EDM을 이용한 발전소 정보관리시스템 개발 ( Plant Configuration System by using Electrical Document Management System )

이숙형,박찬국 한국에너지학회 2000 한국에너지공학회 학술발표회 Vol.2000 No.-

통합교육 운영 사례

이숙형 국립특수교육원 2004 직무연수 Vol.- No.9-10

Safety and Reliability Assessment by Using Dynamic Reliability Analysis Method

이숙형,박종운,임재천,Daved W Lloyed 한국에너지학회 1996 한국에너지공학회 학술발표회 Vol.1996 No.-

통합교육 사례

이숙형 국립특수교육원 2004 직무연수 Vol.- No.1.2.3

Test of Dynamic Pressurizer Model for CANDU Reactor System Simulation

이숙형,임재천,박지원 한국에너지학회 1993 한국에너지공학회 학술발표회 Vol.1993 No.-

자궁의 임신의 초음파 진단상

이숙형(SH Lee),이두진(DJ Lee),정성희(SH Chung),박종근(JK Park),이태호(TH Lee) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.5

확진된 자궁외 임신 32예의 초음파상을 아래와 같이 요약할 수 있었다. 자궁의 임신을 확진할 수 있는 자궁의 태낭, 태아 및 심장활동의 확인 예는 7예로 21.9%에 불과하였고, 심 장활동을 볼 수 있었던 것은 비파열 22예 중 단 1예로 4.5%이었다. 자궁강내 태낭을 확인할 수 없었던 것은 전례이었다. 부속기종유는 17예로 53.1%이었다. 자궁 의 증대는 15예로 46.9%이었다. 자궁의 변위는 자궁 의 임신파열 10예 중 4예로 40%이었다. 뇨임신반응양 성 예는 13예로 40.6%이었다. 복강내 출혈묘사 예는 32예 중 15예로 46.9%이었다. 이상의 성적으로 미루어 초음파를 이용한 자궁의 임 신의 확진은 단독인자만으로는 힘든 경우가 많으나, 자궁강내 태낭 및 태아 확인의 여부는 자궁의 임신을 부정 혹은 긍정할 수 있는 중요인자로 생각하며, 특히 정상임신을 제외하는 부정적인 인자에 보다 초점을 두 어야 될 것으로 사료되며, 기타 adnexal mass, 자궁의 증대 및 변위, 양성임신반응, 복강내유동현 등의 제인 자를 포괄적으로 고려하면 높은 정진율을 기대할 수 있을 것으로 생각된다. Ultrasonographic studies were made on 32 cases of surgically confirmed ectopic pregnancy. The criteria which able to make confirmatory diagnosis upon ectopic pregnancy such as identification of extra uterine gestational sac, fetal cardiac movement revealed 7 cases out of 32 cases or 21.9%. Among 22 cases recognized cardiac movement was only one case or 4.5%. All cases were unable to reveal intrauterine gestational sac and adenexal masses revealed 17 cases or 53.1%. An enlargement of uterus showed in 15 cases or 46.9% and cases of detected intra abdominal bleeding by ultrasonogram wae 15 cases or 46.9%. It was suggested that whether or not confirmation of exsistence of intra uterine gestational sac or identification of fetus was playing as important role for ultrasonic diagnosis of ectopic pregnancy and furthur more placing the focus on negative factor such as exclusion of intra uterine pregnancy is indispensable. We can conclude through data obtained much improved accuracy will be anticipated when integrated supportive criteria such as adenexal mass, enlargement of uterus and deⅵation, positive urine pregnancy test, intra abdominal blood were involved for diagnosis.

흰쥐 재생간의 Glutathione S-Transferase 및 Glutathione Reductase의 활성치

이숙형,문교철,김여희,곽춘식 啓明大學校 醫科大學 1989 계명의대학술지 Vol.8 No.1

Changes in the activities of the following enzymes have been studied over a period of ten days after 70% (median and left lateral loves) partial hepatectomy in rats: cytosolic, mitochondrial and microsomal glutathione S-transferase, cytosolic glutathione reductase and cvtosolic glutathione peroxidase of regenerating liver. The activity of cytosolic glutathione S-transferase in the regenerating rat liver significantly diminished between the second and sixth days after the partial hepatectomy and that of mitochondrial glutathione S-transferase slightly decreased between the second and the thrid days after operation. However, the microsomal glutathion S-transferase activity in the regenerating rat liver showed a slight increase between the thrid and sixth days after operation. The cytosolic glutathione reductase activity in the regenerating rat liver slightly decreased between the first and thrid days after operation and the cytosolic glutathione peroxidase activity in the regenerating rat liver had a significant diminution between the second and the tenth days after the partial hepatectomy.

