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Effect of a Flavon Extracted from Artemisia absinthium onCollagen Induced Arthritis in Mice
최경민,황대환,신경미,윤도영*,김동수 대한소아청소년과학회 2004 Clinical and Experimental Pediatrics (CEP) Vol.47 No.6
Purpose:In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods:DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies and a stimulation index of the splenocytes of the mice were measured. IL-10 and TNF-α in the supernatants of the mice sera were measured by ELISA. mRNA expression for IL-10 and TNF-α in the splenocytes were tested. Results:Flavon extracted from Artemisia absinthium appears to be an effective suppressor of CIA in mice. The serum anti-collagen antibody level and stimulation index of the cultured splenocytes showed no significant differences among the three experimental groups. Also serum IL-10 and TNF-α levels did not show any significant differences among the three experimental groups. An increased expression of mRNA for IL-10 was observed in the splenocytes treated with flavon. Conclusion:With these results, flavon extracted from Artemisia absinthium appears to have a suppressive effect of CIA. The mechanism of the suppressive effect of flavon extracted from Artemisia absinthium may be from a stimulation of IL-10 production. Artemisia absinthium (애엽)에서 추출한 Flavon이 마우스에서 Collagen InducedArthritis에 미치는 영향연세대학교 의과대학 소아과학교실, 한국과학기술연구소*최경민·황대환·신경미·윤도영*·김동수목 적 : 애엽에서 추출한 flavon이 마우스에서 유발된 CIA의 염증을 억제하는 효과를 조사하고자 하였다.방 법 : DBA/1 mouse에서 chicken type II collagen을 피내주사하였고, 접종 3주 후부터 flavon을 경구투여하였다. 세 실험군에서 관절염의 발생과 관절염 지수를 측정하였으며, 항콜라겐항체와 비장세포의 자극지수를 측정하였다. ELISA를 이용하여 IL-10과 TNF-α의 농도를 측정하였다. 비장세포에서의 IL-10과 TNF-α의 mRNA 표현을 조사하였다.결 과 : 애엽에서 추출한 flavon은 마우스의 CIA에 대한 억제 효과를 지닌다. 실험군간의 혈청내 항콜라겐항체 농도와 배양된 비장세포에서의 자극지수에는 통계적으로 의미있는 차이는 없었다. 뿐만 아니라 세 실험군간의 혈청 IL-10과 TNF-α 농도의 통계적으로 의미있는 차이도 관찰되지 않았다. Flavon을 투여한 마우스의 비장세포에서 IL-10의 mRNA 표현이 증가되어 있음이 관찰되었다.
온도에 의존하는 전기적 측정을 이용한 분자 메모리 소자의 전하 이동 메커니즘 분석
최경민,구자룡,김영관,권상직,Choi, Kyung-Min,Koo, Ja-Ryong,Kim, Young-Kwan,Kwon, Sang-Jik 한국전기전자재료학회 2008 전기전자재료학회논문지 Vol.21 No.7
A molecular memory device which has a structure of Al/$Al_2O_3$/ASA-15 LB monolayer/Ti/Al device, was fabricated. To study a charge transfer mechanism of molecular memory devices, current density-voltage (J-V) characteristics were measured at an increasing temperature range from 10 K to 300 K with an interval of 30 K. Strong temperature-dependent electrical property and tunneling through organic monolayer at low bias (below 0.5 V) were appeared. These experimental data were fitted by using a theoretical formula such as the Simmons model. In comparison between the theoretical and the experimental results, it was verified that the fitting results using the Simmons model about direct tunneling was fairly fitted below 0.5 V at both 300 K and 10 K. Hopping conduction was also dominant at all voltage range above 200 K due to charges trapped by defects located within the dielectric stack, including the $Al_2O_3$, organic monolayer and Ti interfaces.
안와, 접형동, 두개저를 침범한 비부비동 B세포 림프종 1예
최경민,김윤정,양시창,김승우 대한이비인후과학회 부산,울산,경남 지부회 2010 임상이비인후과 Vol.21 No.2
Primary sinonasal B cell lymphoma is usually presenting with unilateral nasal mass. Mainly its pathologic subtypes by WHO classification are NK/T cell and diffuse large B-cell type in order of frequency. A-65-year-old-male came to emergency room, complaining with loss of visual acuity and ocular pain for one month. PNS CT showed right unilateral nasal mass involving the orbit, skull bass and the sphenoid sinus. We performed the endoscopic sinus surgery, final pathologic diagnosis was diffuse large B-cell lymphoma. He received six cycles of R-CHOP chemotherapy, and gained complete remission. No recurrence is observed until three years. We report a unique case of sinonasal lymphoma with related literature review. (J Clinical Otolaryngol 2010;21:261-264)