Preparation of Novel T-Type Nonlinear Optical Polyimide with High Thermal Stability of Second Harmonic Generation

이가영,이가영,장한나,정원택,이주연 한국고분자학회 2008 Macromolecular Research Vol.16 No.8

Three-Month Daily Consumption of Sugar-Sweetened Beverages Affects the Liver, Adipose Tissue, and Glucose Metabolism

이가영,한지혜,맹효진,임수 대한비만학회 2020 The Korean journal of obesity Vol.29 No.1

Background: Growing evidence suggests links between sugar-sweetened beverages (SSBs) and metabolic disorders. We investigated the effects of SSBs commonly consumed by adolescents and their relationships to glucose metabolism and fatty liver. Methods: We treated 7-week old male C57BL/6 mice with water (control) or one of three different SSBs, carbonated soda (Coca-Cola), sweetened milk coffee (Maxwell), or chocolate-added cocoa (Choco-Latte), for 13 weeks (n=10 in each group). Half of the animals were fed a regular chow diet and the other half a high-fat diet (40% fat). Body composition and biochemical variables were investigated at the end of treatment. Histology of the liver and adipose tissue, as well as molecular signaling related to glucose and lipid metabolism, were also evaluated. Results: During the 13-week treatment, mice treated with chocolate-added cocoa or sweetened milk coffee showed significantly greater increases in body weight compared with controls, especially when fed a high-fat diet. Fasting glucose level was higher in the three SSB-treated groups compared with the control group. Lipid droplets in the liver, fat cell size, and number of CD68-positive cells in adipose tissue were greater in the SSB-treated groups than in the control group. SSB treatments increased the expression of genes related to inflammatory processes in the liver and adipose tissue. Phosphorylation of AKT and glycogen synthase kinase in muscle was significantly reduced in SSB-treated groups. Conclusion: Daily consumption of SSBs over 3 months lead to metabolic impairment and weight gain and may contribute to development of metabolic diseases.

NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors

이가영,신승현,신현우,전양숙,박종완 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Expression of hypoxia-inducible factors (HIFs) and N-myc downstream-regulated gene 3 (NDRG3) are oxygendependently regulated by prolyl hydroxylase domain (PHD) enzymes. Little is known about the role of NDRG3 in the cellular adaptation to hypoxia, whereas the roles of HIFs are well understood. In this study, we investigated how NDRG3 affects the hypoxic response in prostate cancer cells. Compared with HIF-1α, hypoxic induction of NDRG3 was observed at a later phase. NDRG3 reduced hypoxic expression of HIF-1α by inhibiting AKT-driven translation of HIF1A mRNA. In addition, NDRG3 functionally inhibited HIF-1 by dissociating the coactivator p300 from HIF-1α. Accordingly, NDRG3 may fine-tune the HIF-1 signaling pathway to cope with long-term hypoxia. Of the diverse effects of HIF-1α on cancer progression, hypoxia-induced cell migration was investigated. In transwell chambers, NDRG3 negatively regulated the migration and invasion of prostate cancer cells under hypoxia. An informatics analysis using Gene Expression Omnibus (GEO) revealed that NDRG3 downregulation is associated with prostate cancer metastasis and high expression of HIF-1 downstream genes. In cancer tissue arrays, NDRG3 expression was lower in prostate cancer tissues with a Gleason score of 8 or greater and was inversely correlated with HIF-1α expression. Therefore, NDRG3 may have an anti-metastatic function in prostate cancer under a hypoxic microenvironment.

한국연구재단 박사후국내연수

이가영 한국성인간호학회 2018 성인간호학회 학술대회 Vol.2018 No.12

요한 세바스찬 바흐와 18세기 초 독일의 신학적 지형: 아브라함 칼로프(Abraham Calov)에서 아우구스트 헤르만 프랑케(August Hermann Francke)까지

이가영 한양대학교 음악연구소 2012 音樂論壇 Vol.27 No.-

이 글은 바흐가 얼마나 신학적인 음악가였는가의 문제를 바흐의 ‘내부’에서가 아니라 그의 ‘외부’를 통해 들여다보는 것을 그 목적으로 한다. 바흐의 외부, 즉 그를 둘러싸고 있던 신학적 문맥 안에 바흐를 위치시킴으로 작곡가와 그의 음악을 이해하고자 하는 것이다. 이를 위해 바흐가 개인적으로 소장하고 있었던 신학문헌들에 주목할 것이며 이 중 특별히 『칼로프 성경』, 『진정한 기독교』, 『경건한 소원』등을 보다 구체적으로 분석할 것이다. 이를 통해 바흐의 신학적 사고가 정통루터교의 그것만으로는 설명되지 않는다는 것, 그리하여 복잡다단한 신학적 겹들이 바흐의 신학적 사고를 이루고 있었다는 것을 드러내고자 하는 것이다. This paper attempts to articulate Johann Sebastian Bach and his music in theological terms, trying to placing him in a theological context in which he lived. By carefully examining Calov Bible, True Christianity, and Pie Desideria, the texts once belonged to Bach's theological library. I will stress that these texts reflect both Lutheran Orthodoxy theology and Pietism, arguing that Bach, theologically speaking, cannot be considered to be an orthodox Lutheran, nor a pietist. Rather, Bach needs to be understood in a crossroad in which the various types of reform movements overlap.

