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후복막강경 근치적 신적출술 : 개복 근치적 신적출술과의 비교
김경영,임동훈,문형윤,노준,김철성 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S
Purpose: Although kidney is located in the retroperitoneal space laparoscopic radical nephrectomy is usually performed by the transperitoneal approach. At our institution the retroperitoneal approach is preferred. We evaluated the surgical outcomes, safety, oncologic outcomes, and compared with the results those of open radical nephrectomy in a contemporary cohort. Materials and Methods: Between January 2000 and December 2005 we performed retroperitoneal laparoscopic radical nephrectomy for renal cell carcinoma in 37 patients with clinical stage cT1 and cT2. Data from the these patients were retrospectively compaired with 30 contemporary cases treated with open radical nephrectomy. The clinical parameters including perioperative outcomes, complications, pathologic data, learning curve and recurrence were evaluated. Results: For the 37 retroperitoneal radical nephrectomies mean tumor size was 4.6cm (range 2.3 to 8.0), surgical time was 203.6min (range 110-410) and blood loss was 241.8cc. Mean specimen size was 10.4cm (8.7-14.4). Mean analgesic used day was 1.3 (0-4) and mean postoperative hospital stay was 4.2 days. minor complications occur in 16 cases and no major complications occurred. Surgical margins were negative for tumor in all patients. Variable parameters were comparable between patients undergoing laparoscopic and open radical nephrectomy. However, laparoscopy resulted in decreased blood loss, surgical times, analgesia use, time to oral intake, time to drain removal and postoperative hospital stay. No different complication rate is between two groups Conclusions: Retroperitoneal laparoscopic radical nephrectomy can be a safe and effective treatment in renal cell carcinoma. Although no long-term follow-up is available, our follow up to mean 31 months confirm the effectiveness of retroperitoneal laparoscopic radical nephrectomy in terms of surgical principles and oncological effectiveness.
Rhodiosin, an Antioxidant Flavonol Glycoside from Rhodiola rosea
Kwon, Hyung-Jun,Ryu, Young-Bae,Jeong, Hyung-Jae,Kim, Jang-Hoon,Park, Su-Jin,Chang, Jong-Sun,Kim, Min-Soo,Rho, Mun-Chual,Lee, Woo-Song The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.5
The EtOAc fraction of Rhodiola rosea ethanolic extracts showed a strong antioxidant activity. Through activity-guided fractionation and purification, we isolated two flavonol glycosides, which were identified as the well known flavonoids, rhodionin (1) and rhodiosin (2). To compare their antioxidant activities, we used an authentic aglycone compound, herbacetin (3). Among the compounds tested, rhodiosin (2) exhibited strong antioxidant activity, with $IC_{50}$ values of 0.21 and 0.15 ${\mu}M$ against ${\cdot}OH$ and ${\cdot}O^-{_2}$, respectively. Rhodiosin (2) (100 mg/kg) reduced MDA content in the liver induced by irradiation when given prior to exposure of ${\gamma}$-radiation.
田丙勳,盧永洙,李鮮亨,趙賢熙,咸泰英 인제대학교 1982 仁濟醫學 Vol.3 No.3
본 교실에서는 최근 14세 된 남아에서 右側下頸部의 瘻管을 동반한 甲狀舌管 襄腫 1例를 치험하였기에 약간의 문헌적 고찰과 더불어 보고하는 바이다. Thyroglossal duct cyst is one of the most common congenital cystic lesions in childhood. And the lesion has long been of interest to surgeons because it can be a source of morbidity resulting from recurrent infection and often pose a problem of different diagnosis. Authors experienced a case of thyrogossal duct cyst which was attested by a fistulogram. The patient was 14 year old and the fistula was extirpated completely from external orifice to foramen cecum by Sistrunk method. The histological examination revealed thyroid follicles around the cyst capsule which was uncommon on thyroglossal duct cyst. This paper was attemted to report a case with a brief review of literatures.
