동일한 혈관 내에 발생한 이식형 약제 주입기 카테터의 위치이상

오대석,김영재,김명훈,조광래,임세훈,이정한,이근무,정순호,신치만 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

저자들은 56세 여성 환자의 왼쪽 쇄골 하 정맥에 시행한 이식형 약제주입기 카테터의 삽입 후 발생한 비정상 위치에 대한 증례를 보고하고자 한다. 카테터의 끝은 환자의 늘 어진 가슴, 체위, 신체의 움직임, 카테터의 유동성 등의 영향으로 천자된 정맥 내에서 견인되고 뒤쪽으로 이동하였다. 환자는 어떠한 증상도 호소하지 않았지만 비정상 위치의 카테터는 심각한 합병증을 유발할 수 있기 때문에 제거되었다. 따라서 시술자는 약제주입기 삽입 전에 환자의 신체 상태와 단순 흉부 촬영상을 확인하고 카테터의 비정상 위치가 발생할 수 있는 위험 징후를 알아차려야 하겠다.

흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

길이진동을 이용하는 PZT계 압전 세라믹 공진자의 온도안정성에 관한 연구

한성훈,임대관,이개명 濟州大學校 産業技術硏究所 1999 산업기술연구소논문집 Vol.10 No.2

The piezoelectric ceramic resonator using length extensional vibration rather than contour extensional vibration in terms of the size is suitable for personal portable communication. In this paper, the ceramics of the six compositions, Pb(Zr_(x)Ti_(1-x))O_(3) + y[wt%]Cr_(2)O_(3) in which x = 0.56(rhombohedral phase). 0.53 (morphotrophic phase). 0.50(tetragonal phase) and y = 0.3 in respective x were fabricated. Temperature stability of length extensional vibration mode of those specimens was investigated. Both ceramic resonators of the composition with x=0.56. y=0 and the composition with 0.53. y=0.3 had better temperature stability frequency than the others, and thermal aging could improve temperature stability in only them.

길이진동을 이용하는 PZT계 압전 세라믹 공진자의 온도안정성에 관한 연구

한성훈,임대관,이개명 제주대학교 산업기술연구소 1999 尖端技術硏究所論文集 Vol.10 No.2

The piezoelectric ceramic resonator using length extensional vibration rather than contour extensional vibration in terms of the size is suitable for personal portable communication. In this paper, the ceramics of the six compositions, Pb(ZrxTil-x)O3 + y(wt%)Cr2O3 in which x=0.56(rhombohedral phase), 0.53(morphotrophic phase), 0.50(tetragonal phase) and y=0, 0.3 in respective x were fabricated. Temperature stability of length extensional vibration mode of those specimens was investigated. Both ceramic resonators of the composition with x=0.56, y=0 and the composition with 0.53, y=0.3 had better temperature stability frequency than the others, and thermal aging could improve temperature stability in only them.

One-Year Mortality of Acute Kidney Injury in Patients with Acute Myocardial Infarction

( Dae Hun Lim ),( Jong Hyeok Jeong ),( Ji Min Jeong ),( Chang Seong Kim ),( Joon Seok Choi ),( Jeong Woo Park ),( Eun Hui Bae ),( Seong Kwon Ma ),( Soo Wan Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.2

Purpose: Acute kidney injury (AKI) is a common complication during hospitalization and is an accepted risk factor for in-hospital mortality. However, the association of severity of AKI with the long-term risk of death is not well known. This study aimed to investigate the incidence and clinical significance of AKI in patients with acute myocardial infarction (AMI). Methods: To examine the effect of the severity of AKI on 1-year risk of death following AMI, we performed an observational study of 1,224 patients admitted for AMI. We evaluated the association between AKI and all-cause mortality. Patients with maintaining hemodialysis treatment (n=7), and who died during hospitalization (n=71) were excluded. Remaining 1146 patients were divided into three groups according to the Acute Kidney Injury Network (AKIN) criteria (Stage-1, -2, and-3). The primary end point of the study was 1-year all-cause mortality after hospital discharge. The relation between the severity of AKI and 1-year mortality after AMI was analyzed. Results: AKI was developed in 222/1,146 (19.3%) patients during the hospital stay. Adjusted hazard ratio for 1-year mortality was 3.064 (95% CI 1.618 to 5.803, p=0.001), 6.112 (95% CI 2.344 to 15.935, p<0.001) and 20.030 (95% CI 5.428 to 73.912, p<0.001) in stage-1, -2, and stage-3 AKI groups compared with that of no AKI group. Conclusion: The severity of AKI is strongly related to 1-year all cause mortality in patients with AMI.

