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손현주,복진영 한국농화학회 1989 Applied Biological Chemistry (Appl Biol Chem) Vol.32 No.4
Eleven lignan compounds in fruits of Schisandra chinensis BAILLON were identified by gas chromatography/mass spectrometry(GC/MS). The GC/MS conditions were as followed: the GC column used was SPB-1 fused silica capillary (0.25㎜ id×30m, Supelco) and the column oven temperature was programmed from 200℃ to 300℃ at the rate of 4℃ per minute; the MS ionization voltage was 70eV (EI mode). The compounds identified were gomisin J (M^+; 388), deoxyschizandrin(M^+; 416), gomisin N (M^+; 400), schizandrin(M^+; 432), wuweizisu C (M^+;384), gomisin A (M^+; 416), angeloylgomisin H (M^+; 500), tigloylgomisin H (M^+; 500), angeloylgomisin Q (M^+; 530), gomisin B (M^+; 514) and benzoylgomisin H(M^+; 522), peaks of which were separated well on the GC chromatogram.
손현주,정기원,박양혜,전효진,강민석,류근호,표성수,Helene Eutamene,Lionel Bueno,선원숙 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
We evaluated the effect of SKI3246, the 50 %ethanol extract of the rhizome of Atractylodes japonica, onvisceral hypersensitivity, which is a major characteristicfeature of IBS. We used various rat models of visceralhypersensitivity to assess the visceral pain responses tocolorectal distension (CRD) in comparison with conventionalIBS treatments. Oral administration of SKI3246 dosedependentlyand significantly attenuated the abdominalwithdrawal reflex (AWR) score in a model of acetic acidinducedvisceral hypersensitivity. We also found that itreduced the number of abdominal contractions in response toCRD in a model of 2,4,6-trinitrobenzenesulfonic acidinducedvisceral hypersensitivity, which was comparable toramosetron or alosetron. Furthermore, treatment withSKI3246 also increased the pain threshold and abolished theelevated AWR scores to CRD in a rat model of neonatalmaternal separation.Wepresumed that the modulation of theNK2 receptor is involved in the inhibitory activity ofSKI3246 on the basis that it significantly inhibited the contractionof the distal colonic muscle induced by neurokininA, the NK2 receptor agonist. The present results indicate thatSKI3246 has the potential to be an effective therapeuticagent for IBS, especially insofar as it can relieve visceralhypersensitivity.
르두의 이상 도시에 미친 18세기 계몽주의의 영향에 관한 연구
손현주,이강업,Son, Hyson-Ju,Lee, Kang-Up 한국건축역사학회 1996 건축역사연구 Vol.5 No.1
This study aims at showing how C.N.Ledoux applied architecturally the idea of Enlightenment in the Ideal City. Enlightenment of 18th century not only developed neo-classicism in the field of art, but also brought about the changes of ideology and philosophy of the era. C.N.Ledoux, one of the most influential architects of this period, expressed abstractly and symbolically the essential idea of Enlightenment; the skepticism of God's authority, the liberty and equality of man, charity and the willingness of controlling the power of nature, and so on.