C형 간염바이러스 항체 면역블롯검사에서 불확정판정을 받은 헌혈자의 HCV 양성 확인

조연정,서동희,황병갑,김동집,정남현 大韓輸血學會 2001 大韓輸血學會誌 Vol.12 No.2

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

도시지역 보건사업에서 컴퓨터의 활용방안에 관한 연구

염용태,이명숙,조병희,송동빈 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.2

Nacessity of new communication media in information society is repidly increasing in many fields of Korea. It includes the field of primary helath care in the courses of collecting informations on demographic feature, social characteristics and health behavior of peoples. In light of above reasons, the authors attempted to utilize personal computers for the primary health services to promote health of unban people as a pilot study in Guro-6- Dong, Seoul. Five nurses working in Guro-6-Dong Health Subcenter completed family health records of 3,930 households among the total of 4,270. A total of 3,904 family health records among 3,930 were computerized and sorted out in categories of population characteristics, population dymanics, characteristics of householders, housing, family planning, maternal and child health(M.C.H), health status of residents and of others. Names of risky category in M.C.H, and family planning were listed and the lists were handed to the nurses concerned in order to practice proper cares in time. Sorted data were compared with ones of City of Seoul, average of other cities, and ones of nationwide. With the results of above practice, in terms of utilization of computer in uban primary health sevices, the following strategy was proposed. In order to provide proper health services the unban people demanded, efficient devices of information collection, processing and interpretation systems on health were urgently needed in every dong unit(health subcenter) of health centers. Recommended was personal computer network as a new communication media. Additional advantages of the devices were continuity and efficiency in services, and utilization in evaluation of health services and analysis of cost -effectiveness.

노인의 식습관과 건강상태에 관한 연구 : 부산시 남ㆍ녀 노인을 중심으로 the Elderly Man and Woman in Pusan

조경자,한동희 慶星大學校 1994 論文集 Vol.15 No.2

This study was undertaken to investigate the relationship between the food habits and the health status. For this purpose, data were collected from deep interviews with 124 the elderly women and men, age 65 or greater in Pusan, Korea. For the data analysis, percentages, frequencies and means were calculated in order to describe the data. t-test, ANOVA, χ²-test were used. As a result of the data anylsis, the following results were obtained : 1. The age about the object person of research was the most numerous in 79% at 65-74 years old, in 70.9% with any their children, most elderly women and men were without job, regular excercise, regular health check and regular income. 2. The average man's weight was 61.89±6.33kg, woman's weight was 52.75±4.42kg, the average man's height was 166.47±7.92cm, woman's height was 154.96±6.02cm. 3. Both of the elderly men and women had regular meals at breakfast, lunch and supper. The most delicious meal was supper. The style of food intake was vegetables or mixed with vegetables and meats. Eventhough the participating at eating out with family was low, having meals with family at home usually. The problem of food habits was too much salty. 4. Eventhough both of the elderly men and women had eating some snacks between meals, they didn't have any nutritious reasons. Usually their child supplied it and in case of spouse, only the elderly women had the charge. 5. The elderly men were higher than the elderly women in case of smoking and drinking. 6. The elderly men wee better score than the elderly women with food habits. 7. Most of the elderly men and women had any chronic illness. 8. The elderly men were higher score with most areas except respiratory organs, the elderly women were score than the elderly men in the state of health. 9. The relationship between the elderly men and women showed a meaningful difference, fatigue showed a symptom as physical health, and nervousness showed a symptom as mental health with having poor food habits. The chronic illness also connected with poor food habits.

Phase-Shift를 이용한 시분할형 부하병렬 고주파 인버터의 특성해석에 관한 연구

조규판,원재선,김동희,노채균,원규식,심광열 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.2

A half bridge time sharing type load parallel high frequency resonant inverter to give VVVF function in the inverter used as power source of induction heating at high frequency is presented in this paper. This proposed inverter can reduce distribution of the switching current because of using the current of serial resonant circuit to the input current of the parallel one and this paper also realize the output control of independence irrespective of the switching frequency using Phase-Shift. The analysis of the proposed circuit is generally described by using the normalized parameters. Also, the principle of basic operation and the its characteristics are estimated by the parameters, such as switching frequency, the variation of phase angle(φ) of Phase-Shift. It is certain that the proposed circuit will be used and expanded in the high frequency power supplies like induction heating systems.

