카메라 렌즈 평가용으로 제작된 nodal slide식 실시간 OTF 측정 장치

이지영,송종섭,조재흥,장수,임천석,이윤우,이인원,Lee, Ji-Young,Song, Jong-Sup,Jo, jae-Heung,Chang, Soo,Rim, Cheon-Seog,Lee, Yun-Woo,lee, In-Won 한국광학회 2002 한국광학회지 Vol.13 No.2

A real-time OTF (optical transfer function) measuring system with on- and off-axis nodal slide bench type for the camera lens is fabricated and evaluated. It consists of a nodal slide bench including a T-bar for the OTF measurement of an off-axis object, two dimensional CCD (charge coupled device) with pixel of 9.9${\mu}{\textrm}{m}$$\times$9.6${\mu}{\textrm}{m}$ for real-time OTF measurment, and a collimating lens of focal length of 300 mm for the optimization of this system. The OTF system is corrected by using the OTF of a SIRA lens of fnumber of F/8 and focal length 50 mm. In order to confirm the reliability of the OTF system, two MTFs (modulus transfer functions) of CCTV & VIDEO lens (JAPAN, AVENIR-SE 2514) of focal length of 25mm and field of view 10.6$^{\circ}$are measured by the camera bench type OTF system of reference OTF system and the nodal slide bench type OTF system and compared with each other. As a result, these two values are agree well with each other within 4% from 0 1p/mm to 100 1p/mm. 초측정 할 수 있는 nodal slide식 실시간 OTF 측정 장치를 제작하였다. 비축 물체를 측정하기 위하여 nodal slide와 T-bar를 사용하고, 실시간 측정을 위하여 화소 간격이 가로 9.9$\mu\textrm{m}$와 세로 9.6$\mu\textrm{m}$인 2차원 CCD(charge coupled device)를 사용하며, 초점 길이 300mm의 시준 렌즈를 사용하여 장치를 소형화하였다. 그리고 F/8, 초점 길이 50 mm인 SIRA사의 표준 렌즈를 이용하여 측정 장치의 정확도를 평가하고 보정하였다. 본 장치의 신뢰도를 위하여 시야각이 10.6$^{\circ}$이고, 초점 길이가 25.0mm인 CCTV & VIDEO 렌즈(JAPAN, AVENIR-SE 2514)의 MTF를 측정하여 카메라 벤취(bench)형 OTF측정 장치로부터 구한 MTF 값들과 상호 비교한 결과 대부분의 공간주파수에서 4% 이내로 일치하였다.

주성분 분석을 이용한 펄스형 전자기장 자극을 통해 DNCB로 유발된 아토피성 피부염의 개선 효과 분석

이지영,김준영,이예린,김고은,이용흠,양세정,Lee, Jiyoung,Kim, Jun-Yong,Lee, Yerin,Kim, Ko Eun,Lee, Yongheum,Yang, Sejung 대한의용생체공학회 2021 의공학회지 Vol.42 No.3

Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by itchy and age-dependent lesions. Previous studies have shown that pulsed electromagnetic field (PEMF) significantly improved chronic ulcers and ununited fractures, providing an evidence for the application of PEMF in resolving inflammation caused by AD. This study investigated the anti-inflammatory effect of PEMF on DNCB-induced AD in animal models. Five male hairless mice (6 weeks old) per group were assigned to a normal group, a sham group, and two PEMF groups (15Hz, 75Hz). Mice were treated with 2,4-Dinitrochlorobenzene (DNCB) to induce uniform AD among all groups excluding a normal group. To examine the inflammatory progress and the improvement of AD after the PEMF stimulation, images are taken with various cameras for non-invasive evaluation and the results are expressed using principal component analysis (PCA) for visualization. The results of this study demonstrated that PEMF effectively improved skin lesions without the use of drugs.

