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Chae, Ari,Jang, Hongje,Koh, Dong-Yeun,Yang, Cheol-Min,Kim, Young-Kwan Elsevier 2020 Talanta Vol.209 No.-
<P><B>Abstract</B></P> <P>The exfoliated MXene (e-MXene) is systematically investigated as a mediator for laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis. Whereas un-exfoliated MXene has no activity for LDI-MS analysis, the e-MXene presents a high resolution, salt-tolerance and efficiency for LDI-MS analysis of various small molecules regardless of their polarity, aromaticity and molecular weight owing to its physicochemical properties such as high laser energy absorption, electrical conductivity and photothermal conversion. Based on our findings, it is clearly confirmed that e-MXene is a promising material for the development of an efficient platform for LDI-MS analysis of small molecules.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The exfoliated MXene is applied to laser desorption/ionization time-of-flight mass spectrometry (LDI-MS) analysis for the first time. </LI> <LI> Various small molecules are successfully detected with the exfoliated MXene without background interference. </LI> <LI> Organic pollutants are successfully detected by using exfoliated MXene with LDI-MS analysis. </LI> <LI> High LDI-MS efficiency of MXene is achieved by its high laser energy absorption capacity, electrical conductivity, and photothermal conversion. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
김연희,윤주희,이재동,황성진,임채춘,정지한,김병기,남궁성은 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.5
원발성 난관암은 빈도가 드문 암의 하나로 여성 생식계 암의 약 1% 정도를 차지한다. 난관암은 조직학적 소견과 임상적인 성향이 난소암과 유사하며, 그 5년 생존율은 약 30-50%로 보고되고 있다. 임상 증상이 비특이적이며, 빈도가 낮아 수술전 진단이 어렵다. 또한 아직까지 질환 특유의 치료가 정립 되지 않았으나 병기 설정과 치료방법이 난소암과 유사하게 이루어지고 있다. 본 저자들은 부속기 종괴와 질출 혈로 외래 방문한 폐경기여성에서 각각 자궁내막종과 자궁내막염을 의심하였으나 시험개복술에서 조직학적으로 확진된 원발성 난관암 2 증례를 경험하였기에 간단한 문헌 고찰과 함께 이를 보고하는 바이다.
( Kyu Yeun Kim ),( Young Ae Yang ),( Jae Hee Kim ),( Sun Hee Park ),( Se Yong Jang ),( Myung Hwan Bae ),( Jang Hoon Lee ),( Dong Heon Yang ),( Hun Sik Park ),( Yong Keun Cho ),( Shung Chull Chae ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Preinfarction angina (PA) has benefi cial effects on early phase of left ventricular (LV) remodeling in patients who underwent thrombolysis for acute myocardial infarction (AMI). However, long-term impact of PA on subsequent changes in infarct size and LV functionin the current era of percutaneous coronary intervention (PCI) is unclear. Methods: Between November 2005 and November 2011, 506 post- MI survivors who underwent follow-up 2D-echocardiogram more than 1-year after baseline echocardiogram were analyzed. The clinical outcome was composite of reverse remodeling (RR) and wall motion score index (WMSI) recovery (WR). RR was defi ned as recovery of LV ejection fraction (EF) more than 5% and WR as improvement of WMSI grade compared to those of index admission. Results: PA was present in 312 (61. 7%). During the follow-up, changes in LVEF (4. 1±26. 9% versus -3. 7±20. 7%, p=0. 001) and WMSI (-7. 4±21. 3% versus -0. 6±22. 5%, p=0. 001) were significantly greater in patients with versus without PA. WMSI signifi cantly decreased compared to WMSI at baseline in patients with PA (1. 50±0. 41 versus 1. 36±0. 41, p Conclusions: PA has a long-term favorable effect on infarct expansion and LV function in late phase of post-MI survivors who underwent PCI.
