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가교제 및 pH 조절제가 수용성 아크릴 점착제의 점착 물성에 미치는 효과
서인선,엄홍철,이명천 동국대학교 산업기술연구원 2001 산업기술논문집 Vol.12 No.1
본 연구에서는 점착제의 유지력 개선과 pH 조절을 위해 각각 첨가해주는 가교제와 pH 조절제의 종류 및 첨가량이 수용성 아크릴 점착제의 점착 물성 및 수용성에 미치는 효과를 알아보기 위하여 중합된 점착 시료에 여러 가지 가교제와 pH 조절을 첨가해 준 후 초기점착력, 유지력 및 점착력 등의 점착 물성과 수용성을 측정하였다. 가교제를 0.2 wt% 미만 첨가해주었을 때, 초기 점착력은 감소하였고 유지력과 점착력은 증가하였다. 그러나 0.2 wt% 이상 첨가해주었을 때는 초기 점착력은 증가하였지만 유지력과 점착력은 감소하는 결과를 보였다. 또한 pH 조절제를 첨가해주었을 때 pH 조절제의 농도가 증가함에 따라 초기점착력과 수용성은 감소하였고 점착력과 유지력은 증가하였으며, LiOH, KOH, NaOH 순으로 점착 물성과 수용성에 미치는 영향이 큰 것으로 나타났다. In this paper, the effects of crosslinking agent and pH controlling agent on adhesive properties and water solubility of water soluble acrylic pressure sensitive adhesives were studied by adding the crosslinking agents of pH controlling agents after the polymerization. The tack, cohesive strength, and peel strength were measured to evaluate adhesive properties. Turbidity was also measured to evaluate water solubility of pressure sensitive adhesives. When the crosslinking agent was added less than 0.2 wt%, the tack increased and cohesive strength and peel strength decreased with increasing concentration. When the crosslinking agent was added more than 0.2 wt%, the results were opposite. When the pH controlling agent was added, the tack and water solubility decreased and peel strength and cohesive strength increased with increasing concentration. The influence of pH controlling agents of adhesive properties and water solubility of pressure sensitive adhesives increased in the order of lithium hydroxide, potassium hydroxide and sodium hydroxide.
Isolation and Characterization of Micrococcaceae in Dental Clinic
Kim, Kang-Ju,Yoo, Soo-Kyung,Kim, Hyeon-Jin,Kim, Seon-Ju,Um, In-Woong The Official Publication of Korean Academy of Oral 1993 International Journal of Oral Biology Vol.17 No.1
It has been reported that staphylococci present in clinic and personnel are transmissible to patients. The purpose of this study is to ascertain the distribution. the drug resistance and plasmid pattern in Micrococcaceae isolated in dental clinic. A dental clinic was monitored in the morning in the afternoon and in the evening. S. hemolyticus was isolated from the cover of instruments and S. hominis was isolated from the margin of tray in the morning. S. epidermidis was isolated from light switch and head rest. S. aureus from cuspidor and head rest. and coagulase-negative staphylococci from suction tip in the afternoon. S. aureus was isolated from head rest and coagulase-negative staphylococci was isolated from suction rubber tip in the evening. Micrococci were isolated from the forceps tip and the switch in the evening. Staphylococci isolated in the afternoon showed susceptibility to ceftriaxone. and those isolated in the evening to ampicillin. carbenicillin. tetracyclin. gentamycin. amikacin. cephalothin. ceftriaxone and cefoxitin. Micrococcus isolated in the evening showed susceptibility to 15 antibiotics. In the analysis of plasmid. there were two clear bands about 4.3 kb, in S. aureus isolated from the head rest in the afternoon. These results show that Micrococcaceae can become ambient in dental clinic. and staphylococci isolated then show antibiotic resistance to some drugs.
