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홍기숙,이순남,함정희 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4
Selective absence of serum IgA is the most commonly diagnosed form of human immnndefi-ciency disease, being reported in about one in 500-700 subjects in population surverys. Datailedclinical and laborattory studies of subjects with selective IgA deficiency generally reveal significantly increased incidence of sinopulmonary infection, gastrointestinal symptomatology, autoimmune disease and autoantibodies. Authors experienced selective IgA deficiency associated with an scleroderma in a 25 yearsold young woman. She had pulmonary tuberculosis, high IgE level, reactive rheumatoid factor,positive for antinuclear antibody, and no presence of anti-IgA antibody.
1, 2-dimethylhydrazine 투여로 유발된 백서 대장점막병변에 vitamin A(retinol)가 미치는 영향에 대한 형태학적 연구
홍기숙 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.4
Induction of intestinal tumor by subcutaneous injection of 1, 2-dimethylhydrazine(DMH), 20 ㎎/㎏/week, during 20 weeks was studied in rats fed by vitamin A(retinol) 50㎍, 500㎍/day. Mucosal epithelial cell hyperplasia and mitosis in one crypt was not significantly inhibited by vitamin A administration(P>0.05). In electron microscopic findings, the cytoplasmic vacuoles were decreased in DMH+vitamin A-treated rats than DMH only. Dysplasia of the colonic mucosa in DMH+vitamin A-treated group were more slowly developed than DMH-treated rats. In DMH-treated rats the tumors were early detected after 14 weeks, but in DMH+vitamin A-treated groups were seen after 20 weeks. All these findings suggest that vitamin A can effectively prevent cytotoxicity of carcinogen in early phase, but can not prevent carcinogenesis in late phase.
홍기숙 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4
Presented study was conducted to determine that the hepatitis C virus(HCV) may playa role in the pathogenesis of chronic liver disease including hepatocellular carcinima andliver cirrbosis. Using 2nd generation EIA author examined serum anti-HCV in total 2,641 cases, includingliver disease, physical check-up subjects at EWHA Womans University Hospital during 1 yearof 1992. The results were as fo11ows : Among total 2641 patients, overall prevalence of anti-HCV was4.5%, 1.7% positive rate for subjects whose physical check-up. Among total 103 anti-HCVpositive patients, the majority was chronic liver disease, liver cirrhosis, and hepatoma. Thepositivity of HBs Ag in anti-HCV positive patients was 4.4% and the anti-HBc was 49.5%. The mean ALT level was 69.3 U/L and the abnormal high level was found in 57.3% in anti-HCV positive patients. On the basis of the results above, anti-HCV test is very useful for the diagnosis and management in not only chronic liver disease such as hepatocellular carcinoma and cirrhosis, butalso chronic hepatitis diagnosed as B-hepatitis.
단일클론항체를 이용한 면역진단법의 연구 : Flow Cytometry에 의한 세표표면 표현형 검사 Flow Cytometry for Cell Surface Phenotyping
홍기숙 梨花女子大學校 醫科大學 醫科學硏究所 1992 EMJ (Ewha medical journal) Vol.15 No.1
With the development of monoclonal antibodies. they have various utilities for in-vitro diagnosis in differentiating tumor cell type, and for therapeutic purposes. I experimented the reaction of many known and new monoclonal antibodies using flow cytometry. The results are as follows: 1) There were 18 cases of B-lineage Acute lymphoblastic leukemia(ALL)(64%), 8 cases of T-lineage ALL(28%), 1 case of B-myloid ALL(4%) and 1 case of B cell All(4%) in 28 cases of ALL. 2) The reactions with anti-CD9, CD10, CD19, CD24, CD34, CD72 and HLA-DR were positive in most cases of non-T-All, and the reaction with ani-CD13, CD33, CD40 were relatively positive in a few cases of non-T-ALL. 3) The reaction with anti-CD24, CD19, CD20, CD72 and HLA-DR was strong positive in 1 case of Hairy cell leukemia(HCL). 4) There were 17 cases of B-Chronic lymphoytic leukemia(CLL)(71%), and 4 cases of T-CLL(17%) in 24 cases of CLL. 5) There were 8 cases of B-non Hodgkin's malignant lymphoma(NHL)(57%), and 4 cases of T-NHL(29%) in cases of MHL. 6) There were positive reaction with anti-CD2 in normal bone marrow, fetal bone marrow with anti-CD19, tonsil with anti-CD4, anti-CD19, and thymus with anti-CD2. Immunophenotype with panel of monoclonal antibodies using flow cytometry is very helpful to take diagnosis and treatment for hematologic malignancies.