네모나프라이드의 유효성 및 추체외로 부작용 : Haloperidol 및 Risperidone과의 자연관찰적 개방형 비교연구 A Naturalistic Open Comparative Study with Haloperidol and Risperidone

서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psycho­pathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.

Survival rate and stylet penetration behavior of current Korean populations of the brown planthopper, Nilaparvata lugens, on resistant rice varieties

Bo Yoon Seo,정진교,Byeong-Reol Choi,Hyung-Man Park,Si-Woo Lee,Bong Hoon Lee 한국응용곤충학회 2010 Journal of Asia-Pacific Entomology Vol.13 No.1

To understand the development of host plant resistance-breaking ability of the current BPH populations in Korea, we conducted nymphal survivorship tests and electrical penetration graph (EPG) studies on susceptible and resistant rice varieties with four different BPH populations, which were collected in the early 1980s (S-BPH) and in 2005, 2006, and 2007. The S-BPH had low survival rates on resistant rice varieties carrying either Bph1 or bph2. However, the current BPH populations have high resistance-breaking ability on the varieties with their elevated survival rates, whereas their survival rates were still low on the other resistant varieties, Gayabyeo (Bph1 the other unknown gene) and Rathu Heenati (Bph3). The EPG analysis also revealed that the ratio of BPH that could reach the phloem sap ingestion waveform (N4-b) within 15 h on the resistant rice varieties containing Bph1 or bph2 was higher in the current BPH populations (16.7–50%)than in the S-BPH population (0-4.2%). However, the pre-reaching time from the penetration start to the first N4-b waveform in the current BPH populations was significantly longer on resistant varieties (Bph1 or bph2)than on susceptible varieties. Furthermore, the total duration of N4-b waveform was significantly shorter on the resistant varieties. From these results, we suggest that, although the current BPHs collected in Korea have a high resistancebreaking ability through the increase of survival rate on resistant rice varieties carrying either Bph1 or bph2,they still have some difficulties feeding on the phloem sap of the resistant rice varieties.

Electrical penetration graphic waveforms in relation to the actual positions of the stylet tips of Nilaparvata lugens in rice tissue

Bo Yoon Seo,Youn-Hee Kwon,김길하,정진교 한국응용곤충학회 2009 Journal of Asia-Pacific Entomology Vol.12 No.2

The stylet penetration behavior of Nilaparvata lugens (Hemiptera: Delphacidae) in rice plants (Oryza sativa)was evaluated through the use of an electrical penetration graph (EPG). To accomplish this, we classified theEPG signals into seven different waveforms, np, N1, N2, N3, N4-a, N4-b, and N5, according to their shapes,amplitudes, and frequencies. The N4-b waveform was always preceded by N3 and N4-a, in that order. Continuous honeydew excretion only occurred during the N4-b period, and the honeydew deposited on afilter paper containing ninhydrin reagent during the N4-b period was stained violet. The tips of the styletsthat were severed in the N3, N4-a, and N4-b periods were in the phloem region of rice. Moreover, the flow ofplant sap after stylectomy only occurred during the N4-b period. Finally, sucrose was the only carbohydratecomponent identified when HPLC analysis of the plant sap was conducted. On the other hand, honeydewexcretion hardly occurred during the N5 period and the tips of the stylets that were severed during the N5period were located in the xylem region of rice. Based on the location of the stylets and honeydew excretion,the EPG waveforms for the stylet penetration behaviors of N. lugens were assigned to the following groups;np: non-penetration of stylets, N1: penetration initiation, N2: salivation and stylet movement, N3: anextracellular activity near the phloem region, N4-a: an intracellular activity in phloem region, N4-b: phloemsap ingestion, and N5: activity in the xylem region

An orange-eye mutant of the brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae)

Bo Yoon Seo,Jin Kyo Jung,Yeong-Tae Kim 한국응용곤충학회 2011 Journal of Asia-Pacific Entomology Vol.14 No.4

