지역 활성화를 위한 유휴 산업시설의 컨버전 적용연구

엄소정 조선대학교 일반대학원 2018 국내석사

시간에 흐름에 따라 생겨난 유휴산업시설의 배경을 고찰하고 유휴 산업시설 활용을 통한 도시재생에 대해 분석 하고자 하며, 유휴 산업시설의 새로운 용도 부여를 통한 도시재생 실현가능 방법으로 컨버전 디자인에 대해 알아본 후 키워드를 뽑아내어 문화시설로 변모한 유휴 산업시설에 대한 사례조사를 통해 컨버전 디자인 특성 추출을 통해 종합한 자료들이 나아가 유휴산업시설의 재생을 위한 참고자료로 활용할 수 있도록 하는데 목적이 있다. 본연구의 방법은 2차 산업의 발전에 중요한 역할을 하였으나 흐름에 따라 사용되지 않게 된 유휴산업시설을 컨버전 디자인을 통한 사례공간을 대상으로 그 구체적인 특성표현(역사적 시간성, 상징성, 접근성, 장소적 통시성, 지속성) 활용에 대해 분석하고자 하며 역사적 시간성에서는 시간의 흔적을 보존함으로써 공간 활용을 통해 경쟁력을 확보하였는지를 알아보고 장소적 통시성에서는 다른 일반적 공간과는 다른 차별성을 두고 구성되어 상호작용을 촉진하고 있는가에 대해 알아보려 하며 접근성에서는 사용자들이 용이하며 해당 공간 주변에서의 문화적 접근이 가능하여 대중적인 인식하에 전환되는가에 대해서도 분석하려 한다. 상징성에서는 새로운 용도와의 결합을 통한 새로운 상징성을 생성하였는가와 기존 구조체의 노출을 통한 기존공간의 상징성을 나타냈는가에 분석하려 하며 지속성에서는 공간의 기존 용도를 사용하던 공간에서 프로그램의 변화를 주어 공간의 사용변화로서 과거·현재에서 미래까지도 지속적인 활용이 가능한가에 맞춰 분석하려 한다. 사례지의 범위로는 문화예술공간으로 변형 된 공간을 지정하여 분석하였고 나아가 지속적인 활용을 위한 방안으로 반영될 수 있도록 종합 분석을 통해 알아본 뒤 결론을 도출하고자 하며 이에 따라서 본 연구의 결과는 다음과 같다. 첫째, 유휴 산업시설의 재생 시 국외의 경우 시간의 흐름을 활용한 컨텐츠를 활용하여 지역민들에게 역사적 시간성을 보여주었으며 새로운 상징성을 통한 랜드마크로서 자리 잡았으며 국내의 경우는 국외의 사례보다 비교적 외형적 혹은 구조를 보존함에 있어 그로 인한 과거의 간접적 체험 및 회상을 중점으로 경쟁력을 확보하는 것을 알 수 있었다. 둘째, 용도의 변화를 공통적으로 지니고 있음을 통해 컨버전 디자인을 적용했을 때 일반 재생과는 다른 차이점을 지니고 있는 공간들로서 시간의 흐름에 따른 공간 컨텐츠의 지속적인 변화 및 활용이 되어야 한다. 분석에 따르면 지속성은 건물의 외부와의 활용을 통해서 활성화를 촉진시킨다. 큰 건축물과 부지를 지니고 있는 건물에서는 프로그램의 변화 시 내·외부의 자유로운 활용에 따라 공간에 활성화를 더한다. 비교적 작은 공간으로 컨버전 디자인을 통해 재생된 금천 예술공장과 담빛 예술창고에서도 차이점이 나타나는데 이 또한 외부의 사용이 자유로움에 따라 프로그램의 변화를 다양하게 줄 수 있으며 이에 따른 공간의 활용과 활성화의 차이를 보이고 있다. 셋째, 접근성은 장소적 통시성과의 연계를 가지고 서로 상호작용하는데 지역이 추구하는 정체성을 위해 발전이 될수록 공간 또한 지속적인 관리를 통해 접근적으로 편리해지며 다양한 정체성을 가진 공간으로 지역의 문화적 공간 혹은 관광지가 많이 생기게 된다면 그에 따른 새로운 지역의 활성화를 도모할 수 있다. 유휴산업시설이 지니고 있는 가치와 가능성을 활용해 재생했을 경우 일시적이고 단순한 물리적인 재생변화가 아닌 미래에도 잠재적 가치와 지속 활용을 통하기 위해 컨버전 디자인이 필요하다. 하지만 우리나라는 충분히 활용 가능한 유휴산업시설이 있음에도 불구하고 새로운 공간의 발전을 통한 흐름의 변화에 맞는 욕구를 충족시키려 한다. 본연구의 결과를 통해서 우리나라의 유휴산업시설이 지닌 가치와 특성을 활용하여 앞으로 우리나라에서 유휴산업시설이 문화공간으로 탈바꿈하는 경우 보다 나은 컨버전 디자인 작업이 될 수 있는 활용방안을 제시하려한다. 그러나 문화예술공간 안에서도 다양한 목적행위가 분류되어있지 않고 동일한 행위들이 이루어지는 사례를 다수에 초점을 두고 진행하여 구체적이고 세부적인 특성의 표현과 차이점을 제안하는데 한계점이 있었다. 향후 연구에서 세부적인 공간 분류를 통한 연구가 진행되어야 할 것이다. he purpose of this study is to review the background of idle industrial facilities that have emerged over time, to analyze urban regeneration using idle industrial facilities, to understand conversion design as a method to realize urban regeneration through the new application of idle industrial facilities, to make materials by extracting characteristics of conversion design through case studies that idle industrial facilities have been transformed into cultural facilities, and to let them utilized as regeneration of idle industrial facilities. The subjects of this study are the idle industrial facilities, which used to play an important role in the development of the secondary industry but it is not used anymore according to the trend. It was tried to analyze the utilization of characteristics the subjects (history, symbolism, accessibility, locational diachrony and sustainability) through conversion design. In the historical time, it was tried to find out if competitiveness was secured through space utilization by preserving the trace of time. In