제주지역에서 브로콜리 노균병 발생 실태 및 품종에 따른 저항성 검정

고순보(Sun Bo Ko),김성배(Seong Bae Kim1),고태신(Tae Sin Ko),홍순영(Sun Young Hong),강성근(Sung Koon Kang),박용봉(Yong Bong Park) 한국원예학회 2008 한국원예학회 학술발표요지 Vol.2008 No.5

Complication of Intraoperative Radiation Therapy (IORT) in Gastric Cancer

김명세(Myung Se Kim),김성규(Sung Kyu Kim),송선교(Sung Kyo Song),김홍진(Hong Jin Kim),권굉보(Koing Bo Kwan),김흥대(Heung Dae Kim) 대한방사선종양학회 1992 Radiation Oncology Journal Vol.10 No.2

영남대학교 의료원 치료방사선과에서 1988년 6월 15일에 위함 환자의 수술중 방사선치료를 시작한 이래 1992년 8월 30일까지 총 58예에서 시도하여 그중 53예에서 IORT를 실시하였으며, 정기적인 추적검사에서 한명의 국소개발 환자도 보고되지 않고 있다. 출혈(3예), 장관폐쇄(3예), 폐혈증(2예), 골수기능저차(1예)를 포함한 총 9예(17%)의 합병증이 보고되었고, 이중 6예(13%)가 사망하였다. IORT(1500cGy), 외부 방사선치료 (-4500cGy)와 강한 항암제를 병합치료 하였음에도 불구하고 주등(수술과 항암제 치료)의 25.2%, 김등(수술 불가능한 환자에서 항암제 투여)의 18%, 리등(수술)의 18.5%, Kraming등(IORT 2800-3500cGy)의 35.3%에 비해 낮은 합병증을 보여 IORT가 위암의 치료에 공헌할 수 있음을 시사하였다. 그러나 비교적 높은 치사율(11.3%)은 더욱 세심한 수술수기 및 수술 후 환자의 치료가 필요하며 외부 방사선치료와 항암제치료의 적절한 시기 조절 및 치료선량의 가감이 필요할 것으로 생각된다. Local control is the important prognostic factor in cancer treatment because local control decrease the relative risk of metastatic spread and increase distant metastasis free survival. IORT is the modality which could increase local control without increasing complication, combined with curative operation. Eventhough we could achieve significant deacreased local failure by IORT and curative resection, it should not be committed as a main treatment modality without proving acceptable complications. Therapeutic Radiology Department of Yeungnam University Medical Center have tried 58 IORT from June 15, 1988 and performed 53 IORT in patients with gastric cancer. No local failure had been reported including interstinal obstrution, hemorrhage, sepsis, and bone marrow depression. These complications could be comparable to Jo's 25.2% (chemotherapy + operation), Kim's 18% (chemotherapy only in inoperable patients), because our treatment regimen is consisted of IORT (1500cGy), external irradiation (--4500cGy) and extensive chemotherapy (FAM, 5FU + MMC, BACOP). Our data encouraged us to re-inforce further IORT in stomach cancer treatment.

경북 성주지역 장수노인의 영양상태(Ⅰ)

백지원(Baek, Ji-Won),구보경(Koo, Bo-Kyung),김규종(Kim, Kyu-Jong),이연경(Lee, Yeon-Kyung),이성국(Lee, Sung-Kook),이혜성(Lee, Hye-sung) 한국영양학회 2000 Journal of Nutrition and Health Vol.33 No.4

경북 성주지역 장수노인의 계절별 식품섭취 상태

백지원(Ji-Won Baek),구보경(Bo-Kyung Koo),김규종(Kyu-Jong Kim),이연경(Yeon-Kyung Lee),이성국(Sung-Kook Lee),이혜성(Hye-Sung Lee) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.4

