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Single Intramuscular-dose Toxicity of Anti-inflammatory Pharmacopuncture in Rats
Jung, Da-Jung,Kim, Sung-Chul,Lee, Hyung-Geol,Choi, Yoo-Min,Sin, Min-Seop,Choi, Seok-Woo,Hong, Seung-Won,Song, Beom-Yong,Kim, Jong-Uk,Yook, Tae-Han KOREAN PHARMACOPUNCTURE INSTITUTE 2013 Journal of pharmacopuncture Vol.16 No.4
Objectives: This study was performed to analyze the toxicity of the test substance, anti-inflammatory pharmacopuncture (AIP), when used as a single intramuscular-dose in 6-week-old, male and female Sprague-Dawley rats and to find the lethal dose. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices. Twenty (20) female and 20 male Spague-Dawley rats were divided into 4 groups of five 5 female and 5 male animals per group. The rats in the three experimental groups received single intramuscular injections with 0.1-$m{\ell}$, 0.5-$m{\ell}$ and 1.0-$m{\ell}$/animal doses of AIP, Groups 2, 3, and 4, respectively, and the control group, Group 1, received a single intramuscular injection with a 1.0-$m{\ell}$ dose of normal saline. Clinical signs were observed and body weight measurements were carried out for 14 days following the injections. At the end of the observation period, hematology, clinical chemistry, histopathological tests and necropsy were performed on the injected parts. Results: No deaths occurred in any of the groups. Also, histopathological tests showed that AIP had no effect on the injected parts in terms of clinical signs, body weight, hematology, clinical chemistry, and necropsy. Conclusions: As a result of single intramuscular-dose tests of the test substance AIP in 4 groups of rats, the lethal dose for both males and females exceeded $1.0m{\ell}$/animal. Therefore, AIP is a relatively safe pharmacopuncture that can be used for treatment, but further studies should be performed.
The Protective Effect of ENA Actimineral Resource A on CCl4-Induced Liver Injury in Rats
Hong, Il-Hwa,Ji, Hoon,Hwa, Sung-Yong,Jeong, Won-Il,Jeong, Da-Hee,Do, Sun-Hee,Kim, Ji-Min,Ki, Mi-Ran,Park, Jin-Kyu,Goo, Moon-Jung,Hwang, Ok-Kyung,Hong, Kyung-Sook,Han, Jung-Youn,Chung, Hae-Young,Jeong, Springer-Verlag 2011 Marine biotechnology Vol.13 No.3
HONG, SANG-WON,JUNG, KYUNG HEE,CHOI, MYUNG-JOO,KIM, DA YOUNG,LEE, HEE-SEUNG,ZHENG, HONG-MEI,LI, GUANG YONG,EL-DEEB, IBRAHIM M.,PARK, BYUNG SUN,LEE, SO HA,HONG, SOON-SUN Spandidos Publications 2012 International journal of oncology Vol.41 No.5
<P>The anticancer effect of a new pyrazole derivative, KI-10F (2-(4-(2-(4-(dimethylamino) phenyl)pyridin-4-yl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol?1-yl) acetonitrile)?3.5HCl) was evaluated in human colon cancer cells. KI-10F strongly suppressed the growth of human colon cancer cells and induced apoptosis by increasing the proportion of sub-G1 presenting apoptotic cells as well as causing cell cycle arrest at the G2/M phase. Apoptosis by KI-10F was confirmed by observation of an increase in the expression of cleaved caspase-3, caspase-8, caspase-9 and Bax, and the decrease of Bcl-2. Decreased expression of HIF-1α and VEGF, and the inhibition of HUVEC tube formation and migration showed that KI-10F effectively inhibited the angiogenesis process. Furthermore, in?vivo study in a mouse xenograft model showed that KI-10F produced a stronger antitumor activity than 5-FU, a conventional anticancer drug prescribed for the treatment of colon cancer. The effects of KI-10F on tumor proliferation (PCNA), angiogenesis (CD34) and apoptosis (cleaved caspase-3) were evaluated by immunohistochemistry using isolated tumor tissue samples. Taken together, our results demonstrated that KI-10F induces apoptosis and inhibits cell growth and angiogenesis both in?vitro and in?vivo. We suggest that KI-10F is an effective chemotherapeutic candidate for use against colon cancer.</P>
Impact of Sufficient Sleep and Its Change During Pregnancy on Reducing Postpartum Depression
( Da Kyung Hong ),( Bo Seong Yun ),( So Hyun Shim ),( Hee Young Cho ),( You Jung Han ),( Dong Wook Kwak ),( Min Hyoung Kim ),( Hee Jin Park ),( Jin Hoon Jung ),( Dong Hyun Cha ),( Moon Young Kim ),( S 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: This study aimed to elucidate whether sufficient sleep in each stage of pregnancy impacted on reducing PPD, and whether changes in sleep pattern during the prenatal period was associated with PPD, using a longitudinal and large cohort. Methods: The study participants were recruited at two special hospitals from Mar 2013 to Nov 2017, and included Korean pregnant women around 12 gestational weeks (GW); women with pregnancy of triplets or quadruplets were excluded. They completed a sleep questionnaire regarding whether or not they had sufficient sleep at 12 GW, 24 GW, and 36 GW. Participants were divided into Group0 (sustained sufficient sleep), Group1 (change from sufficient to insufficient sleep), Group2 (change from insufficient to sufficient sleep), and Group3 (sustained insufficient sleep). Depressive symptoms were assessed by the Edinburgh Postnatal Depression Scale (EPDS) at postpartum 4 weeks and cutoff score for PPD was ≥10. Results: Out of 2512 participants, 410 (16.3%) women were diagnosed with PPD. Only sufficient sleep at 36 GW was significantly associated with lowering PPD, after adjusting for confounding factors in multivariate regression analysis (odds ratio, 0.560; 95% confidence interval, 0.440-0.714; P < .001). When the sleep change between three time points (pre-pregnancy, 12 GW, or 24 GW) and 36 GW was assessed, both Group1 (worsening sleep) and Group3 (sustained insufficient sleep) were significantly associated with developing PPD at all starting time points in the multivariate analysis, while there was no significant association between Group2 (improving sleep) and PPD. Conclusion: Sufficient sleep in late pregnancy (at 36 GW) had the impact of lowering PPD. Whether or not participants had sufficient sleep at the pre-pregnancy or prenatal periods until 36 GW, having insufficient sleep at 36 GW was highly associated with developing PPD.