the locational diachrony, it was tried to identify if interactions were promoted with differentiation from general spaces. In accessibility, it was tried to analyze whether users were able to easily access and culturally approach the space, and whether they were converted with public awareness. In symbolism, it was tried to analyze whether a new symbolism was created with the combination of new usages, and whether it represented the symbolism of existing space through exposure of exiting structures. In the sustainability, it was tried to analyze if the changes in the use of a space by changing programs could make the space used constantly from the past and the present to the future. The scope of the subject spaces were limited to the spaces which were converted to cultural and art spaces. It was tried to induce conclusion after the comprehensive analysis so that it could be reflected as a measure for continuous use. The results of this study are as follows. First, in the regeneration of the idle industrial facilities in overseas, they showed history of the space using the contents utilizing flow of time to local residents and they became landmarks through new symbolism. In domestic cases, they secured competitiveness focusing on indirect experience and recall of the past by preserving exterior structure more strictly. Second, as they have common change of uses, they should be able to have constant changes and utilization of the spatial contents according to time flow as spaces with difference from general regeneration. In a building with a large building area and land, the space cab be activated by the free use of the interior and exterior of the building with the program change. In Geumcheon Art Factory and Dambit Art Warehouse regenerated through conversion design as relatively small spaces, differences are shown. Depending on whether to use exterior of the building or not, the program can be varied and they may be difference in space utilization and activation. Third, accessibility, the spaces become more convenient and accessible through continuous management, and if there are many cultural spaces or tourist attractions in the space with diverse identities, the mew area can be activated accordingly. Conversion design is required in the regeneration of idle industrial facilities to utilize their potential values and sustainability in the future rather than to make simple, temporal and physical regeneration. Although we have many idle industrial facilities in Korea, they are not regenerated well enough to satisfy the change of trends through development into the new space. Through the result of this study, it was tried to present a method to apply conversion design when idle industrial facilities in Korea were to be converted to cultural space utilizing their values and characteristics. There were limitations in suggesting the expressions and differences of specific and detailed characteristics as this study focused on the cases where the same activities were made without classification of detailed characteristics. Future researches should be conducted through detailed spatial classification.