본 연구는 우리나라 장수노인들의 식품섭취상태를 분석 평가하고 건강한 장수를 위한 식생활 지침의 설정을 위한 기초자료를 얻고자 수행되었다. 연구 대상은 경상북도 성주군에 거주하는 85세 이상 고령노인 중에서 일상 생활에 문제가 없는 224명이었으며 이들을 대상으로 반복 24시간 회상법을 이용하여 1년간 4회의 계절별 식품 섭취 조사를 실시하였으며 결과를 요약하면 다음과 같다. 계절별 식품군별 섭취량에 있어서 남자노인은 감자류의 섭취량이 여름철에 유의적으로 높고, 버섯류의 섭취량이 가을철에 유의하게 높은 것을 제외하고는 모든 식품군의 섭취량에 있어 계절별 차이가 나타나지 않았다. 여자노인의 경우 곡류, 당류, 두류, 채소류, 과일류, 조미료류, 음료 및 주류, 육류, 우유류, 어패류의 섭취량이 겨울철에 유의하게 높았으며, 종실류, 해조류, 난류의 섭취량은 계절에 따른 차이가 없었다. 조사 대상자들의 연평균 1일 총 식품 섭취량은 594.4±186.1 g이었으며 이 중에서 513.5±161.2 g(86.4%)는 식물성 식품군으로부터 섭취하였고 79.3±56.7 g(13.3%)는 동물성 식품군으로부터 섭취하였다. 섭취량이 가장 높았던 식품군은 곡류였으며그 다음이 채소류, 과일류, 어패류, 음료 및 주류, 조미료류, 두류, 육류, 우유류, 감자류 등의 순이었다. 장수 노인대상자들의 음식별 섭취빈도는 밥류에 있어서는 쌀밥의 섭취비율이 80.1~89.2%로 가장 높았으며 국과 찌개류에서는 쇠고기국, 된장국, 된장찌개의 섭취 비율이 높았다. 어육류 식품의 경우 조기구이의 섭취비율(9.4~12.7%)이 높았으며, 해조류 식품의 경우 김구이의 섭취비율(7.4~20.5%)이 높았고, 각 계절마다 계절식품의 섭취비율이 높았다. 김치류의 경우 배추김치의 섭취비율이 4계절 모두 70% 이상으로 높게 나타났다. 일품요리류는 손쉽게 조리할 수 있는 라면과 국수의 섭취비율이 높았다.<br/> 본 연구의 결과에서 경북 성주지역 장수 노인들의 계절별 식품 섭취량에 있어 겨울철의 식품 섭취량이 다른계절에 비해 유의하게 높았으며, 남자노인보다는 여자노인이 식품섭취에 계절에 의한 영향을 더욱더 많이 받는 것으로 나타났다. 또한 장수 노인들은 가공식품보다는 계절마다 제철에 생산되는 자연 식품의 섭취비율이 높았다. 전반적으로 장수노인들은 소식의 경향을 보였으며 이와 같은 소식습관과 신선한 식물성 식품들의 일상 섭취가 건강한 장수에 영향을 미쳤을 가능성도 있을 것으로 사료된다. The purpose of this study was to estimate food intakes of the long-lived elderly and to obtain the data for establishing dietary guidelines that may be recommended for the general population for the sake of longevity. The subjects of the study were 224 elderly people of age over 85 years living in Kyungpook Sung-Ju area who have no problem in daily living. The food consumption survey was carried out seasonally by the repeated 24-hr recall method for one year. The subject group for this study was composed of 58 males and 166 females, the average age being 87 years old. Food intakes of the winter were more than any other seasons. The mean daily total food intake per capita was 594.4 g, 513.5 g (86.4%) from plant foods and 79.3 g (13.3%) from animal foods. The sequence of high intakes of food groups were cereals, vegetables, fruits, fishes, legumes and meats. Boiled white rice, beef soup, soybean paste soup, soybean paste stew, broiled yellow croaker, kimchi, ra myon and broiled noodles were consumed most frequently. In conclusion, the subjects consumed much more plants foods than animal foods and consumed more natural and seasonal foods than processed foods and also showed food habits of eating small meals. Dietary habits of eating small meals containing abundant amount of fresh plant foods might partially contribute to the longevity of the subjects.

