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진행된 자궁경부암환자에서 Interferon alpha, 13-cis-Retinoic acid와 방사선치료의 복합요법 : 예비보고 Preliminary Study
이정필,박찬규,김수녕 대한부인종양 콜포스코피학회 1995 Journal of Gynecologic Oncology Vol.6 No.3
Locally advanced cancer of the uterine cervix is a major cause of death worldwide. Standard treatment with radiolherapy for locally advanced cancer of the uterine cervix has a response rate of less than 50%. Recently concurrent chemoradirothcrpay has been introduced but with some controversy. Interferon and retinoic acid are inducible proteins which posses many hiologic activities such as, antiproliferative, immunomodulatory and antineoplastic properties. Combination of interferon and retinoic acid has produced high response rates especially for patients with squamous cell carcinoma . And they may potentiate the radiation cytotoxicity as adiosensitizer. This study was undertaken to assess the clinical efficacy of combination regimen with interferon - a 2a, 13-cis-retinoic acid and radiotherapy from Dec. 1988 to Dec. 1994 at Severance hospital Yonsei university. Twenty seven patients of locally advanced squamous cell carcionma of the uterine cervix enrolled in this study are evaluated for response and toxicity. The results were as follow : 1. Preliminary results of interferon-α_(2α) 13-cis-retinoic acid and radiotherapy are 46.7% of response rate(33.3% complete response) and those of concurrent chemoradiotherapy are 41.7% of response rate(16.7% complete response). 2. Major toxicity of interferon-α_(2α) 13-cis-retinoic acid and rakiotherapy is fever (60.0%), and only one case of grade 2 anemia and one case of grade 1 AST/ALT elevations was noted. There was no grade 3 or 4 toxicity. Systemic interferon-α_(2α) 13-cis-retinoic acid and radiotherapy is highly active, well tolerated therapy for locally advanced cervical cancer.