내과계 중환자실에 입원한 객혈 환자들에 있어 APACHE 3 점수 체계의 예후적 가치에 관한 연구
양성연(Sung Yeun Yang),고윤석(Youn Suck Koh),임채만(Chae Man Lim),이무송(Moo Song Lee),유미란(Mi Ran Yoo),최강현(Gang Heun Choi),이상도(Sang Do Lee),김우성(Woo Sung Kim),김동순(Dong Soon Kim),김원동(Won Dong Kim) 대한내과학회 1997 대한내과학회지 Vol.53 No.3
N/A Background: Massive hemoptysis is one of the major medical emergency with high risk of mortality. Though the best predictor of mortality associated with hemoptysis appears to be the amount of bleeding within the first 24 hours, catastrophic hemorrhage could be occurred to the patients who were apparently in a stable condition with scanty hemoptysis at the time of admission. We evaluated APACHE III score system to find if it could be a prognostic index that can predict the mortality of the patients with hemoptysis. Methods : We identified all the patients who had admitted with hemoptysis in the Medical Intensive Care Unit of Asan Medical Center between May 25, 1989, and July 31, 1995. A retrospective analysis was done in 66 patients with hemoptysis on APA- CHE III score. Results: The overall mortality rate was 17.4% (12/69). In univariate analysis of possible prognostic factors, independent predictors of mortality were age(P=0.016), amount of hemoptysis(P=0.012), AaDO2 (P=0.017), requirement of transfusion(P=0.036), mechanical ventilatory care(P<0.05) and APACHE III score(P=0.02), In multivariate analysis with sex, age, amount of hemoptysis, AaDO2, requirement of transfusion and APACHE III score, APACHE III score was the only independent predictor of mortality(P=0.015, odd ratio=19.3, 95% confidence interval, 3.4 to 249.7) Conclusion: APACHE IU score may be a clinically significantly important independent predictor of outcome in the patients with hemoptysis. In addition, invasive procedure, such as bronchial artery embolizaticn or operation, could be considered in advance in the patients with more than 30 points of APACHE III.
( Young Ae Yang ),( Gyu Yeun Kim ),( Jae Hee Kim ),( Sun Hee Park ),( Se Yong Jang ),( Myung Hwan Bae ),( Jang Hoon Lee ),( Dong Heon Yang ),( Hun Sik Park ),( Yong Keun Cho ),( Shung Chull Chae ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Despite prognostic value of anemia, there have been few effective risk models incorporating anemia to predict major adverse cardiac events (MACEs). We aimed to assess whether modifi ed clinical SYNTAX score (mCSS) would improve the ability of the SYNTAX score (SS) and the Clinical SYNTAX score (CSS) to predict MACEs of patients undergoing primary percutaneous coronary intervention (PCI) after ST-elevation myocardial infarction (STEMI). Methods: The CSS was calculated in 642 patients by multiplying the SS to an ACEF score (age/left ventricular ejection fraction + 1 if estimated glomerular fi ltration rate >60ml/min). The mCSS was calculated by adding anemia to ACEF score (ACEF score + 1 if hemoglobin levels < 12. 0g/dL in women and Results: During the follow-up, rate of MACE was signifi cantly higher in the highest tertile group compared with patients in the lower 2 tertiles (1. 4% versus 4. 2% versus 14. 7%; log-rank p Conclusions: Novel mCSS incorporating anemia improves the discrimination accuracy of SS and CSS to predict MACEs of patients underwent primary PCI after STEMI.
Loxoprofen sodium 플라스타의 소염 , 진통 작용 및 혈중 약물 농도에 대한 연구
채주병(Joo Byung Chae),전홍렬(Hong Ryeol Jeon),이승목(Seung Mok Lee),정남주(Nam Joo Jeong),김수균(Soo Kyun Kim),조길도(Kil Do Cho),김동연(Dong Yeun Kim) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.2
Loxoprofen-Na (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate) is a potent analgesic drug. We developed loxoprofen-Na plasters to extend duration time of analgesic activity and to reduce side effect on gastrointestinal tract. Analgesic effect of Loxoprofen-Na plasters was investigated. Loxoprofen-Na plaster had good analgesic effect in rat paw pressure test, Tail-flick latency test and acetic acid-induced writhing test. Also, it had anti-inflammatory effect on carrageenan-induced rat hind paw edema. In pharmacokinetic study of Loxoprofen-Na, plasters dosage form showed that plasma drug concentration was prolonged up to 14 hours. So, we can conclude that loxoprofen-Na plasters, when applied on skin, will he a new type of drug for controlling the various local pain or inflammation.
