지능형 화재예측플랫폼 고도화를 위한 연구

박은석,이재문,오정배,민세홍 한국재난정보학회 2019 한국재난정보학회 학술대회 Vol.2019 No.09

본 논문에서는 어떻게 지능형 화재예측플랫폼을 고도화시킬 것인지에 대한 계획을 수립하였다. 경제 발전과 함께 도시로 인구가 집중됨에 따라 급속도로 증가하는 수요에 발맞추어 도시는 초고층화, 과밀화가 진행되고 있다. 이에 따라, 국내에서는 연평균 4만건 이상에 달하는 화재가 발생하고 있으며, 소방청에서는 국가화재정보센터를 통해 화재발생 관련정보를 수집하고 있으나 데이터의 량이 방대하여 화재발생패턴 분석에 어려움이 있다. 화재예측플랫폼은 소방청 화재통계데이터 10년치와 다 양한 화재영향인자 데이터를 수집하고 인공지능을 통해 빅데이터를 분석하여 화재발생확률을 예측할 수 있는 시스템을 구축 하였다. 이렇게 구축된 화재예측플랫폼의 정확도 및 신뢰성을 향상시키기 위해 사용처의 Test-Bed 및 인터뷰, 설문조사를 3차 년도에 진행하고자 한다. Test-Bed에 적용되는 대상은 화재예측플랫폼과 수보자 템플릿 PC로 3개월 동안 진행되며, 1개월을 기준으로 인터뷰와 설문조사를 통해 의견수렴을 진행하여 최종 화재예측플랫폼을 완성할 예정이다.

겔제제로부터 인도메타신의 피부투과

박은석,지상철,감성훈 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.2

In order to reduce the systemic side effects and the gastrointestinal irritation of indomethacin following its oral administration, the drug was formulated as a transdermal gel using poloxamer 407. In vitro diffusion cells fitted with excised rat skins were used to evaluate the effects of formulation variables on skin permeation of indomethacin from poloxamer gels. The formulation variables were the concentrations of indomethacin, poloxamer 407 and ethanol, and the gel pH. The increase of the drug amount in the gel from 0.5% to 2.0% induced a direct but nonlinear increase in the skin permeation rate of indomethacin. The increase of poloxamer concentration from 17.5% to 25% in the gel resulted in a decrease of skin permeation rate of indomethacin, which was due to a reduction in the amount of free drug molecules available for permeation through skin by entrapping more drug molecules within the micelles formed by poloxamer. The increase of ethanol concentration from 10% to 20% in the gel resulted in a linear increase of permeation rate of indomethacin through skin, possibly due to the penetration enhancing effect of ethanol. The skin permeation of indomethacin was substantially influenced by the gel pH, exhibiting a maximum at pH 4.

승강기 인명대피 실험시스템에 대한 실효성 검증

박은석,이재문,임성빈,김재범,최대현,민세홍 한국화재소방학회 2018 한국화재소방학회 학술대회 논문집 Vol.2018 No.추계

Cardioprotective effect of KR-33889, a novel PARP inhibitor, against oxidative stress-induced apoptosis in H9c2 cells and isolated rat hearts

박은석,강도현,강준철,장용창,이민주,정훈종,이규양,김대은,김보경,신화섭 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.5

Oxidative stress plays a critical role in cardiacinjury during ischemia/reperfusion (I/R). Despite a potentcardioprotective activity of KR-33889, a novel poly (ADPribose)polymerase inhibitor, its underlying mechanismremains unresolved. This study was designed to investigatethe protective effects of KR-33889 against oxidative stressinducedapoptosis in rat cardiomyocytes H9c2 cells andisolated rat hearts. H2O2 caused severe injury to H9c2 cells,mainly due to apoptosis, as revealed by TUNEL assay. However, KR-33889 pretreatment significantly attenuatedH2O2-induced apoptosis of H9c2 cells, which wasaccompanied by decrease in expression of both cleavedcaspase-3 and Bax and increase in Bcl-2 expression and theratio of Bcl-2/Bax. KR-33889 also significantly enhancedthe expression of anti-oxidant enzymes including hemeoxygenase-1, Cu/Zn-superoxide dismutase (SOD), Mn-SOD, and catalase, thereby inhibiting production of intracellularROS. Furthermore, KR-33889 reversed H2O2-induceddecrease in phosphorylation of Akt, GSK-3b, ERK1/2, p38 MAPK, and SAPK/JNK during most H2O2 exposuretime. In globally ischemic rat hearts, KR-33889 inhibitedboth I/R-induced decrease in cardiac contractility andapoptosis by increasing Bcl-2, decreasing both cleavedcaspase-3 and Bax expression, and enhancing expression ofanti-oxidant enzymes. Taken together, these results suggestthat KR-33889 may have therapeutic potential to preventI/R-induced heart injury in ischemic heart diseases mainlyby reducing oxidative stress-mediated myocardialapoptosis.

상피세포성장인자의 수용성 외용제제화

박은석,지상철,이유철 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.3

In order to formulate an aqueous topical preparation of epidermal growth factor(EGF) for the treatment of open wound and burn, the stability of EGF in aqueous vehicles containing various stabilizers was evaluated and the pharmacological activity of gel preparations formulated with poloxamer 407 was determined with wound model. Various additives, which are known as potent stabilizers far proteins and polypeptides so far, were used to increase the stability of EGF in aqueous vehicles. The contents of EGF in the vehicles containing stabilizers were determined with an HPLC method after the storage at 37℃. EGF was more stable in ultrapure water than RO water or saline. All the additives studied resulted in deleterious effects on EGF stability. Therefore, it was speculated that any additives or impurities in the vehicle made EGF unstable. However, nitrogen purge of solution increased the stability of EGF in aqueous vehicles. The aqueous topical preparations of EGF were formulated with poloxamer 407 as a gel base in saline. Gelatin or amastatin was employed as a protease inhibitor. The pharmacological effect of EGF gel was studied with open wound model in mice. EGF preparations, made of oleaginous base or poloxamer gel base, showed significant healing effect compared to the control group(p<0.05). The addition of protease inhibitor in poloxamer 407 gel resulted in significant healing effect compared to the gel without it(p<0.05). Body weights of mice treated with EGF preparation were increased at the first day after the formation of open wound, while those of the control group were decreased. The EGF gel made of poloxamer 407 containing a protease inhibitor would be a promising aqueous topical preparation for EGF.

