역전사 중합효소연쇄반응을 이용한 태아혈액의 interleukin-1β, tumor necrosis factor-α, transforming growth factor-β의 발현 양상

최석태 서울대학교 대학원 1997 국내박사

목초추출물(목탄+목초액) 첨가가 Holstein 숫소의 비육능력, 도체성적 및 혈액의 지방산 조성 농도에 미치는 영향

최석태 建國大學校 農畜大學院 1998 국내석사

목초추출물(목탄+목초액)을 0, 0.5 및 1.0% 수준으로 사료에 첨가하여 120일간 Holstein 비육우 12두를 시험동물로 공시하여 비육능력, 사료이용성, 도체성적 및 혈액내 지방의 지방산 조성 등을 조사하여 얻은 결과는 다음과 같다. 1. 시험기간 동안의 평균 일당증체량은 0.70kg, 0.77kg 및 0.85kg으로 목초추출물(목탄+목초액) 첨가수준이 증가함에 따라 유의하게(P<0.05) 증가하였다. 2. 사료요구율(건물 섭취량/일당증체량)은 11.80, 10.75 및 9.76으로 목초추출물(목탄+목초액) 첨가수준이 증가함에 따라 유의하게(P<0.05) 개선되었으며, TDN 이용율도 7.94, 7.23 및 6.56으로 유의하게(P<0.05) 개선되었다. 3. 도체율은 목초추출물(목탄+목초액) 1.0% 첨가구가 60.75%로서 0% 첨가구의 57.95%, 0.5%첨가구의 58.33%에 비하여 유의하게(P<0.05) 높게 나타났다. 배최장근 단면적도 목초추출물(목탄+목초액) 1.0% 첨가구가 78.50㎠로서 0% 첨가구의 66.75%, 0.5% 첨가구의 68.75㎠에 비하여 유의하게(P<0.05) 넓게 나타났다. 4. 육량등급은 목초추출물(목탄+목초액) 0% 첨가구의 경우 B등급 3두, C등급 1두, 0.5% 첨가구는 B등급 4두 그리고 1.0% 첨가구는 A등급 2두, B등급 2두로 나타났다. 육질등급을 보면 모두 3등급으로 비슷한 결과를 나타냈다. 5. 혈액내 지방의 지방산 조성을 보면 목초추출물(목탄+목초액) 첨가에 따른 변화는 없었으나 포화도에 따른 변화에서 포화지방산의 경우 목초추출물(목탄+목초액)의 첨가수준이 증가함에 따라 감소하는 경향을 보인 반면 불포화지방산은 목초추출물의 첨가수준이 증가함에 따라 증가하는 경향을 나타내었다. This experiment was conducted to investigate of beef performances, carcass characteristics and plasma fatty acids composition of Holstein bulls fed on charcoal and woodvinegar mixture. Charcoal and woodvinegar mixture supplementation levels were 0, 0.5 and 1.0% of dry matter, and 12 Holstein bulls(A.V. 480kg) were used in this experiment for 120 days from 10th, Nov., 1997 to 10th, Mar., 1998. The results of this experiment are as follows. 1. Average daily weight gain of 0, 0.5 and 1.0% charcoal and woodvinegar mixture supplementation up to marketing were 0.70, 0.77, and 0.85kg/day, respectively, and with increased significantly by supplementation level(P<0.05). 2. The amount of feed requirements per growth(feed, kg/gain, kg) of 0, 0.5 and 1.0% charcoal and woodvinegar mixture supplementation were 11.80, 1075 and 9.76, and TDN requirements were 7.94, 7.23 and 6.56, respectively. TDN and dry matter requirement for growth was improved by the increased chatrcoal and woodvinegar mixture supplementation in the feed(P<0.05). 3. Dressing rate of 1.0% of charcoal and woodvinegar mixture supplementation was higher(60.75%) than that of 0%(57.95%) and 0.5%(58.33%) supplementation, significantly(P<0.05). Loin eye area of 1.0% of charcoal and woodvinegar mixture supplementation was higher(78.50㎠) than that of 0%((66.75㎠) and 0.5% supplementation(68.75㎠), significantly(P<0.05). 4. From the yield and quality trait of experimental animal, Off of charcoal and woodvinegar mixture supplementation was observed 3 of grade B, 1 of grade C, and 0.5% supplementation was 4 of grade B, 1.0ff of supplementation was 2 of grade A and 2 of grade B, respectively. 5. The changes, in blood fatty acids composition were not observed an long treatment, however unsaturated fatty acids composition was tend to be increased by supplementation of charcoal and woodvinegar mixture of increasing.

