정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

Rat periodontal ligament cell에서의 RANKL mRNA의 발현

김현수,정현주,김영준,김옥수,Kim, Hyun-Soo,Chung, Hyun-Ju,Kim, Young-Joon,Kim, Ok-Su 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.2

As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor $^{\kappa}B$ ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease. This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1 ${\beta}in$ the concentration of $0.01{\sim}10$ ng/ml. The results are as follows; 1. Periodontal ligament cells which stimulated by 1L-1 ${\beta}$ increased soluble RANKL synthesis by dose-dependent pattern in the concentration of $0.01{\sim}10$ ng/ml. 2. 1L-1 ${\beta}$ induced mRANKL expression in dose-dependent manner in the concentration of $0.01{\sim}5$ ng/ml. 3. mOPG expression was not to be influenced by 1L-1 ${\beta}$. These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.

스카이브릿지 설치위치에 따른 고층건물의 진동제어 성능평가

김현수,박용구,고현,이의현,이동근,Kim, Hyun-Su,Park, Yong-Koo,Ko, Hyun,Lee, Ui-Hyun,Lee, Dong-Guen 한국공간구조학회 2010 한국공간구조학회지 Vol.10 No.3

In this study, the vibration control effect according to the installation location of the sky-bridge and the difference of natural periods of the connected buildings has been investigated. To this end, 40-story and 50-story building structures connected by a sky-bridge were used as example structures and the equivalent modeling method was used. Boundary nonlinear time history analyses were performed using El Centro and Taft earthquakes to investigate the dynamic behavior of the example structures and vibration control effect of the sky-bridge. Based on numerical results, it has been shown that displacement responses can be effectively controlled as the installation floor of the sky-bridge increases and acceleration responses can be effectively reduced when the sky-bridge is installed on the mid-stories of the example building. 본 연구에서는 스카이브릿지 설치위치 및 연결된 구조물의 고유진동주기 차이에 따른 전체 구조물의 진동제어 효과를 분석하였다. 이를 위하여 스카이브릿지로 연결된 40층과 50층 구조물을 예제 구조물로 사용하였고, 등가모형화기법을 이용하여 예제 모델을 구성하였다. El Centro 및 Taft 지진을 사용하여 경계비선형 시간이력해석을 수행하였고 구조물의 동적거동과 진동제어 효과를 분석하였다. 해석결과 변위응답은 스카이브릿지를 상부층에 설치할수록 더 효과적으로 제어할 수 있었고 가속도응답은 구조물의 중간층부근에 설치할 때 더 효과적으로 저감시킬 수 있었다.

2방향 중공슬래브의 진동성능 검토

김현수,Kim, Hyun-Su 한국공간구조학회 2010 한국공간구조학회지 Vol.10 No.1

스마트 TMD를 이용한 개폐식 대공간 구조물의 지진응답제어

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2016 한국공간구조학회지 Vol.16 No.4

A retractable-roof spatial structure is frequently used for a stadium and sports hall. A retractable-roof spatial structure allows natural lighting, ventilation, optimal conditions for grass growth with opened roof. It can also protects users against various weather conditions and give optimal circumstances for different activities. Dynamic characteristics of a retractable-roof spatial structure is changed based on opened or closed roof condition. A tuned mass damper (TMD) is widely used to reduce seismic responses of a structure. When a TMD is properly tuned, its control performance is excellent. Opened or closed roof condition causes dynamic characteristics variation of a retractable-roof spatial structure resulting in off-tuning. This dynamic characteristics variation was investigated. Control performance of a passive TMD and a smart TMD were evaluated under off-tuning condition.

다이어그리드 메가프레임 초고층 건물을 위한 효율적인 해석모델의 개발

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2011 한국공간구조학회지 Vol.11 No.3

비정형 초고층건물을 위한 구조시스템 중에서 다이어그리드 구조시스템은 구조적인 효율성 및 조형성 때문에 널리 사용되고 있다. 근래에는 초고층건물을 위한 구조시스템으로 메가부재의 조합을 통하여 횡방향 강성을 효과적으로 발휘할 수 있는 메가프레임 시스템이 널리 사용되고 있다. 두 가지 구조시스템의 장점을 혼합한 다이어그리드 메가프레임 구조시스템은 미래형 초고층건물에 적용될 유망한 구조시스템으로 평가받고 있다. 그러나 이러한 다이어그리드 메가프레임 구조시스템을 적용한 건물의 거동을 예측하기 위해서는 매우 많은 수의 절점과 요소로 이루어진 유한요소 모델을 해석해야 하므로 상당한 양의 해석시간과 엔지니어의 노력이 필요하게 된다. 따라서 본 연구에서는 다이어그리드 메가프레임시스템을 적용한 초고층건물의 거동을 효율적으로 해석할 수 있는 기법을 제안하여 다이어그리드 메가프레임 초고층건물의 해석과 설계에 소요되는 시간과 노력을 줄이고자 한다. 이를 위하여 다이어그리드 메가프레임의 특정을 활용한 효율적인 모형화기법과 행렬응축기법을 사용하여 해석에 사용되는 자유도수를 최소화한 해석기법을 제안하였다. 예제구조물의 해석을 수행하여 본 연구에서 제안된 해석방법과 일반적인 해석방법에 의한 결과와 비교함으로써 제안된 방법의 효율성과 정확성을 검증하였다. Among structural systems for complex-shaped tall buildings, diagrid system is widely used because of its structural efficiency and beauty of form. Recently, mega frame is favorably employed as a suitable structural system for skyscrapers because this structural system has sufficient stiffness against the lateral forces by combination of mega members which consist of many columns and girders. Diagrid mega frame system is expected to be promising structural system for future super tall buildings. However, it takes tremendous analysis times and engineer's efforts to predict the structural behavior of tall buildings applied with diagrid mega frame system because the diagrid mega frame structure has significant numbers of elements and nodes. Therefore, efficient analytical method for all buildings applied with diagrid mega frame system has been proposed in this study to reduce the efforts and time required for the analysis and design of diagrid mega frame structure. To this end, an efficient modelling technique using the characteristics of diagrid mega frame structures and an efficient analytical model using minimal DOFs by the matrix condensation method were proposed in this study. Based on the analysis of an example structure, the effectiveness and accuracy of the proposed method have been verified by the comparison between the results of the proposed method and the conventional method.