시판 까나리(Ammodytes personatus) 액젓의 biogenic amines 함량
엄인선 ( In Seon Um ),박권삼 ( Kwon Sam Park ) 한국수산과학회 2015 한국수산과학회지 Vol.48 No.6
This study investigated the quality of seven commercial salted and fermented sand lance Ammodytes personatus sauces by measuring their chemical compositions, bacteria concentrations, and biogenic amine contents. The sauces had a 63.97-67.32% (mean: 65.72%) moisture content, 23.16-24.03% (mean: 23.60%) salinity, 5.51-6.14 (mean: 5.81) pH, 164.76-217.98 mg/100 g (mean: 182.97 mg/100 g) volatile basic nitrogen, 0.94-1.42% (mean: 1.24%) total nitrogen, and 673.77-791.86 mg/100 g (mean: 720.76 mg/100 g) amino nitrogen content. Viable cell counts ranged from 1.2×101 to 2.9×102 CFU/mL, and number of biogenic amine-forming bacteria was very low or not detected. Overall, the tested samples had average levels of histamine of 301.02 mg/kg, cadaverine of 29.78 mg/kg, tyramine of 199.21 mg/kg, putrescine of 183.00 mg/kg, and tyramine of 13.01 mg/kg. This strongly suggests that it is necessary to monitor the biogenic amine contents of commercial salted and fermented sand lance sauces carefully to ensure consumer health.
시판 까나리(Ammodytes personatus) 액젓에서 putrescine 생성균의 분리 및 특성
엄인선 ( In-seon Um ),김태옥 ( Tae-ok Kim ),박권삼 ( Kwon-sam Park ) 한국수산과학회(구 한국수산학회) 2016 한국수산과학회지 Vol.49 No.5
Bacterial decarboxylation of amino acids in food leads to the production of biogenic amines, which can cause reactions in human that include headaches, nausea, palpitations, chills, and severe respiratory distress. The amine putrescine is an especially effective inhibitor of metabolizing enzymes and amplifies histamine intoxication and tyramine poisoning. Using an L-ornithine decarboxylating medium, we isolated 14 putrescine-producing bacteria from sand lance, Ammodytes personatus, sauces. The isolates were identified, using an API kit and 16S rRNA analysis, as Lysinibacillus fusiformis (1 strain), Lysinibacillus xylanilyticus (6 strains), Lysinibacillus macroides (1 strain), Lysinibacillus sphaericus (3 strains), Bacillus fusiformis (1 strain), Paenibacillus favisporus (1 strain), and Staphylococcus caprae (1 strain). These strains produced between 1.66 to 236.97 μg/mL of putrescine after 48 h incubation. Lysinibacillus spp. were the dominant putrescine-producing bacteria in sand lance sauces, which produced 236.97 μg/mL of putrescine from a culture broth containing 0.5% L-ornithine. This is the first report on the isolation and identification of putrescine-producing bacteria from sand lance sauces.
시판 까나리(Ammodytes personatus) 액젓에서 분리한 tryptamine 생성균의 특성
엄인선 ( In-seon Um ),김태옥 ( Tae-ok Kim ),김희대 ( Hee-dai Kim ),박권삼 ( Kwon-sam Park ) 한국수산과학회(구 한국수산학회) 2016 한국수산과학회지 Vol.49 No.6
We isolated seven tryptamine-producing bacteria from commercial salted and fermented sand lance (Ammodytes personatus) sauces using an L-tryptophan decarboxylating medium. These tryptamine-producing bacteria, identified using an API kit and 16S rRNA analysis, included Lysinibacillus xylanilyticus (one strain), Lysinibacillus fusiformis (four strains), and Staphylococcus epidermidis (two strains). Lysinibacillus spp. produced the highest levels of tryptamine in culture broth containing 0.5% L-tryptophan, compared with 1.0% and 2.0% preparations. After 72 h of incubation, Staphylococcus epidermidis produced the highest levels of tryptamine (60.50 μg/mL and 664.86 μg/ mL) in culture broth containing 2.0% L-tryptophan. While Lysinibacillus spp. comprised the dominant tryptamine-producing bacteria in sand lance sauces, Staphylococcus epidermidis also showed high tryptamine-producing active-ity. This is the first report on the isolation and identification of tryptamine-producing bacteria in sand lance sauces.