Anti-tumorigenic and anti-angiogenic activities of Rubia alata Roxb extract in vitro and in vivo : 시험관 내 및 생체 내 Rubia alata Roxb 추출물의 항 종양형성과 항 혈관신생활성

최석태 경북대학교 대학원 2018 국내석사

Melanoma is the most serious form of skin cancer, and its incidence is increasing worldwide (5). Although detection and treatment have improved considerably, melanoma is highly resistant to chemotherapy and radiotherapy, and the prognosis remains very poor due to rapid metastasis (7). Therefore, new treatments for melanoma are greatly needed. Recently, research on new natural products has been actively carried out with some research results using natural products. Rubia alata Roxb is a plant species distributed in the southern region of China that has been used as a folk remedy. However, little is known about its anti-cancer and anti-angiogenic effects (1). In this study, the anticancer and anti-angiogenic effects of a Rubia alata Roxb methanol extract (RAE) were investigated in melanoma cells (B16F10) and endothelial cells (SVEC4-10). We demonstrated that RAE has anti-cancer effects on melanoma cells, and promotes cell cycle arrest and apoptosis, and inhibits angiogenesis in endothelial cells. Rubia alata Roxb는 중국의 남부 지역에 분포하고 있으며 민간요법으로 사용되어 왔습니다. 그러나 Rubia alata Roxb의 항암 효과 및 혈관 신생 억제 효과에 대해서는 알려진 바가 거의 없다. 그러므로, 본 연구에서는 Rubia alata Roxb 메탄올 추출물 (RAE)에 대한 항암 및 혈관 신생 억제 효과를 흑색종 세포 (B16F10) 및 내피 세포 (SVEC4-10)에서 조사하였다. 우리는 RAE가 내피세포의 독성이 없는 농도에서 암세포 독성을 조사하였다. 또한 RAE에 의해 CDK4 및 cyclinD1의 세포 주기 조절인자 발현을 조절함으로써 흑색종 세포의 세포주기가 억제하였다. 게다가 세포 자멸사를 유도하는 여러 조절인자 중에 Bax와 bcl-2에 발현 변화는 세포를 분해에 관련하는 cleaved caspase3를 증가시켰다. 다른 한편으로는 RAE가 혈관 내피세포의 세포이동 및 혈관형성은 감소시켰다. 이러한 결과는 혈관 신생을 유도하는 조절 인자인 FAK/Src의 활성화를 감소를 통한 결과임을 확인하였다. 본 연구에서는, 흑색종에 RAE의 항암효과 및 혈관내피세포의 혈관신생 억제를 처음 검증하였으며, 이를 활용한 새로운 신약 개발 가능성을 제공한다.