음악 개념 이해를 통한 음악 요소별 창작 교수·방법 연구

엄소정 공주대학교 교육대학원 2015 국내석사

약콩(Rhynchosia Nolubilis, 鼠目太) 및 대두 처리에 의한 MG-63 조골세포 증식에서 ER α의 역할에 대한 연구

엄소정 경희대학교 동서의학대학원 2003 국내석사

폐경 후 골다공증은 에스트로겐의 분비가 감소함에 따라 골 형성을 담당하는 조골세포 작용의 감소와 파골세포 작용의 상대적인 증가로 인한 골 흡수가 증가되어 골 밀도가 낮아지는 질환이다. 치료법으로 에스트로겐 보충요법이 사용되어 왔으나, 이로 인한 부작용이 심각하여 에스트로겐의 기능을 갖는 활성물질이 풍부한 천연물의 활성성분을 이용한 대체요법에 대한 연구가 활발히 진행되고 있다. 약콩 (Rhynchosia Nolubilis, 鼠目太)은 식물성 에스트로겐 성분이 풍부한 것으로 알려져 있으며, 예로부터 한의학 및 민간요법에서 폐경기 여성의 골다공증 예방 및 치료에 이용되어 왔다. 또한 약콩 추출물은 저 농도 이소플로본계 혼합체로 MG-63 조골세포에 투여 시 시너지 효과를 내어 증식을 증가시키며 IGF-1 등 증식관련 인자의 발현을 선택적으로 유도한다고 연구된 바 있다. 본 연구에서는 대두 추출물과 약콩 추출물을 처리했을 때 MG-63 조골세포에서 ER-α, β가 모두 현저히 증가했던 것을 바탕으로 hERα와 hERα-antisense를 이용하여 ERα의 발현정도가 cell proliferation에 미치는 영향을 연구하고자 하였다. ERα의 항시 발현 (ERα-MG63 cells)은 증식을 ∼36.8% 증가시켰으며 약콩 및 대두 추출물의 첨가 처리는 증식을 ∼110%까지 더욱 현저히 증가시켰다. Antisense ERα의 gene transfection은 ERα의 발현을 현저히 억제하였으며 이와 병행하여 증식이 ∼30% 억제되었고 약콩 및 대두 추출물의 첨가 처리에 의해서도 미비한 증식 증가 효과를 나타내었다. 0.001과 0.1 mg/ml 농도의 약콩 또는 대두 추출물을 처리한 ERα-MG63 cells에서 에스트로겐 수용체의 발현 변화를 살펴본 결과 ERα와 ERβ의 발현은 특히 대두 추출물 처리에 의해 더욱 현저하였으며 antisense-ERα-MG63 cells에서 ERα 및 ERβ 수용체의 발현은 parental MG-63 수준으로 증가하였으나 그 효과는 미비하였다. 에스트로겐 및 이소플라본에 의한 MG-63 조골세포의 증식 증가는 ERβ 수용체보다는 ERα 수용체에 의해 유도되었다. ERα-MG63 조골세포에 이소플라본 혼합체인 약콩 추출물의 처리는 에스트로겐 및 이소플라본 단일 표준물질보다 더욱 현저히 증식을 증가하였는데 이는 저 농도의 이소플라본 혼합물이 혼합체들 간의 시너지 효과를 나타내어 고농도의 이소플라본 단일 처리보다 더욱 현저한 ERα-MG-63 조골세포의 증식 증가 효과를 나타냄을 의미하며 이소플라본이 ERα보다 ERβ에 대한 결합력이 큰 것으로 알려져 있음에도 불구하고 약콩과 대두 추출물의 MG-63 조골 세포에 대한 증식 증가 효과는 ERβ 보다는 ERα 수용체의 발현 증가와 함께 이루어지는 것을 제안한다. Bone is an active organ, which undergoes the continuous remodeling cycle with resorption and formation processes during the entire life. Of three major bone cells, the resorption is initiated by osteoclasts that destroy bone. The osteoclasts are then replaced by osteoblasts that form osteoid rich in collagen. The mineralization of the osteoid completes this remodeling cycle. In healthy humans, the resorption and formation processes are in balance and bone mass is maintained by various signals including hormones, growth factors and cytokines. Estrogen is transported to the nucleus where is binds to the estrogen receptor(ER). Subsequently estrogen-estrogen receptor complex undergoes dimerization and conformational change resulting in the formation of transcriptionally competent complex that binds to response elements(ERE) in target genes and releases many kinds of factors. Among theses are transforming growth factor(TGF-β) and insulin like growth factor(IGF), interleukin(IL) -1 and -, tumor necrosis factor(TNF) and , macrophage colony stimulating factors(M-CSF), IL-6, IL-11, and etc. 1 These observations suggest that estrogen exerts multiple effects on bone by modulating the production of one or more of these regulating factors released in osteoblasts and osteoclasts. Followed by the cessation of ovarian functions in menopause woman, the low level of estrogen increased the osteoclastic resorption with altered expression of these bone regulating factors. In postmenopausal osteoporosis, bone resorption is not fully compensated by bone formation and bone mass is reduced resulting in the high incidence of bone fracture. Medically, there is now convincing evidence that estrogen therapies capable of preventing osteoporosis in postmenopausal women. However estrogen therapy can not be considered as an ideal method because the major drawbacks of estrogen have the side effects such as cramping, nausea diarrhea or uterus bleeding and the possible increase in the incidence of breast cancer. Thus we need to detect development of safety and effective agents to prevent osteoporosis. Phytoestrogens, especially soy-derived isoflavones, are receiving great scrutiny as a food supplement