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안영환,고영일,김주희,반가영,이연경,홍가나,진유람,Byung-Joo Choi,Yoo Seob Shin,박해심,예영민 대한의학회 2015 Journal of Korean medical science Vol.30 No.3
Both immediate and delayed hypersensitivity reactions to iodinated contrast media (ICM)are relatively common. However, there are few data to determine the clinical utility ofimmunologic evaluation of ICM. To evaluate the utility of ICM skin testing in patients withICM hypersensitivity, 23 patients (17 immediate and 6 delayed reactions) were enrolledfrom 3 university hospitals in Korea. With 6 commonly used ICM including iopromide,iohexol, ioversol, iomeprol, iopamidol and iodixanol, skin prick (SPT), intradermal (IDT) andpatch tests were performed. Of 10 patients with anaphylaxis, 3 (30.0%) and 6 (60.0%)were positive respectively on SPTs and IDTs with the culprit ICM. Three of 6 patients withurticaria showed positive IDTs. In total, 11 (64.7%) had positive on either SPT or IDT. Threeof 6 patients with delayed rashes had positive response to patch test and/or delayed IDT. Among 5 patients (3 anaphylaxis, 1 urticaria and 1 delayed rash) taken subsequentradiological examinations, 3 patients administered safe alternatives according to the resultsof skin testing had no adverse reaction. However, anaphylaxis developed in the other 2patients administered the culprit ICM again. With 64.7% (11/17) and 50% (3/6) of thesensitivities of corresponding allergic skin tests with culprit ICM for immediate and delayedhypersensitivity reactions, the present study suggests that skin tests is useful for thediagnosis of ICM hypersensitivity and for selecting safe ICM and preventing a recurrence ofanaphylaxis caused by the same ICM.
안영환 대한의사협회 2023 대한의사협회지 Vol.66 No.1
Background: Glossopharyngeal neuralgia (GPN) is a rare type of cranial nerve rhizopathy that accounts for roughly 1% of trigeminal neuralgia cases and presents as extreme neuralgic pain in the ipsilateral deep throat, tongue base, or ear. Pain is usually intense and electric shock-like, occurring either without warning or triggered by swallowing. The purpose of this article is to provide a comprehensive review of the diagnosis and treatment of GPN and to differentiate it from trigeminal neuralgia. Current Concepts: In this review, our experiences, including cases of misdiagnosis and diagnostic pitfalls, are presented in detail. Treatment of GPN with microvascular decompression (MVD) has a success rate of over 90%. The use of “off-the-root entry zone” MVD, which eliminates the need for an adjuvant rhizotomy, is the best treatment for GPN. In addition, although gamma knife radiosurgery is categorized as a destructive procedure, it can still be another option if a patient is ineligible for MVD. Discussion and Conclusion: Practitioners must consider GPN when diagnosing patients with cranial nerve rhizopathy; it should be distinguished from other pain syndromes, especially trigeminal neuralgia. With an accurate diagnosis, an appropriate treatment plan can be developed.
Bcl-XL 유전자 과발현에 의한 사람 신경원조 세포주의 생존율 증강 효과
안영환,신용삼,윤수한,조기홍,조경기,김승업 대한신경외과학회 2004 Journal of Korean neurosurgical society Vol.35 No.4
Objective : This study is aimed whether bcl-xl could protect C4 cells from the cell death induced by serum deprivation. Methods : The transient transfection of the bcl-xl gene was made with a LipofectAMINE reagent. An immunohistocytochemical assay and Western-blotting were performed to examine the bcl-xl transfection into the C4 cells. In order to analyze the effect of the bcl-xl transfection, the number of cells on the well plate were serially counted each day, for 5 days, from the 2nd to the 6th day after transfection. The number of GFP-positive cells in the defined fields, following serum deprivation, was counted using fluorescence microscopy, and the total number of viable cells, including transfected cells, were also assessed. Results : Immunocytochemical staining showed positive cells in 52% of nestin staining, 60% of GFAP and 20% of MAP-2. The number of cells decreased after transfection using the LipofectAMINE in the serum free medium (p<0.001). Western blotting using an anti-human bcl-xl antibodies showed that bcl-xl was expressed in both the non-transfected and bcl-xl transfected C4 cells. Cell death in the C4 cells, and the number of cells, were serially monitored each day for 5 days. In the bcl-xl transfected cells, the cell death induced by serum deprivation was significantly inhibited and delayed compared to that in the control cells (p<0.001). Conclusion : It is suggested that the bcl-xl transfected human neural progenitor cells might improve the survival of the grafted cells, and may be an alternative source of cells for neural transplantation in degenerative diseases.at
안영환,김후곤,최동구 한국교통연구원 2018 交通硏究 Vol.25 No.3
Linear programming (LP) is widely used for development of energy and emission reduction analysis models because of its simplicity and ease of operation, but actual model users sometimes do not understand all the structures of models based on linear programming. The reason for this is that the bottom-up models have become more complicated with decision variables and constraints while subdividing the space, time, and operating modes. Besides LP's core constraints, various user-defined constraints added to reflect various restrictions of reality can be another obstacle for users. This paper summarizes efficient structures of LP formulation which have core decision variables and constraints specific to the road transport sector and minimal types of additional constraints for bottom-up energy system models. It shows the process of systematically extending from the most basic formulation to the case of technology with vintage and multiple activities. It also defines three types of constraints and their combinations that can encompass all kind of constraints often used by energy modelers. This work will contribute to better understanding of bottom-up energy models developed with LP and efficient building-up of the models for the road transport sector.