Comparison of biomechanical properties between acupuncture and non-penetrating sham needle
Chae, Younbyoung,Um, Seo-In,Yi, Seung-Ho,Lee, Hyejung,Chang, Dong-Seon,Yin, Chang Shik,Park, Hi-Joon Elsevier 2011 COMPLEMENTARY THERAPIES IN MEDICINE Vol.19 No.suppl1
<P><B>Summary</B></P><P><B>Objectives</B></P><P>A non-penetrating sham needle has been considered as a reliable control treatment in the field of acupuncture research. However, some concerns with regard to the credibility of sham needles have also been raised. We investigated whether there were differences in biomechanical properties and acupuncture sensation ratings in the process of needling between verum acupuncture (VA) and sham acupuncture (SA).</P><P><B>Methods</B></P><P>To quantify biomechanical force during needling in a cross-over design, we used a computer-controlled needling system. Fourteen participants received VA or SA at acupuncture point LI4, with no visual impact. They were asked to complete an acupuncture sensation form, including penetration, acute pain and <I>DeQi</I> sensations, and to identify the needling type they received.</P><P><B>Results</B></P><P>We found that there was a significant difference in insertion force between VA and SA (68.5±12.2 vs. 27.2±3.9gf; <I>p</I><0.001<B>)</B>. Participants clearly distinguished between the two kinds of stimulation and rated higher sensory ratings in the VA session (penetration sensation: 4.9±3.1 vs. 1.7±2.3, acute pain: 4.9±2.7 vs. 1.9±2.6, respectively; <I>p</I><0.01).</P><P><B>Conclusions</B></P><P>Our findings demonstrate that differential biomechanical forces such as insertion and pullout force contribute to the sensation of real and non-penetrating sham needles.</P>
Hyun Sik Na,Seon-young Lee,Hong Ki Min,Jooyeon Jhun,Jeong-Won Choi,Jeong Su Lee,In Gyu Um,Sung-Min Kim,Seung-Ki Kwok,Mi-La Cho,Sung-Hwan Park 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Background: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compounds developed using modern drug technologies. Methods: We used a collagen-induced arthritis (CIA) model in Macaca fascicularis. CIA was induced by the immunization of chicken type II collagen. Swelling was measured as the longitudinal and transverse axes of 16 proximal interphalangeal joints. Results: A new system for visual evaluation was created, with a perfect score of 16. Individual behavioral analysis was also conducted. Serum was collected once a week after the first immunization. Blood chemistry and inflammatory cytokine parameters were higher in the CIA group than in the wild type group. Conclusion: In conclusion, we established CIA in M. fascicularis, and the results can be used for drug evaluation models
Lee A Ram,Lee Seon-Yeong,Choi Jeong Won,Um In Gyu,Na Hyun Sik,Lee Jung Ho,Cho Mi-La 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Keloid disorder is an abnormal fibroproliferative reaction that can occur on any area of skin, and it can impair the quality of life of affected individuals. To investigate the pathogenesis and develop a treatment strategy, a preclinical animal model of keloid disorder is needed. However, keloid disorder is unique to humans, and the development of an animal model of keloid disorder is highly problematic. We developed the patient-derived keloid xenograft (PDKX), which is a humanized mouse model, and compared it to the traditional mouse xenograft model (transplantation of only keloid lesions). To establish the PDKX model, peripheral mononuclear cells (PBMCs) from ten keloid patients or five healthy control subjects were injected into NOD/SCID/IL-2Rγnull mice, and their keloid lesions were grafted onto the back after the engraftment of immune cells (transplantation of keloid lesions and KP PBMCs or HC PBMCs). Four weeks after surgery, the grafted keloid lesion was subjected to histologic evaluation. Compared to the traditional model, neotissue formed along the margin of the grafted skin, and lymphocyte infiltration and collagen synthesis were significantly elevated in the PDKX model. The neotissue sites resembled the margin areas of keloids in several respects. In detail, the levels of human Th17 cells, IL-17, HIF-1a, and chemokines were significantly elevated in the neotissue of the PDKX model. Furthermore, the weight of the keloid lesion was increased significantly in the PDKX model, which was due to the proinflammatory microenvironment of the keloid lesion. We confirmed that our patient-derived keloid xenograft (PDKX) model mimicked keloid disorder by recapitulating the in vivo microenvironment. This model will contribute to the investigation of cellular mechanisms and therapeutic treatments for keloid disorders.