Phase I Dose-Escalation Study of Proton Beam Therapy for Inoperable Hepatocellular Carcinoma

Kim, Tae Hyun,Park, Joong-Won,Kim, Yeon-Joo,Kim, Bo Hyun,Woo, Sang Myung,Moon, Sung Ho,Kim, Sang Soo,Koh, Young-Hwan,Lee, Woo Jin,Park, Sang Jae,Kim, Joo-Young,Kim, Dae Yong,Kim, Chang-Min Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.1

<P><B>Purpose</B></P><P>The purpose of this study is to determine the optimal dose of proton beam therapy (PBT) in hepatocellular carcinoma (HCC) patients.</P><P><B>Materials and Methods</B></P><P>Inoperable HCC patients who had naïve, recurrent, or residual tumor to treatment were considered eligible for PBT. Patients received PBT with 60 GyE in 20 fractions (dose level 1; equivalent dose in 2 Gy fractions [EQD2], 65 GyE<SUB>10</SUB>); 66 GyE in 22 fractions (dose level 2; EQD2, 71.5 GyE<SUB>10</SUB>); or 72 GyE in 24 fractions (dose level 3; EQD2, 78 GyE<SUB>10</SUB>). Dose-limiting toxicity was determined by grade ≥ 3 acute toxicity.</P><P><B>Results</B></P><P>Twenty-seven patients were enrolled; eight, seven, and 12 patients were treated with dose levels 1, 2, and 3, respectively. Overall, treatment was well tolerated, with no dose-limiting toxicities. The complete response (CR) rates of primary tumors after PBT for dose levels 1, 2, and 3 were 62.5% (5/8), 57.1% (4/7), and 100% (12/12), respectively (p=0.039). The 3-and 5-year local progression-free survival (LPFS) rates among 26 patients, excluding one patient who underwent liver transplantation after PBT due to its probable significant effect on disease control, were 79.9% and 63.9%, respectively, and the 3-and 5-year overall survival rates were 56.4% and 42.3%, respectively. The 3-year LPFS rate was significantly higher in patients who achieved CR than in those who did not (90% vs. 40%, p=0.003).</P><P><B>Conclusion</B></P><P>PBT is safe and effective and an EQD2 ≥ 78 GyE<SUB>10</SUB> should be delivered for achievement of local tumor control.</P>

Comparison of capecitabine and 5-fluorouracil in chemoradiotherapy for locally advanced pancreatic cancer

Kim, Yeon-Joo,Lee, Woo Jin,Woo, Sang Myung,Kim, Tae Hyun,Han, Sung-Sik,Kim, Bo Hyun,Moon, Sung Ho,Kim, Sang Soo,Koh, Young Hwan,Park, Sang-Jae,Kim, Joo-Young,Kim, Dae Yong,Park, Joong-Won BioMed Central 2013 Radiation oncology Vol.8 No.-

<P><B>Background</B></P><P>Although capecitabine has theoretical advantages in the pharmacokinetics, such as higher intratumoral and lower systemic concentration, relative to bolus 5-fluorouracil (5-FU), outcomes of chemoradiotherapy (CRT) with capecitabine or bolus 5-FU have not been directly compared in patients with locally advanced pancreatic cancer. Therefore, we retrospectively compared the outcomes, including toxicity, tumor response, and overall survival, of oral capecitabine plus radiotherapy (RT) with bolus 5-FU plus RT, in patients with locally advanced pancreatic cancer.</P><P><B>Methods</B></P><P>Between August 2006 and January 2012, 98 patients with locally advanced pancreatic cancer received CRT, with 52 receiving concurrent oral capecitabine and 46 receiving bolus injection of 5-FU. Primary tumor and overall response after CRT were evaluated radiologically, and toxicity, tumor response, and overall survival (OS) were compared in the two groups.</P><P><B>Results</B></P><P>Baseline clinical parameters of the two groups were similar. The rates of ≥ Grade 3 hematologic (0% vs. 8.7%, <I>p</I> = 0.045) and non-hematologic (0% vs. 8.7%, <I>p</I> = 0.045) toxicities were significantly lower in the capecitabine group than in the 5-FU group. Primary tumor (30.7% vs. 28.2%, <I>p</I> = 0.658) and overall (13.7% vs. 15.2%, <I>p</I> = 0.273) response rates and median OS time (12.5 months vs. 11.6 months, <I>p</I> = 0.655) were similar in the two groups.</P><P><B>Conclusions</B></P><P>Capecitabine plus RT may be a safe and feasible regimen for patients with locally advanced pancreatic cancer, with similar efficacy and low rates of toxicities compared with bolus 5-FU plus RT.</P>

Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy.

