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Phospholipids from Bombycis corpus and Their Neurotrophic Effects
권학철,정연,조세연,조옥련,양민철,이성옥,허진영,김선유,양종범,이강노 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.6
Three phospholipids (4-6) and three aromatic amines (1-3) were obtained from the methanol extract of Bombycis corpus. Based on spectral data, their structures have been elucidated as nicotiamide (1), cytidine (2), adenine (3), 1-O-(9 Z-octadecenoyl)-2-O-(8 Z,11 Z-octadecadienoyl)- sn-glycero-3-phosphorylcholine (4), 1,2-di-O-hexadecanoyl- sn-glycero-3-phosphorylcholine (5) and 1,2-di-O-9 Z-octadecenoyl- sn-glycero-3-phosphorylcholine (6). We examined the effects of compounds on synthesis of NGF in cultured astrocytes. By RT-PCR analysis, expresison of NGF mRNA in astrocytes cultured in serum-starvation increased after the addition of phospholipid (10 mM). The NGF content in the culture medium was significantly increased by compound 5, compared with the control value. These results suggest that three phospholipid compounds isolated from the methanol extract of Bombycis corpus may exert neurotrophic effects by stimulation of NGF synthesis in astrocytes.