무신집권기 명종의 위상과 정국운영

최석태 연세대학교 교육대학원 2017 국내석사

1170년 발생한 무신정변으로 인해 고려는 100년간 무신들의 집권이 이어졌다. 무신집권기 무신들은 중요 관직을 차지하고 정치의 전면에 나섰다. 무신들은 잦은 권력 투쟁을 벌였고, 무신집권자의 교체는 빈번하게 발생했다. 이는 무신집권기에 고려가 처했던 혼란함을 상징한다. 무신집권은 국왕에게도 영향을 미쳤다. 무신들은 의종을 폐위하고 명종을 옹립했다. 무신들의 손에 의해 옹립된 명종은 무신들의 억압과 권력 사유화에 대응할 힘이 없었다. 하지만 명종이 허수아비처럼 무신들에게 휘둘리기만 한 존재였는지는 다시 생각해 볼 필요가 있다. 고려의 왕실은 태조 때부터 山神과 龍孫이라는 신성함을 통해 국왕의 상징성을 드러냈다. 명종도 왕실의 신성함을 통해 국왕의 상징성을 유지하고 있었다. 또한 불교의례와 유교의례를 적극적으로 시행하여 왕실의 신성함을 부각하기도 했다. 그리고 명종은 이의방‧정중부‧경대승‧이의민과 같은 무신집권자 및 무신들과 타협하여 왕실을 수호하려고 했다. 명종의 타협은 현실적인 한계에서 기인한 것이다. 무신들의 손에 의해 옹립된 명종이, 무신들과 대립하는 것은 왕실을 수호하는 측면에서 문제가 발생할 수 있었다. 또한 무신들 역시도 자신들이 옹립한 왕을 통해 권력을 사유화할 수 있었다. 따라서 이들의 타협은 서로에게 필요한 상황이었다. 명종은 이의민 집권기에 이르러 정국운영의 주도권을 회복하려고 한다. 명종이 반포한 王命을 통해, 자의적 판단을 내리고 있는 명종의 모습을 발견할 수 있다. 그리고 개혁안을 반포하여 최고 통치권자로서의 모습을 보이기도 한다. 또한 개혁안에는 고려 전기부터 내려오던 유교의 천명민본사상이 담겨있음을 확인할 수 있다. 천명민본사상을 담았다는 것은 국왕으로서의 존재감을 드러내려는 목적이 있다고 할 수 있다. 명종은 과거제와 국자감 학생의 선발을 지속적으로 실시하여 유학교육을 강조한다. 명종은 국왕의 위상과 정국운영의 주도권을 확보하기 위해 유교정치이념을 이용했으므로, 유학교육은 반드시 필요했다. 그리고 국가의 중요 관직에 자신의 측근을 임명하여 안정적인 정국운영을 시도했다. 하지만 명종은 최충헌의 정변으로 인해 1197년 폐위를 당하고 만다. 명종이 폐위를 당했다는 것은 왕실을 수호하고 정국운영의 주도권을 회복하려고 했던 노력이 실패로 끝났다는 것을 의미한다. Due to the outbreak of the military coup d'état, Koryo kingdom would be dominated by the military subjects for 100 years. During this period, the military subjects occupied most of the important public offices, leading the politics. They struggled with each other for the political power, and thus, the regimes were changed frequently. Such situations may well suggest that Koryo kingdom suffered a great confusion during the military regime. The military regime also affected the kings. The military subjects dethroned King Uijong and instead enthroned Myongjong. King Myongjong who was enthroned by the military subjects could not afford to counter his military subjects' oppression and privatization of the power. Nevertheless, we need to review the history again whether king Myongjong was controlled completely by his military subjects. Since king Taejo or the founder of Koryo kingdom, the royal family had been upheld as holly mountain spirits and dragon's descendents. King Myongjong maintained his holly symbol through such divinity of Koryo royal family. In addition, he implemented Buddhism and Confucianism rituals actively to highlight king's divineness. Furthermore, king Myongjong compromised with such influential military subjects as Lee Ui-bang, Jeong Jung-bu, Gyeong Dae-seung and Lee Ui-min to keep his royal family. His compromise was caused by the stark political reality. King Myongjong who was enthroned by the military subjects could not but confront them to keep his royal family. The military subjects could privatize the power through the king they enthroned. So, the compromise was needed by the king as well as his military subjects. When Lee Ui-min grasped the power, king Myongjong attempted to recover the hegemony of the statecraft. Thus, king Myongjong announced royal order and thereby, made decisions for himself. He also announced a reform measure to highlight his status as the supreme ruler. Furthermore, his reform measure included the Confucian 'Heaven's Order and People as Basis of the Kingdom, which might well highlight the sense of his existence. King Myongjong continued to select the officials and national academy (Gukjagam) students only to emphasize the Confucian education. In order to recover the hegemony of the statecraft as well as his status as king, he used the Confucian ideology, so the Confucian education was essential for him. Furthermore, he appointed his close subjects to the important positions of the kingdom in an effort to operate the kingdom in a stable way. However, king Myongjong would be dethroned in 1197 due to Choi Chung-heon's coup d'état. The fact that he was dethroned suggests that his efforts to recover the hegemony of the statecraft had failed.