연구논문 : 국가산림정보를 활용한 생물다양성 및 생태서비스 가치평가 연구
정다정 ( Da Jung Jung ),강경호 ( Kyung Ho Kang ),허준 ( Joon Heo ),손민수 ( Min Soo Sohn ),김홍석 ( Hong Suk Kim ) 한국환경영향평가학회 2011 환경영향평가 Vol.20 No.5
As United Nation (UN) declared 2010 to be the International Year of Biodiversity, the biodiversity issue has gained much attention since the issue of climate changes. Also, related researches for protecting and conserving the biodiversity are accompanied in the world. In this study, National Ecology Information is obtained from Ministry of Environment and Korea Forest Service and is utilized to valuate biodiversity and ecosystem services in Pyeongchang, Kangwon-do in Korea. For this, they are categorized into direct- or indirect- use value and nonuse value. Research results show that the biodiversity and ecosystem services in Pyeongchang are assessed as 2 trillion and 460 billion won. From this research, we evaluate the economic value of biodiversity and ecosystem services, and also suggest the possibility to utilize them as basic information for a decision making to establish the biodiversity protection plan.
정다정(Jung Da-jung),허준(Heo Joon),유수홍(Yoo Su Hong),김홍석(BRIAN H.S. KIM) 대한공간정보학회 2010 한국공간정보학회 학술대회 Vol.2010 No.1
본 연구의 목적은 생물의 다양성의 가치를 경제학적 증거와 타당한 분석방법 통해 평가하므로써 종 다양성에 대한 보호대책의 중요성을 말하고자하는데 있다. 본 연구에서는 강원도 평창군의 종 다양성의 가치를 비 사용가치, 사용가치(직접사용가치, 간접사용가치)로 평가하였다. 그 결과 총 1400억원의 비사용가치가 CVM분석방법을 통해 도출되었으며, 직접사용가치는 산림의 임분재적량을 통해 약 135백억으로 평가되었으며, 간접사용가치는 탄소가치평가를 이용하여 약 170만ton의 탄소가 저장된 것으로 산정되었다.
Park, Sun Hong,Baek, Seung-Il,Yun, Jieun,Lee, Seungmin,Yoon, Da Young,Jung, Jae-Kyung,Jung, Sang-Hun,Hwang, Bang Yeon,Hong, Jin Tae,Han, Sang-Bae,Kim, Youngsoo American Association of Immunologists 2015 Journal of Immunology Vol. No.
<P>Mice lacking the IL-1R-associated kinase 4 (IRAK4) are completely resistant to LPS-induced endotoxic disorder or the TLR9 agonist CpG DNA plus D-galactosamine-induced acute liver injury (ALI), whereas wild-type strains succumb. However, translational drugs against sepsis or ALI remain elusive. Lonicerae flos extract is undergoing the clinical trial phase I in LPS-injected healthy human volunteers for sepsis treatment. In the current study, chlorogenic acid (CGA), a major anti-inflammatory constituent of lonicerae flos extract, rescued endotoxic mortality of LPS-intoxicated C57BL/6 mice, as well as ameliorated ALI of LPS/D-galactosamine-challenged C57BL/6 mice. As a mechanism, CGA inhibited various TLR agonist-, IL-1 alpha-, or high-mobility group box-1-stimulated autophosphorylation (activation) of IRAK4 in peritoneal macrophages from C57BL/6 or C3H/HeJ mice via directly affecting the kinase activity of IRAK4, a proximal signal transducer in the MyD88-mediated innate immunity that enhances transcriptional activity of NF-kappa B or AP-1. CGA consequently attenuated protein or mRNA levels of NF-kappa B/AP-1 target genes encoding TNF-alpha, IL-1 alpha, IL-6, and high-mobility group box-1 in vivo under endotoxemia or ALI. Finally, this study suggests IRAK4 as a molecular target of CGA in the treatment of innate immunity-related shock and organ dysfunction following insult of various TLR pathogens from bacteria and viruses.</P>