대용량 에너지 저장장치용 2세대 고온 초전도 코일의 특성해석

이지영,이세연,김영일,박상호,최경달,이지광,김우석,Lee, Ji-Young,Lee, Seyeon,Kim, Yungil,Park, Sang Ho,Choi, Kyeongdal,Lee, Ji-Kwang,Kim, Woo-Seok 한국전력공사 2015 KEPCO Journal on electric power and energy Vol.1 No.1

대용량 초전도 에너지저장장치(Superconducting Magnetic Energy Storage, SMES)용 초전도 권선을 제작하기 위해서는 높은 자장특성을 가고 있는 2세대 고온초전도 (2nd Generation High-Temperature Superconductor, 2G HTS) 선재를 사용하는 것이 효율적이다. 자기에너지 저장 밀도를 높이기 위해서는 권선에 높은 전류밀도를 인가해야 하는데, 도체의 평면에 수직 방향으로 인가되는 자속밀도가 커지면 임계전류가 작아지는 2세대 HTS 선재의 특성상 토로이드 형태의 권선을 구성하는 것이 일반적이다. 이러한 고온초전도 권선을 설계하기 위해서는 권선 특성의 정확한 해석이 필요한데 이를 위해 유한요소법을 사용한 프로그램을 이용하여 해석이 가능하나 토로이드 형태의 권선은 대칭성의 문제로 3차원 해석을 해야만 하며, 이는 모델링에 많은 어려움과 높은 컴퓨터 사양, 그리고 매우 긴 계산 소요시간이 필요함을 의미한다. 본 논문에서는 이러한 문제점을 해결하기 위해 분석적이고 통계적으로 고온 초전도 코일에서 작용하는 최대 수직자장과 저장된 에너지를 결정하는데 이해하기 쉽고 효율적으로 계산하는 방법을 제시했다. 이 방법은 현저한 시간단축과 효율적인 설계를 할 수 있는 새로운 계산 방법으로 기존의 유한요소법에 의해 소요되는 계산 시간에 비해 1/1000정도로 계산시간 단축을 할 수 있었다. Large scale superconducting magnetic energy storage (SMES) system requires very high magnetic energy density in its superconducting coils to enhance the energy capacity and efficiency of the system. The recent high temperature superconducting (HTS) conductors, so called 2G conductors, show very good performance under very high magnetic field so that they seem to be perfect materials for the large scale SMES coils. A general shape of the coil system with the 2G HTS conductor has been a tor oid, because the magnetic field applied perpendicularly to the surface of the 2G HTS conductor could be minimized in this shape of coil. However, a toroid coil requires a 3-dimensional computation to acquire the characteristics of its critical current density - magnetic field relations which needs very complicated numerical calculation, very high computer specification, and long calculation time. In this paper, we suggested an analytic and statistical calculation method to acquire the maximum magnetic flux density applied perpendicularly to the surface of the 2G HTS conductor and the stored energy in the toroid coil system. Although the result with this method includes some errors but we could reduce these errors within 5 percent to get a reasonable estimation of the important parameters for design process of the HTS toroid coil system. As a result, the calculation time by the suggested method could be reduced to 0.1 percent of that by the 3-dimensional numerical calculation.

진행성 대장직장암 환자군에 있어서 5-FU 혹은 capecitabine의 최적 시간 치료법에 대한 체계적 고찰 : 메타분석

이지영,오혜경,류한성,윤성우,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Yoon, Seong Woo 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.1

Background : The purpose of this study is to investigate the efficacy and safety of the circadian delivery schedule of fluorouracil or capecitabine based chemotherapy for advanced colorectal cancer. Patients and methods : A meta-analysis was performed using individual data from eight international randomized clinical trials, especially phase II or III trials, comparing 5-fluorouracil, or capeticabine in chronomodulated or conventional schedule. The data from 8 studies was composed of 692 patients receiving chronomodulated chemotheray and 684 patients receiving conventional chemotherapy. The main end point was response rate. Results : Response rate was insignificantly different from each group (RR 1.14, 95%CI 0.74-1.74, p=0.55). Overall survival and progresseion-free survival were not significant either. Chemotherapy induced anemia, diarrhea, and nausea/vomiting were worse in the chronotherapy group, with statistic significance respectively. On the other hand, chemotherapy induced thrombocytopenia, stomatitis, peripheral neuropathy, and dermatotoxicity were better but they were not statistically significant results. Conclusions : Patients lived longer but not significantly on chronomodulated chemotherapy rather than on conventional chemotherapy. Patients on chronomodulated chemotherapy experienced adverse events more. The chronomodulated chemotherapy schedule needs adjustment of its delivery schedule and further research is required.