스마트 TMD의 최적설계를 위한 파라메터 연구

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2017 한국공간구조학회지 Vol.17 No.4

A smart tuned mass damper (TMD) was developed to provide better control performance than a passive TMD for reduction of earthquake induced-responses. Because a passive TMD was developed decades ago, optimal design methods for structural parameters of a TMD, such as damping constant and stiffness, have been developed already. However, studies of optimal design method for structural parameters of a smart TMD were little performed to date. Therefore, parameter studies of structural properties of a smart TMD were conducted in this paper to develop optimal design method of a smart TMD under seismic excitation. A retractable-roof spatial structure was used as an example structure. Because dynamic characteristics of a retractable-roof spatial structure is changed based on opened or closed roof condition, control performance of smart TMD under off-tuning was investigated. Because mass ratio of TMD and smart TMD mainly affect control performance, variation of control performance due to mass ratio was investigated. Parameter studies of structural properties of a smart TMD was performed to find optimal damping constant and stiffness and it was compared with the results of optimal passive TMD design method. The design process developed in this study is expected to be used for preliminary design of a smart TMD for a retractable-roof spatial structure.

경사진 고층건물의 진화최적화 알고리즘에 기반한 지진응답 제어

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2021 한국공간구조학회지 Vol.21 No.3

A tilted tall building is actively constructed as landmark structures around world to date. Because lateral displacement responses of a tilted tall building occurs even by its self-weight, reduction of seismic responses is very important to ensure structural safety. In this study, a smart tuned mass damper (STMD) was applied to the example tilted tall building and its seismic response control performance was investigated. The STMD was composed of magnetorheological (MR) damper and it was installed on the top floor of the example building. Control performance of the STMD mainly depends on the control algorithn. Fuzzy logic controller (FLC) was selected as a control algorithm for the STMD. Because composing fuzzy rules and tuning membership functions of FLC are difficult task, evolutionary optimization algorithm (EOA) was used to develop the FLC. After numerical simulations, it has been seen that the STMD controlled by the EOA-optimized FLC can effectively reduce seismic responses fo the tilted tall building.

열차진동하중을 받는 첨단시설물의 스마트 면진시스템을 이용한 미진동제어

김현수,강주원,김영식,Kim, Hyun-Su,Kang, Joo-Won,Kim, Young-Sik 한국공간구조학회 2012 한국공간구조학회지 Vol.12 No.2

정밀한 공정을 요구하는 반도체 및 TFT-LCD와 같은 첨단 기술산업 공장의 미진동 문제는 제품의 성능에 영향을 주는 주요한 인자로서 정밀기기 및 부품의 제조공정에 있어서 중요시 되어왔다. 본 논문에서는 이러한 첨단시설물의 미진동 문제를 해결하기 위하여 기초면진시스템의 미진동제어성능을 검토하였다. 이를 위하여, 기차에서 유발되는 인공지반운동을 생성하여 시간이력해석을 수행하였고 3층 예제구조물을 사용하였다. 수치해석을 통하여 수동 기초면진 및 스마트 면진시스템의 미진동제어성능을 고정기초구조물과 비교하였다. 그 결과 스마트 면진시스템이 미진동제어에 있어서 우수한 제어성능을 나타내는 것을 확인하였다. Microvibration problem of high-technology facilities, such as semi-conductor plants and TFT-LCD plants, has been considered as important factors that affects the performance of products and thus it is regarded as important in facilities with high precision equipments. In this paper, various base isolation control systems are used to investigate their microvibration control performance. To this end, train-induced ground acceleration is used for time history analysis and three-story example building structure is employed. Microvibration control performance of passive and smart base isolation systems have been investigated in this study. Based on numerical simulation results, it has been verified that smart base isolation system can control microvibration of a high-technology facility subjected to train-induced excitation.

적응형 스마트 공유 TMD의 MIMO 제어알고리즘개발

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2015 한국공간구조학회지 Vol.15 No.2

A shared tuned mass damper (STMD) was proposed in previous research for reduction of dynamic responses of the adjacent buildings subjected to earthquake loads. A single STMD can provide similar control performance in comparison with two traditional TMDs. In previous research, a passive damper was used to connect the STMD with adjacent buildings. In this study, a smart magnetorheological (MR) damper was used instead of a passive damper to compose an adaptive smart STMD (ASTMD). Control performance of the ASTMD was investigated by numerical analyses. For this purpose, two 8-story buildings were used as example structures. Multi-input multi-output (MIMO) fuzzy logic controller (FLC) was used to control the command voltages sent to two MR dampers. The MIMO FLC was optimized by a multi-objective genetic algorithm. Numerical analyses showed that the ASTMD can effectively control dynamic responses of adjacent buildings subjected to earthquake excitations in comparison with a passive STMD.