for preventing postmenopausal osteoporosis. The beneficial effect of phytoestrogens in soy food are caused by functioning as partial against or antagonists of estrogens. Soybean and most soy products contain large amounts of the isoflavones, genistein and daidzein. Recent studies showed that feeding soy protein to ovariectomized rats prevented bone loss and this positive effect was due to the isoflavones in the soy. Anderson and Garner found that the positive effect of genistein on bone is dose dependent, but higher doses of genistein did not prevent ovariectomy-induced bone loss. Moreover, cell culture experiments with osteoclasts indicated that pure genistein inhibits osteoclast function. Results from experimental animals support the concept that a threshold dose of isoflavone needs to be consumed for a sufficiently long period time. In contrast to the common usage of soy bean, Blackbean (Rhynchosia Moluvilis 鼠目太 Yak-kong) has been used as supplements of estrogen for preventing postmenopausal osteoporosis in oriental medicine. Blackbean has been commonly prescribed in oriental medicine because it is reported to be efficacious in treating bone disease including postmenopausal osteoporosis. Paralleled with high expectation, there is a demand of scientific proffer the effects of blackbean on postmenopausal osteoporosis. Because contents of daidzein and genistein in blackbean were much higher than other soy products, black beans might be more effective on preventing osteoporosis. In this study, we investigated compared the effect of blackbean and soybean extracts on proliferation of MG-63 osteoblastic cell and delineate the possible mechanism of it based on estrogen signaling. Isoflavones from two different soybeans were extracted by 70% methanol treatment. The quantitative analysis of the isoflavones in soybeans and blackbean was evaluated by an analysis with high performance liquid chromatography (HPLC). In blackbean methanol extracts, 0.4 X 10^(-14) M genistein and 0.354 X 10(-14)M daidzein were contained. In soybean methanol extracts, 0.04 X 10(-14)M genistein and 0.2 X 10(-14)M daidzein were contained. Trace amount of other isoflavones such as glycitein was detected only. Blackbean treatment of MG-63 cells resulted in an increase of cell proliferation to a maximum of 63% compared to 51% of soybean treatment. This increased effect of blackbean or soybean treatment was comparable to the combined treatment of daidzein and genistein standards (10(-14)M+10(-14)M), which resulted in an increase of cell proliferation to a maximum of 48%. The highly increased proliferation with blackbean treatment was further confirmed in MTT assay. Highly expressed level of estrogen receptor (ERα) and (ERβ) in blackbean treatment was also comparable to combined treatment of daidzein and genistein standards. However soybean treatment did not increase ER and ER expression as much as blackbean treatment. 4 Treatment of MG-63 cells with black bean extract also resulted in an increase of transactivation of an ERE(estrogen response element)-luciferase reporter plasmid and IGF-1 expression selectively. The increased expression of IGF-1 reflected black bean extract-induced changes in mRNA. Despite moderate effects of both bean treatments on estrogen receptor expression soy bean treatment did not further enhance transactivation of an ERE-luciferase reporter plasmid and decreased IGF-1 expression. Together, our data demonstrate that the synergic effect of isoflavones in blackbean caused an remarkable increase of cell proliferation. The greater estrogenic response with black bean extract for MG-63 cell proliferation is mediated by ER derived transactivation of ERE and selective induction of IGF-1 expression.