의료복지용 센서 및 시스템의 개발(Ⅱ)

조진호,강희동 경북대학교 센서기술연구소 1997 연차보고서 Vol.1997 No.-

본 연구에서는 향후 중요한 의료 복지시스템으로 국내외에서 널리 쓰이게 될 MSGC형 온라인 X선 촬영 사진 촬영 장치를 개발하고자 하였다. MSGC형 은라인 X선 촬영장치는 기존의 X선 필름에 비해 조사선량을 크게 낮출 수 있으며 계조도(gray level)및 범위가 디지털 x-ray 시스템에 비해 훨씬 넓다. 그리고 MSGC형 센서는 비슷한 메카니즘으로 작동되는 MWPC형 위치검출센서 보다 높은 해상도를 얻을 수 있으며 센서제작에 대량화와 간편성을 동시에 제공할 수 있는 잇점이 있다. 본 연구는 MSGC센서를 제작하여 이로부터 X선 조사선량에 관계되는 기체 증폭펄스를 얻기 위한 연구 분야와, 이 센서를 이용하여 영상이 얻어질 수 있도록 시스템을 제어하고 영상을 재구성 및 처리하는 두 가지 연구 분야로 나누어 진행된다. MSGC형 센서개발에서는 해상도가 높고 기체증폭이 안정적으로 일어날수 있는 센서를 설계 제작하였고 다양한 실험자료를 수집하였다. MSGC형 센서 개발에서 핵심부분은 기판의 재질과 마이크로스트립형 전극 그리고 챔버 및 기체 증폭이 일어났을 때의 펄스를 샤프하게 분리시켜 계수할 수 있는 기술이다. 디지털 X선 장치 제어 및 영상처리 연구에서는 1차 년도에 제작된 제어 컴퓨터와 X-ray 인터페이스 회로가 가진 수동 조작의 불편함, 타이밍 제어시 오차 발생 및 X-선 Expose속도의 한계 등의 문제점을 개선시킨 인터페이스 보드를 개발하였다. We have developed the MSGC type on-line digital radiography system that will used widely in medical welfare system in future. The MSGC type can reduce the X-ray exposure to the object significantly as compared with X-ray film and its the dynamic range of gray level is more wide than the conventional digital X-ray system. And the MSGC type sensor can obtain much higher resolution than the position detecting sensor of MWPC type which has a similar mechanism to MSGC type and also it can provide an advantage of mass-production and a simplicity to produce the sensors. We divided into two research fields. One is the field of implementing the MSGC sensor and measuring pulses produced by gas multiplication related with the X-ray. The other field is developing the method of controlling digital image acquisition part, image reconstructing, and processing. In the development of MSGC type sensor, we designed and implemented the sensor with a high resolution and a stable gas multiplication. And we collected various experimental data. In the development of MSGC type sensor, the core parts are the materials of substrate, microstrip type electrode and chamber, and technique to split the pulses of gas multiplication sharply and count them. In the field of system controlling and image processing, we developed the new-interface board which has been improved some problems in the first research step, i.e. inconvenient operations of control computer and X-ray interface circuit, error occurrence in timing control, and the limitation of X-ray expose velocity.

시중 판매중인 Fresh-Cut 채소 제품의 품질평가

조순덕,박주연,김은정,김동만,김건희 덕성여자대학교 대학원 2007 덕성여자대학교 대학원 논문집 Vol.9 No.-

Fresh-cut 채소 제품이 소비자에 의해 선택되어 소비되려면 이의 친환경적 원료생산과 가공, 포장, 서빙에 이르는 전 과정에서 체계적인 품질관리가 이루어져야 하며 갈변제어, 연화제어 및 미생물적 제어 등 관련 기술의 연구개발이 요구된다. 본 연구에서는 시중 유통 · 판매되고 있는 fresh-cut 채소제품의 품질을 비교평가하기 위해 현재 유통되고 있는 9개사 제품을 선정하였으며, 관능검사를 포함하여 vitamin C, 무기질, 중금속 함량, 잔류농약 및 미생물오염 정도를 조사하였다. 관능평가에서는 갈변 등 품질변화로 인해 전반적인 기호도가 그다지 높지 않았다. 채소류에서 중요 영양성분인 vitamin C 함량은 9개사 모든 제품의 주재료인 양상추에서 거의 검출되지 않았고 다른 채소류의 vatimin C 함량 역시 식품성분표보다 소량이었다. 무기질 함량 역시 극히 소량이었는데, 이는 박피, 절단 등의 최소 가공 공정을 거치면서 파괴되기 쉬운 vitamin C와 무기질이 대부분 손실되었기 때문으로 사료된다. 안전성측면에서 평가한 잔류 중금속 함량의 경우 몇 개의 제품에서 구리와 납이 소량 검출되었으며 잔류농약은 검출되지 않았다. Most fresh-cut agri-food products are less stable than the unprocessed materials from which they are made. The objective of this study was the development of a quality control system for fresh-cut agri-food products. In this study, the vitamin C, mineral, residual heavy metal contents and pesticides of various fresh-cut agri-food products were analysed. Through the sensory evaluation, the reason for the lower than expected overall acceptability in most products is that cut products are likely to cause browning and easily lose their freshness. Therefore, the postharvest technology that can maintain the quality, freshness and appearance must be supplied. Vitamin C contents did not exist in all salad products of the selected 9 companies, although vitamin C and mineral contents that are main nutrients that can be supplied mainly in salads. The results showed that vitamin C and mineral contents were very small and extremely small in other vegetables compared with the standard of a food ingredient, It is possible that vitamin C and most minerals are easily destroyed were lost through the minimal process like peeling and cutting. In safety side, the remaining heavy metal contents of fresh-cut agri-food were investigated and the results showed that copper and lead existed in some products because cadmium in agricultural produce is only controlled by the minimum standard of heavy metal contents in Korea. No residual pesticides were detected in all products.