Kim, Bo Hyun,Cho, Kyoung Im,Kim, Seong Man,Kim, Jee-Yeon,Choi, Bo Gwang,Kang, Ji Hyun,Jeon, Yun Kyung,Kim, Sang Soo,Kim, Seong-Jang,Kim, Yong Ki,Kim, In Joo Japan Endocrine Society 2012 Endocrine journal Vol.59 No.10

<P>This study evaluated the effects of irbesartan and propranolol on thyroid hormone (TH)-induced cardiac functional and structural remodeling. A rat model of thyrotoxicosis was established by daily intraperitoneal injections of L-thyroxine (T(4), 100 μg/kg) for 4 weeks. Forty Sprague-Dawley rats were randomly divided into four groups (n = 10 each): control group, T(4) group (T(4) alone), T(4) plus irbesartan group (T(4)-Irb, 30 mg/kg), and T(4) plus propranolol group (T(4)-Pro, 0.5mg/mL of drinking water). Cardiac chamber size and functional parameters were measured by echocardiography and cardiomyocyte diameter. Heart rate (HR) and cardiac fibrosis were determined. T(4) alone showed significantly increased HR and cardiomyocyte width (25.0 1.77 vs. 18.8 0.84 μm, P < 0.001) with fibrosis, reduced left ventricle (LV) longitudinal strain (S(long); -16.0 6.27 vs. -22.7 5.19 %, P < 0.001) compared with control. When compared with T(4) alone, T(4)-Irb showed significantly improved LV S(long) (-21.4 1.84 vs. -16.0 6.27 %, P =0.017) and reduced cardiomyocyte width (21.0 1.0 vs. 25.0 1.77 μm, P =0.002) with comparable HR (458.4 24.3 vs. 486.6 30.1 bpm, P = 0.086). However, T(4)-Pro showed significantly reduced HR with improved LV S(long) without alteration of cardiomyocyte width and fibrosis compared with T(4) alone. In conclusion, renin-angiotensin system (RAS) blocking by irbesartan could significantly attenuate TH-induced cardiac structural and functional remodeling. However, HR reduction by propranolol could not alternate structural remodeling, which may implicate the RAS as having an important role in thyrotoxic cardiomyopathy beyond tachycardia.</P>

High metabolic tumor volume and total lesion glycolysis are associated with lateral lymph node metastasis in patients with incidentally detected thyroid carcinoma

Kim, Bo Hyun,Kim, Seong-Jang,Kim, Keunyoung,Kim, Heeyoung,Kim, So Jung,Kim, Won Jin,Jeon, Yun Kyung,Kim, Sang Soo,Kim, Yong Ki,Kim, In Joo Springer Japan 2015 Annals of nuclear medicine Vol.29 No.8

<P><B>Objective</B></P><P>The objective of this study was to investigate whether total lesion glycolysis (TLG) and metabolic tumor volume (MTV) measured by <SUP>18</SUP>F-fluorodeoxyglucose (<SUP>18</SUP>F-FDG) positron emission tomography/computed tomography (PET/CT) could predict the aggressiveness and lymph node metastasis (LNM) in patients with incidentally detected differentiated thyroid carcinoma.</P><P><B>Methods</B></P><P>A total 358 patients with focal FDG-avid thyroid incidentaloma during cancer evaluation were enrolled. Among 235 patients in whom fine-needle aspiration biopsy was performed, 51 patients underwent total thyroidectomy with LN dissection. We analyzed the relationship between volume-based parameters and clinicopathologic characteristics.</P><P><B>Results</B></P><P>The mean age and tumor size were 57.1 ± 11.3 years and 1.15 ± 0.81 cm, respectively. The prevalence of malignancy was 21.7 % (51/235). When SUV<SUB>max</SUB> > 5.91, MTV2.5 > 2.05 cm<SUP>3</SUP>, and TLG2.5 > 9.09 were used as cutoff points, sensitivity, specificity, and area under curve (AUC) for prediction of lateral LNM were 77.9, 69.1 %, 0.716 (<I>P</I> = 0.047), 77.8, 88.1 %, 0.839 (<I>P</I> < 0.001), 77.8, 85.1 %, and 0.815 (<I>P</I> = 0.002), respectively. However, MTV and TLG had no value in prediction of central LNM, extrathyroidal extension, and multifocality. On comparison ROC curve analysis, the MTV and TLG showed the statistical differences for the prediction of lateral LNM compared with SUV<SUB>max</SUB> (all <I>P</I>’s < 0.05).</P><P><B>Conclusions</B></P><P>This study has shown for the first time that volume-based PET functional parameters had a significant value for the prediction of lateral LNM in incidentally detected PTC. These results suggest that higher MTV and TLG can be potential new risk factors for preoperative risk stratification. The usefulness of TLG and MTV in preoperative risk stratification in patients with PTC needs to be confirmed in further large studies.</P>

