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Mediating Effect of Resilience on the Association between Emotional Neglect and Depressive Symptoms
Sang Won Lee,Geum Ye Bae,Hyo-Deog Rim,Seung Jae Lee,Sung Man Chang,Byung-Soo Kim,Seunghee Won 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.1
ObjectiveaaPrevious studies have reported that childhood maltreatment experiences could induce biological and psychological vulnerability in depressive disorders. However, it is still unclear that type-specific effects of childhood maltreatment on psychological resilience, depressive symptoms and interactions among childhood maltreatment experiences, resilience, and depressive symptoms. MethodsaaA total of 438 medical students were included in the study. The Childhood Trauma Questionnaire-Short Form, the Conner-Davidson Resilience Scale, and the Beck Depression Inventory were used for measuring childhood maltreatment experiences, psychological resilience, and depressive symptoms, respectively. We investigated the effects of childhood maltreatment experiences on resilience and depressive symptoms using correlation analysis. In addition, we analyzed the mediating effect of resilience on the association between childhood maltreatment and symptoms of depression. ResultsaaAmong childhood maltreatment, emotional neglect was a significant predictor of the scores of low resilience and high depressive symptoms in both gender groups (all ps<0.05). Furthermore, resilience was found to be a mediator connecting emotional neglect experiences with depressive symptoms. ConclusionaaOur results suggest that emotional neglect has detrimental effects on mood and resilience, and clinicians need to focus on the recovery of resilience when they deal with depressive symptoms in victims of childhood maltreatment.
윤혜림,이원기,배금예,이상원,우정민,원승희,Yun, Hyerim,Lee, Won-Kee,Bae, Geumye,Lee, Sang-Won,Woo, Jungmin,Won, Seunghee 대한불안의학회 2017 대한불안의학회지 Vol.13 No.2
Objective : The experiences in close relationships questionnaire-revised (ECR-R) (Fraley, Waller & Brennan, 2000) is a valuable tool for measuring adult attachment, and its Korean version, the ECRR-K (Kim, 2004), is widely used in Korea. However, given its substantial length, this study was aimed to develop and validate a short version of the ECRR-K called the ECRR-K14. Methods : Two hundred and ninety-four medical students participated in this study in 2016. They completed the ECRR-K, the Perceived Stress Scale (PSS), the Rosenberg Self-Esteem Scale (RSES), and the UCLA Loneliness Scale (UCLA-LS). The study authors applied the Rasch rating scale to check each item's model fit and then performed confirmatory factor analyses (CFAs) to test the new scale's validity. Results : The authors selected seven items each for the anxiety and avoidance subscales, and the ECRR-K14 showed fair to good internal consistency (Cronbach's ${\alpha}=0.93$ and 0.92 for anxiety and avoidance, respectively). The anxiety subscale showed concurrent validity with the PSS and the RSES while the avoidance subscale showed concurrent validity with the UCLA-LS. The CFAs also demonstrated the validity of the model with a goodness-of-fit index of 0.916. Conclusion : The ECRR-K14 showed excellent reliability and validity and appears to be a promising instrument for measuring the two attachment dimensions in adults.