이뇨제를 사용한 급성 신손상 환자에서 FEUrea의 진단적 유용성

임대훈 ( Dae Hun Lim ),정지민 ( Ji Min Jeong ),오슬현 ( Seul Hyun Oh ),이형철 ( Hyung Chul Lee ),최준석 ( Joon Suk Choi ),김민지 ( Min Jee Kim ),박정우 ( Jeong Woo Park ),배은희 ( Eun Hui Bae ),마성권 ( Seong Kwon Ma ),김남호 ( Na 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.3

목적: 임상적으로 FENa가 일과성 신손상 (T-AKI)과 지속성 신손상 (P-AKI)을 감별하는 데 많이 사용되지만 이뇨제를 사용한 환자에서 FENa는 유효 혈류량 결핍 상태에서도 증가하게 되어 진단적 정확성이 떨어진다고 알려져 있다. 본 연구에서는 이뇨제 투여상황에서 FE(Na)와 비교하여 FE(Urea)의 진단적 유용성에 대하여 알아보고자 하였다. 방법: 107명의 급성 신손상 환자를 임상적 특성에 따라 일과성과 지속성 신손상 군으로 나누고 이를 다시 이뇨제 투여 유무에 따라 재분류하였다. ROC 곡선에 따라 계산된 cutoff value에 따라서 일과성 신손상을 정의하였고 이뇨제 투여로 인한 cutoff value의 변화에 따른 민감도와 특이도를 비교하였다. 결과: AKI가 발생한 107명의 모든 환자중 검사 이전에 경험적으로 이뇨제를 사용한 경우가 67명으로 63%를 보였고, 일과성 신손상군의 경우는 52명 중 27명으로 52%를, 지속성 신손상군의 경우는 55명 중 45명으로 73%를 보였다. ROC curve에 따라 cutoff value를 FE(Na)≤1.5 FE(Urea)≤30으로 하였을 때 T-AKI를 진단하는 데 사용된 두 값의 민감도와 특이도는 모든 환자군에서 FE(Na)가 81%, 98%를, FE(Urea) 가 94%, 82%를 보였다. 이뇨제 비투여군에서는 FE(Na)가 96 %, 100%를, FEUrea가 92%, 87%를 보였으며, 이뇨제 투여군에서는 FE(Na)가 63%, 98%를, FE(Urea)가 96%, 83%를 보였다. 결론: 이뇨제를 사용한 경우 P-AKI를 진단하는데 FE(Urea)도 FE(Na) 정도의 진단적 유용성을 가진다. Purpose: Although fractional excretion of sodium (FE(Na)) has been used to distinguish transient-acute kidney injury (T-AKI) from persistent-AKI (P-AKI), the availability of FE(Na) in the diagnosis of T-AKI is reported low in patients with diuretics use. We compared the diagnostic performance of fractional excretion of urea (FE(Urea)) with that of FE(Na) in patients with diuretics use. Methods: One hundred seven AKI patients were classified as having T-AKIor P-AKI according to the clinical context. Each group was again subdivided according to exposure to diuretics. According to the cut off value generated by receiver operating characteristic (ROC) curves, sensitivity and specificity of FE(Na) and FE(Urea) were compared with each other. Results: The numbers of patients administered with diuretics were 67 out of total 107 AKI patients (63%), 27 out of 52 (52%) of T-AKI patients, and 40 out of total (65) 55 (73%) of P-AKI patients. When the cutoff value of T-AKI was defined as FE(Na) ≤1.5 and FE(Urea) ≤30 according to the ROC curves, sensitivity and specificity of FE(Na) were 96% and 100% in non-diuretics group, and 63% and 98% in diuretics group, respectively. Sensitivity and specificity of FE(Urea) were 92% and 87% in non-diuretics group, and 96% and 83% in diuretics group, respectively. Conclusion: FE(Urea) is as good as FE(Na) at distinguishing T-AKI from P-AKI in patients administered with diuretics.

