AMAT DPS-II 유도 결합 플라즈마 식각 장치의 Load Lock 배기특성

정진용,유영군,최용섭,주정훈 한국진공학회 2014 한국진공학회 학술발표회초록집 Vol.2014 No.8

Usefulness of the bispectral index during cardiopulmonary resuscitation -A case report-

정진용,Yeonbaek Kim,Jung-Eun Kim 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.64 No.1

The usefulness of using the bispectral index (BIS) for monitoring during cardiopulmonary resuscitation (CPR) is not clearly understood. However, BIS has been a popular anesthetic monitoring device used during operations. The case presented is of a pregnant woman going into cardiac arrest due to an amniotic fluid embolism during a Cesarean section. CPR was performed, but neither the return of spontaneous circulation (ROSC) nor the return of consciousness was achieved, despite 50 min of effective CPR. However, CPR was continued based on BIS. ROSC was achieved, and an alert consciousness state was reached 1 day postoperation. This finding suggests that BIS be used as a basic monitoring device during CPR and that it may help in deciding to continue CPR.

한반도 연안에서의 12.5 km 해상도 QuikSCAT 해상풍 검증

정진용,심재설,이동규,민인기,권재일 한국해양과학기술원 2008 Ocean and Polar Research Vol.30 No.1

Several validation studies have been made for QuikSCAT(QSCAT) wind data around the world, mainly in the offshore. However, until now, there were no validation studies for QSCAT wind with resolution of 12.5 km (‘QSCAT 12.5 km wind’) in the vicinity of Korean Peninsula. To validate ‘QSCAT 12.5 km wind’ and to investigate its characteristics around Korean Peninsula, the wind data from Ieodo Ocean Research Station, KMA buoys, and KORDI Realtime Observation Stations have been compared. Validation results showed that ‘QSCAT 12.5 km wind’ RMSE of wind direction and speed were 25.85o and 1.83 m/s, respectively, at Ieodo Station. The mean wind speed correlation coefficient of KMA buoys and KORDI Realtime Observation Station were 0.78 and 0.61, and the mean wind speed RMSE were 2.2 m/s and 3.2 m/s, respectively. This seems to be mainly because of the distance between QSCAT and in-situ observation stations. The RMSE of wind direction were bigger than 40o at all in-situ observation stations located near the shore, within 20 km from coastlines. Geophysical features where in-situ observation stations are located seem to affect wind validation scores. Several validation studies have been made for QuikSCAT(QSCAT) wind data around the world, mainly in the offshore. However, until now, there were no validation studies for QSCAT wind with resolution of 12.5 km (‘QSCAT 12.5 km wind’) in the vicinity of Korean Peninsula. To validate ‘QSCAT 12.5 km wind’ and to investigate its characteristics around Korean Peninsula, the wind data from Ieodo Ocean Research Station, KMA buoys, and KORDI Realtime Observation Stations have been compared. Validation results showed that ‘QSCAT 12.5 km wind’ RMSE of wind direction and speed were 25.85o and 1.83 m/s, respectively, at Ieodo Station. The mean wind speed correlation coefficient of KMA buoys and KORDI Realtime Observation Station were 0.78 and 0.61, and the mean wind speed RMSE were 2.2 m/s and 3.2 m/s, respectively. This seems to be mainly because of the distance between QSCAT and in-situ observation stations. The RMSE of wind direction were bigger than 40o at all in-situ observation stations located near the shore, within 20 km from coastlines. Geophysical features where in-situ observation stations are located seem to affect wind validation scores.

염증이 유발된 인간기관지상피세포에서 오미자가 Microarray를 이용한 유전자 발현 분석에 미치는 영향

정진용,정승기,정희재,이형구,Jung, Jin-Yong,Jung, Sung-Ki,Jung, Hee-Jae,Rhee, Hyung-Koo 대한한방내과학회 2008 대한한방내과학회지 Vol.29 No.3

Objective: The goal of this study was to determine the anti-asthma mechanism of SF on TNF-${\alpha}$ induced activation on A549 (human type II-like epithelial) cells. Using oligonucleotide microarray, we sought to establish the molecular mechanism of the protective effects of SF on A549 cells. Material & Methods : Cells were cultured in three different conditions: 1) negative control group was cultured in normal condition of DMEM, 2) positive control group was activated with TNF-${\alpha}$, IL-4. and IL-1${\beta}$, and 3) SF treated group was previously treated with 0.1${\mu}g/ml$ SF after TNF-${\alpha}$, IL-4. and IL-1 activation. Cells of positive control and SF treated groups were cultured for 30 min, 1hr, 3hr and 6hr. Results : The comparative analysis of the gene expression profile revealed that proinflammatory cytokines such as IL1F8, IL1F9, IL1R1. IL1RN, IL1RAPL1, IL8, TNFRSF4, TNFSF10c, TNFSF13, TRAF5, and TRAF7 and inflammation-related genes including MMP2, MMP11, MMP14, MMP15, MMP16, MMP19, MMP25, and MMP27 were down regulated with SF treatment. Cell adhesion molecule genes such as ITGB1, ITGBL1, selectin P ligand, selectin E, ICAM2, ICAM3, VCAM1, PECAM, FCER1G and MMP28 genes were also down-regulated in SF treated A549 cells. Conclusion : These results suggest that the anti-asthmatic effects of SF could be mediated by regulating specific genes related with cell adhesion, proinflammatory cytokine and inflammation-related genes in A549 cells.