민들레추출물이 당뇨유발 흰쥐의 장내 미생물 균총에 미치는 영향
박지윤(Ji-Yoon Park),장주연(Joo-Yeun Jang),이미경(Mi-Keung Lee),박은미(Eun-Mi Park),김명주(Myung-Joo Kim),손동화(Dong-Hwa Son),정현채(Hyun-Chae Chung),조수열(Soo-Yeul Cho) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.6
민들레의 추출물을 급여한 흰쥐에게 streptozotocin으로 당뇨를 유발하여 장내 미생물 균총에 미치는 영향을 구명하기 위하여 Wistar계의 이유한 웅성 흰쥐 64 마리를 난괴법으로 8군으로 나누어 streptozotocin(55 mg/kg BW)과 식이 kg당 11.45 g의 민들레가 함유되도록 부위와 분획별로 나누어 식이에 첨가하여 50일간 사육하였다. 당뇨-대조군의 총혐기성균은 14일간 증가하다가 당뇨로 인하여 감소를 나타내었으며 잎 추출물 급여시 50일에는 당뇨-대조군에 비하여 증가되었다. 뿌리-에틸아세테이트 추출물 급여군은 당뇨-대조군에 비하여 총혐기성균수가 많은 것으로 나타났다. 민들레의 잎과 뿌리의 추출물 급여초기인 14일의 총호기성균은 당뇨-대조군에 비하여 높았으나 35일에는 당뇨-대조군에 비하여 낮은 것으로 나타났으며 50일에 총호기성균수의 변화결과는 총혐기성균의 변화양상과 유사한 것으로 관찰되었다. 장내 미생물의 변화는 당뇨가 유발된 50일에 당뇨-대조군에 비하여 민들레 잎-열수 추출물군과 잎-에틸아세테이트 추출물군에서 Lactobacillus 증가가 현저하였으며, E. coli 감소는 잎과 뿌리의 열수 추출물군과 에틸아세테이트 추출물군이 당뇨-대조군과 유사한 수준이며 특히 열수 추출물군의 E. coli 억제효과가 관찰되었다. 본 실험결과 민들레추출물이 당뇨유발된 흰쥐의 장내 미생물에 유익한 효과로 숙주의 감염에 대한 저항력이 있는 것으로 나타났다. This study was designed to test the effect of dandelion (Taraxacum officinale) extracts on the intestinal micro-organisms of streptozotocin-induced diabetic rats. Male Wistar rats were divided into normal, diabetic control and dandelion extract groups. The extracts were prepared by water, ethylacetate and ether from leaf and root, respectively. Diabetes was induced by injecting streptozotocin (55 mg / kg BW, i.p.) in citrate buffer. The extract was supplemented in 11.45 g of raw dandelion / kg diet for 50 days. The growth of Lactobacillus was more enhanced in dandelion leaf-water and leaf-ethylacetate extract group than that of the diabetic control group, whereas the growth of E. coli decreased. Results indicate that the dandelion extracts would be effective to improve the intestinal microorganisms.
이차원 수소자기공명분광법을 이용한 BPTI의 공명주파수 지정
한규훈,정동호,박규환,채동연,김수경,유현주,Han, Kyou-Hoon,Choung, Dong-Ho,Park, Kyu-Hwan,Chae, Dong-Yeun,Kim, Soo-Kyung,Yoo, Hyun-Ju 생화학분자생물학회 1994 한국생화학회지 Vol.27 No.5
BPTI(Basic Pancreatic Trypsin Inhibitor)에 phase-sensitive COSY(shift COrrelation SpectroscopY), DQF(Double Quantum Filtered)-COSY, TOCSY(TOtal shift Correlation SpectroscopY), NOESY(two-dimensional NOE SpectroscopY) 등의 2차원 핵자기공명분광법을 사용하여 수소 공명주파수를 지정하고 $^{3}J_{HNa}$ 값을 측정하여 기존 문헌치(Wagner et al., 1987; Berndt et al., 1992)와 비교한 결과 chemical shift 값, 공명주파수 지정에 사용된 순차적 NOE 및 $^{3}J_{HNa}$ 값 등이 거의 일치한다. 한편, 본 연구에서는 기존 문헌에서 지정하지 않은 14개의 수소 공명주파수를 추가로 지정할 수 있었다. Two-dimensional NMR methods such as phase-sensitive COSY (shift COrrelation SpectroscopY), DQF (Double Quantum Filtered)-COSY, TOCSY (TOtal shift Correlation SpectroscopY), NOESY (two-dimensional NOE SpectroscopY) in $H_{2}O$ and $D_{2}O$ have been used to achieve resonance assignment for basic pancreatic trypsin inhibitor. Results are in good agreement with the previous reports by Wuthrich and his coworkers (Wagner et al., 1987; Bemdt et al., 1992). In addition, in this work, we have assigned 14 additional resonances that were not assigned before.