그램에서도 사용 가능하다. 7. 개개의 치아파일은 이 결과 파일에 따라 삼차원적인 위치로 배열되어 선택한 특정환자의 유한요소 모델을 완성하게 된다. 상기와 같은 여러 단계를 거친 후 임의로 선택한 부정교합자의 상, 하악 유한요소 모델구축을 위한 기초 자료를 구출할 수가 있었으며, 개개인 환자의 모형에서 얻은 정보로 유한요소 모델로 재현하기 위한 전처리과정의 기초 알고리즘을 마련하였다. The purpose of this study is to develop the basic algorithm for the finite element method modeling of individual malocclusions. Usually, a great deal of time is spent in preprocessing. To reduce the time required, we developed a standardized procedure for measuring the position of each tooth and a program to automatically preprocess. The following procedures were carried to complete this study. 1. Twenty-eight teeth morphologies were constructed three-dimensionally for the finite element analysis and saved as separate files. 2. Standard brackets were attached so that the FA points coincide with the center of the brackets. 3. The study model of a patient was made. 4. Using the study model, the crown inclination, angulation, and the vertical from the tip of a tooth was measured by using specially designed tools. 5. The arch form was determined from a picture of the model with an image processing technique. 6. The measured data were input as a rotational matrix. 7. The program provides an output file containing the necessary information about the three-dimensional position of teeth, which is applicable to several finite element programs commonly used. The program for a basic algorithm was made with Turbo-C and the subsequent outfile was applied to ANSYS. This standardized model measuring procedure and the program reduce the time required, especially for preprocessing and can be applied to other malocclusions easily.

두부손상 환자의 정신과적 합병증에 관한 장애 감정례의 일반 사항에 관한 분석

신석철,왕성근,신윤오,김덕호,김상국,강동숙 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

Authorst ried retrospective analysis to find out general characteristics of the patients undergoing disability evaluation at the department of psychiatry Chungnam National University Hospital from 1986 to 1990. The subjects, who were suffered from psychiatric complications due to head trauma by traffic accident, were 66 patients and they were classified depending on the demographic status, situations of traffic accident, evalaution periods, whether or not perform operation, and rates of evaluated disability and diagnosis. The results were summarized as follows. 1. General background of the subjects were as follows. 1) The frequency order of request were court(59 %) and insurance company(19.7%). 2) The place of accident was more common in large city, common accident vehicle were bus, truck, and cabs. 3) The season of accident were more common in Spring and Autumn. 2. Male(71.2%) was more common than in female and more common in the age group of 5-19 years old(37.9%). The most frequent job of the patients was labour, and the education level was more common in the graduates of elementary school(47.9% ). 3. The interval between accident and evaluation was most frequent in 12-23 months(47.5%), and duration of evaluation was mostly 14 to 21 days. Performed brain operation was 31.8% and non-operated patients was 50.0%. The rates of disability according to the McBride's disability evaluation were mostly belonged to the group of beow 40%(74.1%). 4. The final diagnosis after evaluation were organic personality disorder(45.5%) and dementia(31.8%).

정향 수침액에 의한 아나필락시의 억제 효과

신태용,김상현,이석봉,엄동옥,임종필,이은희,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of Caryophylli Flos water extract(CFWE) to regulate immediate allergic reaction by control of histamine release. CFWE was found to exhibit a ingibitory activity on the compound 48/80-induced anaphylaxis. CFWE inhibited the serum histamine release induced in anaphylaxis by compound 48/80. CFWE was also showed a dose-depent activity on the conpound 40/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. This result suggest that CFWE may be useful for the prevention and treatment of allergy related disease.