An orange-eye mutant of the brown planthopper (BPH), Nilaparvata lugens (Stål), was found in a green house and has since been maintained together with a normal-eye phenotype of BPH in an insectary. The orange color was expressed in all developmental stages of BPH: the eye spots of eggs and the eyes of nymphs and adults of both sexes and wing forms. Cross-mating results suggested that the inheritance of the orange-eye phenotype is controlled by a single autosomal recessive allele. The gene symbol related to this mutant was designated as “org”. Developmental duration and mortality of nymphal stages were not significantly different between the normal phenotype (homozygous and heterozygous) and the mutant. In addition, reproduction was not significantly different among mating combinations of the three BPH genotypes (+/+, +/org, org/org). The effect of eye color on mating of BPH was insignificant in a mate choice test which consisted of one orange-eye female, one orange-eye male, and one homozygous normal-eye male. Offspring produced by the orange-eye female BPH hatched and developed into adults normally, indicating that the eye color mutant found in this study is different from the red-eye BPH (Mochida, 1970) which showed the egg lethal effect in the red-eye BPH female

Efficient Red Organic Light-Emitting Diodes Using 2-(2-(4-Pentylbicyclo[2.2.2]octan-1-yl)-6-(2-(1,1,7-trimethyl-7-triphenysiliyllethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)vinyl)-4H-pyran-4-ylidene)malononitrile as a Fluorescent Red Emitter

Seo, Bo Min,Seo, Ji Hoon,Kim, Jun Ho,Park, Jung Sun,Lee, Kum-Hee,Park, Min Hye,Yoon, Seung Soo,Kim, Young Kwan Informa UK (TaylorFrancis) 2011 MOLECULAR CRYSTALS AND LIQUID CRYSTALS - Vol.550 No.1

Introduction of Neodryinus typhlocybae and biological control of invasive Metcalfa pruinosa

Bo Yoon Seo,Jum-Rae Cho,Chang-Gyu Park,Jeong Hwan Kim,Gwan-Seok Lee,Kwang-Ho Kim,Jin-Kyo Jung,Sung Jun Hong,Ki-Su Ahn 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

미국선녀벌레(Metcalfa pruinosa)는 외래 침입해충으로 조사가 시작된 2009년 이후 발생지역과 발생면적이 계속 증가하여 2018년에는 123개 시군구의 21,154ha에서 발생이 보고되고 있다. 미국선녀벌레는 농경지와 그 주변 산림지에서 활동하기 때문에 정부와 지자체간 협업을 통해 농림지 동시방제를 5월하순경(부화약충 대상)과 7월 중순경(성충 대상) 2회 실시하고 있다. 농촌진흥청에서는 미국선녀벌레의 기생천적인 선녀벌레집게벌(Neodryinus typhlocybae)의 안정적인 도입과 미국선녀벌레에 대한 생물적 방제원으로서 국내 정착을 위해 이탈리아 파도바대학과 국제협력사업을 2017년부터 수행하고 있다. 선녀벌레집게벌은 완주에서 월동이 가능하였으며 6월 초에 50%이상 우화를 하였다. 2018년도에 온실(완주)과 야외(수원, 태안)에서 증식하여 1,000여 개체 이상을 확보하였으며 도입천적의 안정적인 국내 정착과 확산 및 활용 방안에 대해 논의하고자 한다.