음악 개념 이해를 통한 음악 요소별 창작 교수·방법 연구

엄소정 공주대학교 교육대학원 2015 국내석사

The change in the desirable human character pursuited by the Ministry of Education allowed the increase of creative activities in musical education, yet in reality, the emphasis of musical education still lies largely in choral and instrumental music education. This research pursues several methods to allow composition creative education to be easily taught in unfavorable circumstances through studying musical techniques such as rhythm, tune, harmony, dynamic, tempo, tone, and form which are found in the different stages of musical and life education and finally form the seven stages of musical education which are internalization, understanding the characteristics of the motive, understanding the terms given, composition, presentation, assessment, revision and completion. Before entering the seven stages in each musical concept, the pre-stage activities related to the concept are proposed which will allow the students to not only recognize the concepts but to allow the students to truly understand the concepts and employ them in composition. For example, before the seven stages on rhythm, the pre-stage activities will include the understanding of duple and triple meter and when a rhythm sequence is given, allowing the students to play percussion instruments to imagine the next sequence, and before the composition of a tune with harmony, as the pre-stage activity, students will learn the idean harmony movement and will add harmony to a given tune. Through pre-stage activities, the students will not only learn the definition of the different musical concepts, but allow them to recognize the ability to compose and draw interest to musical composition. When the understanding the concept stage is completed, the students will participate in the internalization stage in which the students will fully intake the musical motives before understanding their characteristics, and through the understanding the characteristics of motives stage, the students will discuss the characteristics of motives based on the initial understanding of the concepts, and lastly, the students will understand the terms given and realize the different methods in which motives could be used, which will allow them to compose a creative piece. When composition in different concepts is completed, the students will present their piece and will explain the motives and conditions and the overall creation stages. Then students will observe peers’ composition, recognize the differences and accept assessment from the peers, revise the pieces while making sure that the individual’s motive and condition remains the same, and complete composition. This research remains as the proposal of a method that will facilitate composition education through rhythm, tune, harmony, tempo, dynamic, tone, and form which are presented in the education stages; however the verification of this method should be conducted in the real educational stage with further research in multiple sides, and further research which will allow diverse creative education method to be included in textbook and conducted in class is required.

중소기업의 기술혁신에 있어서 외부컨설턴트의 역할

엄소정 광운대학교 대학원 2014 국내석사

국내 정부에서는 최근 들어 기업 간의 경쟁 심화와 시장 환경 변화 등의 문제로 낙후되고 있는 중소기업의 문제를 해결하고자 다양한 정책적 노력을 진행하고 있다. 하지만 아직까지 정부의 다양한 지원 정책에도 불구하고 그 효과성을 검증한 연구가 미비하며, 대기업과의 양극화 현상이 해결되지 않고 있다. 따라서 본 연구에서는 정부의 지원프로그램 중 최근 급증하고 있는 외부컨설팅을 수혜 받은 중소기업을 대상으로 그 효과성을 검증하였으며, 외부컨설팅의 효과성을 높이기 위한 방안을 제시하였다. 또한, 외부의 지원을 수혜 받은 중소기업들 간의 효과성의 차이가 나는 원인을 밝히고자 중소기업의 내부역량과 수혜 만족도를 상황변수로 사용하였다. 연구 결과, 컨설팅을 수행하는 컨설턴트와 수혜기업과의 커뮤니케이션과 상호협력 정도가 높을수록 중소기업의 기술적 성과가 향상됨을 보였고, 중소기업의 규모가 작을수록 외부의 지원을 효과적으로 받아들일 수 있는 것으로 검증되었으며, 중소기업 내에 기술전문인력이 많을수록 외부와의 커뮤니케이션과 상호협력이 활발하여 기술적 성과를 높일 수 있음을 알 수 있었다. 그리고 서비스 업종에 포함되는 컨설팅사업의 특성상 수혜기업의 만족도가 성과에 큰 영향을 미치는 것으로 나타났다. 따라서 본 연구의 결과를 통해 정부의 중소기업 육성을 위한 지원프로그램 중 실제 경기도 지자체에서 시행하고 있는 ‘기술닥터사업’을 대상으로 실증연구를 통해 그 효과성을 검증하였으며, 외부컨설팅의 성과를 높이기 위한 구체적인 방안을 제시함에 의의가 있다. 또한, 외부의 지원만이 아닌 중소기업의 내부역량의 중요성을 제시함으로써 정부에서도 조금 더 소규모적인 중소기업을 대상으로 지원한다면 그 효과성이 더욱 클 것으로 기대되며, 중소기업은 기술직의 중요성과 필요성을 인식하게 되어 향후 기술직에 대한 고용창출의 효과가 있을 것으로 예상된다. 또한, 컨설팅사에서는 서비스질 개선과 컨설턴트의 역량강화를 위한 교육의 필요성을 제시함에 의의가 있다. Our government has recently been making various political efforts in order to solve many problems related to small and medium-sized companies which have fallen behind due to serious competitions among companies and change of the market environment. Despite the government's various supporting policies, however, few studies has been conducted which have verified their effectiveness so far and thus a polarizing effect between large companies and them has not been solved yet. Therefore, this study verified the effectiveness of the small and medium-sized companies which have benefited from outside consulting service that has recently increased drastically among the government's supporting programs and presented a method to enhance the effectiveness of the outside consulting service. Furthermore, the subject study used their internal capacities and satisfaction levels of benefits as situation variables in order to establish the reason why there was a difference in the effectiveness among the small businesses that have benefited from outside supporting. The results of this study showed that the higher communication and mutual corporation between consultants and beneficiary companies were, the more enhanced technological performances of those small businesses were, and verified the fact that the smaller those small businesses were, the more effectively they were able to accept outside supporting. Furthermore, the results determined that the more technicians small businesses had, the greater they were able to enhance their technological performances thanks to active communication and mutual corporation with the outside environment. In addition, they illuminated the fact that satisfaction levels of beneficiary companies have a great influence on their performance, considering that consulting business falls in the service industry. Therefore, this study verified the effectiveness through an empirical research for the 'technological doctor business' which has actually been implemented in Gyunggi-do among some supporting programs for promoting small businesses by the government through its results, and has a significance that it suggests a specific method to enhance the performance of outside consulting service. Moreover, it is expected that if the government supports small businesses more by realizing the importance of internal capacities of small business in addition to outsider supporting, the effectiveness will become greater. It is also expected that small business will have an opportunity to realize the importance and necessity of technical posts and thus they will enjoy the effect of jobs creation for technicians. Finally, this study has another significance that for consulting companies, it presents the need of education for strengthening the capacities of consultants as well as the enhancement of service quality.