참여정부의 사립학교 개혁정책 분석과 대안 연구 : 장기 국가발전 전략차원을 중심으로

최석태 韓國外國語大學校 政策科學大學院 2007 국내석사

Renovation Strategy Analysis and Alternative Study of Private School of the Roh Administration -focused on the context of the long-term national development strategy- Choi Suk-Tae Department of Public Policy The Graduate School of Policy Sciences Hankuk University of Foreign Studies The President Roh's administration established the amendment of The Private School Policy as one of the four renovation acts for the four renovative administration reforms, and Uri Party passed the Revised Private School Act with the focus on open trustee system through the Assembly plenary session on Dec. 9th, 2005 despite the strong opposition of the Grand National Party. Ever since the Revised Private School Act has been passed, because religious organizations and the Korean Private School Corporation United, who strongly opposed to the legislation of the Revised Private School Act, established "The Organization of Civil Movement for the Protection of the Private Institution" and developed the rejection movement and the re-amendment movement to the Revised Private School Act, the serious conflict has arisen in the Korean education and society. This current circumstance is the background of the research, and it is the purpose of the research to analyze and study problems associated with the policy of the revised private school act and to draw the proper solutions. The range of the research is limited to the political aspect of the revised private school act and the public administrative aspect of the public administration. In addition to that, the approach of the research places an emphasis on the analysis of the revised private school act and the study of the behaviors of the private school as the subject of the act. The summary of the analyzed and studied facts of the research and the ultimate solution are suggested as follows: 1) The main summary and purpose of the Revised Private School Act and its following private school reforms are to expose and prevent all irrational behaviors and to focus and to accept the open trustee system for the maintenance of clarity and fairness. 2) Through the thorough analysis of behavioral type of the private institution as the subject of the revised private school act, we understood the behavioral types of the irrational schools, and after we analyzed and studied the characteristics of the sound schools, their individual culture, and the composition of the foundation body of the Korean private schools, we came to a conclusion where we found that the reason why organized demonstrations have been put in action is because of the standardized enforcement without any consideration of the characteristics of these private schools. 3) We analyzed that the government's continuous investment in educational facilities can not satisfy the rapidly increasing educational investment, as the social SOC, the educational role of the private institutions, and the economic SOC. As a result, in the future, we suggested that the public utility corporation developed by the motive of voluntary citizens and the private school's investment-induced policy can play a major role as the nation's long-term strategy. 4) As an alternative policy to maintain the private school's fairness, its autonomy, and adaptability and to realize the public policy in the name of the national development more effectively, we suggested that the flexibility policy of the dominating structure. The effect of the flexibility policy will improve the quality of the education through creativity by maintaining fairness as sending temporary trustee to the troublesome private institutions and normalizing the school's management. Furthermore, because it will activate the citizens' participation and investment motivation for the private schools, invest the nation's reduction of the financial burden and a decreased human resource in an important sector of the government through realization of the substantial governance, and bring the effect in terms of the long-term growth to improve the nation with balance. In this research, through the analysis of the Roh's administration's amendment to the private school act and the study of the alternatives, we reviewed that without any consideration of the unique characteristics of the certain minor units, the private schools, how the result of the unilateral legislation could have given a rise to such problems. In addition, to ensure the adaptability of the policy, we proved that the policy decision with the knowledge of characteristics of the subject of the policy and enough research about the rationality of its applications, that is, instead of being decided by policy makers' personal point of views, the policy should be legislated with through research about the subject's traits to successfully establish the reformed acts and suggested it as one of the alternative solutions. However, in spite of the conclusion of the research with a focus on an aspect of dominating management construction of an educational foundation, the establishing subject of a private school, based on the revised private school act, in the future, until the improved quality of the education can be contributed to the national development, the continuous efforts of education policy or education department should be attained.