Female mate choice test of the brown planthopper (BPH) in the male-male competition-free conditions

Bo Yoon Seo,Jin Kyo Jung 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.10

In the previous study, the effect of orange-eyed color on mating of BPH was not clearly occurred, and the mating preference and multiple mating of female were cautiously suggested. To understand about the BPH female mate selection in the male-male competition-free conditions and the point of time for multiple mating, we designed four different combinations of the mate choice test with one virgin orange-eyed female (org/org) and two male BPH adults, orange-eyed male (org/org) and homozygous normal-eyed male (+/+). We gave the four different mating chances to female by the order of incubation (the first male and the following second male) and the incubation time (one day and days on end) of the second male. The distribution of the eye-color phenotype in F1 progeny and their hatching-order were observed in each mating combination. In the results, fourteen females out of twenty in four combinations produced progenies in accordance with mating chance priority of the first male, while three females of one combination selected the second male as a gamete. Interestingly, in three females of one combination with the continuous incubation of the second male, after eggs fertilized by the first male were continuously produced and then egg-laying was finished, progenies of the second male were started to be produced. From these results, it was suggested that mating order determines egg-laying order of female and the second mating of female would be occurred when sperm of the first male was almost exhausted in the reproductive organ.

The complete mitochondrial genome of Thrips palmi (Thysanoptera: Thripidae) in Korea

Bo Yoon Seo,Gwan-Seok Lee 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

오이총채벌레(Thrips palmi Karny)는 동남아시아지역이 원산으로 국내 침입 외래해충이다. 주로 노지와 하우스에서 재배되는 박과(Cucurbitaceae)와 가지과(Solanaceae) 작물에 직접 섭식과 바이러스 매개에 의한 피해가 크다. 본 연구에서는 차세대염기서열분석기술(NGS)을 통해 오이총채벌레의 미토콘드리아 전장 게놈을 해독하였으며 염기서열 신규 조립(de novo assembly) 결과 전체 길이가 16,414bp인 원형의 유전체로 추정되었다. 미토콘드리아 게놈 전체에서 뉴클레오티드는 A와 T가 78.5%를 차지는 특징을 보였다. 동물의 미토콘드리아 게놈에서 일반적으로 발견되는 37개 유전자 영역에 대해 BLAST 검색을 한 결과 trnV는 탐색되지 않았다. 본 발표에서는 신규 조립된 오이총채벌레 미토콘드리아 게놈 유전체에 포함된 유전자의 종류와 배열 등에 대한 기초 통계자료를 정리하였다.

Resistance-breaking ability and feeding behavior of the brown planthopper, Nilaparvata lugens, recently collected in Korea

Bo Yoon Seo,Jin Kyo Jung,Byeong-Reol Choi,Hyung Man Park 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.05

Resistance-breaking ability of wild brown planthopper (BPH), Nilaparvata lugens, on resistant rice cultivars has been reported in many Asian countries. To understand the development of resistance-breaking ability of wild BPH in Korea, we conducted the nymphal survivorship test and the electrical penetration graph (EPG) on susceptible and resistant rice cultivars with four different BPH populations, which were collected in the early 1980s (S-BPH), 2005, 2006, and 2007, respectively. The S-BPH showed low survival rates on resistant rice cultivars carrying Bph1 and bph2, respectively. On the other hand, recent(2005~2007) wild BPH populations seemed to have high resistance-breaking ability because they maintained elevated survival rates on most other resistant rice cultivars except Gayabyeo (Bph1 and bph2) and Rathu Heenati (Bph3). In the EPG monitoring, however, wild BPHs could not easily feed on the phloem sap of resistant rice cultivars, Cheongcheongbyeo (Bph1), ASD7 (bph2), and Gayabyeo. Wild BPHs spent more time on reaching the phloem sieve elements of resistant cultivars. Ph waveform duration and honeydew excretion amount of wild BPHs also decreased. From the results, we suggest that though recent wild BPHs collected in Korea have high resistance-breaking ability simultaneously on rice cultivars carrying Bph1 and bph2 through the increase of survivorship, they still have to pay some cost to feed on the phloem sap of resistant rice cultivars.

Registance Mechanism of the Diamondback Moth (Plutella xylostella) to Prothiofos

Seo Bo-Yoon,Lee Dae-Weon,Chung Bu-Keun,Boo Kyung-Saeng 한국응용곤충학회 2004 한국응용곤충학회 학술대회논문집 Vol.2004 No.1