语言与文化结合的初中汉语教材开发

엄소정 이화여자대학교 외국어교육특수대학원 2018 국내석사

Asymmetric dimethylation of Arginine-617 of Caprin1 regulates stress granule associated transcripts

엄소정 Graduate School, Korea University 2021 국내석사

Stress granule (SG) is a form of dynamic RNP granules, which consists of various mRNAs in translation initiation state, translation factors, RNAbinding proteins, and non-RNA-binding proteins. In mammalian cells, Caprin1 and G3BP1 play an important role in forming SGs by oxidative stress. Cell cycle associated protein 1(Caprin1) is a phosphoprotein which is highly conserved in vertebrates. It is well known that expression of carpin1 increases when resting cells enter the cell cycle. Here, I found that asymmetric dimethylation of Caprin1 by PRMT1 affects SG-associated transcripts. Refer to the other article, Caprin1 was methylated by PRMT1, and also when endo IP was conducted using PRMT1 f/f mouse and PRMT1 LKO mouse liver tissue, I could confirm that in case of PRMT1 LKO mouse liver tissue, methylation of Caprin1 was almost disappear. With the idea that Caprin1 is a component of SG, next I tried to see if this difference affects the SGs. First, I wanted to see whether methylation of Caprin1 by PRMT1 changes Caprin1’s tendency to consist SG or SG assembly. I used Caprin1 R617K mutation form which lost its ability to be methylated and PRMT1 KO cell line with Hepa1c1c7 cells. As a result, I could confirm that asymmetric dimethylation of Caprin1 have no impact on localization of Caprin1 or SG assembly. Secondly, because Caprin1 is an RNA binding protein, I took an experiment to see whether methylation of Caprin1 by PRMT1 affects RNA binding capacity of Caprin1. I carried out RNA immunoprecipitation (RIP). It was discovered that amounts of transcripts from granule enriched fraction decreased when Caprin1 arginine-617 were mutated. Moreover, specific transcripts which could be extracted from immunoprecipitated sample seems to enrich less to SG when Caprin1 arginine-617 were mutated. Results collectively suggested that losing asymmetric dimethylation of Caprin1 by PRMT1 because of arginine-617 mutation affected Caprin1’s binding affinity with specific SG-associated transcripts.