A Destruction Pattern Analysis of a Turbo-Molecular Pump According to the Foreline Clamp Damage in an ICP Dry Etcher for 300 mm Wafers

정진용,이인택,주정훈 한국진공학회 2015 Applied Science and Convergence Technology Vol.24 No.2

We analyzed the destruction patterns of a turbo-molecular pump (TMP) resulting fromits sudden exposure of a foreline to the atmospheric pressure due to a destruction of theforeline connecting clamp of an ICP dry etcher for 300 mm wafers during high-vacuumoperation (5×10−6 Torr). Unlike in the case of view port’s breakage, the TMP’s rotor modulewas crashed inside the chamber. The primary damage resulted from the collision of the bladesand stators, and the secondary damage resulted from the breaking of the rotor - driving shaftassembly. The fixing screws of the rotor and axial shaft were bent and broken when theTMP controller output the maximum current even after the crash event. Electrical powerconsumption analysis of the TMP power controller confirmed it. The stress distributions wereanalyzed by a finite element method using CFD-ACE+ multi physics software. Rotating inertiaof each parts and kinetic energies were calculated as well. 68% of the rotational kinetic energyis deposited by the rotor - shaft module.

흉부수술전 흉막유착에 대한 초음파검사

정진용,박형주,신재승,조원민,이인성 대한흉부외과학회 2010 Journal of Chest Surgery Vol.43 No.4

Background: Video-Assisted Thoracic Surgery can be performed with the lung collapsed. During the procedure, pleural adhesion may result in lung injury, bleeding, and thoracotomy conversion. Identifying the presence of pleural adhesion before surgery can make it easy to plan trocar introduction and perform the procedure. Material and Method: Between June 2009 and November 2009, we performed ultrasound in 24 patients to detect pleural adhesion before surgery and compared the results with the operative findings. We primarily examined the lateral chest, where the trocar would be inserted, and, occasionally, the anterior or posterior chest. Result: Patient diseases were: 6 hyperhidroses, 8 interstitial lung diseases, 5 lung cancers, 2 mediastinal tumors, 1 peripheral pulmonary embolism, 1 metastatic lung cancer, and 1 sarcoidosis. Of the 22 patients who did not have pleural adhesions on ultrasound, four revealed mild adhesions not related to the trocar insertion sites. However, ultrasound showed pleural adhesions in two patients, consistent with the operative findings. There was no air leak or thoracotomy conversion related with trocar insertion. Conclusion: Ultrasound requires only a few minutes to detect the presence of the pleural adhesion and was very useful in identifying the pleural adhesion before VATS. 배경: 비디오흉강경수술은 폐를 허탈시켜 흉강내의 공간을 확보함으로써 시행되는데 흉막유착은 이러한 공간을 확보하는데 커다란 장애요인이 되어 폐손상 및 출혈을 유발할 수 있으며, 개흉술로 전환하는 원인이 되기도 한다. 흉강경수술을 시행하기 전에 흉막유착 유무를 확인하면 투관침의 위치선정 및 삽입방법을 포함한 수술과정을 계획하는데 매우 유용한 정보를 얻을 수 있다. 대상 및 방법: 2009년 6월부터 2009년 11월까지 비디오흉강경수술을 시행한 24명의 환자에서 수술 전에 흉막유착을 확인하기 위하여 초음파검사를 시행하고 흉강경수술시의 소견과 비교하였다. 검사부위는 투관침 삽입부위인 전액와선에서 후액와선까지의 흉부 측면을 주로 검사하였으며, 경우에 따라서는 흉부 전면이나 후면을 관찰하기도 하였다. 결과: 환자는 다한증 6예, 간질성폐병변 8예, 폐종양 5예, 종격동종양 2예, 말초폐동맥색전증 1예, 전이성폐종양 1예, Sarcoidosis 1예로 구성되었다. 초음파검사를 통해 흉막유착이 없다고 진단한 22예 중 4예는 검사부위와 동떨어진 곳에 일부 국한되어 경미한 유착이 있었으나 투관침 삽입부위와는 관련이 없었다. 흉막유착이 있다고 진단한 2예는 수술시 동일한 소견이었다. 수술중 투관침 삽입으로 인한 폐손상은 없었으며 개흉으로의 전환도 없었다. 결론: 초음파검사는 짧은 시간내에 검사가 이루어지며, 비디오흉강경수술을 계획하고 시행하는데 초음파를 이용한 흉막유착 여부의 확인은 매우 유익한 시술법이라고 사료된다.