온백원이 암세포에 미치는 항암활성 효과

이지영,오혜경,류한성,김남재,정원용,오현아,최혁재,윤성우,류봉하,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Kim, Nam Jae,Jung, Won-Yong,Oh, Hyun-A,Choi, Hyuck Jai,Yoon, Seong Woo,Ryu, Bong-Ha 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.2

Objective : The objective of this study was to investigate the experimental efficacy of anti-tumor activity of the complexed herbal formula, Onbaekwon (OBW), which was derived from the literature of Traditional Korean Medicine, Dongeuibogam. Methods : Nine Cancer cell lines, LoVo, MCF-7, HepG2, AGS, A549, NCI-H69, HL-60, Sarcoma 180, LL/2, were prepared and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-dephenyl tetrazolium bromide (MTT) assay. Four of them, NCI-H69, HL-60, Sarcoma 180, and LL/2, showed strong cytotoxic activities and they were additionally undergone flow cytometry to find out their effects on apoptosis. ICR male mice were implanted with Sarcoma 180 intraperitoneally and divided into 8 species for each group. Control group was treated with normal saline, positive control group was treated with cyclophosphamide 8mg/kg, and experimental group was treated with OBW 1 g/kg. Results : Among 9 cancer cell lines, NCI-H69, HL-60, Sarcoma 180, and LL/2, expressed less than 0.10 mg/ml of $IC_{50}$ under 0.1~1mg/ml of OBW. NCI-H69, HL-60, Sarcoma 180, and LL/2, showed dose-dependent efficacy of apoptosis. When Sarcoma 180 cancer cell was implanted in ICR male mice and treated with the OBW, they prolonged the median overall survival for 0.8 days, from 17.5 to 18.3. Conclusion : OBW showed strong cytotoxicity to some cancer cells, which are NCI-H69, HL-60, Sarcoma 180, and LL/2, and its apoptotic activity was dose-dependent. OBW prolonged the median survival of mice implanted with Sarcoma 180. Further researches would be expected to support the efficacy of OBW.

항-Porphyromonas gingivalis heat shock protein 60 단클론항체의 생성과 특성 규명

이지영,이주연,김성조,최점일,Lee, Ji-Young,Lee, Ju-Youn,Kim, Seong-Jo,Choi, Jeom-Il 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.4

Purpose: Porphyromonas gingivalis(P. gingivalis) heat shock protein (HSP)60 may play a role in the immunopathogenesis of periodontitis as well as atherosclerosis by modulating autoimmune reaction due to its high level of sequence homology between bacteria and human counterpart. The purpose of this study was to identify immunodomiant epitope of P. gingivalis HSP60 that is reactive exclusively to the homologous bacteria without reacting with human HSP. Materials and methods: The present study was performed to identify the peptide specifically recognized by anti-P. gingivalis HSP60 monoclonal antibodies mono-reactive to P. gingivalis HSP60. Results: Four different hybridomas were cloned producing monoclonal IgG antibodies exclusively to P. gingivalis HSP60. Thirty seven synthetic peptides (20-mer with 5-amino acid overlapping) were synthesized. All of these peptide were subject to SDS-PAGE for immunblot analysis. One peptide (TVPGGGTTYIRAIAALEGLK) and the other peptide (TLVVNRLRGSLKICAVKAPG) were recognized by all and one of the four monoclonal antibodies, respectively, that reacted solely with P. gingivalis HSP60. Immunohistochemistry to identify the localization of the HSP60 in the diseased gingival tissues revealed that all of the four monoclonal antibodies were highly reacted with the diseased gingival tissue than normal gingival tissue. Conclusion: The P. gingivalis HSP60 peptides (TVPGGGTTYIRAIAALEGLK and TLVVNRLRGSLKICAVKAPG, respectively) are positively involved in the immunopathologic process of periodontal disease. The peptide may potentially be developed as vaccine candidates. Further investigations are under way to identify more clones producing monoclonal antibodies reactive to P. gingivalis HSP and to other periodontopathogenic bacteria as well, while maintaining specificities to human counterpart.