地域 公營放送 活性化 方案에 관한 硏究

최석태 釜山大學校 1995 국내박사

토끼의 자궁경부내 세균주입후 조산의 유발 및 양수내감염과의 연관성

최석태 서울대학교 대학원 1995 국내석사

韓國作曲家들의 作品에 나타나는 韓國的인 要素들에 對한 考察 : 羅運榮, 白秉東, 安一雄 作品中心으로

최석태 慶星大學校 大學院 1991 국내석사

한국 음악이라는 것은 국악이나 전통음악을 의미하는 것도 아니다. 한국인이 작곡한 곡이니까 한국음악이 아니냐 라는 의미에서의 한국 음악도 아니다. 음악의 구조적 측면으로 보아 과거 어느시대 어느 지역의 음악과도 다른, 이 땅에서만 생성되는 유닉한(독특한) 음악을 낳는 불변적 요인에 바탕을 둔 창작물을 말한다. 본 논문에서 한국적인 요소들을 고찰해 본 결과 다음과 같은 사실을 알 수 있었다. 5음 음계를 주로 많이 사용하고, 선율은 5음 음계 바탕위에 변화음, 생략음 등을 사용했다. 리듬(장단)은 전통적인 리듬형을 바탕으로 하고 있으며 또한 일정한 박의 속박에서 벗어난 완전히 자유로운 자유리듬과 박은 일정하지만 극히 불규칙한 리듬 즉 주기성(cycle)이 자유로운 리듬을 사용하고 있었다. 화성은 4도와 5도 화성을 많이 사용하고 있으며 작곡자 나름대로 화성체계를 세워 음향적 측면의 울림에 의한 화성을 사용하고 있었다. 꾸밈음(장식음)은 여러가지의 복잡한 유형의 범위를 벗어나지 않은 상태에서 자유스러운 기법을 사용하고 있었다. 이상에서 작품이 성공하는 조건이 될 수 있는 통일성 · 복잡성 · 경제성 등에만 작곡가의 관심이 쏠릴 것이 아니라 음악에 있어서의 불변적인 요소를 창조하는데 관심을 가져야 한다. 그러므로 우리들은 문화적 주체성을 바탕에 둔 한국음악을 창조해야만 한다. Korean music does not mean traditional music in Korea, and in a strict sense also does not mean all pieces created by only Korean composers. The true sense of Korean music, on the basis of music structural, has a uniqueness and peculiarity which is produced by immutability section in Korea. We can get conclusion as follows through studying of the Korean factor : Korean music relatively use pantatonic scale and the melody use altered sound and abbreviated sound on the basis of pantatonic scale. Rhythm has a traditional pattern and use a rhythm freely which is a free from a uniform beat. And a beat, although it has a consistence, use irregular rhythm, that is, the cycle is free. Korean music use fourth and fifth harmony and establish the system of harmony on purpose of composer. And it use a harmony produced by a vibration from the sound point. Decorative sound use a variable technique on the surround which is not escape from many complex pattern. We does not concered only on unification, complexity and economical efficiency, which is term to success for a piece. But we concern on creation of unchangeable Korean factor in music. Therefore we have to produce Korean music on basis of the cultural independence.

데이타 베이스 시스템의 Performance evaluation에 關한 硏究 : Queueing 分析을 中心으로

최석태 東國大學校 1984 국내석사