Ring-Opening Metathesis Polymerization of Dicyclopentadiene and Tricyclopentadiene

박은석,박지해,전종엽,성종운,황운성,이분열 한국고분자학회 2013 Macromolecular Research Vol.21 No.1

환경, 에너지 그리고 순환 : 구두 ; 폐기물 열처리 및 배기가스 처리 : 청정오일 생산을 위한 하수슬러지의 열분해

박은석,강보성,김주식 한국폐기물자원순환학회(구 한국폐기물학회) 2007 공동 학술대회 초록집 Vol.2007 No.1

중국어의 보충형, 동형형, 수량결과빈어형 사동

박은석 한국중국어문학회 2012 中國文學 Vol.71 No.-

在漢語裏典型的詞匯致使就是補充型致使結構。同形型致使結構和數量結果賓語型致 使結構是典型的詞匯致使和形態致使之間的連續體。如果把詞匯致使的范圍擴大, 把不典 型的詞匯致使結構也包括進來的話, 同形型致使結構和數量結果賓語型致使結構也會包括在內。本文硏究,比較了補充型致使, 同形型致使和數量結果賓語型致使的如下特征, 卽, 蘊涵性,能表達的語義范圍,致使者種類,致使者的意圖性,被致使者種類,被致使者對被致使事件的自控度,被致使謂詞特征,致使的直接性等特征。通過特征比較發現了他們之間的共同點和不同點。這些種種特徵表明, 在詞匯致使的典型性方面, 補充型致使是最典型的詞匯致使, 數量結果賓語型致使的典型性相對較差一些, 同形型致使處在補充型致使和數量結果賓語型致使的中間位置。

현대 표준 중국어의 술보형 사동 연속체 ― 허사격리술보형 사동, 목적어격리술보형 사동, 비분리술보형 사동 연구

박은석 중국어문학회 2017 中國語文學誌 Vol.0 No.59

This study is about Mandarin Chinese resultative causative continuum, expletive separating resultative causatives, object separating resultative causatives, non-separable resultative causatives. These three resultative causatives are the continuum between analytic causatives and morphological causatives. This study investigates and compares the formal features and semantic features of these three resultative causatives. The features are causer type features, causer hierachy of animacy features, causer`s volition features, causee type features, causee`s control of result event features, causative predicate type features, implicativity features, and sentence type features.

중성자별과 블랙홀 쌍성의 병합

박은석,이창환 한국물리학회 2007 새물리 Vol.54 No.3

현재 가동중이거나 앞으로 가동될 중력장 검출 장치 (LIGO)에서 수년 내에 관측될 중력파의 후보로 중성자별-중성자별 쌍성이 주목을 받고 있다. 최근 중력파의 후보로서 질량이 작은 블랙홀과 중성자별 (LMBH-NS) 쌍성의 병합이 중성자별과 중성자별 (NS-NS) 쌍성의 병합보다 많을 수 있다는 제안이 제시된 바 있다. 이러한 제안은 이론적으로 가능한 중성자별의 최대 질량이 태양의 1.5배를 넘지 않는다는 연구 결과와 천체 외각에서 가스층 겹침 진화 (common envelope evolution)의 과정에서 에딩턴 한계를 넘어선 질량유입이 가능하다는 이론에 근거하고 있다. 이 이론에서는, 먼저 형성된 중성자별이 짝별로부터 질량을 유입하여 블랙홀로 진화함으로써 블랙홀-중성자별 쌍성을 형성하게 된다. 이와같은 질량 유입을 피하기 위해서는 초기 쌍성의 질량이 4 \% 이내에 있어야 하고, 이 경우에는 두별이 거의 동시에 진화를 하여 중성자별-중성자별 쌍성을 형성하게 된다. 따라서 초기 쌍성의 질량 차이가 4 \% 보다 클 확률이 4 \% 이내일 확률보다 크므로 블랙홀-중성자별의 쌍성이 훨씬 많이 분포하게 된다. 본 연구에서는 중성자별 모체의 질량에 따른 분포비를 균일 분포 (flat distribution)로 가정하고, 이 경우에 LMBH-NS 와 NS-NS의 비가 5 정도임을 보였다. Recently, the merger of a low-mass black hole and a neutron star binary (LMBH-NS) was suggested to be a candidate for a gravitational wave source for the LIGO (laser interferometer gravitational-wave observatory), which should be detected within several years. This suggestion is based on the study that showed the theoretical upper limit of the neutron star$^\prime$s mass to be about 1.5 M$\odot$ and hypercritical accretion to be possible during the spiral-in at the common envelope evolution. In this theory, the first-born neutron star evolves into a black hole due to accretion from a companion star, and a LMBH-NS binary is formed as a result. In order to avoid the accretion, the two giant progenitors have to be within 4 \% of each other in ZAMS mass, in which case they evolve into a NS-NS binary. In a flat distribution, since the probability of having a ZAMS mass difference bigger than 4 \% is more than 80 \%, a LMBH-NS binary population is much more likely than a NS-NS binary population. In this study, by assuming a flat distribution, we obtained five times more LMBH-NS binaries than NS-NS binaries as sources for the LIGO.