Treatment outcomes of IMEP as a front-line chemotherapy for patients with peripheral T-cell lymphomas

이지영,Sang Min Lee,Moon Young Choi,Ki Hyang Kim,Young Don Joo,Sung Nam Im,Won Sik Lee 대한혈액학회 2016 Blood Research Vol.51 No.3

BackgroundThis study aimed to assess the treatment outcomes of ifosphamide, mesna, etoposide, and prednisolone (IMEP) combination regimen as a front-line chemotherapy in patients with peripheral T-cell lymphomas (PTCLs).MethodsClinical data of 38 newly diagnosed PTCLs patients who underwent IMEP at Busan Paik Hospital from January 2002 to December 2013 were retrospectively analyzed. ResultsThe overall response rate was 68.5%, with 21 (55.3%) complete response/complete re-sponse unconfirmed and 6 (15.8%) partial response (PR). The median follow-up duration was 25.5 months (range, 0.2‒87.3). The median overall survival was not reached and 2-year survival rate was 67%. The median progression free survival was 23 months. The most frequently reported adverse effects higher than grade 3 were hematologic toxicities including neutropenia (68.4%), thrombocytopenia (42.1%). There was no treat-ment-related mortality.ConclusionIMEP regimen is effective and safe as a front-line chemotherapy in patients with PTCLs.

(Zn_1-xMg_x)₂SiO₄:mn 형광체의 제조와 발광특성

이지영,유일,Lee, Ji-Young,Yu, Il 한국전기전자재료학회 2009 전기전자재료학회논문지 Vol.22 No.5

$Zn_{2}SiO_{4}$:Mn green phosphors doped with Mg for PDP were synthesized by solid state reaction method. $Zn_{2}SiO_{4}$:Mn, Mg phosphors with increasing Mg concentration were changed from Rhombohedral to Orthorhombic structure. Photoluminescence intensity of $Zn_{2}SiO_{4}$:Mn phosphors doped with Mg 0.5 mol was definitely higher than that of Mg non-doped sample. The enhanced luminescence with doping Mg in the $Zn_{2}SiO_{4}$:Mn phosphors was interpreted by the increase of energy transfer from host to Mn ions with substitution Mg for Zn in the $Zn_{2}SiO_{4}$:Mn host.

학교건축의 친환경적 계획수법에 대한 사례연구 - 미국, 일본, 한국의 학교건축을 중심으로 -

이지영,이경선,Lee, Ji-Young,Lee, Kyung-Sun 한국교육시설학회 2011 敎育施設 Vol.18 No.2

This study aims to identify differences and lessons in eco-school planning techniques and sustainable design methods by analyzing comparatively green building certification system and the cases of sustainable schools in US, Korea and Japan. As a result of the comparative analysis, green building certification system for school facilities, both domestic and international, is categorized into external environment, energy, materials and resources, and indoor environment. From the case study, it is common that roof garden and biotopes are installed for external environment, while energy saving, passive energy utilization methods for natural lighting and ventilation such as arrangement planning, courtyard, top-light, shading devices, solar panel and insulation by roof garden are most frequently used. Also, storm water uses, water saving equipment and sustainable materials are often introduced for resource savings. Concerns for indoor environment is frequently addressed by introducing natural light and ventilation in the buildings, which makes ultimately a comfortable space.

유미쿼터스 환경에서의 위치인식 기술

이지영,양성원,이영화,차호정,Lee, Ji-Yeong,Yang, Seong-Won,Lee, Yeong-Hwa,Cha, Ho-Jeong 한국인터넷정보학회 2006 인터넷정보학회지 Vol.7 No.2