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TB와 냅색 기반의 향상된 다기능 레이다 스케줄링 기법
황민영,양우용,신상진,전주환 한국전자파학회 2018 한국전자파학회논문지 Vol.29 No.12
현대의 레이다는 위상 배열 안테나로 전자기파 빔을 생성하여 여러 가지 작업을 수행한다. 레이다가 수행하는 작업으로는 목표물의 탐지와 추적, 미사일 유도 등이 있다. 다기능 레이다가 개발되기 이전에는 레이다는 한 가지 작업만을수행할 수 있기에, 각 작업을 수행하는 독립된 레이다가 필요했다. 하지만 다기능 레이다는 다양한 작업을 총괄하여 수행할 수 있는 기능을 탑재하고 있기 때문에, 하나의 레이다로 필요한 여러 작업을 수행할 수 있다. 레이다의 한정된 시간자원을 효율적으로 이용하기 위해 예약된 작업을 적당한 순서로 나열하는 기법을 스케줄링이라고 한다. 본 연구에서는두 가지의 스케줄링 기법들을 파악하여 효율적인 스케줄링 기법을 제시하여 보았다.
Functional Role of Parkin against Oxidative Stress in Neural Cells
황민영,이자명,김영화,금동호 대한내분비학회 2014 Endocrinology and metabolism Vol.29 No.1
Background: Parkinson disease (PD) is caused by selective cell death of dopaminergic neurons in the substantia nigra. An early onset form of PD, autosomal recessive juvenile parkinsonism has been associated with a mutation in the parkin gene. The function of parkin is known to remove misfolding proteins and protect cell death. We aimed to investigate the role of parkin against oxidative stress in neuronal cells. Methods: Parkin knockout embryonic stem cells (PKO ES cells) were differentiated into neurons by adherent monolayer culture method. Oxidative stress was induced by the treatment of 1-methyl-4-phenylpyridinium (MPP+) in neurons derived from wild type and PKO ES cells, and cell viability was examined by MTT assay. After exposure to MPP+, Tuj1-positive cell population was compared between PKO and wild type cells by fluorescence activated cell sorter (FACS) analysis. The activated caspase3 protein level was also measured by Western blot analysis, FACS and immunocytochemistry. Results: There was no difference in the efficiency of neuronal differentiation between wild type and PKO ES cells. After exposure to MPP+, no significant differences were found in cell viability and Tuj1-positive cell population between the two groups determined by MTT assay and FACS analysis, respectively. The activated caspase3 protein levels examined by Western blot analysis, FACS and immunocytochemistry were not changed in PKO cells compared with those of wild type cells after MPP+ treatment. Conclusion: These results suggest that PKO neuronal cells including dopaminergic neurons are not sensitive to caspase3-dependent cell death pathway during the response against MPP+-induced oxidative stress.