흰쥐 담즙울체간의 Carboxylesterase , Arylesterase 및 Cholinesterase 의 활성도

곽춘식,이숙형 ( Chun Sik Kwak,Sook Hyung Lee ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.3

A study was made on the changes of carboxylesterase, arylesterase and cholinesterase activities in cholestatic rat liver. The cytosolic, mitochondrial and microsomal carboxylesterase, arylesterase and cholinesterase activities were determined in the cholestatic rat liver induced by common bile duct ligation over a period of forty two days. The activities of these esterases in the serum were measured. The rats were sacrificed on the 14th day after common bile duct ligation for the values of the K_m and V_(max) in their hepatic esterases. The incorporation rates of orotic acid-(6)-^(14)C into nuclear and extranuclear RNA in their wet liver and the incorporation rates of amino acid mixture-(U)-^(14)C into protein of the cytosolic, mitochondrial and microsomal fractions in their liver were also measured. The activities of cytosolic and mitochondrial carboxylesterase of the cholestatic rat liver showed a remarkable decrease between the 7th and the 42nd days following the ligation of the common bile duct. On the other hand, the microsomal carboxylesterase activity in the cholestatic liver markedly decreased between the 1st and the 42nd days after the ligation. The carboxylesterase activity of the serum markedly decreased between the 3rd and the 42nd days after the ligation. The cytosolic and mitochondrial arylesterase activities in the cholesatatic liver had a marked diminution between the 14th and the 42nd days after the ligation, but the microsomal arylesterase activity in the cholestatic liver showed a marked decrease between the 1st and the 42nd days after the operation. The arylesterase activity in the serum showed a marked decrease throughout the experiments. The mitochondrial and microsomal cholinesterase activities of the cholestatic liver each showed a marked decrease between the 14th and the 42nd days and the 12th hour and the 42nd day respectively after the ligation. However, the cytosolic cholinesterase activity did not change. That of the serum cholinesterase also showed a marked decrease between the 1st and th 42nd days after the ligation. The values of Vmax of the cytosolic, mitochondrial and microsomal carboxylesterase and arylesterase, and of the mitochondrial and microsomal cholinesterase in cholestatic rat liver showed a marked decrease from the 14th day after the ligation, however, the values of K_m of above hepatic esterases did not change. The incorporation rates of orotic acid-(6)-^(14)C into nuclear and extranuclear RNA in cholestatic rat liver showed a significant diminution from the 14th day after the ligation. The incorporation rates of amino acid mixture-(U)-^(14)C into protein of the cytosolic, mitochondrial and microsomal fractions in their liver had a marked diminution from the 14th day after ligation. Viewed from above results, carboxylesterase, arylesterase and cholinesterase in the liver with cholestasis seem to be decreasing activities of enzymes seemingly due to the decrement of biosynthesis.

시공성 기술 개발을 위한 설계 및 엔지니어링에의 3D CADDS 모델 응용 ( Application of 3D CADDS ( Computer Aided Design and Drafting ) Model to Design and Engineering for Constructibility Improvement )