Facile synthesis of monodispersed silica-coated magnetic nanoparticles
Rho, Won-Yeop,Kim, Hyung-Mo,Kyeong, San,Kang, Yoo-Lee,Kim, Dong-Hyuk,Kang, Homan,Jeong, Cheolhwan,Kim, Dong-Eun,Lee, Yoon-Sik,Jun, Bong-Hyun Elsevier 2014 Journal of industrial and engineering chemistry Vol.20 No.5
<P><B>Abstract</B></P> <P>Silica-coated magnetic nanoparticles (MNPs) have great potential for use in field of biotechnology owing to their unique properties, which can be manipulated by an external magnetic field gradient. Herein, we describe a method for facile synthesis of monodispersed silica-coated MNPs (MNP@SiO<SUB>2</SUB> NPs). Commercially available oleate-MNPs were successfully converted to polyvinylpyrrolidone-MNPs (PVP-MNPs), and then coated with silica by the modified Stöber method. More than 95% of MNPs were individually coated with a silica shell; non-magnetic core silica nanoparticles (NPs) were not detected. Notably, the MNP@SiO<SUB>2</SUB> NPs are highly monodispersed in size (size distribution<2.5%) and synthesis at the scale of grams was easily obtained by a simple scale up process. Moreover, aggregation was not detected upon storage of over three months.</P>
( Hun Jun Park ),( Tai Ho Rho ),( Chan Seok Park ),( Sung Won Jang ),( Woo Seung Shin ),( Yong Seog Oh ),( Man Young Lee ),( Eun Ju Cho ),( Ki Bae Seung ),( Jae Hyung Kim ),( Kyu Bo Choi ) 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.3
Background: The brachial-ankle pulse wave velocity (baPWV) is a useful parameter to assess arterial stiffness. However, it is difficult to evaluate arterial stiffness in hypertensive patients because the baPWV is affected by the blood pressure itself. This study was designed to estimate the relationship between the change of the blood pressure parameters and the baPWV (ΔbaPWV) when hypertensive patients were subjected to an acute reduction of blood pressure. Methods: Thirty patients with essential hypertension and whose blood pressure was higher than 140/90 mmHg were enrolled. In all the patients, the blood pressure and baPWV were measured using an automatic waveform analyzer with the patients at a resting state. When the reduction of blood pressure was more than 10 mmHg after sublingual administration of nifedipine 10 mg, then the blood pressure and baPWV were measured again in the same manner and then they were compared with the baseline values. Spearman`s correlation and multiple linear regression tests were performed to estimate the relationship between the change of the blood pressure parameters (ΔSBP, ΔDBP, ΔMAP and ΔPP) and the ΔbaPWV. Results: The baPWV was significantly decreased shortly after the administration of nifedipine (1903.6±305.2 cm/sec vs. 1716±252.0 cm/sec, respectively, p<0.01). The ΔbaPWV was correlated with the ΔSBP (r=0.550, p<0.01), ΔDBP (r=0.386, p<0.05), ΔMAP (r=0.441, p<0.05), and ΔPP (r=0.442. p<0.05). On the multiple regression analysis, the ΔSBP was the only significant variable for predicting the ΔbaPWV, and the linear equation was ΔbaPWV=8.7×SBP-48. Conclusions: The baPWV is affected by the systolic blood pressure level to a large degree and careful attention must be paid to the blood pressure level when evaluating arterial stiffness with using the baPWV.
Kim, Hyung-Mo,Kang, Yoo-Lee,Chung, Woo-Jae,Kyeong, San,Jeong, Sinyoung,Kang, Homan,Jeong, Cheolhwan,Rho, Won-Yeop,Kim, Dong-Hyuk,Jeong, Dae Hong,Lee, Yoon-Sik,Jun, Bong-Hyun Elsevier 2015 Journal of industrial and engineering chemistry Vol.21 No.-
<P><B>Abstract</B></P> <P>A better understanding of protein–protein interactions can be obtained from multiplex protein detection technologies, and spectrally encoded beads can provide fast and efficient means for this type of detection methods. However, high-throughput detection is challenging due to the requirement of using labeled secondary proteins to detect protein binding events. We have previously reported that polydiacetylene-coated surface-enhanced Raman scattering-encoded beads (PDA–SERS beads) can provide an enhanced encoding capacity owing to their SERS properties as well as their potential for label-free detection from the PDA layer. In this study, we introduced ligands to the PDA–SERS beads by using methods for making free-floating vesicles and planar solid substrates, which enabled the detection of target proteins by PDA fluorescence in a PDA–SERS beads system. By using PDA–SERS beads immobilized with biotin, the fluorescence intensities of biotin-conjugated PDA–SERS beads were increased with an increase in the concentration of streptavidin. And, we could detect 2×10<SUP>−8</SUP> M of streptavidin by measuring the fluorescence intensity without the requirement of an additional labeling step.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>