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박상서,최운호 한국융합보안학회 2001 융합보안 논문지 Vol.1 No.-
우리 군도 하루 속히 사이버전에 대비한 정보보호 요원들을 양성하여 우리 사이버 국토가 외국 사이버 전사들에 의한 경유지로 활용되는 것을 차단하고, 유사시 적절히 군을 보호할 수 있는 역량을 강화하여야 할 필요성이 절실해지고 있어서 향후 국방 정보보호 인력 양성을 위하여 고려되어야 할 사항들을 제시한다. As soon as possible, our military have to trainning the information security manpower for Cyber Warfare, it should be block the foreign infowarrior to go by way of other country from our system. An emergency, we can protect our military information system and this thesis provide checkpoint about how we consider about trainning the infowarrior for future war.
박상서,김태운,성윤희,박윤진,김명기,신말순 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.S2
Purpose: Poloxamer-407 (P-407) is used to induce hyperlipidemia. Exercise is effective in improving arteriosclerosis and cognitive impairment. In this research, the effect of treadmill running on short-term memory in the P-407-treated hyperlipidemia rats was studied focusing on neuroinflammation. Methods: Rats were classified in normal group, normal and treadmill exercise group, P-407-treated group, and P-407-treated and treadmill exercise group. Hyperlipidemia rats were made by single intraperitoneal injection with P-407 (500 mg/kg). Treadmill exercise was conducted for 30 minutes once a day, 5 days per week during 28 days. Step-down avoidance task was done to measure short-term memory. Glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 were assessed by immunohistochemistry. Expression of adhesion molecules and proinflammatory cytokines was determined by western blot analysis. Results: Treadmill exercise alleviated lipid profiles in the P-407-induced hyperlipidemia rats. Treadmill exercise improved short-term memory, inhibited reactive astrogliosis and microglia activation, and suppressed expression of adhesion molecules and proinflammatory cytokines in the hyperlipidemic rats. Conclusions: Treadmill exercise exerts alleviating effect on memory deficits by inhibiting hippocampal neuroinflammation in the hyperlipidemia. The current results suggest that treadmill running serves as the treatment strategy for the cognitive dysfunction caused by hyperlipidemia.
박상서,박혜상,정형모,곽효범,노미현,허준원,유수지,김태운 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.S1
Purpose: Chemotherapy is associated with the side effects including damage to the mitochondrial DNA. Doxorubicin (DOX) serves as a chemotherapeutic agent for the patients with breast cancer or prostate cancer. DOX causes muscle weakness and fatigue. We investigated the effects of treadmill exercise on DOX-induced apoptosis and mitochondrial dysfunction in relation to central fatigue. For this study, we used the rat model of DOX-induced muscle damage. Methods: DOX (2 mg/kg) was intraperitoneally injected 1 time per week for 4 weeks. Treadmill running continued 5 days per week for 4 weeks. Muscle strength and fatigue index in the gastrocnemius were measured. Immunohistochemistry for the expressions of tryptophan hydroxylase (TPH) and 5-hydroxytryptamine (5-HT) in the dorsal raphe was conducted. We used western blot analysis for the expressions of Bax, Bcl-2, and caspases-3 in the gastrocnemius. Mitochondrial function in the gastrocnemius was also evaluated. Results: DOX treatment decreased muscle strength with increase of fatigue index in the gastrocnemius. Mitochondria function was deteriorated and apoptosis in the gastrocnemius was enhanced by DOX treatment. Expressions of TPH and 5-HT in the dorsal raphe were increased by DOX treatment. Treadmill exercise attenuated DOX-induced muscle fatigue and impairment of mitochondria function. Apoptosis in the gastrocnemius was inhibited and over-expression of TPH and 5-HT was suppressed by treadmill exercise. Conclusions: Apoptosis was enhanced and mitochondria function was deteriorated by DOX treatment, resulting in muscle weakness and central fatigue. Treadmill exercise suppressed apoptosis and prevented deterioration of mitochondria function in muscle, resulting in alleviation of muscle weakness and central fatigue during DOX therapy.
박상서,김창주,김성현,김태운,이삼준 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.S2
Purpose: Wnt pathway is closely related to neurodevelopmental process associated with cognitive function. After administration of valproic acid to the pregnant mice, the effect of swimming exercise of pregnant mice on the memory, neuronal production, and apoptosis of pups was studied in relation with Wnt/β-catenin signaling pathway. Methods: On day 12 of pregnancy, mice were injected subcutaneously with 400-mg/kg valproic acid. The pregnant mice in the control with swimming exercise group and in the valproic acid injection with swimming exercise group were allowed for swimming for 30 minutes one time per a day, repeated 5 days per a week, during 3 weeks. Step-through avoidance task and Morris water maze task for memory function, immunohistochemistry for 5-bromo-2’-deoxyuridine (BrdU)-positive cells and western blot for brain-derived neurotrophic factor (BDNF), Wnt, β-catenin, Bcl-2 related X protein (Bax), B-cell lymphoma 2 (Bcl-2), cleaved caspase-3 were carried out. Results: Maternal swimming exercise during pregnancy improved memory function, increased BDNF expression, and neuronal proliferation in the valproic acid injected pups. Maternal swimming exercise during pregnancy suppressed Wnt expression and phosphorylation of β-catenin in the valproic acid injected pups. Maternal swimming exercise inhibited Bax and cleaved caspase-3 expression and increased Bcl-2 expression in the valproic acid injected pups. Conclusions: Maternal swimming exercise during pregnancy improved memory function by increasing cell proliferation and inhibiting apoptosis through Wnt/β-catenin signaling cascade activation in the valproic acid injected pups. Maternal swimming exercise during pregnancy may have a protective effect on factors that induce autism in the fetus.
조직내 정보시스템 보안 전략의 성공적 구현을 위한 정보시스템 보안 전략의 특성
박상서,박춘식 한국융합보안학회 2008 융합보안 논문지 Vol.8 No.3
조직의 정보시스템 보안을 향상시키기 위해서는 전략의 도입이 필수적이다. 그리고, 이들 전 략을 조직내에 성공적․효율적으로 구현하기 위해서는 전략의 특성 중 전략의 구현에 영향을 주는 요인들을 고려하여야 한다. 본 논문에서는 전략의 여러 특성들 중 이러한 특성들을 연구하 였다. It is essential for organizations to employ strategies for improving their information systems security. It is also required to consider features of information systems security strategies which affect their successful and efficient implementation in organizations. This paper identifies those features from various information systems security and strategies literatures.