Development and intralaboratory validation of three Arcidae species using a multiplex polymerase chain reaction assay combined with capillary electrophoresis

이가영,양승민,김해영 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.10

Recently, various commercial ark shell products were being sold, and in the case of processed foods, the loss of morphological traits makes species identification visually challenging, which can lead to seafood fraud. Therefore, a multiplex polymerase chain reaction (PCR) assay was developed to simultaneously identify three ark shells. The specific PCR amplicon sizes of the generated species-specific primer pairs were observed to be 99 bp for Anadara kagoshimensis, 148 bp for Anadara broughtonii, and 207 bp for Tegillarca granosa. Specificity was confirmed for 17 fish and shellfish, and only the target was amplified without cross-reactivity. The detection limit for the multiplex PCR assay was 1 pg. Furthermore, 31 commercial products were evaluated to assess the developed assay’s applicability. Therefore, the analytical approach used in this study can rapidly and accurately identify ark shells in commercial food, and may be used as an authentication tool in the seafood industry.

Evaluation of gas freshness indicator for determination of skate (Raja kenojei) quality during storage

이가영,이시형,신한승 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.5

A gas freshness indicator consisting of the pH-sensitive dye bromothymol blue-phenol red (BTB-PR) was investigated for visible color changes of fish product quality based on the quantity of volatile amines. Chromaticity values of the gas indicator accurately tracked an increase in the ammonia content in the packaging headspace of fish products, especially skate (Raja kenojei). Gradual color changes of the gas indicator response correlated with the quality of fish including pH values during storage. Ammonia content was evaluated during the fish storage using headspace solid-phase microextraction analysis with gas chromatography-flame ionization detection. The validation results suggested that good linearity (R²=0.99) and recovery of 84.00%. The limits of detection and quantification were 8.70 and 26.30 mg/L, respectively. A pH values of skate and chromaticity of gas indicator were measured and the correlation with ammonia content was evaluated. Results of this study could prove the application of gas indicator as intelligent package for improvement of food safety.

파이지엘로(Giovanni Paisiello), 솔러(Vicente Martin y Soler), 치마로사(Domenico Cimarosa) 그리고 모차르트의 오페라 부파 들여다보기

이가영 한국서양음악학회 2009 서양음악학 Vol.12 No.2

This article explores the musical as well as dramatic convention of opera buffa, focusing on its characters and plots. Moreover, it addresses the intertextuality of the genre, by examining the genre in terms of opera seria, parody, and pastoral. In order to do so, the study analyzes the most representative works of the period, including the opera buffi of Paisiello, Soler, Cimaroso and Mozart. Through my analysis of these composers’ operas in light of their musical as well as dramatic conventions, I argue that the essence of the genre lies in the intertextuality in which various types of texts interwoven together in order to creates musical and dramatic meanings through which the works and the audiences of the time continuously communicate. This article explores the musical as well as dramatic convention of opera buffa, focusing on its characters and plots. Moreover, it addresses the intertextuality of the genre, by examining the genre in terms of opera seria, parody, and pastoral. In order to do so, the study analyzes the most representative works of the period, including the opera buffi of Paisiello, Soler, Cimaroso and Mozart. Through my analysis of these composers’ operas in light of their musical as well as dramatic conventions, I argue that the essence of the genre lies in the intertextuality in which various types of texts interwoven together in order to creates musical and dramatic meanings through which the works and the audiences of the time continuously communicate.

국내 자생 장수버섯의 형태적 특성

이가영,구창덕,이화용,이희수,박용우,김세경,조경진 한국산림휴양복지학회 2013 한국산림휴양학회 학술발표회 자료집 Vol.2013 No.4

시판중인 불소 바니쉬의 불소이온 유리량 및 초기우식병소의 재광화 효과 비교

이가영,이상호,이난영,지명관,Lee, Kayoung,Lee, Sangho,Lee, Nanyoung,Jih, Myeongkwan 대한소아치과학회 2016 大韓小兒齒科學會誌 Vol.43 No.4

본 연구는 현재 시판되고 있는 불소 바니쉬 제품의 불소이온 유리 능력을 측정하고 이와 함께 정량 광 형광기를 이용하여 치질의 재광화 효과를 비교, 분석하였다. 평가하고자 하는 불소 바니쉬는 다음과 같은 6가지 제품을 대상으로 하였다; $FluoroDose^{(R)}$ (FD, Centrix Inc., USA), $Enamelast^{TM}$ (EL, Ultradent Product Inc., USA), $Clinpro^{TM}$ white varnish (CW, 3M ESPE, USA), $CavityShield^{TM}$ (CS, 3M ESPE, USA), V $varnish^{TM}$ (VV, Vericom, Korea), MI $varnish^{TM}$ (MI, GC, Japan). MI $varnish^{TM}$와 V $varnish^{TM}$에서 누적 불소이온 유리량과 재광화율이 가장 높게 나타난(p < 0.05) 반면 CS $varnish^{TM}$가 가장 낮은 누적 불소이온 유리량과 재광화율을 보였다(p < 0.05). Subjects of this study were : $FluoroDose^{(R)}$ (FD, Centrix Inc., USA), $Enamelast^{TM}$ (EL, Ultradent Product Inc., USA), $Clinpro^{TM}$ white varnish (CW, 3M ESPE, USA), $CavityShield^{TM}$ (CS, 3M ESPE, USA), V $varnish^{TM}$ (VV, Vericom, Korea), MI $varnish^{TM}$ (MI, GC, Japan). The amount of fluoride ion release was measured eight times during 168 hours to see change in accumulation with the course of time using a measuring instrument. And the remineralization rate was measured with Quantitative Light-induced Fluorescence (QLF). V $varnish^{TM}$ group and MI $varnish^{TM}$ group showed high remineralization rates with statistically significance while $CavityShield^{TM}$ group was the lowest rate of remineralization (p < 0.05). After that, several chosen samples were scanned through electron microscope (SEM). Demineralized enamel was observed as the number of enamel crystal was very small; enamel rods and crystals were highly protruding. Remineralized groups with fluoride varnishes show the decreasing tendency of the surface roughness compared to the demineralized enamel.