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李聖洙,金相仁,金勇一,全鍾暉,宋宣普,玄瑗 서울대학교 1963 서울대학교 論文集 Vol.14 No.-
An autopsy case of disseminated cryptococcosis in a 20 year old Korean female has been reported. Both gelatinous and granulomatous lesions are observed in the lungs, liver, extrahepatic biliary system, spleen, pancreas, adrenals, kidneys, small intestine, lymphnodes, bone marrow, skin, and leptomeninges and brain. Large numbers of micro-organism, that are spherical or ovoid, non-sporulating, non-mycelial, yeast-like with evidence of budding measuring 5-20 microns in diameter, and with thick gelatinous capsules, are found in the lesions. These morpholomans, gical characteristics of the organisms are strongly consistant with cryptococcus neofor-although cultures of the organisms have been failed to be performed. The gelatinous lesions consist mainly of masses of micro-organisms with little inflammatory response, while the granulomatous lesions reveal numerous lymphocytes, plasma cells, epitheloid cells and macrophages frequently forming giant cells, occasional neutrophils and variable number of fibroblastic cells. In case, caseous or coagulative type of necrosis is observed, and these focal lesions contain many degenerated organisms in the periphery. Neutrophilic infiltration is meager, and calcification in the lesions is not observed. These anatomical changes characterized by non-suppurative and granulomatous reaction and by gelatinous appearance of the lesion appear to be distinctly different from other mycotic infections than cryptococcosis. In this case, extensive leptomeningeal and limited cerebral cortical involvement is assumed to have been a late event, that formed the probable direct cause of death of the patient. The portal of entry of the organisms in this case has been discussed with special emphasis on the respiratory tract infection. This is believed to be the first reported autopsy case of cryptococcosis in the Korean literature.
혈구용적치로 보정한 Zinc Protoporphyrin과 혈중연농도 및 다른 연폭로 지표들과의 상관성
안규동,이병국,이성수 순천향대학교 1994 논문집 Vol.17 No.4
The measurement of zinc protoporphyrin(ZPP) in the whole blood with potable hematofluorometer is often used as primary screening tool to identify high lead absorption in the field setting for its' convenience and direct readability. The current unit of ZPP with hematofluorometer adopted in Korea is ug per 100 ml of whole blood with the adjustment of hematocrit(Hct) correction of 42% which is the unit of OSHA in U.S.A. But the average of Hct of male and female is quite different and real expected ZPP can be under or over estimated by individual Hct value if it is adjusted with Hct 42%. This study intended to investigate the effect of Hct adjustment of ZPP on the inter-relationship of other lead exposure indices such as lead in whole blood(PbB) and delta-aminolevulinic acid(DALA) and to check whether hematocrit adjusted ZPP will change the validity of ZPP in screening of lead workers under current lead regulation of Industrial Safety and Health Act. Authors studied 435 male and 12 female lead workers working in storage acid battery and secondary smelting industries. The selected variables for this study were PbB, Hct and hemoglobin(Hb) in the blood and DALA in urine. The results were as follows : 1. While the mean values of Hct in male and female workers were 46.5% and 40.2%, those of Hb in male and female workers were 15.7g/이 and 13.2g/이, respectively. 2. While the correlation coefficients between PbB and un-corrected ZPP were 0.604 in male lead workers and 0.635 in female lead workers, those between PbB and corrected ZPP were reduced to 0.586 in male and 0.603 in female lead workers, but the correlation coefficient of corrected ZPP and others variables in male and female were increased. 3. The prevalence of screening positive(ZPP≥151ug/이) by un-corrected ZPP in male lead workers was 10.0%, but it was decreased to 8.1% by applying Hct corrected ZPP. On the contrary, the prevalence of screening positive(ZPP≥151ug/이) in female lead workers increased from 20.3% to 22.8% by Hct correction of ZPP. It was confirmed that for the screening of lead workers with ZPP male workers are likely overestimated with current Hct 42% adjusted ZPP and underestimated in female lead workers accordingly.