P-105 : Poster ; Spontaneous Regression in Advanced Squamous Cell Lung Carcinoma

( Bo Mi Park ),( Sun Young Kim ),( Ju Ock Kim ),( Sung Soo Jung ),( Hee Sun Park ),( Jae Young Moon ),( Jeong Eun Lee ) 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Spontaneous regression (SR) of malignant tumors is rare especially of lung tumor and biological mechanism of such remission has not been addressed. There were all 6 documented NSCLC SR cases which satisfied the modified everson and cole criteria to date from 1950. Among them, total of 4 cases were squamous cell lung cancer. We report the case of a 79-year-old Korean patient with non-small cell lung cancer, squamous cell cancer with a right hilar tumor and multiple lymph nodes, lung to lung metastasis that spontaneously regressed without any therapies. He was referred to our respiratory medicine outpatient for discovered right hilar mass on chest X-ray for health screening. He was taken chest computed tomography (CT) on first visit, as a result, there was a lobulated mass size of about 4.8cm to right upper lobe anterior segment. Lung metastasis on same lobe, ipsilateral and contra-lateral lobe and metastatic lymphadenopathy in right highest, right upper and lower paratracheal, right hilar area were also showed on the chest CT. Percutaneous needle biopsy was performed in the main mass, and the biopsy result was a squamous cell carcinoma. We decided to advise to undergo chemotherapy to the patient, but refused and he wanted only conservative therapy. The patient took further four of chest CT for 8 months in two month intervals thereafter, main mass was reduced to 1.1cm finally, and the size of metastatic lung nodules and lymph nodes has no change as compared with those of 2 months after diagnosis up to now. Spontaneous regression (SR) of malignant tumors is rare especially of lung tumor and biological mechanism of such remission has not been addressed. There were all 6 documented NSCLC SR cases which satisfied the modified everson and cole criteria to date from 1950. Among them, total of 4 cases were squamous cell lung cancer. We report the case of a 79-year-old Korean patient with non-small cell lung cancer, squamous cell cancer with a right hilar tumor and multiple lymph nodes, lung to lung metastasis that spontaneously regressed without any therapies. He was referred to our respiratory medicine outpatient for discovered right hilar mass on chest X-ray for health screening. He was taken chest computed tomography (CT) on first visit, as a result, there was a lobulated mass size of about 4.8cm to right upper lobe anterior segment. Lung metastasis on same lobe, ipsilateral and contra-lateral lobe and metastatic lymphadenopathy in right highest, right upper and lower paratracheal, right hilar area were also showed on the chest CT. Percutaneous needle biopsy was performed in the main mass, and the biopsy result was a squamous cell carcinoma. We decided to advise to undergo chemotherapy to the patient, but refused and he wanted only conservative therapy. The patient took further four of chest CT for 8 months in two month intervals thereafter, main mass was reduced to 1.1cm finally, and the size of metastatic lung nodules and lymph nodes has no change as compared with those of 2 months after diagnosis up to now.

The Risk of psoriasis in postgastrectomy gastric cancer survivors: A nationwide population-based cohort study

( Bo Ri Kim ),( Dong Ho Lee ),( Hyun Ik Shim ),( Jee Woo Kim ),( Sanghyun Park ),( Cheol Min Shin ),( Kyung-do Han ),( Sang Woong Youn ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1