박찬국,이숙형,박경석 한국에너지학회 2000 한국에너지공학회 학술발표회 Vol.2000 No.-

흰쥐 담즙울체간의 Carboxylesterase, Arylesterase 및 Cholinesterase의 활성도

곽춘식,이숙형,Kwak, Chun-Sik,Lee, Sook-Hyung 생화학분자생물학회 1992 한국생화학회지 Vol.25 No.3

담즙울체간에서 carboxylesterase, arylesterase 및 cholinesterase의 활성변동을 알아보기 위하여 시행한 실험으로서 흰쥐의 총담관을 결찰하고 12시간부터 42일까지의 담즙울체간에서 세포질, mitochondria 및 microsome의 carboxylesterase, arylesterase 및 cholinesterase활성도를 측정하는 한편 혈청에서 이들 효소활성도도 함께 측정하였다. 또한 흰쥐의 총담관을 결찰한 후 14일 경과한 쥐의 담즙울체간에서 이들 효소의 $K_m$과 $V_{max}$를 측정하였으며 아울러 세포핵 및 핵외 RNA합성속도와 세포질, mitochondria 및 microsome의 단백합성속도를 측정하였다. 흰쥐 담즙울체간의 cytosolic 및 mitochondrial carboxylesterase 활성도는 총담관결찰 후 7일부터 42일까지 현저한 감소를 나타내었다. microsomal carboxylesterase활성도는 총담관결찰 후 1일부터 42일까지 현저한 감소를 나타내었다. 혈청의 carboxylesterase 활성도는 총담관결찰 후 3일부터 42일까지 현저한 감소를 나타내었다. 흰쥐 담즙울체간의 cytosolic 및 mitochondrial arylesterase활성도는 총담관결찰 후 14일부터 42일까지 현저한 감소를 나타내었다. 그러나 microsomal arylesterase 활성도는 총담관결찰 후 1일부터 42일까지 현저한 감소를 나타내었다. 혈청의 arylesterase 활성도는 실험 전기간 동안 현저한 감소를 나타내었다. 흰쥐 담즙울체간의 cytosolic cholinesterase 활성도는 실험 전기간 동안 별 변동이 없었다. 그러나 mitochondrial 및 microsomal cholinesterase 활성도는 각각 총담관결찰 후 14일부터 42일까지 그리고 12시간부터 42일까지 현저한 감소를 나타내었다. 혈청의 cholinesterase 활성도는 총담관결찰 후 1일부터 42일까지 현저한 감소를 나타내었다. 흰쥐의 총담관을 결찰한 후 14일 경과한 쥐의 담즙울체간에서의 carboxylesterase, arylesterase 및 cholinesterase의 $K_m$치는 변동이 없었다. 그러나 이들효소의 $V_{max}$치는 현저한 감소를 나타내었다. 흰쥐의 총담관을 결찰한 후 14일 경과한 쥐의 담즙울체간에서의 세포핵 RNA와 세포핵외 RNA합성속도는 모두 유의한 감소를 나타내었다. 흰 쥐의 총담판을 결찰한 후 14일 경과한 쥐의 담즙울체간에서의 세포질, mitochondria 및 microsome의 단백합성속도도 모두 유의한 감소를 나타내었다. 이상 결과로 보아 흰쥐 담즙울체간의 carboxylesterase, arylesterase 및 cholinesterase는 그 활성이 감소되는 효소이며 이들 효소의 활성감소는 담즙울체간에서 그 합성이 저하되어 나타난 결과라 생각된다. A study was made on the changes of carboxylesterase, arylesterase and cholinesterase activities in cholestatic rat liver. The cytosolic, mitochondrial and microsomal carboxylesterase, arylesterase and cholinesterase activities were determined in the cholestatic rat liver induced by common bile duct ligation over a period of forty two days. The activities of these esterases in the serum were measured. The rats were sacrificed on the 14th day after common bile duct ligation for the values of the $K_m$ and $V_{max}$ in their hepatic esterases. The incorporation rates of orotic acid-(6)-$^{14}C$ into nuclear and extranuclear RNA in their wet liver and the incorporation rates of amino acid mixture-(U)-$^{14}C$ into protein of the cytosolic, mitochondrial and microsomal fractions in their liver were also measured. The activities of cytosolic and mitochondrial carboxylesterase of the cholestatic rat liver showed a remarkable decrease between the 7th and the 42nd days following the ligation of the common bile duct. On the other hand, the microsomal carboxylesterase activity in the cholestatic liver markedly decreased between the 1st and the 42nd days after the ligation. The carboxylesterase activity of the serum markedly decreased between the 3rd and the 42nd days after the ligation. The cytosolic and mitochondrial arylesterase activities in the cholesatatic liver had a marked diminution between the 14th and the 42nd days after the ligation, but the microsomal arylesterase activity in the cholestatic liver showed a marked decrease between the 1st and the 42nd days after the operation. The arylesterase activity in the serum showed a marked decrease throughout the experiments. The mitochondrial and microsomal cholinesterase activities of the cholestatic liver each showed a marked decrease between the 14th and the 42nd days and the 12th hour and the 42nd day respectively after the ligation. However, the cytosolic cholinesterase activity did not change. That of the serum cholinesterase also showed a marked decrease between the 1st and th 42nd days after the ligation. The values of Vmax of the cytosolic, mitochondrial and microsomal carboxylesterase and arylesterase, and of the mitochondrial and microsomal cholinesterase in cholestatic rat liver showed a marked decrease from the 14th day after the ligation, however, the values of $K_m$ of above hepatic esterases did not change. The incorporation rates of orotic acid-(6)-$^{14}C$ into nuclear and extranuclear RNA in cholestatic rat liver showed a significant diminution from the 14th day after the ligation. The incorporation rates of amino acid mixture-(U)-$^{14}C$ into protein of the cytosolic, mitochondrial and microsomal fractions in their liver had a marked diminution from the 14th day after ligation. Viewed from above results, carboxylesterase, arylesterase and cholinesterase in the liver with cholestasis seem to be decreasing activities of enzymes seemingly due to the decrement of biosynthesis.