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        Au Nanocucumbers with Interior Nanogap for Multiple Laser Wavelength-Compatible Surface-Enhanced Raman Scattering

        황재호,Nitin Kumar Singhal,임동권,남좌민 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.3

        It is critical to design and synthesize plasmonic nanostructures that can generate very strong and quantitative surface-enhanced Raman scattering (SERS) signals that could be amplified by multiple laser wavelengths to realize the full potential of SERS nanoprobes. Here, we report the synthesis of Au-nanobridged nanogap cucumbers (Au-NNCs) from DNA-modified Au nanorods and comparison of their SERS signals with three different Raman dyes with our recently reported Au-nanobridged nanogap spheres (Au-NNSs). Although the Au-NNSs generate highly stable and reliable signals, these spherical nanogap structures with a smooth surface produce strong SERS signals (SERS enhancement factor at ~108) only with 633 nm excitation laser. The Au-NNCs with a bumpy surface generated up to ~3-, ~23-, and ~130-fold higher SERS signals with 514, 633, and 785 nm excitation laser wavelengths, respectively, compared to the Au-NNSs.

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        South Asian Working Action Group on SARCOpenia (SWAG-SARCO) – A consensus document

        Minakshi Dhar,Nitin Kapoor,Ketut Suastika,Mohammad E. Khamseh,Shahjada Selim,Vijay Kumar,Syed Abbas Raza,Umal Azmat,Monika Pathania,Yovan Parikshat Rai Mahadeb,Sunny Singhal,Mohammad Wali Naseri,IGP S 대한골다공증학회 2022 Osteoporosis and Sarcopenia Vol.8 No.2

        The South Asian population is rapidly ageing and sarcopenia is likely to become a huge burden in this region if proper action is not taken in time. Several sarcopenia guidelines are available, from the western world and from East Asia. However, these guidelines are not fully relevant for the South Asian healthcare ecosystem. South Asia is ethnically, culturally, and phenotypically unique. Additionally, the region is seeing an increase in non-communicable lifestyle disease and obesity. Both these conditions can lead to sarcopenia. However, secondary sarcopenia and sarcopenic obesity are either not dealt with in detail or are missing in other guidelines. Hence, we present a consensus on the screening, diagnosis and management of sarcopenia, which addresses the gaps in the current guidelines. This South Asian consensus gives equal importance to muscle function, muscle strength, and muscle mass; provides cost-effective clinical and easy to implement solutions; highlights secondary sarcopenia and sarcopenic obesity; lists commonly used biomarkers; reminds us that osteo-arthro-muscular triad should be seen as a single entity to address sarcopenia; stresses on prevention over treatment; and prioritizes nonpharmacological over pharmacological management. As literature is scarce from this region, the authors call for more South Asian research guided interventions.

      • KCI등재

        Zinc oxide nanopillars as an electrocatalyst for direct redox sensing of cadmium

        Gaurav Bhanjana,Neeraj Dilbaghi,Nitin Kumar Singhal,김기현,Sandeep Kumar 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-

        In this paper, we report an ultrasensitive and selective technique for direct electrochemical sensing of cadmium (Cd) by zinc oxide nanopillars (ZONPs) synthesized using a facile chemical method. The synthesized ZONPs have been characterized in terms of their topological, morphological, elemental, structural, and optical properties using various microscopic and spectroscopic techniques. A gold electrode was modified with the as-synthesized ZnO nanostructures and utilized for direct redox sensing of Cd using cyclic voltammetry (CV) and chronoamperometric techniques. This fabricated sensor demonstrated excellent sensitivity and selectivity for direct redox sensing of Cd in real and laboratory samples. Using chronoamperometry, the developed sensor demonstrated ultra-sensitivity (10 mA cm2 ppb1) with a detection limit of 4 ppb (p-value < 0.0001, R-value > 0.99) in a linear range of 5–50 ppb. The enhanced reproducibility of the sensor in the presence of common interfering ions offers the potential for use in diagnostic applications involving food adulteration and in clinical healthcare.

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