Molecular Surveillance for Tick-Borne Rickettsial and Protozoal Infectious Diseases of Dog in Korea
Keun-Ho Kim(Keun-Ho Kim),Mi-Sun Yoo(Mi-Sun Yoo),Hyun-Ji Seo(Hyun-Ji Seo),Kyu-Won Kwak(Kyu-Won Kwak),Hyunkyoung Lee(Hyunkyoung Lee),Jung-Won Park(Jung-Won Park),Seunghee Lee(Seunghee Lee),Soon-Seek Yoo 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
Distribution of Dog Ticks in the Republic of Korea, 2017
Hyun-Ji Seo(Hyun-Ji Seo),Mi-Sun Yoo(Mi-Sun Yoo),Keun-Ho Kim(Keun-Ho Kim),Kyu-Won Kwak(Kyu-Won Kwak),Hyunkyoung Lee(Hyunkyoung Lee),Jung-Won Park(Jung-Won Park),Seunghee Lee(Seunghee Lee),Soon-Seek Yoo 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
Scientific Approach to Fashion Websites Using Eye Trackers
( Seunghee Lee ),( Jung Won Choi ) 한국패션비즈니스학회 2020 패션 비즈니스 Vol.24 No.6
This study analyze consumers’ unconscious visual attention to color and images of internet shopping malls by using eye-tracking method. Twenty-nine participants, including 15 females and 14 males, participated. The average ages of the male and female participants were 27.3 years and 27.7 years, respectively. Ten images of five layouts (multi-composition images, single-model images, gender-composed images, videos, and moving banner images) of internet shopping malls were shown on an eye-tracker computer screen. Quantitative analyses of the eye-tracking responses were conducted. SPSS was used to analyze the descriptive characteristics and to conduct an independent-sample t-test, along with an ANOVA. The data analysis showed that the image area generally had the shortest time to first fixation (TFF), the longest duration of fixation (DOF), the highest number of fixations (NOF), and the highest numbers of revisits(NOR).Notably, visual attention towards female models was high among various images. The results can be used to improve credibility and design online shopping layout with a scientific evidence that helps consumers through their purchase decisions.
Studies of Square Pyramidal Nickel(Ⅱ)-Containing Coenzyme F430 Model Complexes
Won, Hoshik,Chun, Hyungphil,Kwak, Bunghun,Chang, Hwanbong,Park, Seunghee 漢陽大學校 基礎科學硏究所 1995 基礎科學論文集 Vol.14 No.-
보조효소 F430은 사각평면의 중앙에 Ni(Ⅱ)원자가 결합하여 있는 tetrapyrrole의 corphin 거대고리 분자이다. 최근 구조연구에 의하면 corphin은 보조효소 B₂에서의 corrin 거대고리와 유사하게 부분적으로 이중결합의 연결되어 있으며 거대고리 전체가 굽혀지고 주름이 잡혀있는 것으로 보고되고 있다. F430의 촉매메카니즘에 관여하는 corphin고리의 역활을 이해하기 위해, 모델착물 Ni((DO)(DOH)pn]I 을 합성하였고 Ni(Ⅱ)[(DO)(DOBF₂)pn]I와 구조적인 비교를 시행하였다. 두착물의 중요한 차이점은 적도방향 리간드가 분자평면으로 부터 다른 굽힘각(α)을 준다는 것이다. Ni((DO)(DOH)pn)I은 평면으로부터 11.6˚의 굽힘각을 나타내고, 반면에 Ni((DO)(DOBF₂)pn)I의 굽힘각은 19.0˚을 나타낸다. 두 화합물에서 결합은 Ni원자는 각각의 diimino 형태들(최대 π-orbital overlap을 유지하기 위해서)과 동일 평면상에 남기위해 수직방향 리간드와 거리가 멀게 위치한다. I방향으로 Ni원자가 4개의 질소평면으로부터 Ni((DO)(DOH)pn)I에서는 0.188Å 만큼 떨어져있고, Ni((DO)(DOBF₂)pn)I에서는 0.23Å 떨어져있다. 또한 Ni((DO)(DOH)pn)I에서 얻어진 긴 Ni-I 결합거리는(DO)(DOH)pn 리간드가 (DO)(DOBF₂)pn보다 더욱 강한 강성(rigidity)을 갖고 있음을 나타낸다. Coenzyme F430 consists of a tetrapyrrole corphin macrocycle with a centrally bound, square planar Ni(Ⅱ) atom. Recent structural studies exhibit that the corphin is not fully conjugated and is thus able to bend or ruffle as in the corrin macrocycle in coenzyme B12. In order to increase the functions of corphin ring in the mechanistic details of F430 - dependent catalysis, model complex Ni [(DO)(DOH)pn] I was synthesized and structural comparison was made with Ni((DO)(DOBF₂)pn) I. Significant difference between complexes was the angle of deviation from planarity of the equatorial ligand (bending angle α). Ni((DO)(DOH)pn) I exhibits deviation from planarity of 11.6˚whereas deviation in Ni((DO)(DOBF₂)pn) I is 19˚. In both compounds, bending is away from the axial ligands such that the Ni atom remains coplanar with each of the diimino moieties(to maintain maximum π-orbital overalp), and is displaced from the 4-N plane towards I by 0.188Å in Ni((DO)(DOH)pn) I and 0.23Å in Ni((DO)(DOBF₂)pn) I. The very long Ni - I bond in Ni((DO)(DOH)pn) I is thus a consequence of the greater rigidity of the (DO)(DOH)pn ligand compared to the (DO)(DOBF₂)pn ligand.