안전한 택시이용을 위한 시스템 및 앱 설계

권대근 ( Dae-geun Kwon ),홍석기 ( Seok-gi Hong ),박건훈 ( Geon-hun Park ),정세훈 ( Se-hun Jung ),임대준 ( Dae-jun Lim ),임양원 ( Yang-won Lim ),임한규 ( Han-kyu Lim ) 한국정보처리학회 2013 한국정보처리학회 학술대회논문집 Vol.20 No.2

택시는 많은 사람들이 이용하고 있는 교통수단이다. 특히 버스나 지하철 같은 대중교통 운행시간이 끝나는 야간에는 택시의 이용률이 더 많을 수밖에 없다. 그러나 최근 택시를 이용한 범죄가 많이 발생하면서 택시에 대한 사람들의 불안감이 커져가고 있다. 본 논문에서는 스마트폰을 이용하여 택시를 보다 안전하게 이용할 수 있는 시스템과 앱을 설계하였다. 스마트폰의 NFC 기술을 이용하여 인증된 택시에 부착된 NFC 태그를 인식하게 되면 택시정보와 탑승정보를 미리 등록된 지인들에게 실시간으로 전송하게 된다. 그로 인해 탑승자들은 보다 더 안전하게 택시를 이용하게 될 것을 기대할 수 있다.

자외선 특정 파장 및 전류 고주파수 노이즈 검출 방법을 이용한 아크플래시 사고 검출 연구

임대식(Dae-Sik Lim),임홍록(Hong-Rok Lim),이정훈(Jeong-Hun Lee),문상근(Sang-Geun Moon),김진오(Jin-O Kim) 대한전기학회 2017 대한전기학회 학술대회 논문집 Vol.2017 No.11

Consumer Adoption of Ubiquitous Technology : Focusing on RFID Technology

Lim Se Hun,Kim Dae Jin,Lee Sang Heon,Ka Hoi Kwang,Kim Jin Soo 한국경영정보학회 2009 한국경영정보학회 학술대회논문집 Vol.2009 No.-

Adenovirus-Mediated p53 Treatment Enhances Photodynamic Antitumor Response

Lim, Dae-Seog,Bae, Su-Mi,Kwak, Sun-Young,Park, Eun-Kyung,Kim, Jong-Ki,Han, Sei-Jun,Oh, Chung-Hun,Lee, Chang-Hee,Lee, Won-Young,Ahn, Woong-Shick Mary Ann Liebert 2006 Human gene therapy Vol.17 No.3

<P>Photodynamic therapy (PDT) has been reported to be effective for treating various tumors and to induce apoptosis in many tumor cells. In this study, we evaluated the ability of PDT combined with a tumor suppressor factor, recombinant adenovirus p53 (AdCMVp53), to induce apoptosis as well as cell growth inhibition in CaSki human cervical cancer cells and in nude mice with implanted CaSki cells. To examine levels of apoptosis, CaSki cells were treated with PDT and/or AdCMVp53, and an annexin V-staining assay was then conducted. In addition, Western blot analysis was done to identify p53 induction at the cellular and tumor tissue levels. PDT+AdCMVp53 cotreatment caused remarkable inhibition of CaSki cell proliferation, as compared with the individual treatments. In parallel with the inhibition of cell proliferation, the cotreatment caused a significantly greater increase in the annexin V-stained cell population compared with the individual treatments, as determined by fluorescence-activated cell-sorting analysis. The Western blotting assay also showed significantly more cellular p53 expressed after PDT+AdCMVp53 cotreatment than after each separate treatment. This was consistent with observations of tumor tissue in the mouse system. However, apoptosis- related protein, p21, was significantly suppressed by PDT+AdCMVp53 cotreatment, contrary to treatment with AdCMVp53 alone. Taken together, these findings suggest that PDT plus AdCMVp53 gene therapy exerts more potent antitumor effects on human cervical cancer cells, with induction of apoptosis at least through activation in p53 protein at the cellular and tumor tissue levels.</P>