Methylcholanthrene 유도 섬유육종세포주에서 Doxorubicin 농도에 따른 세포독성과 자멸사의 변화

정진용,왕영필,나석주 대한흉부심장혈관외과학회 2001 Journal of Chest Surgery Vol.34 No.6

Background: Although pulmonary resection is the standard approach for the management of pulmonary metastases from soft tissue sarcoma, most of them are unresectable and chemotherapy remains the only option. The effectiveness of the cytotoxic drugs may be limited by the toxicities that occur before the therapeutic dose is reached. The regional administration of doxorubicin using pulmonary arterial perfusion in a rodent model can produce 10 to 25 times higher concentrations in the lung than systemic administration with minimal systemic toxicities. However, it is unclear whether a high concentration of doxorubicin has beneficial effects for killing cancer cells. Material and Method: We studied this to evaluate the dose-dependent cytotoxic and apoptotic effects of doxorubicin on methylcholanthrene-induced rat fibrosarcoma(MCA) cells. This study examined the cytotoxicity and apoptosis-related gene expressions(Fas, FasL, Bax, caspase 1, caspase 2, caspase 8, Bcl-2, Bcl-xL, Bcl-xS) in MCA cells after 24 hours exposure to various concentrations of doxorubicin such as 1, 5, 10, 50, and 100 $\mu$M. Result: Dose-dependent cytotoxicity was observed after 24 hours exposure to doxorubicin. However, peak apoptosis after 24 hours exposure was observed at 5 $\mu$M of doxorubicin. Above 5 $\mu$M, apoptotic activity was decreased with dose-increment. All mRNA levels of apoptosis-related genes after 24 hours exposure were up-regulated above the control level at 1 $\mu$M of doxorubicin and then decreased by doxorubicin dose-increment except caspase 8, which showed higher levels than the control level at 5 $\mu$M. Apoptosis-related protein levels were highest at 1 $\mu$M of doxorubicin and then decreased by doxorubicin dose-increment. However, Bax and Bcl-xL proteins steadily showed higher levels than the control throughout the different concentrations of doxorubicin. Conclusion: These results suggest that apoptosis is the main cytotoxic mechanism in low concentrations of doxorubicin in MCA cells and apoptosis-related genes, such as Bax, caspase 8, and Bcl-xL, are involved. At high concentrations, doxorubicin still can kill MCA cells, even when apoptosis is inhibited, and have its propriety for achieving much cytotoxicity against MCA cells.

기판변화에 따른 CoFeB 박막의 Exchange Stiffness Constant 특성 연구

정진용,조신용,조재훈,유천열 한국자기학회 2012 한국자기학회 학술연구발표회 논문개요집 Vol.2012 No.5

단일통로 복강경 담낭 절제수술의 초기경험

정진용,최은혜,김우영 대한내시경복강경외과학회 2010 Journal of Minimally Invasive Surgery Vol.13 No.1

Purpose: Laparoscopic cholecystectomy is a standard procedure for cholelithiasis. However, with the advance of minimal invasive surgery, much research has recently been performed into single port laparoscopic surgery (SPLS).1 The aim of this study is to evaluate single port laparoscopic cholecystectomy (SPLC) in comparison to the classical method (three port laparoscopic cholecystectomy, TPLC) through our initial experience. Methods: This study was performed retrospectively by a review of medical charts and phone calls to patients. We checked for chronic calculous cholecystitis or cholesterol polyps in 56 patients who had undergone cholecystectomy between April 2009 and February 2010. We divided into two groups the patients who had undergone SPLC and TPLC. We then checked the sex, age, hospital day, operating time,mobilization time, pain scale, cosmetic satisfaction, surgical wound infection and BMI for each patient. Results: Cosmetic satisfaction with SPLC was higher than with the classical method, but this was not significant. Hospital day and mobilization time of SPLC were shorter, but this was also not significant. There was no difference in patient age,hospital day, mobilization and BMI between SPLC and TPLC. The operating time and pain scale with TPLC were less than with SPLC. Conclusion: SPLC has the benefit of cosmetic satisfaction and relatively fewer complications. However, the operating time and pain scale of SPLC are higher than those of TPLC. Therefore, SPLC requires much concentration and effort from the surgeon to compensate for its deficiencies.

브릴루앙 광산란을 이용한 열처리에 따른 CoFeB 박막의 Exchange Stiffness Constant 특성

정진용,김가언,조재훈,유천열 한국자기학회 2012 한국자기학회 학술연구발표회 논문개요집 Vol.2012 No.11