Lee, Seunghee,Jung, Ji-Won,Park, Sang-Bum,Roh, Kyounghwan,Lee, Su Yeon,Kim, Ju Han,Kang, Soo-Kyung,Kang, Kyung-Sun SP Birkhäuser Verlag Basel 2011 Cellular and molecular life sciences Vol.68 No.2
<P>Cellular senescence involves a reduction in adult stem cell self-renewal, and epigenetic regulation of gene expression is one of the main underlying mechanisms. Here, we observed that the cellular senescence of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) caused by inhibition of histone deacetylase (HDAC) activity leads to down-regulation of high mobility group A2 (HMGA2) and, on the contrary, to up-regulation of p16<SUP>INK4A</SUP>, p21<SUP>CIP1/WAF1</SUP> and p27<SUP>KIP1</SUP>. We found that let-7a1, let-7d, let-7f1, miR-23a, miR-26a and miR-30a were increased during replicative and HDAC inhibitor-mediated senescence of hUCB-MSCs by microRNA microarray and real-time quantitative PCR. Furthermore, the configurations of chromatins beading on these miRNAs were prone to transcriptional activation during HDAC inhibitor-mediated senescence. We confirmed that miR-23a, miR-26a and miR-30a inhibit HMGA2 to accelerate the progress of senescence. These findings suggest that HDACs may play important roles in cellular senescence by regulating the expression of miRNAs that target HMGA2 through histone modification.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00018-010-0457-9) contains supplementary material, which is available to authorized users.</P>
Conformational Studies of Zn(Ⅱ)-binding Tallysomycin Complex by NMR
Park,Seunghee,Kim,Daesung,Won,Hoshik,Chung,Hansun 漢陽大學校 自然科學硏究所 1997 自然科學論文集 Vol.16 No.-
Zn가 항암제 tallysomycin과 착물을 형성할 때 Zn, NC3, C6등 착물의 입체구조와 연관된 가능한 키랄성을 결정하였다. NMR 실험결과는 β-aminoalanine, β-hydroxyhistidine, 그리고 pyrimidinemoiety의 질소주게와 금속과의 결합을 가지고 있음을 나타내는데, 여러 배위결합 양식에 따라 미결정된 NC3-C6의 키랄성을 결정하였다. 실험은 tallysomycin의 β-aminoalanine, sugar ring, β-hydroxyhistidine등 작용기들의 입체특이성을 고려하였다. Mannose의 carbamide, propionamide 곁가지의 수소결합 가능성과 연관된 입체구조, Zn과 H₂O의 결합에 따른 입체구조도 고려 하였다. NMR 실험결과를 기초로한 체계적인 키랄성의 결정 결과는 NC3-C6에 대하여 S-S 형태가 구조적으로 유리한 것이 얻어졌으며, 만일 NC3가 R-입체구조를 가질 경우 C6 키랄중심에 내부 strain에너지가 있어야 하는 결과를 얻었다. The systematic chirality investigations were made on the basis of the fact that zinc-binding tallysomycin (ZnTLMA) could have chiral centers (Zn, NC3, C6) at possible 4-, 5-, and 6-coordination models. Although our NMR data exhibit that the ligation sites are β-aminoalanine, β-hydroxyhistidine, and pyrimidine moiety, all possible coordination modes were tested out to see what kind of chiralities on NC3-C6 are favorable to each coordination mode. Tests were also made by considering the specific configuration of functional groups, including β-aminoalanine, sugar ring, and β-hydroxyhistidine. Tests were finally extended to zinc-water binding and specific conformational studies by introducing various hydrogen bonding networks associated with the propionamide side chain and the carbamide group of mannose. Results of systematic chirality investigations exhibit that the S-S configuration of NC3-C6 is favorable to all of coordination models, but the R-S configuration, if exist, should have internal strain on C6 chiral center.