시분할 방식 고주파 공진 인버터의 특성해석

조규판,원재선,김동희,노채균,배영호 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

In this paper, we propose the high frequency resonant inverter of the time sharing type which has the effects that the duty cycle of each elements and the thermal loss can be reduce. The analysis of the proposed circuit is described generally by using the normalized parameters. Also, the principle of basic operation and the characteristics of drive were estimated by the switching frequency and the load parameters. And we got the data for designing by the characteristic values obtained at the estimate of characteristic. At the same time, the example of the design's method was proposed and the waveforms of simulation were compared with theoretical waveforms. It is certain that the proposed circuit will be used and expanded in the high frequency power supplies like induction heating systems.

Random Amplified Polymorphic DNA Typing에 의한 동물과 사람 유래 Vancomycin 내성 장구균의 유전학적 비교

조윤상,이희수,김종만,류판동,박용호,유한상,이문한 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.1

It has been recently reported the possibility in the transfer of antimicrobial resistant to other animals and humans. In particular, the occurrence of vancomycin resistant enterococci (VRE), which have been known as a principal antimicrobial resistant bacteria in humans, has been increased as a pathogen of nosocomial infections. And then animal VRE were suspected as an origin of human VRE. In this work, we investigated the relatedness between VRE from animals and humans through random amplified polymorphic DNA (RAPD) typing. The genetic relatedness of vanA, vanB, vanC-1 and vanC-2 genotypes was examined by RAPD typing, respectively. van4 genotypes have not been shown high genetic relationship each other, containing VRE from humans (n = 8) and chickens (n = 5). In vanB genotypes from humans (n = 3), 2 isolates were made up one cluster, shown 77.8% homology. Chicken isolates of vanC-1 genotypes (n = 11) were constituted 2 clusters and the homology of 2 clusters was 81.8% and 80.0%, respectively. In case of vanC-2 genotypes (n = 19), 2 isolates from pigs have been shown 76.9% homology. But, between VRE from animals and humans, the isolates of high genetic relationship could not be found and RAPD typing was a useful epidemiological method that could be confirmed the genetic relationship among VRE.

동물과 사람유래 Vancomycin 내성 장구균의 항균제 감수성 비교

조윤상,이희수,김종만,류판동,박용호,유한상,이문한 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.1

It has been recently reported the possibility in the bansfer of antimicrobial resistance to other animals and humans. In particular, vancomycin resistant enterococci (VRE), which have been known as a principal antimicrobial resistant bacteria in humans, have been increased as a pathogen of nosocomial infections. And then animal VRE were suspected as an origin of human VRE. In this study, we isolated Enterococcus spp. from animals, identified by bio- chemical tests, examined for antimicrobial susceptibility, and then compared the antimicrobial susceptibility of VRE among each other as well as human VRE. Enterococcus iecium (29%) was predominant in Enterococcus species (n=122) isolated from animal feces in this study. E. hirae, E. iecalis, E. casseliflam and E. gallinarum were also isolated as rates of 24%, 21%, 16% and 7%, respectively. The resistance of enterococci to penicillin and tetracycline were 66% and 78%, respectively, and the susceptibility of them to chloramphenicol was 66%. Antimicrobial susceptibility test has shown that 91% of VRE from humans (n=11) was susceptible to chloramphenicol and all resistant to penicillin, rifampin and streptomycin. Seventy-five percentage of VRE from chickens (n = 12) was susceptible to rifampin and resistances of them to penicillin, tetracycline and sbeptomycin were 75%, 83%, and l00%, respectively. Therefore, we confirmed the difference of antimicrobial susceptibility from animals and humans, and the antimicrobial susceptibility test could be one of the simple and useful methods for the epidemiological survey of VRE.